The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - D3ZG53 (D3ZG53_RAT)
Protein
Submitted name:
Atonal bHLH transcription factor 7
Gene
Atoh7
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- circadian rhythm Source: RGD
- entrainment of circadian clock Source: RGD
- entrainment of circadian clock by photoperiod Source: RGD
- neural retina development Source: RGD
- neuron differentiation Source: GO_Central
- optic nerve development Source: RGD
- positive regulation of retinal ganglion cell axon guidance Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to auditory stimulus Source: Ensembl
Keywordsi
Molecular function | Developmental proteinARBA annotation, DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Atonal bHLH transcription factor 7 |
Gene namesi | Name:Atoh7Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1304957, Atoh7 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Other locations
- axon ARBA annotation
- Perikaryon ARBA annotation
Nucleus
- nucleus Source: GO_Central
Other locations
- axon Source: Ensembl
- perikaryon Source: Ensembl
Keywords - Cellular componenti
Cell projectionARBA annotation, NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000000384, Expressed in liver and 9 other tissues |
Interactioni
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000432 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 93 | BHLHInterPro annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | KOG4395, Eukaryota |
GeneTreei | ENSGT00940000161556 |
HOGENOMi | CLU_145503_0_0_1 |
InParanoidi | D3ZG53 |
OMAi | WVSLHCE |
OrthoDBi | 1453771at2759 |
PhylomeDBi | D3ZG53 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR032663, Atoh7 IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF99, PTHR19290:SF99, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZG53-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSACKPHGP PAGARGAPPC AGAAERAVSC AGPGRLESAA RRRLAANARE
60 70 80 90 100
RRRMQGLNTA FDRLRRVVPQ WGQDKKLSKY ETLQMALSYI VALTRILAEA
110 120 130 140
ERDWVGLRCE QRGRNHPYLP FPGARLQVDP EPYGQKFFGF QPESFPMAS
Sequence databases
RefSeqi | NP_001163953.1, NM_001170482.1 |
Genome annotation databases
Ensembli | ENSRNOT00000000432.3; ENSRNOP00000000432.1; ENSRNOG00000000384.3 |
GeneIDi | 365564 |
KEGGi | rno:365564 |
UCSCi | RGD:1304957, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001163953.1, NM_001170482.1 |
3D structure databases
AlphaFoldDBi | D3ZG53 |
SMRi | D3ZG53 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000432 |
Proteomic databases
PaxDbi | D3ZG53 |
Genome annotation databases
Ensembli | ENSRNOT00000000432.3; ENSRNOP00000000432.1; ENSRNOG00000000384.3 |
GeneIDi | 365564 |
KEGGi | rno:365564 |
UCSCi | RGD:1304957, rat |
Organism-specific databases
CTDi | 220202 |
RGDi | 1304957, Atoh7 |
Phylogenomic databases
eggNOGi | KOG4395, Eukaryota |
GeneTreei | ENSGT00940000161556 |
HOGENOMi | CLU_145503_0_0_1 |
InParanoidi | D3ZG53 |
OMAi | WVSLHCE |
OrthoDBi | 1453771at2759 |
PhylomeDBi | D3ZG53 |
TreeFami | TF315153 |
Gene expression databases
Bgeei | ENSRNOG00000000384, Expressed in liver and 9 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR032663, Atoh7 IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR19290:SF99, PTHR19290:SF99, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZG53_RAT | |
Accessioni | D3ZG53Primary (citable) accession number: D3ZG53 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |