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Entry version 75 (17 Jun 2020)
Sequence version 2 (22 Jul 2015)
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Protein

FYN-binding protein 1

Gene

Fyb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-202433 Generation of second messenger molecules
R-RNO-391160 Signal regulatory protein family interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FYN-binding protein 1By similarity
Alternative name(s):
Adhesion and degranulation promoting adaptor proteinBy similarity
Short name:
ADAPBy similarity
FYB-120/130By similarity
Short name:
p120/p130By similarity
FYN-T-binding proteinBy similarity
SLAP-1301 Publication
SLP-76-associated phosphoproteinBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fyb1Imported
Synonyms:FybImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
1563421 Fyb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004484841 – 830FYN-binding protein 1Add BLAST830

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13N6-acetyllysineBy similarity1
Modified residuei38PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1
Modified residuei329PhosphoserineBy similarity1
Modified residuei456PhosphoserineBy similarity1
Modified residuei570PhosphotyrosineBy similarity1
Modified residuei572PhosphoserineBy similarity1
Modified residuei698PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

T-cell receptor ligation leads to increased tyrosine phosphorylation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZIE4

PeptideAtlas

More...
PeptideAtlasi
D3ZIE4

PRoteomics IDEntifications database

More...
PRIDEi
D3ZIE4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000013886 Expressed in spleen and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex consisting of SKAP2, FYB1 and PTPNS1 (By similarity).

Part of a complex consisting of SKAP2, FYB1 and LILRB3 (By similarity).

Part of a complex consisting of SKAP1, FYB1 and CLNK (PubMed:12681493).

Interacts with CLNK (via its SH2 domain) and FYN; this interaction allows SKAP1 and FYB1 to recruit FYN to the complex, thus promoting the phosphorylation of CLNK by FYN (By similarity).

Interacts with FYN (By similarity).

Interacts with LCP2 (By similarity).

Interacts with SKAP1 (PubMed:12681493).

Interacts with SKAP2 (By similarity).

Interacts with FASLG (By similarity).

Interacts with EVL (By similarity).

Interacts with TMEM47 (By similarity).

Interacts with LCK (By similarity).

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000018634

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZIE4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini510 – 571SH3 1PROSITE-ProRule annotationAdd BLAST62
Domaini747 – 815SH3 2PROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni347 – 447Interaction with SKAP1By similarityAdd BLAST101

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili465 – 502Sequence analysisAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi461 – 464SH2-bindingSequence analysis4
Motifi479 – 486Nuclear localization signalPROSITE-ProRule annotation8
Motifi595 – 598SH2-binding; to LCP2By similarity4
Motifi626 – 629SH2-binding; to FYNBy similarity4
Motifi732 – 739Nuclear localization signalPROSITE-ProRule annotation8

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEQF Eukaryota
ENOG410YD3U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063460

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_339375_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSSTWSW

Database of Orthologous Groups

More...
OrthoDBi
831692at2759

TreeFam database of animal gene trees

More...
TreeFami
TF337003

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11867 hSH3_ADAP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030635 FYB
IPR035540 FYB_hSH3
IPR029294 hSH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR16830:SF13 PTHR16830:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14603 hSH3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZIE4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGKTDVKSL MAKFNTGSNP TEEVSTSSRP FKVAGQNSPS GIQSKKNLFD
60 70 80 90 100
NQGNASPPAG PSNMSKFGTT KPPLAAKPTY EEKSEKEPKP PFLKPTGVSP
110 120 130 140 150
RFGTQPNSVS RDPEVKVGFL KPVSPKPTSL TKEDSKPVIL RPPGNKLHNL
160 170 180 190 200
NQESDLKTLG PKPGSTPPVP ENDLKPGFSK IAGAKSKFMP APQDADSKPR
210 220 230 240 250
FPRHTYGQKP SLSTEDAQEE ESIPKNTPVQ KGSPVQLGAK SRGSPFKPAK
260 270 280 290 300
EDPEDKDHGT PSSPFAGVVL KPAASRGSPG LSKNSEEKKE ERKTDIPKNI
310 320 330 340 350
FLNKLNQEEP ARFPKAPSKL TAGTPWGQSQ EKEGDKDSAT PKQKPLPPLS
360 370 380 390 400
VLGPPPSKPS RPPNVDLTRF RKADSANSSN KSQTPYSTTS LPPPPPTQPA
410 420 430 440 450
SQPPLPASHP AHLPAPSLPP RNIKPPLDLK HPINEENQDG VMHSDGTGNL
460 470 480 490 500
EEEQESDGEM YEDIESSKER DKKREKEEKK RLELERKEQK EREKKEQELR
510 520 530 540 550
KKFKLTGPIQ VIHHAKACCD VKGGKNELSF KQGEDIEIIR ITDNPEGKWL
560 570 580 590 600
GRTARGSYGY IKTTAVKIDY DSLKRKKNTI NAVPPRPVEE DQDVYDDVAE
610 620 630 640 650
QDAPNSHSQS GSGGMFPPPP ADDDIYDGIE EEDADDGSVP QVDEKTNAWS
660 670 680 690 700
WGILKMLKGK DERKKSIREK PKVSESDSNE GSSFPSPHKQ LDVGEEVYDD
710 720 730 740 750
VDASDFPPPP AEMSQGMSVG KTKAEEKDPK KLKKQEKEEK DLRKKFKYDG
760 770 780 790 800
EIRVLYSTKV ASSLTSKKWG TRDLQIKPGE SLEVIQSTDD TKVLCRNEEG
810 820 830
KYGYVLRSYL VDNDGEIYDD IADGCIYDND
Length:830
Mass (Da):91,412
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4734DA9759534259
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07008397 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006232081.1, XM_006232019.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000018634; ENSRNOP00000018634; ENSRNOG00000013886

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
499537

UCSC genome browser

More...
UCSCi
RGD:1563421 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008397 Genomic DNA No translation available.
RefSeqiXP_006232081.1, XM_006232019.3

3D structure databases

SMRiD3ZIE4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018634

Proteomic databases

PaxDbiD3ZIE4
PeptideAtlasiD3ZIE4
PRIDEiD3ZIE4

Genome annotation databases

EnsembliENSRNOT00000018634; ENSRNOP00000018634; ENSRNOG00000013886
GeneIDi499537
UCSCiRGD:1563421 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2533
RGDi1563421 Fyb1

Phylogenomic databases

eggNOGiENOG410IEQF Eukaryota
ENOG410YD3U LUCA
GeneTreeiENSGT00530000063460
HOGENOMiCLU_339375_0_0_1
OMAiKSSTWSW
OrthoDBi831692at2759
TreeFamiTF337003

Enzyme and pathway databases

ReactomeiR-RNO-202433 Generation of second messenger molecules
R-RNO-391160 Signal regulatory protein family interactions

Gene expression databases

BgeeiENSRNOG00000013886 Expressed in spleen and 8 other tissues

Family and domain databases

CDDicd11867 hSH3_ADAP, 1 hit
InterProiView protein in InterPro
IPR030635 FYB
IPR035540 FYB_hSH3
IPR029294 hSH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR16830:SF13 PTHR16830:SF13, 1 hit
PfamiView protein in Pfam
PF14603 hSH3, 2 hits
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFYB1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZIE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2019
Last sequence update: July 22, 2015
Last modified: June 17, 2020
This is version 75 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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