Hairy/enhancer-of-split related with YRPW motif-like (Predicted)

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• AF-1 domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "HeyL promotes neuronal differentiation of neural progenitor cells."
    Jalali A., Bassuk A.G., Kan L., Israsena N., Mukhopadhyay A., McGuire T., Kessler J.A.
    J. Neurosci. Res. 89:299-309(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
    Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., Nakagawa O.
    J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats."
    Kanno K., Ishiura S.
    J. Neurosci. Res. 89:562-575(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts."
    Fischer A., Klattig J., Kneitz B., Diez H., Maier M., Holtmann B., Englert C., Gessler M.
    Mol. Cell. Biol. 25:8960-8970(2005) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "HeyL promotes neuronal differentiation of neural progenitor cells."
    Jalali A., Bassuk A.G., Kan L., Israsena N., Mukhopadhyay A., McGuire T., Kessler J.A.
    J. Neurosci. Res. 89:299-309(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "HeyL promotes neuronal differentiation of neural progenitor cells."
    Jalali A., Bassuk A.G., Kan L., Israsena N., Mukhopadhyay A., McGuire T., Kessler J.A.
    J. Neurosci. Res. 89:299-309(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors."
    Heisig J., Weber D., Englberger E., Winkler A., Kneitz S., Sung W.K., Wolf E., Eilers M., Wei C.L., Gessler M.
    PLoS Genet. 8:e1002728-e1002728(2012) [PubMed] [Europe PMC] [Abstract]
• transcription corepressor activity Source: RGDInferred from sequence orthologyⁱ
  • "HeyL promotes neuronal differentiation of neural progenitor cells."
    Jalali A., Bassuk A.G., Kan L., Israsena N., Mukhopadhyay A., McGuire T., Kessler J.A.
    J. Neurosci. Res. 89:299-309(2011) [PubMed] [Europe PMC] [Abstract]
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anterior/posterior pattern specification Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• atrioventricular valve morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• cardiac epithelial to mesenchymal transition Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• cardiac ventricle morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to BMP stimulus Source: RGDInferred from sequence orthologyⁱ
  • "HeyL promotes neuronal differentiation of neural progenitor cells."
    Jalali A., Bassuk A.G., Kan L., Israsena N., Mukhopadhyay A., McGuire T., Kessler J.A.
    J. Neurosci. Res. 89:299-309(2011) [PubMed] [Europe PMC] [Abstract]
• circulatory system development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• endocardial cushion morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• glomerulus development Source: RGDInferred from sequence orthologyⁱ
  • "Segmental expression of Notch and Hairy genes in nephrogenesis."
    Chen L., Al-Awqati Q.
    Am. J. Physiol. Renal Physiol. 288:F939-52(2005) [PubMed] [Europe PMC] [Abstract]
• mesenchymal cell development Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of androgen receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors."
    Heisig J., Weber D., Englberger E., Winkler A., Kneitz S., Sung W.K., Wolf E., Eilers M., Wei C.L., Gessler M.
    PLoS Genet. 8:e1002728-e1002728(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism."
    Kathiriya I.S., King I.N., Murakami M., Nakagawa M., Astle J.M., Gardner K.A., Gerard R.D., Olson E.N., Srivastava D., Nakagawa O.
    J. Biol. Chem. 279:54937-54943(2004) [PubMed] [Europe PMC] [Abstract]
  • "Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts."
    Fischer A., Klattig J., Kneitz B., Diez H., Maier M., Holtmann B., Englert C., Gessler M.
    Mol. Cell. Biol. 25:8960-8970(2005) [PubMed] [Europe PMC] [Abstract]
  • "HeyL regulates the number of TrkC neurons in dorsal root ganglia."
    Mukhopadhyay A., Jarrett J., Chlon T., Kessler J.A.
    Dev. Biol. 334:142-151(2009) [PubMed] [Europe PMC] [Abstract]
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes."
    Maier M.M., Gessler M.
    Biochem. Biophys. Res. Commun. 275:652-660(2000) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron differentiation Source: RGDInferred from sequence orthologyⁱ
  • "HeyL regulates the number of TrkC neurons in dorsal root ganglia."
    Mukhopadhyay A., Jarrett J., Chlon T., Kessler J.A.
    Dev. Biol. 334:142-151(2009) [PubMed] [Europe PMC] [Abstract]
  • "HeyL promotes neuronal differentiation of neural progenitor cells."
    Jalali A., Bassuk A.G., Kan L., Israsena N., Mukhopadhyay A., McGuire T., Kessler J.A.
    J. Neurosci. Res. 89:299-309(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
  • "Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats."
    Kanno K., Ishiura S.
    J. Neurosci. Res. 89:562-575(2011) [PubMed] [Europe PMC] [Abstract]
• proximal tubule development Source: RGDInferred from sequence orthologyⁱ
  • "Segmental expression of Notch and Hairy genes in nephrogenesis."
    Chen L., Al-Awqati Q.
    Am. J. Physiol. Renal Physiol. 288:F939-52(2005) [PubMed] [Europe PMC] [Abstract]
• pulmonary valve morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of neurogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation."
    Rajan S., Chu Pham Dang H., Djambazian H., Zuzan H., Fedyshyn Y., Ketela T., Moffat J., Hudson T.J., Sladek R.
    Physiol. Genomics 44:183-197(2012) [PubMed] [Europe PMC] [Abstract]
• ventricular septum morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition."
    Fischer A., Steidl C., Wagner T.U., Lang E., Jakob P.M., Friedl P., Knobeloch K.-P., Gessler M.
    Circ. Res. 100:856-863(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• AF-1 domain binding Source: RGDInferred from sequence orthologyⁱ
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors."
    Lavery D.N., Villaronga M.A., Walker M.M., Patel A., Belandia B., Bevan C.L.
    J. Biol. Chem. 286:17796-17808(2011) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "HeyL promotes neuronal differentiation of neural progenitor cells."
    Jalali A., Bassuk A.G., Kan L., Israsena N., Mukhopadhyay A., McGuire T., Kessler J.A.
    J. Neurosci. Res. 89:299-309(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKRPRAPSGS DGESDGPIDV GQENDLSQMA RPLTTPSPSQ MQARKKRRGI 
        60         70         80         90        100
IEKRRRDRIN SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA 
       110        120        130        140        150
SGGAGFFDAR ALAVDFRSIG FRECLTEVVR YLGVLEGPSS HADPVRIRLL 
       160        170        180        190        200
SHLNSYAAEM EPSPTTTGAL AFPVWPWSFL HSCPGLPSLS SQLAILGRVP 
       210        220        230        240        250
GPVLPNVSSP PYPISALRSA PVHRVPGTIP PAQRNLLPSR GVTSSQRAHP 
       260        270        280        290        300
PERPAAPPPT ALGVRAARSI VPILPCSSPA APGAGKSDDS ASGSISSPSP 
       310        320 
LGPTGRPAGA VFYHSWVSEI TEIGAF                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ