UniProtKB - D3ZGE2 (D3ZGE2_RAT)
Protein
Submitted name:
Myeloperoxidase
Gene
Mpo
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- heme binding Source: InterPro
- heparin binding Source: RGD
- peroxidase activity Source: RGD
GO - Biological processi
- aging Source: RGD
- defense response to bacterium Source: GO_Central
- defense response to fungus Source: RGD
- hydrogen peroxide catabolic process Source: RGD
- hypochlorous acid biosynthetic process Source: RGD
- low-density lipoprotein particle remodeling Source: RGD
- oxidation-reduction process Source: RGD
- removal of superoxide radicals Source: RGD
- respiratory burst involved in defense response Source: RGD
- response to food Source: RGD
- response to gold nanoparticle Source: RGD
- response to lipopolysaccharide Source: RGD
- response to mechanical stimulus Source: RGD
- response to oxidative stress Source: RGD
- response to yeast Source: RGD
Keywordsi
Molecular function | Oxidoreductase, PeroxidaseImportedARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: MyeloperoxidaseImportedSubmitted name: Myeloperoxidase (Mapped)Imported |
Gene namesi | ORF Names:rCG_32763Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1592081, Mpo |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: RGD
Lysosome
- azurophil granule Source: RGD
Other locations
- secretory granule Source: RGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5014087626 | 23 – 458 | Sequence analysisAdd BLAST | 436 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000008310, Expressed in thymus and 18 other tissues |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 40 – 60 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000161343 |
HOGENOMi | CLU_006087_2_0_1 |
Family and domain databases
Gene3Di | 1.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal IPR029609, MPO |
PANTHERi | PTHR11475:SF108, PTHR11475:SF108, 2 hits |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS50292, PEROXIDASE_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
D3ZGE2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLFLALAGL LAPLAMLQTS TGATPALPGE VANSVVLDCM EEAKRLVNKA
60 70 80 90 100
YKERRESIKQ SLRSGSASPM ELLSYFKQPV AGTRTAVRAA DYLHVALDLL
110 120 130 140 150
KRKLQPLWPR PFNVTGDMRS SEMPELTSMH TLFVREHNRL ATELKRLNPR
160 170 180 190 200
WNGEKLYQEA RKIVGAMVQI ITYRDYLPLV LGPAAMKKYL PQYRSYNDSV
210 220 230 240 250
DPRIANVFTN AFRYGHTLIQ PFMFRLDNQY RSTGPNPRVP LSRVFFASWR
260 270 280 290 300
VVLEGGIDPI LRGLMATPAK LNRQNQIAVD EIRERLFEQV MRIGLDLPAL
310 320 330 340 350
NMQRSRDHGL PGYNAWRRFC GLPQPSTVGE LGTVLKNLEL ARKLMAQYGT
360 370 380 390 400
PNNIDIWMGG VSEPLEPNGR VGQLLACLIG TQFRKLRDGD RFWWENPGVF
410 420 430 440 450
SKQQRQALAT ISLPRIICDN TGITTVSKNN IFMSNSHPRD FVSCNTLPKL
NLASWKET
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K1A2 | A0A0G2K1A2_RAT | Myeloperoxidase | Mpo | 718 | Annotation score: | ||
D3ZYH8 | D3ZYH8_RAT | Myeloperoxidase | Mpo | 523 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07030188 Genomic DNA No translation available. CH473948 Genomic DNA Translation: EDM05612.1 |
RefSeqi | NP_001100506.1, NM_001107036.1 |
Genome annotation databases
Ensembli | ENSRNOT00000065910; ENSRNOP00000062232; ENSRNOG00000008310 |
GeneIDi | 303413 |
KEGGi | rno:303413 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07030188 Genomic DNA No translation available. CH473948 Genomic DNA Translation: EDM05612.1 |
RefSeqi | NP_001100506.1, NM_001107036.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSRNOT00000065910; ENSRNOP00000062232; ENSRNOG00000008310 |
GeneIDi | 303413 |
KEGGi | rno:303413 |
Organism-specific databases
CTDi | 4353 |
RGDi | 1592081, Mpo |
Phylogenomic databases
GeneTreei | ENSGT00940000161343 |
HOGENOMi | CLU_006087_2_0_1 |
Gene expression databases
Bgeei | ENSRNOG00000008310, Expressed in thymus and 18 other tissues |
Family and domain databases
Gene3Di | 1.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal IPR029609, MPO |
PANTHERi | PTHR11475:SF108, PTHR11475:SF108, 2 hits |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS50292, PEROXIDASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZGE2_RAT | |
Accessioni | D3ZGE2Primary (citable) accession number: D3ZGE2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |