UniProtKB - D3ZG27 (UBIA1_RAT)
Protein
UbiA prenyltransferase domain-containing protein 1
Gene
Ubiad1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (By similarity).By similarity
: menaquinone biosynthesis Pathwayi
This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
Pathwayi: ubiquinone biosynthesis
This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- antioxidant activity Source: UniProtKB
- prenyltransferase activity Source: UniProtKB
GO - Biological processi
- circulatory system development Source: UniProtKB
- endothelial cell development Source: UniProtKB
- menaquinone biosynthetic process Source: UniProtKB
- ubiquinone biosynthetic process Source: UniProtKB
- ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate Source: GO_Central
- vitamin K biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Prenyltransferase, Transferase |
Biological process | Menaquinone biosynthesis, Ubiquinone biosynthesis |
Enzyme and pathway databases
Reactomei | R-RNO-6806664, Metabolism of vitamin K |
UniPathwayi | UPA00079 UPA00232 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ubiad1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309588, Ubiad1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- integral component of Golgi membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: RGD
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 134 – 154 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 209 – 229 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 245 – 267 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 277 – 297 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 315 – 335 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000403783 | 2 – 338 | UbiA prenyltransferase domain-containing protein 1Add BLAST | 337 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | D3ZG27 |
PRIDEi | D3ZG27 |
PTM databases
iPTMneti | D3ZG27 |
PhosphoSitePlusi | D3ZG27 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000009575, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | D3ZG27, RN |
Interactioni
Subunit structurei
Interacts with HMGCR and SOAT1.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000012691 |
Family & Domainsi
Sequence similaritiesi
Belongs to the UbiA prenyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4581, Eukaryota |
GeneTreei | ENSGT00390000012439 |
HOGENOMi | CLU_043611_0_0_1 |
InParanoidi | D3ZG27 |
OMAi | PMAFPLE |
OrthoDBi | 1146311at2759 |
PhylomeDBi | D3ZG27 |
TreeFami | TF323238 |
Family and domain databases
CDDi | cd13962, PT_UbiA_UBIAD1, 1 hit |
InterProi | View protein in InterPro IPR000537, UbiA_prenyltransferase IPR026046, UBIAD1 |
Pfami | View protein in Pfam PF01040, UbiA, 1 hit |
PIRSFi | PIRSF005355, UBIAD1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
D3ZG27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVQAPGEK INIQAGETTQ VGDTDQQRND WPEEDRLPER SWRQKCASYV
60 70 80 90 100
LALRPWSFSA SLTPVALGSA LAYRSQGVLD PRLLLGCAVA VLAVHGAGNL
110 120 130 140 150
VNTYYDFSKG IDHKKSDDRT LVDRILEPQD VVRFGVFLYT LGCVCAAYLY
160 170 180 190 200
YLSTLKLEHL ALIYFGGLSG SFLYTGGIGF KYVALGDLVI LITFGPLAVM
210 220 230 240 250
FAYAVQVGSL AIFPLVYAIP LALSTEAILH SNNTRDMESD REAGIVTLAI
260 270 280 290 300
LIGPTLSYIL YNTLLFLPYL IFTILATHCS ISLALPLLTS PMAFSLERQF
310 320 330
RSQAFNKLPQ RTAKLNLLLG LFYVFGIILA PAGSLPRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473968 Genomic DNA Translation: EDL81120.1 |
RefSeqi | NP_001101463.1, NM_001107993.1 |
Genome annotation databases
Ensembli | ENSRNOT00000012692; ENSRNOP00000012691; ENSRNOG00000009575 |
GeneIDi | 313706 |
KEGGi | rno:313706 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473968 Genomic DNA Translation: EDL81120.1 |
RefSeqi | NP_001101463.1, NM_001107993.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000012691 |
PTM databases
iPTMneti | D3ZG27 |
PhosphoSitePlusi | D3ZG27 |
Proteomic databases
PaxDbi | D3ZG27 |
PRIDEi | D3ZG27 |
Genome annotation databases
Ensembli | ENSRNOT00000012692; ENSRNOP00000012691; ENSRNOG00000009575 |
GeneIDi | 313706 |
KEGGi | rno:313706 |
Organism-specific databases
CTDi | 29914 |
RGDi | 1309588, Ubiad1 |
Phylogenomic databases
eggNOGi | KOG4581, Eukaryota |
GeneTreei | ENSGT00390000012439 |
HOGENOMi | CLU_043611_0_0_1 |
InParanoidi | D3ZG27 |
OMAi | PMAFPLE |
OrthoDBi | 1146311at2759 |
PhylomeDBi | D3ZG27 |
TreeFami | TF323238 |
Enzyme and pathway databases
UniPathwayi | UPA00079 UPA00232 |
Reactomei | R-RNO-6806664, Metabolism of vitamin K |
Miscellaneous databases
PROi | PR:D3ZG27 |
Gene expression databases
Bgeei | ENSRNOG00000009575, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | D3ZG27, RN |
Family and domain databases
CDDi | cd13962, PT_UbiA_UBIAD1, 1 hit |
InterProi | View protein in InterPro IPR000537, UbiA_prenyltransferase IPR026046, UBIAD1 |
Pfami | View protein in Pfam PF01040, UbiA, 1 hit |
PIRSFi | PIRSF005355, UBIAD1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIA1_RAT | |
Accessioni | D3ZG27Primary (citable) accession number: D3ZG27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2011 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families