Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 84 (25 May 2022)
Sequence version 1 (20 Apr 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Aldo-keto reductase family 1 member C15

Gene

Akr1c15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NADPH-dependent reduction of a variety of substrates including aromatic and aliphatic aldehydes, quinones, ketones, dicarbonyl compounds and 17-ketosteroids (PubMed:17574202).

Catalyzes the NADP+-dependent oxidation of aromatic, alicyclic and aliphatic alcohols, and 17beta-hydroxysteroids (PubMed:17574202).

To a lesser extent, can also catalyze the reduction of some aldoses and ketoses and the oxidation of some sugar alcohols (PubMed:17574202).

In the stomach, lung and colon tissues, mediates the reduction of farnesal and geranylgeranial into farnesol and geranylgeraniol respectively (PubMed:21187079).

By reducing 4-hydroxy-2-nonenal (HNE), produced during lipid peroxidation, into 1,4-dihydro-2-nonene (DHN), protects vascular endothelial cells from damage elicited by oxidized lipoproteins (PubMed:21187080).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The dehydrogenase activity is inhibited by 3',3'',5',5''-tetraiodophenolphthalein, phenolphthalein, genistein, quercetin, zearalenone and diethylstilbestrol.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.2 µM for 4-nitrobenzaldehyde1 Publication
  2. KM=3.1 µM for benzaldehyde1 Publication
  3. KM=20 µM for pyridine-4-aldehyde1 Publication
  4. KM=25 µM for 2-phenyl-2-propenal1 Publication
  5. KM=2.4 µM for NADP+1 Publication
  6. KM=1430 µM for NAD+1 Publication
  7. KM=0.6 µM for NADPH1 Publication
  8. KM=43 µM for NADH1 Publication
  9. KM=0.3 µM for 1-decanal1 Publication
  10. KM=0.9 µM for 1-nonanal1 Publication
  11. KM=1.1 µM for 1-octanal1 Publication
  12. KM=1.1 µM for 1-hexanal1 Publication
  13. KM=112 µM for D-lactoaldehyde1 Publication
  14. KM=125 µM for L-lactoaldehyde1 Publication
  15. KM=225 µM for 4-methylpentanal (isocaproaldehyde)1 Publication
  16. KM=0.4 µM for all-trans-retinal1 Publication
  17. KM=3.5 µM for trans-2,4-nonadienal1 Publication
  18. KM=3.3 µM for trans-2-nonenal1 Publication
  19. KM=2.3 µM for 9-cis-retinal1 Publication
  20. KM=2.5 µM for 4-hydroxy-2-nonenal (HNE)1 Publication
  21. KM=0.8 µM for 6-tert-butyl-2,3-epoxy-4-benzoquinone (TBE)1 Publication
  22. KM=2.7 µM for 1,4-naphthoquinone1 Publication
  23. KM=14 µM for 5-hydroxy-1,4-naphthoquinone (juglone)1 Publication
  24. KM=22 µM for 1-indanone1 Publication
  25. KM=22 µM for 3-hydroxy-2-butanone1 Publication
  26. KM=0.5 µM for 1H-indole-2,3-dione (isatin)1 Publication
  27. KM=0.6 µM for 16-ketoestrone1 Publication
  28. KM=2 µM for 2,3-hexanedione1 Publication
  29. KM=5.5 µM for butane-2,3-dione (diacetyl)1 Publication
  30. KM=16 µM for methylglyoxal1 Publication
  31. KM=30 µM for 21-dehydrocortisol1 Publication
  32. KM=12 µM for S-indan-1-ol1 Publication
  33. KM=32 µM for farnesol1 Publication
  34. KM=5.6 µM for farnesal1 Publication
  35. KM=16 µM for geranylgeraniol1 Publication
  36. KM=0.2 µM for geranylgeranial1 Publication
  37. KM=15 µM for 1-nonanol1 Publication
  38. KM=8.2 µM for 1-decanol1 Publication
  39. KM=11 µM for 5-beta-androstane-3,17-dione (etiocholanedione)1 Publication
  40. KM=8.7 µM for 5-alpha-androstane-3,17-dione (androstanedione)1 Publication
  41. KM=5.6 µM for 4-androstene-3,17-dione1 Publication
  42. KM=36 µM for 5-alpha-androstan-3alpha-ol-17-one1 Publication
  43. KM=8.7 µM for 5-beta-androstan-3alpha-ol-17-one1 Publication
  44. KM=8.5 µM for 5-beta-androstane-3alpha,17beta-diol1 Publication
  45. KM=12 µM for 5-beta-androstan-17beta-ol-3-one1 Publication
  46. KM=6.9 µM for 5-alpha-androstane-3-alpha,17-beta-diol1 Publication
  47. KM=18 µM for testosterone1 Publication
  48. KM=18 µM for 5-alpha-androstan-17beta-ol-3-one1 Publication

pH dependencei

Optimum pH is 10.5 for the dehydrogenase activity. Optimum pH is 6 for the reductase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei51NADPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei56Proton donorUniRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei85Lowers pKa of active site TyrUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei191NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi24 – 26NADPBy similarity3
Nucleotide bindingi167 – 168NADPBy similarity2
Nucleotide bindingi217 – 225NADPBy similarity9
Nucleotide bindingi269 – 281NADPBy similarityAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldo-keto reductase family 1 member C15Curated (EC:1.1.1.-3 Publications, EC:1.1.1.2162 Publications)
Alternative name(s):
RAKc1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akr1c151 PublicationImported
Synonyms:Akr1clImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17
  • UP000234681 Componenti: Chromosome 17

Organism-specific databases

Rat genome database

More...
RGDi
1307514, Akr1c15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004455461 – 324Aldo-keto reductase family 1 member C15Add BLAST324

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZF77

PeptideAtlas

More...
PeptideAtlasi
D3ZF77

PRoteomics IDEntifications database

More...
PRIDEi
D3ZF77

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZF77

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZF77

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung, specifically in bronchiolar Clara cells, type II alveolar cells and epithelial cells of the duct of the bronchial gland (at protein level) (PubMed:17574202, PubMed:7511002, PubMed:21187079). Expressed in gastric parietal cells and in epithelial cells of the large intestine and colon (at protein level) (PubMed:17574202, PubMed:21187079). Expressed in brown adipocytes (at protein level) (PubMed:17574202). Expressed in vascular endothelial cells (at protein level) (PubMed:17574202).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000021735, Expressed in lung and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3ZF77, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000055113

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
D3ZF77

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZF77

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1577, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023205_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZF77

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECSPAIN

Database of Orthologous Groups

More...
OrthoDBi
1016440at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZF77

TreeFam database of animal gene trees

More...
TreeFami
TF106492

Family and domain databases

Conserved Domains Database

More...
CDDi
cd19108, AKR_AKR1C1-35, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020471, AKR
IPR044482, AKR1C
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00248, Aldo_ket_red, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000097, AKR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00069, ALDKETRDTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51430, SSF51430, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZF77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLKHSRSVK LNDGNLMPVL GFGTFASKEI PKSKAAEATK VAIDVGFRHI
60 70 80 90 100
DAAYFYQNEE EVGQALRDKM ADGTVKREDL FYTTKIWITF LRPELVRQCL
110 120 130 140 150
ERSLKKLGLD YVDLCIIHIP IAMKPGEELL PKDANGKFIF DTVDIRDTWE
160 170 180 190 200
ALEKCKDAGL SKSIGVSNFN HKQLELILNK PRLKYKPTCN QVECHPYLNQ
210 220 230 240 250
SKLLEFCKSK DIVLVAYSAL GSHRDSSWVS SDSPYLLEDP VLMTIAKKHN
260 270 280 290 300
QTPGQVALRY QLQRGVVVLA KSFNEKRIKE NFQVFDFELT PEDMKTIDSL
310 320
NRNFRYSQMA FALDHPDYPF LEEY
Length:324
Mass (Da):37,195
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i851BFF1FD9476B13
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07028443 Genomic DNA No translation available.
CH473990 Genomic DNA Translation: EDL78576.1

NCBI Reference Sequences

More...
RefSeqi
NP_001103370.1, NM_001109900.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000058312; ENSRNOP00000055113; ENSRNOG00000021735

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
361267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:361267

UCSC genome browser

More...
UCSCi
RGD:1307514, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07028443 Genomic DNA No translation available.
CH473990 Genomic DNA Translation: EDL78576.1
RefSeqiNP_001103370.1, NM_001109900.1

3D structure databases

AlphaFoldDBiD3ZF77
SMRiD3ZF77
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055113

PTM databases

iPTMnetiD3ZF77
PhosphoSitePlusiD3ZF77

Proteomic databases

PaxDbiD3ZF77
PeptideAtlasiD3ZF77
PRIDEiD3ZF77

Genome annotation databases

EnsembliENSRNOT00000058312; ENSRNOP00000055113; ENSRNOG00000021735
GeneIDi361267
KEGGirno:361267
UCSCiRGD:1307514, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
361267
RGDi1307514, Akr1c15

Phylogenomic databases

eggNOGiKOG1577, Eukaryota
GeneTreeiENSGT00940000163184
HOGENOMiCLU_023205_0_0_1
InParanoidiD3ZF77
OMAiECSPAIN
OrthoDBi1016440at2759
PhylomeDBiD3ZF77
TreeFamiTF106492

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZF77

Gene expression databases

BgeeiENSRNOG00000021735, Expressed in lung and 20 other tissues
ExpressionAtlasiD3ZF77, baseline and differential

Family and domain databases

CDDicd19108, AKR_AKR1C1-35, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR020471, AKR
IPR044482, AKR1C
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248, Aldo_ket_red, 1 hit
PIRSFiPIRSF000097, AKR, 1 hit
PRINTSiPR00069, ALDKETRDTASE
SUPFAMiSSF51430, SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1CA_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZF77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
Last sequence update: April 20, 2010
Last modified: May 25, 2022
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again