Rarg

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retinoic acid receptor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 11072095
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bone morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to retinoic acid
Source: RGD
Inferred from expression patternⁱ
- 11072095
epithelium development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
gland development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
hormone-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
multicellular organism development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 11072095
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of myelination
Source: RGD
Inferred from direct assayⁱ
- 20648638
response to lipid
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to retinoic acid
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retinoic acid receptor signaling pathway
Source: RGD
Inferred from mutant phenotypeⁱ
- 11072095
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationUniRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-5362517 Signaling by Retinoic Acid

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-5362517 Signaling by Retinoic Acid

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: RCG50849Imported Submitted name: Retinoic acid receptor, gammaImported
Gene namesⁱ	Name:RargImported ORF Names:rCG_50849Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	1583230 Rarg

RGDⁱ

1583230 Rarg

Keywords - Cellular componentⁱ

NucleusUniRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	D3ZF61

PRIDEⁱ

D3ZF61

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000012499 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasⁱ	D3ZF61 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	D3ZF61
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	87 – 162	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	185 – 419	NR LBDInterPro annotationAdd BLAST		235

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136372
KEGG Orthology (KO) More...KOⁱ	K08529
OMAⁱ	QKVSKAH

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

D3ZF61-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATNKERLFA PNALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG 
        60         70         80         90        100
QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY 
       110        120        130        140        150
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC 
       160        170        180        190        200
FEVGMSKEAV RNDRNKKKKE VKEEGPPDNY ELSPQLEELI TKVSKAHQET 
       210        220        230        240        250
FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG 
       260        270        280        290        300
FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 
       310        320        330        340        350
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV 
       360        370        380        390        400
DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL 
       410        420        430        440        450
KMEIPGPMPP LIREMLENPE MFEDDSSKPG PHPKASSEDE APGSQGKRGQ 

SPQPDQGP

Length:458

Mass (Da):51,016

Last modified:April 20, 2010 - v1

Checksum:ⁱ0AD290AE7C163E70

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3ZWV0	D3ZWV0_RAT		Retinoic acid receptor, gamma Retinoic acid receptor, gamma	Rarg	485	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC110347 Genomic DNA No translation available. CH474035 Genomic DNA Translation: EDL86852.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001128721.1, NM_001135249.1 XP_008764007.1, XM_008765785.2 XP_008764008.1, XM_008765786.2
UniGeneⁱ	Rn.198797

Genome annotation databases

Ensemblⁱ	ENSRNOT00000017096; ENSRNOP00000017096; ENSRNOG00000012499
GeneIDⁱ	685072
KEGGⁱ	rno:685072

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
D3ZF61	Retinoic acid receptor gamma		MOUSE		458	UniRef90_P18911
Uncharacterized protein		COLAP		461
Uncharacterized protein		FELCA		459
Uncharacterized protein		PROCO		458
retinoic acid receptor gamma isoform X1		PHYCD		458
+123

Protein	Similar proteins		Species	Score	Length	Source
D3ZF61	Retinoic acid receptor gamma		MOUSE		458	UniRef50_P18911
Retinoic acid receptor gamma-B		DANRE		489
Uncharacterized protein		COLAP		461
Uncharacterized protein		FELCA		459
Retinoic acid receptor gamma		SHEEP		458
+523

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC110347 Genomic DNA No translation available. CH474035 Genomic DNA Translation: EDL86852.1
RefSeqⁱ	NP_001128721.1, NM_001135249.1 XP_008764007.1, XM_008765785.2 XP_008764008.1, XM_008765786.2
UniGeneⁱ	Rn.198797

3D structure databases

SMRⁱ	D3ZF61
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	D3ZF61

PRIDEⁱ

D3ZF61

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000017096; ENSRNOP00000017096; ENSRNOG00000012499
GeneIDⁱ	685072
KEGGⁱ	rno:685072

Organism-specific databases

CTDⁱ	5916
RGDⁱ	1583230 Rarg

Phylogenomic databases

GeneTreeⁱ	ENSGT00870000136372
KOⁱ	K08529
OMAⁱ	QKVSKAH

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-5362517 Signaling by Retinoic Acid

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-5362517 Signaling by Retinoic Acid

Gene expression databases

Bgeeⁱ	ENSRNOG00000012499 Expressed in 9 organ(s), highest expression level in lung
ExpressionAtlasⁱ	D3ZF61 baseline and differential

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZF61_RAT
Accessionⁱ	D3ZF61Primary (citable) accession number: D3ZF61
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZF61 (D3ZF61_RAT)

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RCG50849

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ