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Entry version 55 (02 Jun 2021)
Sequence version 1 (20 Apr 2010)
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Protein

Sentrin-specific protease 7

Gene

Senp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei847By similarity1
Active sitei979By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C48.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sentrin-specific protease 7 (EC:3.4.22.-)
Alternative name(s):
SUMO-1-specific protease 2
Sentrin/SUMO-specific protease SENP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Senp7
Synonyms:Susp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11
  • UP000234681 Componentsi: Chromosome 11, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1305510, Senp7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003955021 – 1037Sentrin-specific protease 7Add BLAST1037

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei189PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZF42

PeptideAtlas

More...
PeptideAtlasi
D3ZF42

PRoteomics IDEntifications database

More...
PRIDEi
D3ZF42

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZF42

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZF42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001616, Expressed in thymus and 20 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3ZF42, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000043376

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZF42

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 28DisorderedSequence analysisAdd BLAST28
Regioni182 – 420DisorderedSequence analysisAdd BLAST239
Regioni747 – 971ProteaseBy similarityAdd BLAST225
Regioni873 – 910DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi182 – 224Polar residuesSequence analysisAdd BLAST43
Compositional biasi312 – 340Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi376 – 402Polar residuesSequence analysisAdd BLAST27
Compositional biasi889 – 910Polar residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0779, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157308

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011967_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZF42

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEMDLHL

Database of Orthologous Groups

More...
OrthoDBi
1241636at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZF42

TreeFam database of animal gene trees

More...
TreeFami
TF350136

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02902, Peptidase_C48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZF42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRARPGRRR ASSEIVTEGK RKKSSPADLQ KITKLLTVKS EDVLAQSPLP
60 70 80 90 100
KLRGSECWWT RSLRNKVICL DHKTTKAAHG CPPKALPKRH LKVMLTNVLW
110 120 130 140 150
TDLGREFRKT LPRNDAKLCD TSKVQSDSLP STSVDSIETC QRLDPLHQSL
160 170 180 190 200
NLSERIPRVI LTDIRQTELG RKYLKIPSVT EASLSDTASP KSEELSSSAD
210 220 230 240 250
GSLESCQNVN HLKSFLSERG SKPSRTGDIS AKEAANGRQE QGDDGDIAPE
260 270 280 290 300
MVTPQSKDFN SGNKGDYHEE GTSNKNTSYS HSETDHTPVS RKRKKRGRSN
310 320 330 340 350
FHNSHNPKSS VDKSTEYIKE EENESTVSSK LEESNEDSHQ DPAPPEGLTP
360 370 380 390 400
DSLETEATNV CSFVVQEPDV SAASGRACSP NKSSESSVSS EVAENSSAAE
410 420 430 440 450
KGEASTVKEA PPPGGNSEEN QLLMSAEPIV VSSDEEGPVE HKNSVILKLQ
460 470 480 490 500
PSQDYEFMSE NQTTSDPQLS ELMLGACESV QVSSELCPYN PDMENISCIN
510 520 530 540 550
PNSEMDLKLD FIFTCVYIGK IKGTSKGCIT FTKKYIKIPF QVSMNEISLT
560 570 580 590 600
VDTARLKRFG LWESKDDDHS KRSHAILFLW VSSNYLQDIQ TQLENPMLSQ
610 620 630 640 650
QSKANEFIFL ELNSPISQRE ELKLKDIMME IGATNGELQL SCPLPWVQAF
660 670 680 690 700
PLFQDLSPQE ISFLHYYCAS ASSFPAVAGA DMKKKPVSQP SNADVVKPTY
710 720 730 740 750
TFLHKQSSGC YSLSITSSPD EEWREVRNTG PVQKLIVYPP PPTKGGLGVT
760 770 780 790 800
NEDLECLEEG EFLNDVIIDF YLKYLLLEKA SDELVERSHI FSSFFYKCLT
810 820 830 840 850
RKENNLTEDN PDLSVAQRRH RRVRTWTRHI NIFNKDYIFV PVNESSHWYL
860 870 880 890 900
AVICFPWLEE AVYEDFPQTV SQEFQDQQSQ HDNKTIDNDP HTTSTVFTSA
910 920 930 940 950
EESQSTETSM SVPKKMCKRP CILILDSLKA ASIQNTVQNL REYLEVEWEV
960 970 980 990 1000
KRKTHREFSK TNMVDLCPKV PKQDNSSDCG VYLLQYVESF FQDPIVNFEL
1010 1020 1030
PIHLEKWFPR HVIKTKREDI RELILKLHLQ QQKGSSS
Length:1,037
Mass (Da):116,872
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i945C78977051CA27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH473967 Genomic DNA Translation: EDM11051.1

NCBI Reference Sequences

More...
RefSeqi
NP_001099358.1, NM_001105888.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000044177; ENSRNOP00000043376; ENSRNOG00000001616

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
288167

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:288167

UCSC genome browser

More...
UCSCi
RGD:1305510, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473967 Genomic DNA Translation: EDM11051.1
RefSeqiNP_001099358.1, NM_001105888.1

3D structure databases

SMRiD3ZF42
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043376

Protein family/group databases

MEROPSiC48.009

PTM databases

iPTMnetiD3ZF42
PhosphoSitePlusiD3ZF42

Proteomic databases

PaxDbiD3ZF42
PeptideAtlasiD3ZF42
PRIDEiD3ZF42

Genome annotation databases

EnsembliENSRNOT00000044177; ENSRNOP00000043376; ENSRNOG00000001616
GeneIDi288167
KEGGirno:288167
UCSCiRGD:1305510, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57337
RGDi1305510, Senp7

Phylogenomic databases

eggNOGiKOG0779, Eukaryota
GeneTreeiENSGT00940000157308
HOGENOMiCLU_011967_0_0_1
InParanoidiD3ZF42
OMAiNEMDLHL
OrthoDBi1241636at2759
PhylomeDBiD3ZF42
TreeFamiTF350136

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZF42

Gene expression databases

BgeeiENSRNOG00000001616, Expressed in thymus and 20 other tissues
GenevisibleiD3ZF42, RN

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C
PfamiView protein in Pfam
PF02902, Peptidase_C48, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSENP7_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZF42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 20, 2010
Last modified: June 2, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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