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Entry version 66 (29 Sep 2021)
Sequence version 2 (22 Jul 2015)
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Protein
Submitted name:

GPRIN family member 3

Gene

Gprin3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neurite outgrowth.

ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GPRIN family member 3Imported
Submitted name:
RCG52360Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gprin3Imported
ORF Names:rCG_52360Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1565690, Gprin3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
D3ZF21

PRoteomics IDEntifications database

More...
PRIDEi
D3ZF21

PTM databases

SwissPalm database of S-palmitoylation events

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SwissPalmi
D3ZF21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000023657, Expressed in liver and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000055378

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D3ZF21

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini636 – 757GRIN_CInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni65 – 173DisorderedSequence analysisAdd BLAST109
Regioni188 – 310DisorderedSequence analysisAdd BLAST123
Regioni423 – 454DisorderedSequence analysisAdd BLAST32
Regioni494 – 624DisorderedSequence analysisAdd BLAST131
Regioni708 – 738DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 41Polar residuesSequence analysisAdd BLAST17
Compositional biasi70 – 108Polar residuesSequence analysisAdd BLAST39
Compositional biasi155 – 169Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi255 – 301Polar residuesSequence analysisAdd BLAST47
Compositional biasi518 – 536Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi586 – 620Polar residuesSequence analysisAdd BLAST35
Compositional biasi714 – 738Polar residuesSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTMW, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00570000079168

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020316_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZF21

Identification of Orthologs from Complete Genome Data

More...
OMAi
PAREDGC

Database of Orthologous Groups

More...
OrthoDBi
612273at2759

TreeFam database of animal gene trees

More...
TreeFami
TF337047

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026646, GPRIN2-like/GPRIN3
IPR032745, GRIN_C

The PANTHER Classification System

More...
PANTHERi
PTHR15718, PTHR15718, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15235, GRIN_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZF21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTVPDPLRV TKASIVAASR KEESPGELQS VSPQPAQPDK NVSGIGNAPA
60 70 80 90 100
ELSLRLSSAA PALMQACVHE SSPQDMTSPG MLNEVEQVSP KNNTPDDSQP
110 120 130 140 150
QGSKESAAPD ANATAKKELT SAPFLMSAVQ HMHHAIRNDP PNTSTCPVPE
160 170 180 190 200
DSLVKSEANS DREKPEKSSC PTRVTCCSSK NKVFCDFPSP ENSQGIVQTP
210 220 230 240 250
DRAVRIHSSP SADRPEGEEQ KAINSTTVVS SEPLARGECS ENRQPSDTVL
260 270 280 290 300
DTTDEKSENP PLSPLTSREA TCSSEARQVQ LPTQHPTSRF KEASTMTCQA
310 320 330 340 350
ESEAKEVPGR AWQDAEVQAV ASVESRSVST SPSILPAFLK ENPALEQENG
360 370 380 390 400
QEQLRVICHD KGSGSRLLEL SNSMVDPQES RQCPSIVPQV HIQAPVATST
410 420 430 440 450
AFKGGCKPAN QPAEGLKSPL VHVASSQTPD TEEDLRSSTS KEATSRELTG
460 470 480 490 500
TNLGSQKATT IAQISVLAGS QAEISLGLGN SGLRAPELVE KIANDHKTEP
510 520 530 540 550
DCKLSNSRGG VNEDQPLESL DPTDKRDAKD KNPASPLIVK DHAPGATSTP
560 570 580 590 600
DAKTLLLNPK SHGSEGPEVS PAPSPGRKST VEEHRQTKTV TSLSLPSDGT
610 620 630 640 650
GDSSPGSGKR TPSRSVKASP RRASRVSEFL KELNVTAAAA QVGLTPGEKK
660 670 680 690 700
KQLGAESKLQ LKQSKRVRDV VWDDQGMTWE VYGASLDPES LGVAIQNHLQ
710 720 730 740 750
RQIREHEKLV KTQSGQTRRS ISSDSSSSKK LKGRQQGVLQ SMLQNFRRPN
760
CCVRPAPSSV LD
Length:762
Mass (Da):81,334
Last modified:July 22, 2015 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6197BD334069AFB5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07060688 Genomic DNA No translation available.
CH474011 Genomic DNA Translation: EDL88021.1

NCBI Reference Sequences

More...
RefSeqi
XP_006225003.1, XM_006224941.3
XP_006225004.1, XM_006224942.3
XP_006236651.1, XM_006236589.3
XP_006236652.1, XM_006236590.3
XP_008761187.1, XM_008762965.2
XP_008761188.1, XM_008762966.2
XP_008773969.1, XM_008775747.2
XP_008773970.1, XM_008775748.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000039316; ENSRNOP00000055378; ENSRNOG00000023657

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
502784

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07060688 Genomic DNA No translation available.
CH474011 Genomic DNA Translation: EDL88021.1
RefSeqiXP_006225003.1, XM_006224941.3
XP_006225004.1, XM_006224942.3
XP_006236651.1, XM_006236589.3
XP_006236652.1, XM_006236590.3
XP_008761187.1, XM_008762965.2
XP_008761188.1, XM_008762966.2
XP_008773969.1, XM_008775747.2
XP_008773970.1, XM_008775748.2

3D structure databases

SMRiD3ZF21
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055378

PTM databases

SwissPalmiD3ZF21

Proteomic databases

PeptideAtlasiD3ZF21
PRIDEiD3ZF21

Genome annotation databases

EnsembliENSRNOT00000039316; ENSRNOP00000055378; ENSRNOG00000023657
GeneIDi502784

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285513
RGDi1565690, Gprin3

Phylogenomic databases

eggNOGiENOG502QTMW, Eukaryota
GeneTreeiENSGT00570000079168
HOGENOMiCLU_020316_0_0_1
InParanoidiD3ZF21
OMAiPAREDGC
OrthoDBi612273at2759
TreeFamiTF337047

Gene expression databases

BgeeiENSRNOG00000023657, Expressed in liver and 19 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026646, GPRIN2-like/GPRIN3
IPR032745, GRIN_C
PANTHERiPTHR15718, PTHR15718, 1 hit
PfamiView protein in Pfam
PF15235, GRIN_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZF21_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZF21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: September 29, 2021
This is version 66 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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