Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 85 (13 Nov 2019)
Sequence version 2 (03 Apr 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

RAS protein activator like 1 (GAP1 like) (Predicted)

Gene

Rasal1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5658442 Regulation of RAS by GAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RAS protein activator like 1 (GAP1 like) (Predicted)Imported
Submitted name:
RAS protein activator-like 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rasal1Imported
Synonyms:Rasal1_predictedImported
ORF Names:rCG_21923Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Rat genome database

More...
RGDi
1311820 Rasal1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001374 Expressed in 7 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001856

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZHY9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 88C2InterPro annotationAdd BLAST88
Domaini135 – 216C2InterPro annotationAdd BLAST82
Domaini300 – 510Ras-GAPInterPro annotationAdd BLAST211
Domaini565 – 672PHInterPro annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili773 – 800Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2059 Eukaryota
ENOG410Y128 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158715

KEGG Orthology (KO)

More...
KOi
K17632

Identification of Orthologs from Complete Genome Data

More...
OMAi
PDWQVRS

Database of Orthologous Groups

More...
OrthoDBi
145372at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05135 RasGAP_RASAL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR028555 RASAL1
IPR037776 RASAL_RasGAP
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif

The PANTHER Classification System

More...
PANTHERi
PTHR10194 PTHR10194, 1 hit
PTHR10194:SF3 PTHR10194:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZHY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKSGSLSIR VVEGRALPAK DVSGSSDPYC LVKVDDEVVA RTATIWRSLS
60 70 80 90 100
PFWGEEYTVH LPLDFHHLAF YVLDEDTVGH DDIIGKISLS KEAITADPRG
110 120 130 140 150
IDSWINLSRV DPDEEVQGEV CLAVKLLEDA RGRCLRCHVR QARDLAPRDI
160 170 180 190 200
SGTSDPFARV FWGSRSLETS TIKKTRFPHW DEVLELREAP GTTSPLRVEL
210 220 230 240 250
WDWDMVGKND FLGMVEFTPQ TLQQKPPNGW FRLLPFPRAE DSGGSLGALR
260 270 280 290 300
LKVRLTEDRV LPSQYYQPLM ELLLESVQGP AEEDTTSPLA LLEELASGDC
310 320 330 340 350
RQDLATKLVK LFLGRGLAGP FLDYLTRREV ARTNDPNTLF RSNSLASKSM
360 370 380 390 400
EQFMKLVGMR YLHEVLRPVI SRVFEEKKYM ELDPSKMDLN RSRRISFKGT
410 420 430 440 450
PTEEQVRETS LGLLTGYLGS VVDAIVSSAG RCPLALRLAF KQLQQCVEKR
460 470 480 490 500
FPGMEHQDVK YLATSGFLFL RFFAPAILTP KLFDLRDHHA DPQTSRSLLL
510 520 530 540 550
LAKAVQSIGN LGQQLGQGKE QWLAPLHPFL LQSISRVRDF LDQLVDVDGD
560 570 580 590 600
EEAGGSTCAL VQPSTIVREG FLLKRKEEPA SLATRFAFKK RYFRLSGRDL
610 620 630 640 650
SYSKTPEWQV HSSIPLSCIR AVERVDEGAF QLPHVMQVVT QDGTGASHTT
660 670 680 690 700
YLQCKNVNDL NQWLSALRKA SAPNPGKLAA CHPGAFRSGR WTCCLQAERS
710 720 730 740 750
AVGCSRTHSA VTLGDWSDPL DPDAEAQMVY RQLLLGRDQL RLKLLEDSSL
760 770 780 790 800
DTAPDVDPGK DSSAVDGPCA EVLAQQREAT TRLLQVLEDL EQAHEEFQKR

G
Length:801
Mass (Da):89,597
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD38A52D4AD3936B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07036386 Genomic DNA No translation available.
CH473973 Genomic DNA Translation: EDM13771.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101805.1, NM_001108335.1
XP_006249457.1, XM_006249395.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000001856; ENSRNOP00000001856; ENSRNOG00000001374

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
360814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:360814

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07036386 Genomic DNA No translation available.
CH473973 Genomic DNA Translation: EDM13771.1
RefSeqiNP_001101805.1, NM_001108335.1
XP_006249457.1, XM_006249395.3

3D structure databases

SMRiD3ZHY9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001856

Genome annotation databases

EnsembliENSRNOT00000001856; ENSRNOP00000001856; ENSRNOG00000001374
GeneIDi360814
KEGGirno:360814

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8437
RGDi1311820 Rasal1

Phylogenomic databases

eggNOGiKOG2059 Eukaryota
ENOG410Y128 LUCA
GeneTreeiENSGT00940000158715
KOiK17632
OMAiPDWQVRS
OrthoDBi145372at2759

Enzyme and pathway databases

ReactomeiR-RNO-5658442 Regulation of RAS by GAPs

Gene expression databases

BgeeiENSRNOG00000001374 Expressed in 7 organ(s), highest expression level in brain

Family and domain databases

CDDicd05135 RasGAP_RASAL, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR028555 RASAL1
IPR037776 RASAL_RasGAP
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif
PANTHERiPTHR10194 PTHR10194, 1 hit
PTHR10194:SF3 PTHR10194:SF3, 1 hit
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZHY9_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZHY9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 13, 2019
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again