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Protein

Sugar transporter SWEET1

Gene

Slc50a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1 (By similarity).By similarity

GO - Molecular functioni

  • glucoside transmembrane transporter activity Source: Ensembl
  • sugar transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter SWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Gene namesi
Name:Slc50a1
Synonyms:Rag1ap1, Rga
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308478 Slc50a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei44 – 63Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei68 – 88Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei102 – 122Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei129 – 149Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei160 – 180Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004054301 – 221Sugar transporter SWEET1Add BLAST221

Proteomic databases

PaxDbiD3ZH22
PeptideAtlasiD3ZH22
PRIDEiD3ZH22

Expressioni

Gene expression databases

BgeeiENSRNOG00000020554 Expressed in 10 organ(s), highest expression level in colon
GenevisibleiD3ZH22 RN

Interactioni

Subunit structurei

Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027878

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 94MtN3/slv 1Add BLAST85
Domaini127 – 212MtN3/slv 2Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 221Mediates interaction with TRPV21 PublicationAdd BLAST73

Sequence similaritiesi

Belongs to the SWEET sugar transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1623 Eukaryota
ENOG4111M4R LUCA
GeneTreeiENSGT00390000007801
InParanoidiD3ZH22
KOiK15382
OMAiVSMYLSP
OrthoDBiEOG091G0J82
PhylomeDBiD3ZH22
TreeFamiTF313635

Family and domain databases

InterProiView protein in InterPro
IPR004316 SWEET_sugar_transpr
PfamiView protein in Pfam
PF03083 MtN3_slv, 2 hits

Sequencei

Sequence statusi: Complete.

D3ZH22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAGGVADSF LSSACVLFTL GMFSTGLSDL RHMQRTRSVD NIQFLPFLTT
60 70 80 90 100
DVNNLGWLSY GVLKGDGTLI IVNTVGAVLQ TLYILAYLHY SPQKHAVLLQ
110 120 130 140 150
TATLLAVLLL GYGYFWLLVP DLETRLQQLG LFCSVFTISM YLSPLADLAK
160 170 180 190 200
IIQTKSTQRL SFSLTIATLL SSTSWSIYGF RLKDPYITVP NLPGILTGFI
210 220
RLVLFYKYPP EQDTKYRLLQ T
Length:221
Mass (Da):24,694
Last modified:April 20, 2010 - v1
Checksum:i53B7483FBDA003E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473976 Genomic DNA Translation: EDM00646.1
RefSeqiNP_001099915.1, NM_001106445.1
UniGeneiRn.823

Genome annotation databases

EnsembliENSRNOT00000027878; ENSRNOP00000027878; ENSRNOG00000020554
GeneIDi295245
KEGGirno:295245
UCSCiRGD:1308478 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473976 Genomic DNA Translation: EDM00646.1
RefSeqiNP_001099915.1, NM_001106445.1
UniGeneiRn.823

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027878

Proteomic databases

PaxDbiD3ZH22
PeptideAtlasiD3ZH22
PRIDEiD3ZH22

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027878; ENSRNOP00000027878; ENSRNOG00000020554
GeneIDi295245
KEGGirno:295245
UCSCiRGD:1308478 rat

Organism-specific databases

CTDi55974
RGDi1308478 Slc50a1

Phylogenomic databases

eggNOGiKOG1623 Eukaryota
ENOG4111M4R LUCA
GeneTreeiENSGT00390000007801
InParanoidiD3ZH22
KOiK15382
OMAiVSMYLSP
OrthoDBiEOG091G0J82
PhylomeDBiD3ZH22
TreeFamiTF313635

Enzyme and pathway databases

ReactomeiR-RNO-189200 Cellular hexose transport

Miscellaneous databases

PROiPR:D3ZH22

Gene expression databases

BgeeiENSRNOG00000020554 Expressed in 10 organ(s), highest expression level in colon
GenevisibleiD3ZH22 RN

Family and domain databases

InterProiView protein in InterPro
IPR004316 SWEET_sugar_transpr
PfamiView protein in Pfam
PF03083 MtN3_slv, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSWET1_RAT
AccessioniPrimary (citable) accession number: D3ZH22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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