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Entry version 85 (12 Aug 2020)
Sequence version 3 (22 Jul 2015)
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Protein

Delta-like protein 4

Gene

Dll4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4 (PubMed:25700513). Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-like protein 41 Publication
Alternative name(s):
Drosophila Delta homolog 4Curated
Short name:
Delta4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dll4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
1309740, Dll4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 530ExtracellularCuratedAdd BLAST503
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 686CytoplasmicCuratedAdd BLAST135

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi65H → A: Strongly decreased binding to Notch1. 1 Publication1
Mutagenesisi66Y → A: Decreased binding to Notch1. 1 Publication1
Mutagenesisi196F → A: Strongly decreased binding to Notch1. 1 Publication1
Mutagenesisi217Y → A: No binding to Notch1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500305334128 – 686Delta-like protein 4Add BLAST659

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 55Combined sources1 Publication
Disulfide bondi62 ↔ 75Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi109N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi162N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi176 ↔ 185PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi189 ↔ 201PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi209 ↔ 218PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi223 ↔ 234PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi227 ↔ 240PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi242 ↔ 251PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi254 ↔ 265Combined sources1 Publication
Disulfide bondi260 ↔ 271Combined sources1 Publication
Disulfide bondi273 ↔ 282PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi289 ↔ 301PROSITE-ProRule annotation
Disulfide bondi295 ↔ 311PROSITE-ProRule annotation
Disulfide bondi313 ↔ 322PROSITE-ProRule annotation
Disulfide bondi329 ↔ 340PROSITE-ProRule annotation
Disulfide bondi334 ↔ 349PROSITE-ProRule annotation
Disulfide bondi351 ↔ 360PROSITE-ProRule annotation
Disulfide bondi367 ↔ 378PROSITE-ProRule annotation
Disulfide bondi372 ↔ 389PROSITE-ProRule annotation
Disulfide bondi391 ↔ 400PROSITE-ProRule annotation
Disulfide bondi407 ↔ 418PROSITE-ProRule annotation
Disulfide bondi412 ↔ 427PROSITE-ProRule annotation
Disulfide bondi429 ↔ 438PROSITE-ProRule annotation
Disulfide bondi445 ↔ 456PROSITE-ProRule annotation
Disulfide bondi450 ↔ 465PROSITE-ProRule annotation
Disulfide bondi467 ↔ 476PROSITE-ProRule annotation
Disulfide bondi485 ↔ 496PROSITE-ProRule annotation
Disulfide bondi490 ↔ 507PROSITE-ProRule annotation
Disulfide bondi509 ↔ 518PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZHH1

PRoteomics IDEntifications database

More...
PRIDEi
D3ZHH1

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
D3ZHH1, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZHH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000014011, Expressed in lung and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NOTCH4 (By similarity).

Interacts (via N-terminal DSL and MNNL domains) with NOTCH1 (via EGF-like domains) (PubMed:25700513).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei111Interaction with Notch11 Publication1
Sitei217Interaction with Notch11 Publication1

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D3ZHH1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000018970

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1686
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZHH1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 218DSLPROSITE-ProRule annotationAdd BLAST45
Domaini219 – 252EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini256 – 283EGF-like 2PROSITE-ProRule annotationAdd BLAST28
Domaini285 – 323EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini325 – 361EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini363 – 401EGF-like 5PROSITE-ProRule annotationAdd BLAST39
Domaini403 – 439EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini441 – 477EGF-like 7PROSITE-ProRule annotationAdd BLAST37
Domaini481 – 519EGF-like 8PROSITE-ProRule annotationAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni186 – 188Interaction with Notch11 Publication3
Regioni192 – 196Interaction with Notch11 Publication5

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157441

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012574_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZHH1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDECIPH

Database of Orthologous Groups

More...
OrthoDBi
406049at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZHH1

TreeFam database of animal gene trees

More...
TreeFami
TF351835

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR011651, Notch_ligand_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 4 hits
PF12661, hEGF, 1 hit
PF07657, MNNL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 9 hits
SM00179, EGF_CA, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS51051, DSL, 1 hit
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZHH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPGSRSACR WALLLLAVLW PQQRAAGSGI FQLRLQEFAN ERGMLANGRP
60 70 80 90 100
CEPGCRTFFR ICLKHYQATF SEGPCTFGNV STPVLGTNSF VIRDKNSGSG
110 120 130 140 150
RNPLQLPFNF TWPGTFSLNI QAWHTPGDDL RPETSPGNSL ISQIIIQGSL
160 170 180 190 200
AVGKNWKSDE QNNTLTRLRY SYRVVCSDNY YGDSCSRLCK KRDDHFGHYE
210 220 230 240 250
CQPDGSLSCL PGWTGKYCDQ PICLSGCHEQ NGYCSKPDEC NCRPGWQGPL
260 270 280 290 300
CNECIPHNGC RHGTCTIPWQ CACDEGWGGL FCDQDLNYCT HHSPCKNGST
310 320 330 340 350
CSNSGPRGYT CTCLPGYTGE HCELELSKCA SNPCRNGGSC KDHENSYHCL
360 370 380 390 400
CPPGYYGQHC EHSTLTCADS PCFNGGSCRE RNQGASYACE CPPNFTGSNC
410 420 430 440 450
EKKVDRCTSN PCANGGQCLN RGPSRTCRCR PGFTGTHCEL HISDCARSPC
460 470 480 490 500
AHGGTCHDLE NGPVCTCPAG FSGRRCEVRI TNDACASGPC FNGATCYTGL
510 520 530 540 550
SPNNFVCNCP YGFVGSRCEF PVGLPPSFPW VAVSLGVGLV VLLVLLVMVA
560 570 580 590 600
VAVRQLRLRR PDDDSREAMN NLSDFQKDNL IPAAQLKNTN QKKELEVDCG
610 620 630 640 650
LDKSNCGKLQ NHTLDYNLAP GFLGRGSTPG KYPHSDKSLG EKVPLRLHSE
660 670 680
KPACRISAIC SPRDSMYQSV CLISEERNEC VIATEV
Length:686
Mass (Da):74,961
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB6B5EDC50CA8498
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC132987 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006234827.1, XM_006234765.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000018970; ENSRNOP00000018970; ENSRNOG00000014011

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
311332

UCSC genome browser

More...
UCSCi
RGD:1309740, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132987 Genomic DNA No translation available.
RefSeqiXP_006234827.1, XM_006234765.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XL1X-ray2.30B/E28-253[»]
4XLWX-ray3.39B/D/F/H28-284[»]
SMRiD3ZHH1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiD3ZHH1, 2 interactors
STRINGi10116.ENSRNOP00000018970

PTM databases

GlyGeniD3ZHH1, 3 sites
iPTMnetiD3ZHH1

Proteomic databases

PaxDbiD3ZHH1
PRIDEiD3ZHH1

Genome annotation databases

EnsembliENSRNOT00000018970; ENSRNOP00000018970; ENSRNOG00000014011
GeneIDi311332
UCSCiRGD:1309740, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54567
RGDi1309740, Dll4

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000157441
HOGENOMiCLU_012574_1_0_1
InParanoidiD3ZHH1
OMAiCDECIPH
OrthoDBi406049at2759
PhylomeDBiD3ZHH1
TreeFamiTF351835

Enzyme and pathway databases

ReactomeiR-RNO-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZHH1

Gene expression databases

BgeeiENSRNOG00000014011, Expressed in lung and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR009030, Growth_fac_rcpt_cys_sf
IPR011651, Notch_ligand_N
PfamiView protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 4 hits
PF12661, hEGF, 1 hit
PF07657, MNNL, 1 hit
SMARTiView protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 9 hits
SM00179, EGF_CA, 6 hits
SUPFAMiSSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS51051, DSL, 1 hit
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLL4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZHH1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: July 22, 2015
Last modified: August 12, 2020
This is version 85 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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