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UniProtKB - D3ZF61 (D3ZF61_RAT)
Protein
Submitted name:
RCG50849
Gene
Rarg
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: RGD
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- nuclear receptor activity Source: RGD
- retinoid X receptor binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- anterior/posterior pattern specification Source: RGD
- bone development Source: RGD
- bone morphogenesis Source: RGD
- cell differentiation Source: GO_Central
- cellular response to leukemia inhibitory factor Source: RGD
- cellular response to retinoic acid Source: RGD
- chondrocyte development Source: RGD
- embryonic camera-type eye development Source: RGD
- embryonic eye morphogenesis Source: RGD
- embryonic hindlimb morphogenesis Source: RGD
- epithelium development Source: RGD
- face development Source: RGD
- gland development Source: RGD
- glandular epithelial cell development Source: RGD
- growth plate cartilage chondrocyte growth Source: RGD
- growth plate cartilage development Source: RGD
- Harderian gland development Source: RGD
- hormone-mediated signaling pathway Source: GO_Central
- limb development Source: RGD
- multicellular organism growth Source: RGD
- negative regulation of cartilage development Source: RGD
- negative regulation of cell differentiation Source: RGD
- negative regulation of cell population proliferation Source: RGD
- negative regulation of chondrocyte differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neural tube closure Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of programmed cell death Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- prostate gland epithelium morphogenesis Source: RGD
- regulation of gene expression Source: RGD
- regulation of myelination Source: RGD
- regulation of myeloid cell differentiation Source: RGD
- reproductive structure development Source: RGD
- response to retinoic acid Source: RGD
- retinoic acid receptor signaling pathway Source: RGD
- trachea cartilage development Source: RGD
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: RCG50849ImportedSubmitted name: Retinoic acid receptor, gamma |
Gene namesi | Name:RargImported ORF Names:rCG_50849Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1583230, Rarg |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: RGD
Other locations
- chromatin Source: RGD
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000012499, Expressed in esophagus and 20 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 162 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 185 – 419 | NR LBDInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 58 – 83 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 409 – 458 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 60 – 74 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 417 – 435 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 443 – 458 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156458 |
OMAi | MQYTCHK |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
D3ZF61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATNKERLFA PNALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG
60 70 80 90 100
QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY
110 120 130 140 150
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC
160 170 180 190 200
FEVGMSKEAV RNDRNKKKKE VKEEGPPDNY ELSPQLEELI TKVSKAHQET
210 220 230 240 250
FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG
260 270 280 290 300
FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH
310 320 330 340 350
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV
360 370 380 390 400
DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL
410 420 430 440 450
KMEIPGPMPP LIREMLENPE MFEDDSSKPG PHPKASSEDE APGSQGKRGQ
SPQPDQGP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3ZWV0 | D3ZWV0_RAT | Retinoic acid receptor, gamma | Rarg | 485 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474035 Genomic DNA Translation: EDL86852.1 |
RefSeqi | NP_001128721.1, NM_001135249.1 XP_008764007.1, XM_008765785.2 XP_008764008.1, XM_008765786.2 |
Genome annotation databases
Ensembli | ENSRNOT00000017096.8; ENSRNOP00000017096.5; ENSRNOG00000012499.8 |
GeneIDi | 685072 |
KEGGi | rno:685072 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH474035 Genomic DNA Translation: EDL86852.1 |
RefSeqi | NP_001128721.1, NM_001135249.1 XP_008764007.1, XM_008765785.2 XP_008764008.1, XM_008765786.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSRNOT00000017096.8; ENSRNOP00000017096.5; ENSRNOG00000012499.8 |
GeneIDi | 685072 |
KEGGi | rno:685072 |
Organism-specific databases
CTDi | 5916 |
RGDi | 1583230, Rarg |
Phylogenomic databases
GeneTreei | ENSGT00940000156458 |
OMAi | MQYTCHK |
Gene expression databases
Bgeei | ENSRNOG00000012499, Expressed in esophagus and 20 other tissues |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003078, Retinoic_acid_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01292, RETNOICACIDR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZF61_RAT | |
Accessioni | D3ZF61Primary (citable) accession number: D3ZF61 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |