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Protein

Neurite extension and migration factor

Gene

Nexmif

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway (PubMed:23615299, PubMed:22531377, PubMed:24071057, PubMed:27822498). May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1) (PubMed:24071057, PubMed:27822498).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurite extension and migration factorBy similarity
Alternative name(s):
KIAA2022 protein associated with intellectual disability, language impairment and autistic behavior homolog1 Publication
Short name:
KIDLIA1 Publication
XLMR protein related to neurite extension1 Publication
Short name:
Xpn1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NexmifBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Rat genome database

More...
RGDi
1561931 Nexmif

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004260941 – 1517Neurite extension and migration factorAdd BLAST1517

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
D3ZGX1

PeptideAtlas

More...
PeptideAtlasi
D3ZGX1

PRoteomics IDEntifications database

More...
PRIDEi
D3ZGX1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZGX1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
D3ZGX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000021589 Expressed in 8 organ(s), highest expression level in brain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3ZGX1 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000036176

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D3ZGX1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFSY Eukaryota
ENOG410XSAZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159746

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZGX1

Identification of Orthologs from Complete Genome Data

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OMAi
REFEEPS

Database of Orthologous Groups

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OrthoDBi
EOG091G00LU

Database for complete collections of gene phylogenies

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PhylomeDBi
D3ZGX1

TreeFam database of animal gene trees

More...
TreeFami
TF332248

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032757 DUF4683

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15735 DUF4683, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZGX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNQQDKVIA ASANGENNLI NGVKENDSEE QDVAMKSFAA LEASTPIQPI
60 70 80 90 100
PVVQKESPMF PRGLLPLPSK KPCMQSPPSP LGLIEAPDHS ATGASVNAIS
110 120 130 140 150
LTSGVAKGLN TWSLPNECEK APFAIMEPAG ISALNGDCLM QPSRTCLGCF
160 170 180 190 200
MESKEAVDPE PGISLKVGDL NRDYETCAVS DIGIQCINAG ENLKYGEQLL
210 220 230 240 250
SDQLLGFPLH KSRAGDRRES EKPDIDLEDP TQKSYYEALL LDKCNTEEAL
260 270 280 290 300
LANSNQDWGY FETFISESKI ELLDLCSKNE LSVNLFSEED VENYMFDDDE
310 320 330 340 350
STLGSDVCSL KIRYESFQDN VRDKTTLLMQ EDAQFNFFPS VFTTCPKRES
360 370 380 390 400
KSGVLKQSSD LSQFKVPDVS IIWGDEDKNL DKKKGKEEVH EDKSIEKKDE
410 420 430 440 450
KDNGEKPALN NKPCSGLEVE QFKNLKPDHL TNSLETSGNF SDDSSFIEVS
460 470 480 490 500
YDAMGEIKDC SRYMARDTNS GSSSSQQNYG LRAKRKVRYS EDYLYDVDSL
510 520 530 540 550
EGEKVNERKE WPPGGSKEED DDEWCPKKRR KVTRKEPPVI IKYIIINRFK
560 570 580 590 600
GEKNMLVKLG KVDASETTVN LSESQLSKYA KLSPLKGFWQ KKKKQKNGNT
610 620 630 640 650
DSVKTPFCQK QSFEPGSFEV SFLPPARKRK SKLGNRHRIQ RIQSMEASAS
660 670 680 690 700
SKQVSFGSDQ KQASNRKEEG GLKGTPKSAL LAAPSSANGS HLRGLIGPDS
710 720 730 740 750
AKVKAQDTEF KGPERKVLNK IKFKSEARLK SKKIKTGQEN KPVVQMSPVS
760 770 780 790 800
EDPSSKANLK NEVTPGTSNS SHMSEFHETK VVKNSTFLPT TCSSEMPLSS
810 820 830 840 850
ANVATNIPVI PGGYLQTLLD ASDLSNNTSI SYFTNHSAEQ NEASLSQTEK
860 870 880 890 900
AFAPLQSAQD CVLSSSSDSQ LQQSSQNFKM EASNYGSLWP DKDTSGSQEF
910 920 930 940 950
MTEVSGEIAT SQSSEFEATQ VVSMENNLTA ITYSPVCLNS GGSGCNKVLY
960 970 980 990 1000
ASVQDSHLAP DDSYQLCHFN NGEICFPFQQ GPISTEDDGQ LFSFDSMTPL
1010 1020 1030 1040 1050
SVSSSSYCPL SLKSCEKDGD DDINDDFLAH CSPKLVIQQS IDEIAPLKES
1060 1070 1080 1090 1100
TDLLDISNFT PDKFRHSSLS EMSPPDTPSL SPQSTRCESI KTLGTMKGFQ
1110 1120 1130 1140 1150
EGVPGSLSSM EKIKWDCSTL SQQVQADDGF TLNNHQFQFH MFNDEDSVGL
1160 1170 1180 1190 1200
LQKNPCLSTF DEPAGQISAN NKVSKSRKKT SPGKSGAVSQ SSSQKNTRKK
1210 1220 1230 1240 1250
SPKASNKGVE KPPSKTSRQV PKSAKKGKYV AAVNGEKMQI GIGHSGGQPN
1260 1270 1280 1290 1300
STSSNGKTLT ECIQHGGPVA PMKIPSQKGL SGDWALGKES RPGWNDMSVV
1310 1320 1330 1340 1350
TNTNNLLDDD QREFQEPSYI LSNIASGMAD VQRFMMASME PLWEPMEHQG
1360 1370 1380 1390 1400
ESNTFYSPDS NSLKLKTLKI LAGTPQESKK KINNGSSGAT KNHRSIKAVS
1410 1420 1430 1440 1450
KSSGKAAVGD PGHADVSGSS EDSRSAFFDK KYSNMNTLGN NGPTHKKLYR
1460 1470 1480 1490 1500
HKSSSKTLRD EKYKGKRVER EQIHKDEAGT TCFEKLRGSS YNLLKAETAF
1510
GVLPVFEEET HIFQKDI
Length:1,517
Mass (Da):166,662
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07F8287E212F4119
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR06105592 Genomic DNA No translation available.

NCBI Reference Sequences

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RefSeqi
NP_001300744.1, NM_001313815.1
XP_008771572.1, XM_008773350.2
XP_017457455.1, XM_017601966.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.203970
Rn.62924

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000035653; ENSRNOP00000036176; ENSRNOG00000021589

Database of genes from NCBI RefSeq genomes

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GeneIDi
302396

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:302396

UCSC genome browser

More...
UCSCi
RGD:1561931 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06105592 Genomic DNA No translation available.
RefSeqiNP_001300744.1, NM_001313815.1
XP_008771572.1, XM_008773350.2
XP_017457455.1, XM_017601966.1
UniGeneiRn.203970
Rn.62924

3D structure databases

SMRiD3ZGX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036176

PTM databases

iPTMnetiD3ZGX1
PhosphoSitePlusiD3ZGX1

Proteomic databases

PaxDbiD3ZGX1
PeptideAtlasiD3ZGX1
PRIDEiD3ZGX1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035653; ENSRNOP00000036176; ENSRNOG00000021589
GeneIDi302396
KEGGirno:302396
UCSCiRGD:1561931 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340533
RGDi1561931 Nexmif

Phylogenomic databases

eggNOGiENOG410IFSY Eukaryota
ENOG410XSAZ LUCA
GeneTreeiENSGT00940000159746
InParanoidiD3ZGX1
OMAiREFEEPS
OrthoDBiEOG091G00LU
PhylomeDBiD3ZGX1
TreeFamiTF332248

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZGX1

Gene expression databases

BgeeiENSRNOG00000021589 Expressed in 8 organ(s), highest expression level in brain
GenevisibleiD3ZGX1 RN

Family and domain databases

InterProiView protein in InterPro
IPR032757 DUF4683
PfamiView protein in Pfam
PF15735 DUF4683, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEXMI_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZGX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 20, 2010
Last modified: December 5, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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