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Entry version 68 (11 Dec 2019)
Sequence version 2 (03 Apr 2013)
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Protein
Submitted name:

Extra spindle pole bodies-like 1, separase

Gene

Espl1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2467813 Separation of Sister Chromatids

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C50.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Extra spindle pole bodies-like 1, separaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Espl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Rat genome database

More...
RGDi
1306266 Espl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZDT7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZDT7

PRoteomics IDEntifications database

More...
PRIDEi
D3ZDT7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZDT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZDT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000012835 Expressed in 9 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000017314

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZDT7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1932 – 2027Peptidase C50InterPro annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1311 – 1351DisorderedSequence analysisAdd BLAST41
Regioni1402 – 1461DisorderedSequence analysisAdd BLAST60
Regioni1495 – 1540DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1313 – 1334PolarSequence analysisAdd BLAST22
Compositional biasi1516 – 1536PolyampholyteSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1849 Eukaryota
COG5155 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004990

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZDT7

KEGG Orthology (KO)

More...
KOi
K02365

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACNQQLT

Database of Orthologous Groups

More...
OrthoDBi
14013at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101169

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005314 Peptidase_C50
IPR030397 SEPARIN_core_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12792 PTHR12792, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51700 SEPARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZDT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNFKGVKFA TLLCCKRETQ ELLPDLKEFL SRSRTDSVSS RTDAERRQVC
60 70 80 90 100
DTILRACTQQ LTAKLDGPGH LRSILDLAEL ACDGYLLSTP QRPPLYLERI
110 120 130 140 150
LFILLRNGLT QGNPDAVLRL AQPLHACLVQ NSREAAPQDY EAVTRGTFSL
160 170 180 190 200
LWKGAEALSE RRAAFSARLK ALSFLVLLED GSLPCEVPHF ASPTACRVVA
210 220 230 240 250
AYQLFDATGQ GLDAADADFV YDLLSRHVIR VLVGEGGRAS GPLSPQRALC
260 270 280 290 300
LLELTLEHCR RLCWNQHHHK ATIAVEKTRD HLGNSNVAPS LQLCQMGVEL
310 320 330 340 350
LEAVEERPGA VAQLLMKAAA ILNSSMDGPS PPLRALYDSC QFFLSGLERT
360 370 380 390 400
IKRHYGVDAI LNLFAFLGGY HSLVRHLREA SEASSKQQQS LLQMHFHTLH
410 420 430 440 450
LFTGIVYDFA QGCQVAELAQ LVDSCRSAVV WMLEALEGLS GGELADYLGV
460 470 480 490 500
TASYTSNLAY SFFSQKLYEE ACAISEPVCQ HLGLAKSGAC PEVPPEKLHR
510 520 530 540 550
CFRLHVESLK KWGKQAQGCK MVTLWLAALK PYGLQHMVEP VTFWVRVKMD
560 570 580 590 600
AAKAGDKELQ LQTLRDSLSC WDPEMQSLLL REELQAYKAV RADTGQERFN
610 620 630 640 650
VICDLLELSP EDTAAGAWAR ATHLVELAQV LCYHSFAQQT NCSALDAIQE
660 670 680 690 700
ALQLLESVSP EAQEQDRLLD DKAQALLWLY ICTLEAKMQE GIERDRRAQA
710 720 730 740 750
PSNLEEFEVN DLNYEDKLQE DRFLYSNIAF NLAADAAQSR CLDQALTLWK
760 770 780 790 800
EVLTKEPAPA VRCLQQTAAS LQILVAIYQL VAKPLQALET LLLLQIVSKR
810 820 830 840 850
LQDHAKAVSS SCQLTQLLLN LGCPSYAQLY LEEAESSLKN LDQATDTCQL
860 870 880 890 900
LSLTCALLRS QLCWACQKVT EGVSLLLSVL RDPALQKSSK AWYLLRVQAL
910 920 930 940 950
QILAFYLSLS SNLLSSALRE ELWDQGWQTP ETALIDAHKL LRSIIILLMG
960 970 980 990 1000
GDVLSVQKAA VESPFLDYGE NLVQKWQVLT EVLTCSERLV SRLGRLGNVS
1010 1020 1030 1040 1050
EAKAFCLEAL KLTTKLQIPR QCALFLVLKG ELELARGDTD LCQSDLQQVL
1060 1070 1080 1090 1100
FLLESSTEFG VVTQHPDSVK RVHTQKGTHK AQVPCSPPLP EEEPFLRGPA
1110 1120 1130 1140 1150
LELVATVLKE PGPIQPSGNS SPVLKTKASP KPGFLSHLPS CDCLLCASPA
1160 1170 1180 1190 1200
LSTVCLRWVL VTAGVRLTTG HKAQGLDLLQ AVLKGCPAAT KRFTQNLQTS
1210 1220 1230 1240 1250
LNHKAPPSCV PSLFDEIMAQ VYTHLALECL NQTSEKSLGK VLASGLKFVA
1260 1270 1280 1290 1300
TRIQYLEFWQ ASLLLVQALA KLARFSCCTS ELFASAWGWQ PPLVKIPPVL
1310 1320 1330 1340 1350
EPSKIRRQKC SGQGRQRVAS APSPLHSSSQ EGLEEGPPCT PKPPGRARQA
1360 1370 1380 1390 1400
GPRVPFTIFE DIHPTKSKLK VPLAPRVHRR AQTRLKVNFS DDSDLEDLVS
1410 1420 1430 1440 1450
AETQLVEEPK RRGTASRTRG QSRKGPSLKT DAAVAVGSTP GHPSLSGRTR
1460 1470 1480 1490 1500
RARKVASRHC EGVGASLGPE IMRSIPEEEL MDSQLEKSFE ILRASDGEDS
1510 1520 1530 1540 1550
ASGEKAAAAE PGLPIGEREV LRRDSSKAER PVLYPDTEAD SDLSPWLPPF
1560 1570 1580 1590 1600
SIPAPIDLST LDSIADSLSI AFRGISHCPP SGLYAHLCRF LALCLGHRDP
1610 1620 1630 1640 1650
YATAFLVAES VSITCRHQLL THLHRQLSKA QKQQGSPELA EHLQRLDLKE
1660 1670 1680 1690 1700
RPGGVPLARV QHLFSFRALG SGCFPQAEKD SFQKRLALIP SGVTVCVLAL
1710 1720 1730 1740 1750
ATLQPGTLSN TLLLTRLEKD NPPITVKIPT AQSKFPLSAV LKEFDAIQKD
1760 1770 1780 1790 1800
QKENSGCTEK RAWWTGRLAL DQRMEELITS LEEHVLGCWR GLLLPCSTDP
1810 1820 1830 1840 1850
GLSQEASQLQ ELLHECGWEY PDYTLLKVIL SGARILSSQD VQALACGLCP
1860 1870 1880 1890 1900
AQPERAQVLL SEAVGRVQSQ AAPPSQHLVL VLDKDLQKLP WESMPCLRAL
1910 1920 1930 1940 1950
PVTRLPSLRF LLSYSIAKEA GASSVLSQGV DPRNTFYVLN PHSNLSSTEE
1960 1970 1980 1990 2000
RFRASFSSEA GWKGVIGEVP SLEQVQAALT EHDLYIYAGH GAGARFLDGQ
2010 2020 2030 2040 2050
AVLRLNCRAV ALLFGCSSAA LAVHGNLEGA GIVLKYIMAG CPLFLGNLWD
2060 2070 2080 2090 2100
VTDRDIDRYT EALLQGWLGA GPGAPLLHYV SQARQAPRLK YLIGAAPVAY

GLPVSLQTS
Length:2,109
Mass (Da):231,615
Last modified:April 3, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE94F3449FF861D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC097309 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001164073.1, NM_001170602.1
XP_006242522.1, XM_006242460.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000017314; ENSRNOP00000017314; ENSRNOG00000012835

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:315330

UCSC genome browser

More...
UCSCi
RGD:1306266 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097309 Genomic DNA No translation available.
RefSeqiNP_001164073.1, NM_001170602.1
XP_006242522.1, XM_006242460.3

3D structure databases

SMRiD3ZDT7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017314

Protein family/group databases

MEROPSiC50.002

PTM databases

iPTMnetiD3ZDT7
PhosphoSitePlusiD3ZDT7

Proteomic databases

jPOSTiD3ZDT7
PaxDbiD3ZDT7
PRIDEiD3ZDT7

Genome annotation databases

EnsembliENSRNOT00000017314; ENSRNOP00000017314; ENSRNOG00000012835
GeneIDi315330
KEGGirno:315330
UCSCiRGD:1306266 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9700
RGDi1306266 Espl1

Phylogenomic databases

eggNOGiKOG1849 Eukaryota
COG5155 LUCA
GeneTreeiENSGT00390000004990
InParanoidiD3ZDT7
KOiK02365
OMAiACNQQLT
OrthoDBi14013at2759
TreeFamiTF101169

Enzyme and pathway databases

ReactomeiR-RNO-2467813 Separation of Sister Chromatids

Gene expression databases

BgeeiENSRNOG00000012835 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR005314 Peptidase_C50
IPR030397 SEPARIN_core_dom
PANTHERiPTHR12792 PTHR12792, 1 hit
PROSITEiView protein in PROSITE
PS51700 SEPARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZDT7_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZDT7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 3, 2013
Last modified: December 11, 2019
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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