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Entry version 81 (07 Apr 2021)
Sequence version 1 (20 Apr 2010)
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Protein

Aldo-keto reductase family 1 member C15

Gene

Akr1c15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NADPH-dependent reduction of a variety of substrates including aromatic and aliphatic aldehydes, quinones, ketones, dicarbonyl compounds and 17-ketosteroids (PubMed:17574202). Catalyzes the NADP+-dependent oxidation of aromatic, alicyclic and aliphatic alcohols, and 17beta-hydroxysteroids (PubMed:17574202). To a lesser extent, can also catalyze the reduction of some aldoses and ketoses and the oxidation of some sugar alcohols (PubMed:17574202). In the stomach, lung and colon tissues, mediates the reduction of farnesal and geranylgeranial into farnesol and geranylgeraniol respectively (PubMed:21187079). By reducing 4-hydroxy-2-nonenal (HNE), produced during lipid peroxidation, into 1,4-dihydro-2-nonene (DHN), protects vascular endothelial cells from damage elicited by oxidized lipoproteins (PubMed:21187080).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The dehydrogenase activity is inhibited by 3',3'',5',5''-tetraiodophenolphthalein, phenolphthalein, genistein, quercetin, zearalenone and diethylstilbestrol.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.2 µM for 4-nitrobenzaldehyde1 Publication
  2. KM=3.1 µM for benzaldehyde1 Publication
  3. KM=20 µM for pyridine-4-aldehyde1 Publication
  4. KM=25 µM for 2-phenyl-2-propenal1 Publication
  5. KM=2.4 µM for NADP+1 Publication
  6. KM=1430 µM for NAD+1 Publication
  7. KM=0.6 µM for NADPH1 Publication
  8. KM=43 µM for NADH1 Publication
  9. KM=0.3 µM for 1-decanal1 Publication
  10. KM=0.9 µM for 1-nonanal1 Publication
  11. KM=1.1 µM for 1-octanal1 Publication
  12. KM=1.1 µM for 1-hexanal1 Publication
  13. KM=112 µM for D-lactoaldehyde1 Publication
  14. KM=125 µM for L-lactoaldehyde1 Publication
  15. KM=225 µM for 4-methylpentanal (isocaproaldehyde)1 Publication
  16. KM=0.4 µM for all-trans-retinal1 Publication
  17. KM=3.5 µM for trans-2,4-nonadienal1 Publication
  18. KM=3.3 µM for trans-2-nonenal1 Publication
  19. KM=2.3 µM for 9-cis-retinal1 Publication
  20. KM=2.5 µM for 4-hydroxy-2-nonenal (HNE)1 Publication
  21. KM=0.8 µM for 6-tert-butyl-2,3-epoxy-4-benzoquinone (TBE)1 Publication
  22. KM=2.7 µM for 1,4-naphthoquinone1 Publication
  23. KM=14 µM for 5-hydroxy-1,4-naphthoquinone (juglone)1 Publication
  24. KM=22 µM for 1-indanone1 Publication
  25. KM=22 µM for 3-hydroxy-2-butanone1 Publication
  26. KM=0.5 µM for 1H-indole-2,3-dione (isatin)1 Publication
  27. KM=0.6 µM for 16-ketoestrone1 Publication
  28. KM=2 µM for 2,3-hexanedione1 Publication
  29. KM=5.5 µM for butane-2,3-dione (diacetyl)1 Publication
  30. KM=16 µM for methylglyoxal1 Publication
  31. KM=30 µM for 21-dehydrocortisol1 Publication
  32. KM=12 µM for S-indan-1-ol1 Publication
  33. KM=32 µM for farnesol1 Publication
  34. KM=5.6 µM for farnesal1 Publication
  35. KM=16 µM for geranylgeraniol1 Publication
  36. KM=0.2 µM for geranylgeranial1 Publication
  37. KM=15 µM for 1-nonanol1 Publication
  38. KM=8.2 µM for 1-decanol1 Publication
  39. KM=11 µM for 5-beta-androstane-3,17-dione (etiocholanedione)1 Publication
  40. KM=8.7 µM for 5-alpha-androstane-3,17-dione (androstanedione)1 Publication
  41. KM=5.6 µM for 4-androstene-3,17-dione1 Publication
  42. KM=36 µM for 5-alpha-androstan-3alpha-ol-17-one1 Publication
  43. KM=8.7 µM for 5-beta-androstan-3alpha-ol-17-one1 Publication
  44. KM=8.5 µM for 5-beta-androstane-3alpha,17beta-diol1 Publication
  45. KM=12 µM for 5-beta-androstan-17beta-ol-3-one1 Publication
  46. KM=6.9 µM for 5-alpha-androstane-3-alpha,17-beta-diol1 Publication
  47. KM=18 µM for testosterone1 Publication
  48. KM=18 µM for 5-alpha-androstan-17beta-ol-3-one1 Publication

    pH dependencei

    Optimum pH is 10.5 for the dehydrogenase activity. Optimum pH is 6 for the reductase activity.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei51NADPBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei56Proton donorUniRule annotation1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei85Lowers pKa of active site TyrUniRule annotation1
    Binding sitei118SubstrateUniRule annotation1
    Binding sitei191NADPBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi24 – 26NADPBy similarity3
    Nucleotide bindingi167 – 168NADPBy similarity2
    Nucleotide bindingi217 – 225NADPBy similarity9
    Nucleotide bindingi269 – 281NADPBy similarityAdd BLAST13

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aldo-keto reductase family 1 member C15Curated (EC:1.1.1.-3 Publications, EC:1.1.1.2162 Publications)
    Alternative name(s):
    RAKc1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Akr1c151 PublicationImported
    Synonyms:Akr1clImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17
    • UP000234681 Componentsi: Chromosome 17, Unassembled WGS sequence

    Organism-specific databases

    Rat genome database

    More...
    RGDi
    1307514, Akr1c15

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004455461 – 324Aldo-keto reductase family 1 member C15Add BLAST324

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    D3ZF77

    PeptideAtlas

    More...
    PeptideAtlasi
    D3ZF77

    PRoteomics IDEntifications database

    More...
    PRIDEi
    D3ZF77

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    D3ZF77

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    D3ZF77

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in lung, specifically in bronchiolar Clara cells, type II alveolar cells and epithelial cells of the duct of the bronchial gland (at protein level) (PubMed:17574202, PubMed:7511002, PubMed:21187079). Expressed in gastric parietal cells and in epithelial cells of the large intestine and colon (at protein level) (PubMed:17574202, PubMed:21187079). Expressed in brown adipocytes (at protein level) (PubMed:17574202). Expressed in vascular endothelial cells (at protein level) (PubMed:17574202).3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSRNOG00000021735, Expressed in lung and 20 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    D3ZF77, baseline and differential

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10116.ENSRNOP00000055113

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    D3ZF77

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1577, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000163184

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_023205_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    D3ZF77

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WLVHWPP

    Database of Orthologous Groups

    More...
    OrthoDBi
    1016440at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    D3ZF77

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106492

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd19108, AKR_AKR1C1-35, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.100, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020471, AKR
    IPR044482, AKR1C
    IPR018170, Aldo/ket_reductase_CS
    IPR023210, NADP_OxRdtase_dom
    IPR036812, NADP_OxRdtase_dom_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00248, Aldo_ket_red, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000097, AKR, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00069, ALDKETRDTASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51430, SSF51430, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00798, ALDOKETO_REDUCTASE_1, 1 hit
    PS00062, ALDOKETO_REDUCTASE_2, 1 hit
    PS00063, ALDOKETO_REDUCTASE_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    D3ZF77-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MDLKHSRSVK LNDGNLMPVL GFGTFASKEI PKSKAAEATK VAIDVGFRHI
    60 70 80 90 100
    DAAYFYQNEE EVGQALRDKM ADGTVKREDL FYTTKIWITF LRPELVRQCL
    110 120 130 140 150
    ERSLKKLGLD YVDLCIIHIP IAMKPGEELL PKDANGKFIF DTVDIRDTWE
    160 170 180 190 200
    ALEKCKDAGL SKSIGVSNFN HKQLELILNK PRLKYKPTCN QVECHPYLNQ
    210 220 230 240 250
    SKLLEFCKSK DIVLVAYSAL GSHRDSSWVS SDSPYLLEDP VLMTIAKKHN
    260 270 280 290 300
    QTPGQVALRY QLQRGVVVLA KSFNEKRIKE NFQVFDFELT PEDMKTIDSL
    310 320
    NRNFRYSQMA FALDHPDYPF LEEY
    Length:324
    Mass (Da):37,195
    Last modified:April 20, 2010 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i851BFF1FD9476B13
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AABR07028443 Genomic DNA No translation available.
    CH473990 Genomic DNA Translation: EDL78576.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001103370.1, NM_001109900.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSRNOT00000058312; ENSRNOP00000055113; ENSRNOG00000021735

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    361267

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    rno:361267

    UCSC genome browser

    More...
    UCSCi
    RGD:1307514, rat

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AABR07028443 Genomic DNA No translation available.
    CH473990 Genomic DNA Translation: EDL78576.1
    RefSeqiNP_001103370.1, NM_001109900.1

    3D structure databases

    SMRiD3ZF77
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000055113

    PTM databases

    iPTMnetiD3ZF77
    PhosphoSitePlusiD3ZF77

    Proteomic databases

    PaxDbiD3ZF77
    PeptideAtlasiD3ZF77
    PRIDEiD3ZF77

    Genome annotation databases

    EnsembliENSRNOT00000058312; ENSRNOP00000055113; ENSRNOG00000021735
    GeneIDi361267
    KEGGirno:361267
    UCSCiRGD:1307514, rat

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    361267
    RGDi1307514, Akr1c15

    Phylogenomic databases

    eggNOGiKOG1577, Eukaryota
    GeneTreeiENSGT00940000163184
    HOGENOMiCLU_023205_0_0_1
    InParanoidiD3ZF77
    OMAiWLVHWPP
    OrthoDBi1016440at2759
    PhylomeDBiD3ZF77
    TreeFamiTF106492

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:D3ZF77

    Gene expression databases

    BgeeiENSRNOG00000021735, Expressed in lung and 20 other tissues
    ExpressionAtlasiD3ZF77, baseline and differential

    Family and domain databases

    CDDicd19108, AKR_AKR1C1-35, 1 hit
    Gene3Di3.20.20.100, 1 hit
    InterProiView protein in InterPro
    IPR020471, AKR
    IPR044482, AKR1C
    IPR018170, Aldo/ket_reductase_CS
    IPR023210, NADP_OxRdtase_dom
    IPR036812, NADP_OxRdtase_dom_sf
    PfamiView protein in Pfam
    PF00248, Aldo_ket_red, 1 hit
    PIRSFiPIRSF000097, AKR, 1 hit
    PRINTSiPR00069, ALDKETRDTASE
    SUPFAMiSSF51430, SSF51430, 1 hit
    PROSITEiView protein in PROSITE
    PS00798, ALDOKETO_REDUCTASE_1, 1 hit
    PS00062, ALDOKETO_REDUCTASE_2, 1 hit
    PS00063, ALDOKETO_REDUCTASE_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1CA_RAT
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZF77
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
    Last sequence update: April 20, 2010
    Last modified: April 7, 2021
    This is version 81 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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