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UniProtKB - D3ZEK9 (D3ZEK9_RAT)
Protein
Submitted name:
Transcription factor 15
Gene
Tcf15
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- bHLH transcription factor binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- E-box binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anterior/posterior pattern specification Source: RGD
- developmental process Source: GO_Central
- ear development Source: RGD
- eating behavior Source: RGD
- establishment of epithelial cell apical/basal polarity Source: RGD
- mesenchymal to epithelial transition Source: RGD
- muscle organ development Source: RGD
- muscle organ morphogenesis Source: RGD
- negative regulation of hematopoietic stem cell differentiation Source: RGD
- neuromuscular process controlling posture Source: RGD
- paraxial mesoderm development Source: RGD
- positive regulation of stem cell differentiation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- post-anal tail morphogenesis Source: RGD
- regulation of extracellular matrix organization Source: RGD
- regulation of gene expression Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- respiratory system process Source: RGD
- skeletal system morphogenesis Source: RGD
- skin development Source: RGD
- somitogenesis Source: RGD
- stem cell population maintenance Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor 15 |
Gene namesi | Name:Tcf15Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308464, Tcf15 |
Subcellular locationi
Nucleus
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000000012, Expressed in heart and 21 other tissues |
Interactioni
GO - Molecular functioni
- bHLH transcription factor binding Source: RGD
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000013 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 122 | BHLHInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 44 – 65 | DisorderedSequence analysisAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161320 |
HOGENOMi | CLU_115077_0_0_1 |
InParanoidi | D3ZEK9 |
OMAi | HPFSYPA |
OrthoDBi | 1511100at2759 |
PhylomeDBi | D3ZEK9 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZEK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGLEAARRG
60 70 80 90 100
PGPGSGRRAS GGAGPVVVVR QRQAANARER DRTQSVNTAF TALRTLIPTE
110 120 130 140 150
PVDRKLSKIE TLRLASSYIA HLANVLLLGD AADDGQPCFR AAGGGKSAVP
160 170 180 190
AADGRQPRSI CTFCLSNQRK GGSRRDLGGS CLKVRGVAPL RGPRR
Sequence databases
RefSeqi | NP_001162051.1, NM_001168579.1 |
Genome annotation databases
Ensembli | ENSRNOT00000000013.6; ENSRNOP00000000013.3; ENSRNOG00000000012.6 |
GeneIDi | 296272 |
KEGGi | rno:296272 |
UCSCi | RGD:1308464, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001162051.1, NM_001168579.1 |
3D structure databases
AlphaFoldDBi | D3ZEK9 |
SMRi | D3ZEK9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000013 |
Proteomic databases
PaxDbi | D3ZEK9 |
PeptideAtlasi | D3ZEK9 |
Genome annotation databases
Ensembli | ENSRNOT00000000013.6; ENSRNOP00000000013.3; ENSRNOG00000000012.6 |
GeneIDi | 296272 |
KEGGi | rno:296272 |
UCSCi | RGD:1308464, rat |
Organism-specific databases
CTDi | 6939 |
RGDi | 1308464, Tcf15 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000161320 |
HOGENOMi | CLU_115077_0_0_1 |
InParanoidi | D3ZEK9 |
OMAi | HPFSYPA |
OrthoDBi | 1511100at2759 |
PhylomeDBi | D3ZEK9 |
TreeFami | TF315153 |
Gene expression databases
Bgeei | ENSRNOG00000000012, Expressed in heart and 21 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZEK9_RAT | |
Accessioni | D3ZEK9Primary (citable) accession number: D3ZEK9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | May 25, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |