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UniProtKB - D3ZIH3 (D3ZIH3_RAT)
Protein
Submitted name:
Hairy/enhancer-of-split related with YRPW motif-like (Predicted)
Gene
Heyl
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- AF-1 domain binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- protein homodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- atrioventricular valve morphogenesis Source: RGD
- cardiac epithelial to mesenchymal transition Source: RGD
- cardiac ventricle morphogenesis Source: RGD
- cellular response to BMP stimulus Source: RGD
- endocardial cushion morphogenesis Source: RGD
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: RGD
- glomerulus development Source: RGD
- mesenchymal cell development Source: RGD
- negative regulation of androgen receptor signaling pathway Source: RGD
- negative regulation of DNA-binding transcription factor activity Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- Notch signaling pathway Source: RGD
- outflow tract morphogenesis Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- proximal tubule development Source: RGD
- pulmonary valve morphogenesis Source: RGD
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- skeletal muscle cell differentiation Source: RGD
- ventricular septum morphogenesis Source: RGD
Keywordsi
Molecular function | RepressorARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Hairy/enhancer-of-split related with YRPW motif-like (Predicted)ImportedSubmitted name: Hes-related family bHLH transcription factor with YRPW motif-like |
Gene namesi | ORF Names:rCG_31478Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305022, Heyl |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000015318, Expressed in brain and 21 other tissues |
Interactioni
GO - Molecular functioni
- AF-1 domain binding Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000020928 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 98 | BHLHInterPro annotationAdd BLAST | 56 | |
Domaini | 120 – 153 | OrangeInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 56 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 224 – 260 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 278 – 304 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 27 – 42 | Polar residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000161351 |
HOGENOMi | CLU_048294_1_1_1 |
OMAi | FLPCPAW |
OrthoDBi | 1201152at2759 |
TreeFami | TF323617 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZIH3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRPRAPSGS DGESDGPIDV GQENDLSQMA RPLTTPSPSQ MQARKKRRGI
60 70 80 90 100
IEKRRRDRIN SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA
110 120 130 140 150
SGGAGFFDAR ALAVDFRSIG FRECLTEVVR YLGVLEGPSS HADPVRIRLL
160 170 180 190 200
SHLNSYAAEM EPSPTTTGAL AFPVWPWSFL HSCPGLPSLS SQLAILGRVP
210 220 230 240 250
GPVLPNVSSP PYPISALRSA PVHRVPGTIP PAQRNLLPSR GVTSSQRAHP
260 270 280 290 300
PERPAAPPPT ALGVRAARSI VPILPCSSPA APGAGKSDDS ASGSISSPSP
310 320
LGPTGRPAGA VFYHSWVSEI TEIGAF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473968 Genomic DNA Translation: EDL80374.1 |
RefSeqi | NP_001101447.1, NM_001107977.1 |
Genome annotation databases
Ensembli | ENSRNOT00000020929.4; ENSRNOP00000020928.2; ENSRNOG00000015318.4 |
GeneIDi | 313575 |
KEGGi | rno:313575 |
UCSCi | RGD:1305022, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473968 Genomic DNA Translation: EDL80374.1 |
RefSeqi | NP_001101447.1, NM_001107977.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000020928 |
Genome annotation databases
Ensembli | ENSRNOT00000020929.4; ENSRNOP00000020928.2; ENSRNOG00000015318.4 |
GeneIDi | 313575 |
KEGGi | rno:313575 |
UCSCi | RGD:1305022, rat |
Organism-specific databases
CTDi | 26508 |
RGDi | 1305022, Heyl |
Phylogenomic databases
eggNOGi | KOG4304, Eukaryota |
GeneTreei | ENSGT00940000161351 |
HOGENOMi | CLU_048294_1_1_1 |
OMAi | FLPCPAW |
OrthoDBi | 1201152at2759 |
TreeFami | TF323617 |
Gene expression databases
Bgeei | ENSRNOG00000015318, Expressed in brain and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR003650, Orange_dom |
Pfami | View protein in Pfam PF07527, Hairy_orange, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00511, ORANGE, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS51054, ORANGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZIH3_RAT | |
Accessioni | D3ZIH3Primary (citable) accession number: D3ZIH3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |