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Entry version 78 (10 Apr 2019)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Kinesin family member 14

Gene

Kif14

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi482 – 489ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5625900 RHO GTPases activate CIT

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kinesin family member 14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kif14Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...
RGDi
1310650 Kif14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3ZE01

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000037211 Expressed in 7 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000012038

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D3ZE01

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini393 – 736Kinesin motorInterPro annotationAdd BLAST344
Domaini860 – 911FHAInterPro annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili963 – 1062Sequence analysisAdd BLAST100
Coiled coili1071 – 1105Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0245 Eukaryota
COG5059 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156834

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZE01

Identification of Orthologs from Complete Genome Data

More...
OMAi
QEVSYHL

TreeFam database of animal gene trees

More...
TreeFami
TF337995

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24115 PTHR24115, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00240 FHA, 1 hit
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZE01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVHTSHSRH NIGSLEVSSS QKISASSGLV HSSRLELRLK SDMSECENHD
60 70 80 90 100
PLANAGTKTI DINSTYVISA CKKARETPAT PDPGRLTLQR RTTWNKESSL
110 120 130 140 150
LGSESGHPTG RTADTSLRLQ RRPLARADYG EKWETSNPVG GNPGSKSASQ
160 170 180 190 200
KGRTEAKLVN NDSCALSSVV SEKDSNDTGL TKRKDPCPAL STSNEKVTVK
210 220 230 240 250
NPNSRAPIGS QRQTEAMRSG HLVVQPVENK ADIQVSGGGN SHHGNAGKGI
260 270 280 290 300
AKHTSTFGSS ETRTPAKCVS EHRSAPRHDL PPPKSPALST QKNNGKDIAK
310 320 330 340 350
HVSTFRNSSS ETQTPAKCVL EHRWAPRHGL PPPKSPALST LKNRIASPRV
360 370 380 390 400
KPRPKSSLLA NKSSQESTLP PEEKSTVQNT FTEPDSLKVE NSQVTVAVRV
410 420 430 440 450
RPFSKREKTE KASQVVFRNG EEITVEHPDM KQIYSFIYDV AFWSFDECHP
460 470 480 490 500
GYANQTTVYE TLAAPLLDRA FEGYNTCLFA YGQTGSGKSY TMMGLNEEPG
510 520 530 540 550
IIPRFCEDLF AQIAKKQASE VSYHLEMSFF EVYNEKIHDL LVCKGENGQR
560 570 580 590 600
KQPLRSEGEH PVSGAYVEGR VNVSAPLSQQ ESWLELGNKQ RATAATGMND
610 620 630 640 650
KSSRSHSVFT LVMTQTKTEF VEGEEHDHRI TSRINLIDLA GSERCSTAHS
660 670 680 690 700
SGERLKEGVS INKSLLTLGK VISALSEQAN GKRVFIPYRE STLTWLLKES
710 720 730 740 750
LGGNSKTAMI ATISPAASNI EETLSTLRYA TQARLIVNVA KVNEDMNAKL
760 770 780 790 800
IRVLRTRASL GKPSCSFTPN FLPKEYTLVG KEISYPRGEL PQQERTWQKI
810 820 830 840 850
QRVWKEKFEQ AEKRKLQETK ELQKAGVTFQ MDNHLPNLVN LNEDPQLSEM
860 870 880 890 900
LLYMVKEGIT TVGKHTPNSS HDIQLSGVLI ADDHCTIRSY GGTVSIVPAG
910 920 930 940 950
EAKTYVNGMH ISEPTVLHHG DRVVLGGDHY FRFNHPVEVQ KGKKTSRNNL
960 970 980 990 1000
TSEGPKDFEF AKNELLAAQR SRLEAEIKDA QLKAKEEMMQ GIQIAKEMAQ
1010 1020 1030 1040 1050
QELSSQRAAY ENKIRALEAE LREESQRKRL EEINNQKASH KIEELEKAKQ
1060 1070 1080 1090 1100
HLEQEVYVNK RRLEMETLAT KQALEDHRIR HARILEALER EKQKIAEEVQ
1110 1120 1130 1140 1150
ILQENRGNRN KTFTIQPNWS SMKLSTMIQE ANAISDKFKK HYVFGRHDAS
1160 1170 1180 1190 1200
DKGRSDPSCE LQGSQVGVNT AWSIEQFRLF LAVMIQLYES NSGTRGEDVF
1210 1220 1230 1240 1250
CDPEDEWEPD ITSTPVSSLS RRRSRSLMKN RRVSGCLHDI HPIQSMHPSH
1260 1270 1280 1290 1300
TSGLMEKPST IYSNSSESFL PGICKELIGS SIDFLGQSFD EEKTIADSLI
1310 1320 1330 1340 1350
NNLLKLYNGV IAISKAHEEQ DEESQDNVFS DRAAQALTIQ VACAFEQLVV
1360 1370 1380 1390 1400
LFKHWLDDFP PCSGSARLEE ELRQDIKKLG GYLQLFLQGC CSDISSMVKE
1410 1420 1430 1440 1450
AQNKVTEIIQ QAVGHVAQLA VLKGSKLCVL EDSNKVSSAQ ELMAALQDGT
1460 1470 1480 1490 1500
ASGMRSLLDS GLETAQELRQ DVSRQSAPEE VTRQMKANAV ELVGSLENIF
1510 1520 1530 1540 1550
AEWRTKSFRT QVEEGSRQQG SKVLNLASEF LKLKSCLQQT IEMVVSALRG
1560 1570 1580 1590 1600
CPSDLRCLRS CTETICGLAH KLHGGFSALS DSAGSCGNEQ PRAVWEELES
1610 1620 1630 1640 1650
LAKSLLLCFE HGERPSFLKP WESCTSNSTE EQRESDRADC SRSVPGRACE
1660 1670
PHRDPTPAES SGDGTPSRIQ WV
Length:1,672
Mass (Da):185,737
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i853B48369A789C50
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07021008 Genomic DNA No translation available.
AABR07021009 Genomic DNA No translation available.
AABR07021010 Genomic DNA No translation available.
AABR07021011 Genomic DNA No translation available.
AABR07021012 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000012038; ENSRNOP00000012038; ENSRNOG00000037211

UCSC genome browser

More...
UCSCi
RGD:1310650 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07021008 Genomic DNA No translation available.
AABR07021009 Genomic DNA No translation available.
AABR07021010 Genomic DNA No translation available.
AABR07021011 Genomic DNA No translation available.
AABR07021012 Genomic DNA No translation available.

3D structure databases

SMRiD3ZE01
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012038

Proteomic databases

PRIDEiD3ZE01

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012038; ENSRNOP00000012038; ENSRNOG00000037211
UCSCiRGD:1310650 rat

Organism-specific databases

RGDi1310650 Kif14

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000156834
InParanoidiD3ZE01
OMAiQEVSYHL
TreeFamiTF337995

Enzyme and pathway databases

ReactomeiR-RNO-5625900 RHO GTPases activate CIT

Gene expression databases

BgeeiENSRNOG00000037211 Expressed in 7 organ(s), highest expression level in colon

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZE01_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZE01
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: April 10, 2019
This is version 78 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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