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UniProtKB - D3ZFS3 (D3ZFS3_RAT)
Protein
Submitted name:
Zinc finger and BTB domain containing 5 (Predicted), isoform CRA_a
Gene
Zbtb5
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger and BTB domain containing 5 (Predicted), isoform CRA_aImportedSubmitted name: Zinc finger and BTB domain-containing 5 |
Gene namesi | ORF Names:rCG_54926Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307367, Zbtb5 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000012726, Expressed in testis and 21 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 93 | BTBInterPro annotationAdd BLAST | 70 | |
Domaini | 606 – 633 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 634 – 666 | C2H2-typeInterPro annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 253 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 268 – 312 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 326 – 382 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 414 – 433 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 442 – 469 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 157 – 181 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 191 – 209 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 269 – 295 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 332 – 349 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 414 – 432 | Polar residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160246 |
HOGENOMi | CLU_407055_0_0_1 |
OMAi | EKDHMRV |
OrthoDBi | 339939at2759 |
TreeFami | TF330979 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
i Sequence
Sequence statusi: Complete.
D3ZFS3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR
60 70 80 90 100
ALFSVAEGDQ TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL
110 120 130 140 150
LAASHLHLNS VVKACKHYLT TRTLPMSPPS ERVQEQSARM QRSFMLQQLG
160 170 180 190 200
LSIVSSALSS SQSGEEPSAP MSSSMRNNLD QRTPFPMRRL HKRKQTVEER
210 220 230 240 250
ARQRLRSSMD ESAISDVTPE SGPSGVHSRE EFFSPDSLKI VDNPKPDGMA
260 270 280 290 300
DNQEDSAMMF DRPFGAQEDA QMPSQSDGSA GNMASRATQV ETSFEQEAVA
310 320 330 340 350
EKGSFQCENP EVGLGEKEHM RVVVKSEPLS SPEPQDEVSD VTSQAEGSES
360 370 380 390 400
VEVEGVVVSA EKIDLSPESS DRSFSDPQSS TDRVGDIHIL EVTNNLEHKT
410 420 430 440 450
SFSISNFLNK SRGSNFSTSQ STDDNLPNTT SDCRLEGEAP YLLSPEAGPA
460 470 480 490 500
GGPSSAPGSH VENPFSEPAD SHFVRPVQEV MGLPCVQTSG YQGEQFGMDF
510 520 530 540 550
PRSGLGLHSS FSRAMMGSPR GGASNFPYYR RIAPKMPVVT SVRSSQISEN
560 570 580 590 600
QASSQLMMNG ASSFENGHSS QPGPPQLTRA SADVLSKCKK ALSEHNVLVV
610 620 630 640 650
EGARKYACKI CCKTFLTLTD CKKHIRVHTG EKPYACLKCG KRFSQSSHLY
660 670
KHSKTTCLRW QSSNLPSTLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473962 Genomic DNA Translation: EDL98801.1 CH473962 Genomic DNA Translation: EDL98802.1 |
RefSeqi | NP_001100127.1, NM_001106657.1 XP_006238108.1, XM_006238046.3 XP_006238109.1, XM_006238047.3 XP_006238110.1, XM_006238048.3 |
Genome annotation databases
Ensembli | ENSRNOT00000017046.7; ENSRNOP00000017047.5; ENSRNOG00000012726.7 ENSRNOT00000092899.2; ENSRNOP00000075930.1; ENSRNOG00000012726.7 |
GeneIDi | 298084 |
KEGGi | rno:298084 |
UCSCi | RGD:1307367, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473962 Genomic DNA Translation: EDL98801.1 CH473962 Genomic DNA Translation: EDL98802.1 |
RefSeqi | NP_001100127.1, NM_001106657.1 XP_006238108.1, XM_006238046.3 XP_006238109.1, XM_006238047.3 XP_006238110.1, XM_006238048.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000017047 |
Genome annotation databases
Ensembli | ENSRNOT00000017046.7; ENSRNOP00000017047.5; ENSRNOG00000012726.7 ENSRNOT00000092899.2; ENSRNOP00000075930.1; ENSRNOG00000012726.7 |
GeneIDi | 298084 |
KEGGi | rno:298084 |
UCSCi | RGD:1307367, rat |
Organism-specific databases
CTDi | 9925 |
RGDi | 1307367, Zbtb5 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160246 |
HOGENOMi | CLU_407055_0_0_1 |
OMAi | EKDHMRV |
OrthoDBi | 339939at2759 |
TreeFami | TF330979 |
Gene expression databases
Bgeei | ENSRNOG00000012726, Expressed in testis and 21 other tissues |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZFS3_RAT | |
Accessioni | D3ZFS3Primary (citable) accession number: D3ZFS3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |