UniProtKB - D3ZDT6 (D3ZDT6_RAT)
Protein
Submitted name:
Polycystic kidney disease 2-like 1 (Predicted)
Gene
Pkd2l1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- alpha-actinin binding Source: RGD
- calcium activated cation channel activity Source: RGD
- calcium-activated potassium channel activity Source: RGD
- calcium channel activity Source: RGD
- calcium ion binding Source: RGD
- cation channel activity Source: RGD
- cytoskeletal protein binding Source: RGD
- identical protein binding Source: RGD
- muscle alpha-actinin binding Source: RGD
- sodium channel activity Source: RGD
- sour taste receptor activity Source: Ensembl
GO - Biological processi
- cation transport Source: RGD
- cellular response to acidic pH Source: RGD
- cellular response to pH Source: RGD
- detection of chemical stimulus involved in sensory perception of sour taste Source: RGD
- detection of chemical stimulus involved in sensory perception of taste Source: RGD
- detection of mechanical stimulus Source: GO_Central
- inorganic cation transmembrane transport Source: RGD
- potassium ion transmembrane transport Source: RGD
- protein homotetramerization Source: RGD
- protein tetramerization Source: RGD
- response to water Source: RGD
- sensory perception of sour taste Source: RGD
- smoothened signaling pathway Source: RGD
- sodium ion transmembrane transport Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: Polycystic kidney disease 2-like 1 (Predicted)ImportedSubmitted name: Polycystin 2-like 1, transient receptor potential cation channelImported |
Gene namesi | ORF Names:rCG_57418Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306261, Pkd2l1 |
Subcellular locationi
Plasma membrane
- cilium membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
Plasma Membrane
- ciliary membrane Source: UniProtKB-SubCell
- integral component of plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- calcium channel complex Source: RGD
- cation channel complex Source: RGD
- cell surface Source: Ensembl
- cytoplasmic vesicle Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: RGD
- membrane Source: RGD
- non-motile cilium Source: RGD
- receptor complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 104 – 129 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 347 – 365 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 385 – 403 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 474 – 496 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 536 – 557 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cytoplasmic vesicleARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSRNOG00000012591, Expressed in testis and 9 other tissues |
Interactioni
GO - Molecular functioni
- alpha-actinin binding Source: RGD
- cytoskeletal protein binding Source: RGD
- identical protein binding Source: RGD
- muscle alpha-actinin binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000062794 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 146 – 564 | PKD_channelInterPro annotationAdd BLAST | 419 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 615 – 656 | Sequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Belongs to the polycystin family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3599, Eukaryota |
GeneTreei | ENSGT00940000157274 |
HOGENOMi | CLU_012097_0_0_1 |
OMAi | PDPWGVQ |
OrthoDBi | 426073at2759 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR013122, PKD1_2_channel IPR003915, PKD_2 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08016, PKD_channel, 1 hit |
PRINTSi | PR01433, POLYCYSTIN2 |
i Sequence
Sequence statusi: Complete.
D3ZDT6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIMENSKEQ ELQTLGSRVW DNPAYSSPPS PNGTPRICTV SSVALPETQP
60 70 80 90 100
KKPEVRRQEK TPRVPVSGCC LLICRGIRGL WGTTLTENTA ENRELYVKTT
110 120 130 140 150
LRELVVYIVF LVDVCLLTYG MTSSSAYYYT KVMSELFLHT PSESAVSFQT
160 170 180 190 200
ISSMSDFWDG PLLDSLYWTK WYNNQSLGSS SHSFIYYENL LLGVPRLRQL
210 220 230 240 250
RVRNDSCVVH EDFREDILNC YDVYSPDKED QLPFGPLNGT AWTYHSQNEL
260 270 280 290 300
GGSSHWGRLT SYSGGGYYLD LPGSRQASAE ALQGLQEGLW LDRGTRVVFI
310 320 330 340 350
DFSVYNANIN LFCILRLVVE FPATGGAIPS WQIRTVKLIR YVNNWDFFIV
360 370 380 390 400
GCEVIFCIFI FYYVVEEILE IRVHRFRYLS SVWNILDLVV ILLSIVAVGF
410 420 430 440 450
HVFRTLEVNR LMGELLQQPD TYPDFEFLAF WQTQYNNMNA VNLFFAWIKI
460 470 480 490 500
FKYISFNKTM TQLSSTLARC AKDILGFAIM FFIVFFAYAQ LGYLLFGTQV
510 520 530 540 550
ESFSTFVKCI FTQFRIILGD FDYNAIDNAN RILGPVYFIT YVFFVFFVLL
560 570 580 590 600
NMFLAIINDT YSEVKEELAG QRDQLQLSDL LKQSYSKTLQ RLRLRKERVS
610 620 630 640 650
DVQKVLKGGE PEIQFEDFTN TLRELTRRVL QLQRVLEGVV SQVDALSSKL
660 670
KMLERKGELA PSPGMARGAS CLGEPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC096352 Genomic DNA No translation available. CH473986 Genomic DNA Translation: EDL94276.1 |
RefSeqi | NP_001099822.1, NM_001106352.1 |
Genome annotation databases
Ensembli | ENSRNOT00000068007; ENSRNOP00000062794; ENSRNOG00000012591 |
GeneIDi | 293937 |
KEGGi | rno:293937 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC096352 Genomic DNA No translation available. CH473986 Genomic DNA Translation: EDL94276.1 |
RefSeqi | NP_001099822.1, NM_001106352.1 |
3D structure databases
SMRi | D3ZDT6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000062794 |
Proteomic databases
PRIDEi | D3ZDT6 |
Genome annotation databases
Ensembli | ENSRNOT00000068007; ENSRNOP00000062794; ENSRNOG00000012591 |
GeneIDi | 293937 |
KEGGi | rno:293937 |
Organism-specific databases
CTDi | 9033 |
RGDi | 1306261, Pkd2l1 |
Phylogenomic databases
eggNOGi | KOG3599, Eukaryota |
GeneTreei | ENSGT00940000157274 |
HOGENOMi | CLU_012097_0_0_1 |
OMAi | PDPWGVQ |
OrthoDBi | 426073at2759 |
Gene expression databases
Bgeei | ENSRNOG00000012591, Expressed in testis and 9 other tissues |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR013122, PKD1_2_channel IPR003915, PKD_2 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08016, PKD_channel, 1 hit |
PRINTSi | PR01433, POLYCYSTIN2 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZDT6_RAT | |
Accessioni | D3ZDT6Primary (citable) accession number: D3ZDT6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | April 7, 2021 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |