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Protein
Submitted name:

Polycystic kidney disease 2-like 1 (Predicted)

Gene

Pkd2l1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Polycystic kidney disease 2-like 1 (Predicted)Imported
Submitted name:
Polycystin 2-like 1, transient receptor potential cation channelImported
Gene namesi
Name:Pkd2l1Imported
Synonyms:Pkd2l1_predictedImported
ORF Names:rCG_57418Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1306261 Pkd2l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei104 – 129HelicalSequence analysisAdd BLAST26
Transmembranei347 – 365HelicalSequence analysisAdd BLAST19
Transmembranei385 – 403HelicalSequence analysisAdd BLAST19
Transmembranei474 – 496HelicalSequence analysisAdd BLAST23
Transmembranei536 – 557HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000012591 Expressed in 5 organ(s), highest expression level in skeletal muscle tissue

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062794

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 564PKD_channelInterPro annotationAdd BLAST419

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili615 – 656Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3599 Eukaryota
ENOG410XTGE LUCA
GeneTreeiENSGT00700000104221
KOiK04990
OMAiFSTFVKC
OrthoDBiEOG091G034F

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR013122 PKD1_2_channel
IPR003915 PKD_2
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08016 PKD_channel, 1 hit
PRINTSiPR01433 POLYCYSTIN2

Sequencei

Sequence statusi: Complete.

D3ZDT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIMENSKEQ ELQTLGSRVW DNPAYSSPPS PNGTPRICTV SSVALPETQP
60 70 80 90 100
KKPEVRRQEK TPRVPVSGCC LLICRGIRGL WGTTLTENTA ENRELYVKTT
110 120 130 140 150
LRELVVYIVF LVDVCLLTYG MTSSSAYYYT KVMSELFLHT PSESAVSFQT
160 170 180 190 200
ISSMSDFWDG PLLDSLYWTK WYNNQSLGSS SHSFIYYENL LLGVPRLRQL
210 220 230 240 250
RVRNDSCVVH EDFREDILNC YDVYSPDKED QLPFGPLNGT AWTYHSQNEL
260 270 280 290 300
GGSSHWGRLT SYSGGGYYLD LPGSRQASAE ALQGLQEGLW LDRGTRVVFI
310 320 330 340 350
DFSVYNANIN LFCILRLVVE FPATGGAIPS WQIRTVKLIR YVNNWDFFIV
360 370 380 390 400
GCEVIFCIFI FYYVVEEILE IRVHRFRYLS SVWNILDLVV ILLSIVAVGF
410 420 430 440 450
HVFRTLEVNR LMGELLQQPD TYPDFEFLAF WQTQYNNMNA VNLFFAWIKI
460 470 480 490 500
FKYISFNKTM TQLSSTLARC AKDILGFAIM FFIVFFAYAQ LGYLLFGTQV
510 520 530 540 550
ESFSTFVKCI FTQFRIILGD FDYNAIDNAN RILGPVYFIT YVFFVFFVLL
560 570 580 590 600
NMFLAIINDT YSEVKEELAG QRDQLQLSDL LKQSYSKTLQ RLRLRKERVS
610 620 630 640 650
DVQKVLKGGE PEIQFEDFTN TLRELTRRVL QLQRVLEGVV SQVDALSSKL
660 670
KMLERKGELA PSPGMARGAS CLGEPL
Length:676
Mass (Da):77,607
Last modified:April 20, 2010 - v1
Checksum:iF4B215BA1E48D03E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096352 Genomic DNA No translation available.
CH473986 Genomic DNA Translation: EDL94276.1
RefSeqiNP_001099822.1, NM_001106352.1
UniGeneiRn.162531

Genome annotation databases

EnsembliENSRNOT00000068007; ENSRNOP00000062794; ENSRNOG00000012591
GeneIDi293937
KEGGirno:293937

Similar proteinsi

Entry informationi

Entry nameiD3ZDT6_RAT
AccessioniPrimary (citable) accession number: D3ZDT6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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