Retinoic acid receptor, beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: RGD
• heterocyclic compound binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways."
    Goncalves M.B., Agudo M., Connor S., McMahon S., Minger S.L., Maden M., Corcoran J.P.
    Dev Biol 326:305-313(2009) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: RGD
• sequence-specific double-stranded DNA binding Source: RGD
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• bone development Source: RGD
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic digestive tract development Source: RGD
• embryonic eye morphogenesis Source: RGD
• embryonic hindlimb morphogenesis Source: RGD
• glandular epithelial cell development Source: RGD
• growth plate cartilage development Source: RGD
• hormone-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• multicellular organism growth Source: RGD
• negative regulation of cartilage development Source: RGD
• negative regulation of cell population proliferation Source: RGD
• negative regulation of chondrocyte differentiation Source: RGD
• negative regulation of transcription by RNA polymerase II Source: RGD
• neural precursor cell proliferation Source: RGDInferred from direct assayⁱ
  • "Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways."
    Goncalves M.B., Agudo M., Connor S., McMahon S., Minger S.L., Maden M., Corcoran J.P.
    Dev Biol 326:305-313(2009) [PubMed] [Europe PMC] [Abstract]
• neurogenesis Source: RGD
• positive regulation of apoptotic process Source: RGD
• positive regulation of programmed cell death Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• regulation of myelination Source: RGDInferred from direct assayⁱ
  • "Retinoic acid regulates myelin formation in the peripheral nervous system."
    Latasa M.J., Ituero M., Moran-Gonzalez A., Aranda A., Cosgaya J.M.
    Glia 58:1451-1464(2010) [PubMed] [Europe PMC] [Abstract]
• retinoic acid receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• striatum development Source: RGD
• ureteric bud development Source: RGD
• ventricular cardiac muscle cell differentiation Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• retinoid X receptor binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of alpha 2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors."
    Wang L., Tankersley L.R., Tang M., Potter J.J., Mezey E.
    Arch Biochem Biophys 428:92-98(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFDCMDVLSV SPGQILDFYT ASPSSCMLQE KALKACLSGF TQAEWQHRHT 
        60         70         80         90        100
AQSIETQSTS SEELVPSPPS PLPPPRVYKP CFVCQDKSSG YHYGVSACEG 
       110        120        130        140        150
CKGFFRRSIQ KNMIYTCHRD KNCVINKVTR NRCQYCRLQK CFEVGMSKES 
       160        170        180        190        200
VRNDRNKKKK EPSKQECTES YEMTAELDDL TEKIRKAHQE TFPSLCQLGK 
       210        220        230        240        250
YTTNSSADHR VRLDLGLWDK FSELATKCII KIVEFAKRLP GFTGLTIADQ 
       260        270        280        290        300
ITLLKAACLD ILILRICTRY TPEQDTMTFS DGLTLNRTQM HNAGFGPLTD 
       310        320        330        340        350
LVFTFANQLL PLEMDDTETG LLSAICLICG DRQDLEEPTK VDKLQEPLLE 
       360        370        380        390        400
ALKIYIRKRR PSKPHMFPKI LMKITDLRSI SAKGAERVIT LKMEIPGSMP 
       410        420        430        440 
PLIQEMLENS EGHEPLTPNS SGNTAEHSPS VSPSSVETSG VSQSPLLQ   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ