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Entry version 75 (16 Oct 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

IQ motif-containing GTPase-activating protein 3

Gene

Iqgap3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5626467 RHO GTPases activate IQGAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IQ motif-containing GTPase-activating protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Iqgap3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
1305951 Iqgap3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZCS4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZCS4

PeptideAtlas

More...
PeptideAtlasi
D3ZCS4

PRoteomics IDEntifications database

More...
PRIDEi
D3ZCS4

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZCS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000027894 Expressed in 9 organ(s), highest expression level in colon

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3ZCS4 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D3ZCS4, 1 interactor

Molecular INTeraction database

More...
MINTi
D3ZCS4

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000029108

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZCS4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 149Calponin-homology (CH)InterPro annotationAdd BLAST116
Domaini671 – 698WWInterPro annotationAdd BLAST28
Domaini989 – 1222Ras-GAPInterPro annotationAdd BLAST234

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili875 – 895Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2128 Eukaryota
COG5261 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183076

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZCS4

KEGG Orthology (KO)

More...
KOi
K05767

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEQPPGC

Database of Orthologous Groups

More...
OrthoDBi
674320at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3ZCS4

TreeFam database of animal gene trees

More...
TreeFami
TF313078

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 1 hit
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 4 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 4 hits
SM00323 RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 4 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZCS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESCTAGQAR TAYDRLTAEE MDEQRRQNVA YQYLCRLEEA KRWMEVCLKE
60 70 80 90 100
ELPSPVELEE SLRNGVLLAK LGHCFAPSVV PLKKIYDMEQ LRYQATGLHF
110 120 130 140 150
RHTDNINFWL SAVAHIGLPS TFLPETTDIY DKKNMPRVIY CIHALSLFLF
160 170 180 190 200
RLGLAPQIHD LYGKVKFTAE ELSNIASELA KYGLQLPAFS KIGGILANEF
210 220 230 240 250
SADEAAVHAA ILAINDAVER GVVEDTLVAL QNPNALLGNL REPLAAVYQE
260 270 280 290 300
LLALAKMEKA ANARNHDDGQ DQDIYESCLT QAEIQGHINL ANVQGALEVV
310 320 330 340 350
DDALERQSPE ALLEALRDPV LALQGVRQAF ADWYLEQLTS DREQKSQELG
360 370 380 390 400
LVRLLEKEEI QAGVAAANEK GDQEQAMLRA VWKINKAIQR GVAADTVKEL
410 420 430 440 450
MCPEAQLPQV YPFASAVYQQ ELALLQKQQQ GELDQEELFV AVEMLSAVVL
460 470 480 490 500
INRALEAGDA CTFWDNLVNP ATGLAQVEEE NAQRYFDALV KVQQLRGTHR
510 520 530 540 550
GFLSWNDLQA AVSQVNAQVQ EETDQVLAIS LINEALDQGC PEKTLSALLL
560 570 580 590 600
PAAGLEDVSL PVAPRYHHLL VAAKRQKAQK TGDPGAVLWL EEIRQGVARA
610 620 630 640 650
NEDTNTAQRI ALGVAAINQA IKEGKAAQTE RVLRNPNVAL RGIVPDCAKS
660 670 680 690 700
YQQALEGAAA KKHRPGDTAF WVPRDMKDGT AYYFHLQTFQ GTWERPPSRH
710 720 730 740 750
LNASHLTWEE IQSVITKVTA AHDRQLLWKA NVGFVIKLQA RLRGFLVRQK
760 770 780 790 800
FAESSHFLRT LLPAVIKIQA HWRGYRQRKT YQERLQYFKA NLNAIITIQA
810 820 830 840 850
WARMWAARRQ YLRRLRYFQK NVDSVVKIQA FFRARKARDD YRMLVHARHP
860 870 880 890 900
PLSVVRKFAH LLNQSQEDFS AEAELLRLQE EVVRKIRSNQ QLEQDLNLMD
910 920 930 940 950
IKIGLLVKNR ITLQEVVSHC KKLTKKNKEQ LSDMMILDKQ KGLKSLSREK
960 970 980 990 1000
RQKLEAYQHL FYLLQTQPIY LAKLIFQMPQ NKTTKFMEGV IFSLYNYASN
1010 1020 1030 1040 1050
RREAYLLLQL FRTALQEEIK SKVEQPQDVV TGNPTVVRLV VRFYRNGRGQ
1060 1070 1080 1090 1100
SALQEILGKV IQDVLEDRSV SIHTDPVHIY KSWINQVEAQ TGQRSHLPYD
1110 1120 1130 1140 1150
VTPEQALSHS EVQRRLDISL RNLLAMTEKF FVAISSSVDH IPYGIRYMAK
1160 1170 1180 1190 1200
VLKTTLETKF PNATERDIYK VVGNLLYYRF LNPAVVAPDA FDIVAMAAGS
1210 1220 1230 1240 1250
SLAAPQRHAL GAVAQLLQHA AAGKVFSGES RHLRILNGYL EDLHHKFRKF
1260 1270 1280 1290 1300
ICRACRVPEP EERFAIDEYS DMVAVAKPMV YITVGELIGT HRLLLEHQDQ
1310 1320 1330 1340 1350
LAPGHQDPLH QLLEDLGEPP TITDLIGDHV ATDGHEDLSR LEVSLTLTNK
1360 1370 1380 1390 1400
FEGLETDADH NSTQSLLLST KQMLADLIQF HPGDSLEEIL TSSAPREHEE
1410 1420 1430 1440 1450
AHHRLMCWRQ ACDTQKPEPL QRRHSLMAHS LLPLAEKQQR VLRNLRRLQG
1460 1470 1480 1490 1500
LGLVRANDCY QGLVDELAKD ICNQRRHRQR RKAEMLRLRA TLQGLDAKTI
1510 1520 1530 1540 1550
FYEEQGDYYN QYTQACLDHL APNPRSSGKG KKQPSLHYTA AQLLEKGVLV
1560 1570 1580 1590 1600
EIEDLPVSHF RNVIFDITPG DEAGRFAVNA KFLGVDMEKF QLHYQDLLQL
1610 1620 1630
QYEGVAVMKL FNKAKVNVNL LIFLLNKKFL RK
Length:1,632
Mass (Da):185,304
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB73C5789E4A2C0B0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07072748 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001178638.1, NM_001191709.1
XP_017446368.1, XM_017590879.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000038589; ENSRNOP00000029108; ENSRNOG00000027894

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
310621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:310621

UCSC genome browser

More...
UCSCi
RGD:1305951 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072748 Genomic DNA No translation available.
RefSeqiNP_001178638.1, NM_001191709.1
XP_017446368.1, XM_017590879.1

3D structure databases

SMRiD3ZCS4
ModBaseiSearch...

Protein-protein interaction databases

IntActiD3ZCS4, 1 interactor
MINTiD3ZCS4
STRINGi10116.ENSRNOP00000029108

PTM databases

PhosphoSitePlusiD3ZCS4

Proteomic databases

jPOSTiD3ZCS4
PaxDbiD3ZCS4
PeptideAtlasiD3ZCS4
PRIDEiD3ZCS4

Genome annotation databases

EnsembliENSRNOT00000038589; ENSRNOP00000029108; ENSRNOG00000027894
GeneIDi310621
KEGGirno:310621
UCSCiRGD:1305951 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
128239
RGDi1305951 Iqgap3

Phylogenomic databases

eggNOGiKOG2128 Eukaryota
COG5261 LUCA
GeneTreeiENSGT00950000183076
InParanoidiD3ZCS4
KOiK05767
OMAiWEQPPGC
OrthoDBi674320at2759
PhylomeDBiD3ZCS4
TreeFamiTF313078

Enzyme and pathway databases

ReactomeiR-RNO-5626467 RHO GTPases activate IQGAPs

Gene expression databases

BgeeiENSRNOG00000027894 Expressed in 9 organ(s), highest expression level in colon
GenevisibleiD3ZCS4 RN

Family and domain databases

CDDicd00014 CH, 1 hit
cd00201 WW, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 4 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 4 hits
SM00323 RasGAP, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 4 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZCS4_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZCS4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 16, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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