UniProtKB - D3ZFD9 (D3ZFD9_RAT)
Protein
Submitted name:
Retinoic acid receptor, beta
Gene
Rarb
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: RGD
- drug binding Source: RGD
- nuclear receptor activity Source: RGD
- protein-containing complex binding Source: RGD
- retinoid X receptor binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- bone development Source: RGD
- cell differentiation Source: GO_Central
- embryonic digestive tract development Source: RGD
- embryonic eye morphogenesis Source: RGD
- embryonic hindlimb morphogenesis Source: RGD
- glandular epithelial cell development Source: RGD
- growth plate cartilage development Source: RGD
- hormone-mediated signaling pathway Source: GO_Central
- multicellular organism growth Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of cartilage development Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of chondrocyte differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neurogenesis Source: RGD
- outflow tract septum morphogenesis Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of neuron differentiation Source: RGD
- positive regulation of programmed cell death Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of myelination Source: RGD
- retina development in camera-type eye Source: RGD
- retinal pigment epithelium development Source: RGD
- retinoic acid receptor signaling pathway Source: RGD
- striatum development Source: RGD
- ureteric bud development Source: RGD
- ventricular cardiac muscle cell differentiation Source: RGD
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-5362517, Signaling by Retinoic Acid |
Names & Taxonomyi
Protein namesi | Submitted name: Retinoic acid receptor, betaImported |
Gene namesi | ORF Names:rCG_42182Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1584366, LOC684994 3535, Rarb |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000024061, Expressed in liver and 20 other tissues |
Interactioni
GO - Molecular functioni
- retinoid X receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000036260 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 153 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 176 – 410 | NR LBDInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 71 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 408 – 448 | DisorderedSequence analysisAdd BLAST | 41 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 170 – 190 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 51 – 65 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 413 – 448 | PolarSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156196 |
HOGENOMi | CLU_007368_18_2_1 |
OMAi | FTENYEM |
OrthoDBi | 1165737at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZFD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFDCMDVLSV SPGQILDFYT ASPSSCMLQE KALKACLSGF TQAEWQHRHT
60 70 80 90 100
AQSIETQSTS SEELVPSPPS PLPPPRVYKP CFVCQDKSSG YHYGVSACEG
110 120 130 140 150
CKGFFRRSIQ KNMIYTCHRD KNCVINKVTR NRCQYCRLQK CFEVGMSKES
160 170 180 190 200
VRNDRNKKKK EPSKQECTES YEMTAELDDL TEKIRKAHQE TFPSLCQLGK
210 220 230 240 250
YTTNSSADHR VRLDLGLWDK FSELATKCII KIVEFAKRLP GFTGLTIADQ
260 270 280 290 300
ITLLKAACLD ILILRICTRY TPEQDTMTFS DGLTLNRTQM HNAGFGPLTD
310 320 330 340 350
LVFTFANQLL PLEMDDTETG LLSAICLICG DRQDLEEPTK VDKLQEPLLE
360 370 380 390 400
ALKIYIRKRR PSKPHMFPKI LMKITDLRSI SAKGAERVIT LKMEIPGSMP
410 420 430 440
PLIQEMLENS EGHEPLTPNS SGNTAEHSPS VSPSSVETSG VSQSPLLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07017067 Genomic DNA No translation available. AABR07017068 Genomic DNA No translation available. CH474010 Genomic DNA Translation: EDL94092.1 |
RefSeqi | NP_113717.1, NM_031529.1 |
Genome annotation databases
Ensembli | ENSRNOT00000033048; ENSRNOP00000036692; ENSRNOG00000024061 |
GeneIDi | 24706 |
KEGGi | rno:24706 |
UCSCi | RGD:1584366, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07017067 Genomic DNA No translation available. AABR07017068 Genomic DNA No translation available. CH474010 Genomic DNA Translation: EDL94092.1 |
RefSeqi | NP_113717.1, NM_031529.1 |
3D structure databases
SMRi | D3ZFD9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000036260 |
Proteomic databases
PRIDEi | D3ZFD9 |
Genome annotation databases
Ensembli | ENSRNOT00000033048; ENSRNOP00000036692; ENSRNOG00000024061 |
GeneIDi | 24706 |
KEGGi | rno:24706 |
UCSCi | RGD:1584366, rat |
Organism-specific databases
CTDi | 5915 |
RGDi | 1584366, LOC684994 3535, Rarb |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156196 |
HOGENOMi | CLU_007368_18_2_1 |
OMAi | FTENYEM |
OrthoDBi | 1165737at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway R-RNO-5362517, Signaling by Retinoic Acid |
Gene expression databases
Bgeei | ENSRNOG00000024061, Expressed in liver and 20 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZFD9_RAT | |
Accessioni | D3ZFD9Primary (citable) accession number: D3ZFD9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 3, 2013 | |
Last modified: | February 10, 2021 | |
This is version 93 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |