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UniProtKB - D3ZIA9 (D3ZIA9_RAT)
Protein
Submitted name:
GLIS family zinc finger 2
Gene
Glis2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- cell differentiation involved in kidney development Source: RGD
- central nervous system development Source: GO_Central
- hematopoietic stem cell homeostasis Source: RGD
- kidney development Source: RGD
- negative regulation of DNA-binding transcription factor activity Source: RGD
- negative regulation of smoothened signaling pathway Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of protein localization to nucleus Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription from RNA polymerase II promoter involved in kidney development Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: GLIS family zinc finger 2 |
Gene namesi | Name:Glis2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309177, Glis2 |
Subcellular locationi
Nucleus
- nuclear speck Source: RGD
- nucleus Source: RGD
Other locations
- non-motile cilium Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000004766, Expressed in adult mammalian kidney and 21 other tissues |
Structurei
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158383 |
HOGENOMi | CLU_031801_1_0_1 |
OMAi | APKDKCL |
OrthoDBi | 1318335at2759 |
TreeFami | TF351425 |
Family and domain databases
InterProi | View protein in InterPro IPR030432, Glis2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR19818:SF84, PTHR19818:SF84, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
D3ZIA9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSLDEPLDL KLSITKLRAA REKRERTLGV PRHHALHREL GLVDDSPTPG
60 70 80 90 100
SPGSPPPGFL LNPKFPEKLD GRFSAAPLVD LSLSPPSGLD SPNGSSSLSP
110 120 130 140 150
ERQGNGDLPP LPTAVDFQPL RYLDGVPSSF QFFLPLGSGG ALHLPASSFL
160 170 180 190 200
TPPKDKCLSP ELPLAKQLVC RWAKCNQLFE LLQDLVDHVN DHHVKPEQDA
210 220 230 240 250
RYCCHWEGCA RHGRGFNASR YKMLIHIRTH TNEKPHRCPT CNKSFSRLEN
260 270 280 290 300
LKIHNRSHTG EKPYVCPYEG CNKRYSNSSD RFKHTRTHYV DKPYYCKMPG
310 320 330 340 350
CHKRYTDPSS LRKHIKAHGH FVSHEQQELL QLRPPPKPPL PTPDSGSYVS
360 370 380 390 400
GAQIIIPNPA ALFGGPSLPG LPLPLAPGPL DLSALACGNG GGGGGGMGPG
410 420 430 440 450
LPGSVLPLNL AKNPLLPSPF GAGGLGLPVV SLLGGSAGSK AEGEKGRGSV
460 470 480 490 500
PARVLGLEDH KTSLERTERS RSRPSPDGLP LLPGTVLDLS TGNSAASSPE
510 520
ALTPGWVVIP PGSVLLKPAV VN
Sequence databases
RefSeqi | NP_001100448.1, NM_001106978.1 XP_017452708.1, XM_017597219.1 |
Genome annotation databases
Ensembli | ENSRNOT00000006680.6; ENSRNOP00000006680.5; ENSRNOG00000004766.6 |
GeneIDi | 302946 |
KEGGi | rno:302946 |
UCSCi | RGD:1309177, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001100448.1, NM_001106978.1 XP_017452708.1, XM_017597219.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006680 |
Genome annotation databases
Ensembli | ENSRNOT00000006680.6; ENSRNOP00000006680.5; ENSRNOG00000004766.6 |
GeneIDi | 302946 |
KEGGi | rno:302946 |
UCSCi | RGD:1309177, rat |
Organism-specific databases
CTDi | 84662 |
RGDi | 1309177, Glis2 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000158383 |
HOGENOMi | CLU_031801_1_0_1 |
OMAi | APKDKCL |
OrthoDBi | 1318335at2759 |
TreeFami | TF351425 |
Gene expression databases
Bgeei | ENSRNOG00000004766, Expressed in adult mammalian kidney and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR030432, Glis2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR19818:SF84, PTHR19818:SF84, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZIA9_RAT | |
Accessioni | D3ZIA9Primary (citable) accession number: D3ZIA9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | May 25, 2022 | |
Last modified: | May 25, 2022 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |