Hairy/enhancer-of-split related with YRPW motif-like (Predicted)

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• AF-1 domain binding Source: RGD
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
• protein homodimerization activity Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• sequence-specific DNA binding Source: RGD

GO - Biological processⁱ

• anterior/posterior pattern specification Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• atrioventricular valve morphogenesis Source: RGD
• cardiac epithelial to mesenchymal transition Source: RGD
• cardiac ventricle morphogenesis Source: RGD
• cellular response to BMP stimulus Source: RGD
• endocardial cushion morphogenesis Source: RGD
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
• glomerulus development Source: RGD
• mesenchymal cell development Source: RGD
• negative regulation of androgen receptor signaling pathway Source: RGD
• negative regulation of DNA-binding transcription factor activity Source: RGD
• negative regulation of gene expression Source: RGD
• negative regulation of transcription, DNA-templated Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• Notch signaling pathway Source: RGD
• outflow tract morphogenesis Source: RGD
• positive regulation of neuron differentiation Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• proximal tubule development Source: RGD
• pulmonary valve morphogenesis Source: RGD
• regulation of neurogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: RGD
• ventricular septum morphogenesis Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• AF-1 domain binding Source: RGD
• protein homodimerization activity Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKRPRAPSGS DGESDGPIDV GQENDLSQMA RPLTTPSPSQ MQARKKRRGI 
        60         70         80         90        100
IEKRRRDRIN SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA 
       110        120        130        140        150
SGGAGFFDAR ALAVDFRSIG FRECLTEVVR YLGVLEGPSS HADPVRIRLL 
       160        170        180        190        200
SHLNSYAAEM EPSPTTTGAL AFPVWPWSFL HSCPGLPSLS SQLAILGRVP 
       210        220        230        240        250
GPVLPNVSSP PYPISALRSA PVHRVPGTIP PAQRNLLPSR GVTSSQRAHP 
       260        270        280        290        300
PERPAAPPPT ALGVRAARSI VPILPCSSPA APGAGKSDDS ASGSISSPSP 
       310        320 
LGPTGRPAGA VFYHSWVSEI TEIGAF                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ