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Entry version 74 (26 Feb 2020)
Sequence version 1 (20 Apr 2010)
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Protein

Filamin-C

Gene

Flnc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-446353 Cell-extracellular matrix interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Filamin-C
Short name:
FLN-C
Alternative name(s):
ABP-280-like protein
ABP-L
Actin-binding-like protein
Filamin-2
Gamma-filamin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Flnc
Synonyms:Abpl, Fln2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1308807 Flnc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004296331 – 2726Filamin-CAdd BLAST2726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphoserineBy similarity1
Modified residuei1003Omega-N-methylarginineBy similarity1
Modified residuei1162PhosphoserineBy similarity1
Modified residuei1339PhosphoserineBy similarity1
Modified residuei2043PhosphoserineBy similarity1
Modified residuei2234PhosphoserineCombined sources1
Modified residuei2237PhosphoserineCombined sources1
Modified residuei2239PhosphothreonineBy similarity1
Modified residuei2587PhosphoserineBy similarity1
Modified residuei2618PhosphoserineBy similarity1
Modified residuei2621PhosphoserineBy similarity1
Modified residuei2633PhosphoserineBy similarity1
Modified residuei2715PhosphoserineBy similarity1
Modified residuei2719PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by FBXL22, leading to proteasomal degradation.By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZHA0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZHA0

PeptideAtlas

More...
PeptideAtlasi
D3ZHA0

PRoteomics IDEntifications database

More...
PRIDEi
D3ZHA0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZHA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZHA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007281 Expressed in skeletal muscle tissue and 9 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3ZHA0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3ZHA0 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; the filamin repeat 24 and the second hinge domain are important for dimer formation (By similarity).

Interacts with FLNB, KCND2, INPPL1, ITGB1A, MYOT, MYOZ1 and MYOZ3 (By similarity).

Interacts with sarcoglycans SGCD and SGCG (By similarity).

Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only) (By similarity).

Interacts with FBLIM1 (By similarity).

Interacts with KY (By similarity).

Interacts with IGFN1 (By similarity).

Interacts with MICALL2 (By similarity).

Interacts with XIRP1; this interaction is mediated by filamin 20 repeat (By similarity).

Interacts with ANK3.

Interacts with SYNPO2 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
263368, 2 interactors

Protein interaction database and analysis system

More...
IntActi
D3ZHA0, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000027237

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZHA0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 143Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST107
Domaini160 – 263Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST104
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati271 – 369Filamin 1Add BLAST99
Repeati371 – 469Filamin 2Add BLAST99
Repeati470 – 566Filamin 3Add BLAST97
Repeati567 – 659Filamin 4Add BLAST93
Repeati663 – 759Filamin 5Add BLAST97
Repeati760 – 862Filamin 6Add BLAST103
Repeati863 – 961Filamin 7Add BLAST99
Repeati962 – 1057Filamin 8Add BLAST96
Repeati1058 – 1150Filamin 9Add BLAST93
Repeati1151 – 1245Filamin 10Add BLAST95
Repeati1246 – 1345Filamin 11Add BLAST100
Repeati1346 – 1438Filamin 12Add BLAST93
Repeati1439 – 1534Filamin 13Add BLAST96
Repeati1535 – 1631Filamin 14Add BLAST97
Repeati1636 – 1735Filamin 15Add BLAST100
Repeati1760 – 1854Filamin 16Add BLAST95
Repeati1855 – 1947Filamin 17Add BLAST93
Repeati1948 – 2034Filamin 18Add BLAST87
Repeati2037 – 2129Filamin 19Add BLAST93
Repeati2245 – 2307Filamin 20; mediates interaction with XIRP1PROSITE-ProRule annotationAdd BLAST63
Repeati2310 – 2402Filamin 21Add BLAST93
Repeati2404 – 2497Filamin 22Add BLAST94
Repeati2501 – 2593Filamin 23Add BLAST93
Repeati2631 – 2725Filamin 24Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 260Actin-bindingAdd BLAST260
Regioni1736 – 1759Hinge 1Add BLAST24
Regioni2163 – 2244Intradomain insert; mediate targeting to Z linesBy similarityAdd BLAST82
Regioni2404 – 2725Interaction with INPPL1By similarityAdd BLAST322
Regioni2594 – 2726Self-association site, tailBy similarityAdd BLAST133
Regioni2594 – 2630Hinge 2Add BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the filamin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0518 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153588

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000783_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZHA0

KEGG Orthology (KO)

More...
KOi
K04437

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRYTAVQ

Database of Orthologous Groups

More...
OrthoDBi
35998at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313685

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.60.40.10, 24 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF00630 Filamin, 23 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00557 IG_FLMN, 24 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF81296 SSF81296, 24 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50194 FILAMIN_REPEAT, 24 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3ZHA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNNSNYSDA SGLGLLDEAD EMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH
60 70 80 90 100
LKCVGKRLTD LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN
110 120 130 140 150
VSVALEFLER EHIKLVSIDS KAIVDGNLKL ILGLIWTLIL HYSISMPMWE
160 170 180 190 200
DEDDEDARKQ TPKQRLLGWI QNKVPQLPIT NFNRDWQDGK ALGALVDNCA
210 220 230 240 250
PGLCPDWEAW DPNQPVQNAR EAMQQADDWL GVPQVIAPEE IVDPNVDEHS
260 270 280 290 300
VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPQG NTVLQPAHFT
310 320 330 340 350
VQTVDAGVGE VLVYIEDPEG HTEEAKVVPN NDKDRTYAVS YVPKVAGLHK
360 370 380 390 400
VTVLFAGQNI ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD
410 420 430 440 450
IYTAGAGTGD VAVVIVDPQG RRDTVEVALE DKGDNTFRCT YRPVMEGPHT
460 470 480 490 500
VHVAFAGAPI TRSPFPVHVA EACNPNACRA SGRGLQPKGV RVKEVADFKV
510 520 530 540 550
FTKGAGSGEL KVTVKGPKGT EEPVKVREAG DGVFECEYYP VIPGKYVVTI
560 570 580 590 600
TWGGYAIPRS PFEVQVSPEA GAQKVRAWGP GLETGQVGKS ADFVVEAIGT
610 620 630 640 650
EVGTLGFSIE GPSQAKIECD DRGDGSCDVR YWPTEPGEYA VHVICDDEDI
660 670 680 690 700
RDSPFIAHIQ PAPPDCFPDK VKAFGPGLEP TGCIVDRPAE FTIDARAAGK
710 720 730 740 750
GDLKLYAQDA DGCPIDIKVI PNGDGTFRCS YVPTKPIKHT VIISWGGVNV
760 770 780 790 800
PKSPFRVNVG EGSHPERVKV YGPGVEKTGL KANEPTYFTV DCSEAGQGDV
810 820 830 840 850
SIGIKCAPGV VGPAEADIDF DIIKNDNDTF TVKYTPPGAG HYTIMVLFAN
860 870 880 890 900
QEIPASPFHI KVDPSHDASK VKAEGPGLSR TGVEVGKPTH FTVLTKGAGK
910 920 930 940 950
AKLDVHFAGA AKGEAVRDFE IIDNHDYSYT VKYTAVQQGN MAVTVTYGGD
960 970 980 990 1000
PVPKSPFVVN VAPPLDLSKV KVQGLNSKVA VGEEQAFLVN TRGAGGQGQL
1010 1020 1030 1040 1050
DVRMTSPSRR PIPCKLEPGS GAEAQAVRYM PPEEGPYKVD ITYDGHPVPG
1060 1070 1080 1090 1100
SPFAVEGVLP PDPSKVCAYG PGLKGGLVGT PAPFSIDTKG AGTGGLGLTV
1110 1120 1130 1140 1150
EGPCEAKIEC QDNGDGSCAV SYLPTEPGEY TINILFAEAH IPGSPFKATI
1160 1170 1180 1190 1200
QPVFDPSKVR ASGPGLERGK AGEAATFTVD CSEAGEAELT IEILSDAGVK
1210 1220 1230 1240 1250
AEVLIHNNAD GTYHITYSPA FPGTYTITIK YGGHPIPKFP TRVHVQPAVD
1260 1270 1280 1290 1300
TSGIKVSGPG VEPHGVLREV TTEFTVDARS LTATGGNHVT ARVLNPSGAK
1310 1320 1330 1340 1350
TDTYVTDNGD GTYRVQYTAY EEGVHLVEVL YDEVAVPKSP FRVGVTEGCD
1360 1370 1380 1390 1400
PTRVRAFGPG LEGGLVNKAN RFTVETRGAG TGGLGLAIEG PSEAKMSCKD
1410 1420 1430 1440 1450
NKDGSCTVEY VPFTPGDYDV NITFGGQPIP GSPFRVPVKD VVDPGKVKCS
1460 1470 1480 1490 1500
GPGLGTGVRA RVPQTFTVDC SQAGRAPLQV AVLGPTGVAE PVEVRDNGDG
1510 1520 1530 1540 1550
THTVHYTPAT DGPYTVAVKY ADQEVPRSPF KIKVLPAHDA SKVRASGPGL
1560 1570 1580 1590 1600
NASGIPASLP VEFTIDARDA GEGLLTVQIL DPEGKPKKAN IRDNGDGTYT
1610 1620 1630 1640 1650
VSYLPDMSGR YTITIKYGGD EIPYSPFRIH ALPTGDASKC LVTVSIGGHG
1660 1670 1680 1690 1700
LGACLGPRIQ IGEETVITVD AKAAGKGKVT CTVSTPDGAE LDVDVVENHD
1710 1720 1730 1740 1750
GTFDIYYTAP EPGKYVITIR FGGEHIPNSP FHVLACDPLP HVEEPAEVLQ
1760 1770 1780 1790 1800
LHQPYAPLRP GTCPTHWATE EPVVPVEPLE SMLRPFNLVI PFTVQKGELT
1810 1820 1830 1840 1850
GEVRMPSGKT ARPNITDNKD GTITVRYAPT EKGLHQMGIK YDGNHIPGSP
1860 1870 1880 1890 1900
LQFYVDAINS GHVSAYGPGL SHGMVNKPAT FTIVTKDAGE GGLSLAVEGP
1910 1920 1930 1940 1950
SKAEITCKDN KDGTCTVSYL PTAPGDYSII VRFDDKHIPG SPFTAKITGD
1960 1970 1980 1990 2000
DSMRTSQLNV GTSTDVSLKI TEGDLSQLTA SIRAPSGNEE PCLLKRLPNR
2010 2020 2030 2040 2050
HIGISFTPKE VGEHVVSVRK SGKHVTNSPF KILVGPSEIG DASKVRVWGK
2060 2070 2080 2090 2100
GLSEGQTFQV AEFIVDTRNA GYGGLGLSIE GPSKVDINCE DMEDGTCKVT
2110 2120 2130 2140 2150
YCPTEPGTYI INIKFADKHV PGSPFTVKVT GEGRMKESIT RRRQAPSIAT
2160 2170 2180 2190 2200
IGSTCDLNLK IPGNWFQMVS AQERLTRTFT RSSHTYTRTE RTEISKTRGG
2210 2220 2230 2240 2250
ETKREVRVEE STQVGGDPFP AVFGDFLGRE RLGSFGSITR QQEGEASSQD
2260 2270 2280 2290 2300
MTAQVTSPSG KTEAAEIVEG EDSAYSVRFV PQEMGPHTVA VKYRGQHVPG
2310 2320 2330 2340 2350
SPFQFTVGPL GEGGAHKVRA GGTGLERGVA GVPAEFSIWT REAGAGGLSI
2360 2370 2380 2390 2400
AVEGPSKAEI AFEDRKDGSC GVSYVVQEPG DYEVSIKFND EHIPDSPFVV
2410 2420 2430 2440 2450
PVASLSDDAR RLTVTSLQET GLKVNQPASF AVQLNGARGV IDARVHTPSG
2460 2470 2480 2490 2500
AVEECYVSEL DSDKHTIRFI PHENGVHSID VKFNGAHIPG SPFKIRVGEQ
2510 2520 2530 2540 2550
SQAGDPGLVS AYGPGLEGGT TGVSSEFIVN TQNAGSGALS VTIDGPSKVQ
2560 2570 2580 2590 2600
LDCRECPEGH VVTYTPMAPG NYLIAIKYGG PQHIVGSPFK AKVTGPRLSG
2610 2620 2630 2640 2650
GHSLHETSTV LVETVTKSSS SRGASYSSIP KFSSDASKVV TRGPGLSQAF
2660 2670 2680 2690 2700
VGQKNSFTVD CSKAGTNMMM VGVHGPKTPC EEVYVKHMGN RVYNVTYTVK
2710 2720
EKGDYILIVK WGDESVPGSP FKVNVP
Length:2,726
Mass (Da):290,986
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA91CE65E935EC2CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UHR7A0A0H2UHR7_RAT
Filamin-C
Flnc
2,693Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR06030202 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001178791.1, NM_001191862.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000088149; ENSRNOP00000070379; ENSRNOG00000007281

Database of genes from NCBI RefSeq genomes

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GeneIDi
362332

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:362332

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06030202 Genomic DNA No translation available.
RefSeqiNP_001178791.1, NM_001191862.1

3D structure databases

SMRiD3ZHA0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi263368, 2 interactors
IntActiD3ZHA0, 3 interactors
STRINGi10116.ENSRNOP00000027237

PTM databases

iPTMnetiD3ZHA0
PhosphoSitePlusiD3ZHA0

Proteomic databases

jPOSTiD3ZHA0
PaxDbiD3ZHA0
PeptideAtlasiD3ZHA0
PRIDEiD3ZHA0

Genome annotation databases

EnsembliENSRNOT00000088149; ENSRNOP00000070379; ENSRNOG00000007281
GeneIDi362332
KEGGirno:362332

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2318
RGDi1308807 Flnc

Phylogenomic databases

eggNOGiKOG0518 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000153588
HOGENOMiCLU_000783_0_0_1
InParanoidiD3ZHA0
KOiK04437
OMAiVRYTAVQ
OrthoDBi35998at2759
TreeFamiTF313685

Enzyme and pathway databases

ReactomeiR-RNO-446353 Cell-extracellular matrix interactions

Miscellaneous databases

Protein Ontology

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PROi
PR:D3ZHA0

Gene expression databases

BgeeiENSRNOG00000007281 Expressed in skeletal muscle tissue and 9 other tissues
ExpressionAtlasiD3ZHA0 baseline and differential
GenevisibleiD3ZHA0 RN

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.60.40.10, 24 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00630 Filamin, 23 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00557 IG_FLMN, 24 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF81296 SSF81296, 24 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50194 FILAMIN_REPEAT, 24 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFLNC_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZHA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: April 20, 2010
Last modified: February 26, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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