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Protein

ATP-dependent RNA helicase DHX29

Gene

Dhx29

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase, Initiation factorUniRule annotation
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DHX29UniRule annotation (EC:3.6.4.13UniRule annotation)
Alternative name(s):
DEAH box protein 29UniRule annotation
Gene namesi
Name:Dhx29Imported
Synonyms:DHX29UniRule annotation, LOC100362324Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2318361 Dhx29

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiD3ZHW0
PeptideAtlasiD3ZHW0
PRIDEiD3ZHW0

Expressioni

Gene expression databases

BgeeiENSRNOG00000010369 Expressed in 9 organ(s), highest expression level in Ammon's horn

Interactioni

Subunit structurei

Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013854

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini582 – 755Helicase ATP-bindingInterPro annotationAdd BLAST174
Domaini849 – 1026Helicase C-terminalInterPro annotationAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili281 – 308UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the DEAD box helicase family. DEAH subfamily.UniRule annotation

Keywords - Domaini

Coiled coilUniRule annotation

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00760000119189
InParanoidiD3ZHW0
KOiK18995
OMAiQTYGWLL
OrthoDBiEOG091G01I0
TreeFamiTF324744

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_03068 DHX29, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR034730 DHX29
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZHW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGKNKKHKA PGAAAMRAAV SASRARSAEA GAVGEAQSKK PVARPAPAVP
60 70 80 90 100
TSAREPRVKQ GPKIYSFNSA NDSGGSANLD KSILKVVINN KLEQRIIGVI
110 120 130 140 150
NEHKKQNNDR GVISGRLSAK KLQDLYMALQ AFSFKTKDIE DAMTNTLLHG
160 170 180 190 200
GDLHSALDWL CLNLSDDALP EGFSQEFEEQ QPKSRPKFQS VQIQATLSPP
210 220 230 240 250
LQTKTKRQEE DPKIKPKKEE KSMEVNMKEW ILRYAEQQNE EEKSEGSKGS
260 270 280 290 300
EDEDKFDPNQ RYLNLAARLL DAKEQAAAFK VEKNKQGQKE AQEKIRKFQR
310 320 330 340 350
EMETLEDHPI FNPAIKISHQ QNERKKAPLA TDGESALNFN LFEKPAAATE
360 370 380 390 400
EEKGKKKEPH DVRNFDYTAR SWTGKSPKQF LIDWVRKNLP KSPNPSFEKV
410 420 430 440 450
PVGRYWKCRV RVVKSEDDVL VVCPTILTED GMQAQHLGAT LALYRLVKGQ
460 470 480 490 500
SVHQLLPPTY RDVWVEWSDE EKKKEELNKM ETNKPRDLFI AKLLSKLKQQ
510 520 530 540 550
QQLQQQRQHP ENKTETAEDP EESWENLVSD EDLSALSLEP TGAEDLEPVR
560 570 580 590 600
NLFRRLQSTP KYQRLLKERQ QLPVFKHRAS IVETLKRHRV VVVAGETGSG
610 620 630 640 650
KSTQVPHFLL EDLLLNDCGA RKCNIVCTQP RRISAVSLAT RVCEELGCEG
660 670 680 690 700
GPGGRNSLCG YQIRMESRAS ESTRLLYCTT GVLLRKLQED GLLADVSHVI
710 720 730 740 750
VDEVHERSVQ SDFLLVILKE ILQKRSDLHL ILMSATVDSD KFSTYFTHCP
760 770 780 790 800
ILRISGRSYP VEVFHLEDIV EETGFILEKD SEYCQKFLEE EEEITINVTS
810 820 830 840 850
KAGGIKKYQE CIPVQSGASP ELSPFYQKYS SRTQYAVLYM NPHKINLDLI
860 870 880 890 900
LELLVYLDKS PQFRNIEGAV LIFLPGLAHI QQLYDLLSND RRFYSERYQL
910 920 930 940 950
IALHSVLSTQ DQAAAFMLPP PGVRKIVLAT NIAETGITIP DVVFVIDTGR
960 970 980 990 1000
TKENKYHESS QMSSLVETFV SKASALQRQG RAGRVRDGFC FRLYTRERFE
1010 1020 1030 1040 1050
GFLEYSVPEI LRVPLEELCL HIMKCDLGSP EDFLSKALDP PQPQVISNAM
1060 1070 1080 1090 1100
NLLRKIGACE PSEPKLTPLG QHLAALPVNV KIGKMLIFGA IFGCLEPVAT
1110 1120 1130 1140 1150
LAAVMTEKSP FITPIGRKDE ADLAKSSLAV ADSDHLTIYN AYLGWKKAQQ
1160 1170 1180 1190 1200
EGGFRSEISY CQRNFLNRTS LLTLEDVKQE LMKLVRAAGF SSSTSWEGKK
1210 1220 1230 1240 1250
GPQALSFQDI ALLKAVLAAG LYDSVGKIMC TKSVDVTEKL ACMVETAQGK
1260 1270 1280 1290 1300
AQVHPSSVNR DLQTYGWLLY QEKVRYARVY LRETTLITPF PVLLFGGDIE
1310 1320 1330 1340 1350
VQHRERLLSV DGWIYFQAPV KIAVIFKQLR VLIDSVLRKK LENPKMSLEN
1360
DKILQIITEL IKTENN
Length:1,366
Mass (Da):154,119
Last modified:April 3, 2013 - v2
Checksum:iF8B513F3164A5476
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106510 Genomic DNA No translation available.
RefSeqiXP_002725935.1, XM_002725889.5
XP_002729053.2, XM_002729007.5

Genome annotation databases

EnsembliENSRNOT00000013854; ENSRNOP00000013854; ENSRNOG00000010369
GeneIDi100362324
KEGGirno:100362324

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106510 Genomic DNA No translation available.
RefSeqiXP_002725935.1, XM_002725889.5
XP_002729053.2, XM_002729007.5

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013854

Proteomic databases

PaxDbiD3ZHW0
PeptideAtlasiD3ZHW0
PRIDEiD3ZHW0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013854; ENSRNOP00000013854; ENSRNOG00000010369
GeneIDi100362324
KEGGirno:100362324

Organism-specific databases

CTDi54505
RGDi2318361 Dhx29

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00760000119189
InParanoidiD3ZHW0
KOiK18995
OMAiQTYGWLL
OrthoDBiEOG091G01I0
TreeFamiTF324744

Gene expression databases

BgeeiENSRNOG00000010369 Expressed in 9 organ(s), highest expression level in Ammon's horn

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_03068 DHX29, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR034730 DHX29
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3ZHW0_RAT
AccessioniPrimary (citable) accession number: D3ZHW0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: November 7, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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