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UniProtKB - D3ZCP6 (D3ZCP6_RAT)

Entry version 70 (10 Feb 2021)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

APC membrane recruitment protein 1

Gene

Amer1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-196299, Beta-catenin phosphorylation cascade
R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
APC membrane recruitment protein 1Imported
Submitted name:
RCG36484Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Amer1Imported
ORF Names:rCG_36484Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Rat genome database

More...RGDi		1560322, Amer1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		D3ZCP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000007984, Expressed in skeletal muscle tissue and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000043681

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D3ZCP6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 251DisorderedSequence analysisAdd BLAST251
Regioni277 – 306DisorderedSequence analysisAdd BLAST30
Regioni340 – 405DisorderedSequence analysisAdd BLAST66
Regioni450 – 485DisorderedSequence analysisAdd BLAST36
Regioni590 – 609DisorderedSequence analysisAdd BLAST20
Regioni615 – 634DisorderedSequence analysisAdd BLAST20
Regioni655 – 680DisorderedSequence analysisAdd BLAST26
Regioni717 – 750DisorderedSequence analysisAdd BLAST34
Regioni904 – 930DisorderedSequence analysisAdd BLAST27
Regioni1043 – 1111DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 24PolarSequence analysisAdd BLAST24
Compositional biasi90 – 111PolyampholyteSequence analysisAdd BLAST22
Compositional biasi116 – 136PolarSequence analysisAdd BLAST21
Compositional biasi145 – 164PolyampholyteSequence analysisAdd BLAST20
Compositional biasi340 – 362PolarSequence analysisAdd BLAST23
Compositional biasi371 – 405AcidicSequence analysisAdd BLAST35
Compositional biasi451 – 474PolarSequence analysisAdd BLAST24
Compositional biasi655 – 675PolarSequence analysisAdd BLAST21
Compositional biasi907 – 923AcidicSequence analysisAdd BLAST17
Compositional biasi1091 – 1111PolarSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Amer family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QT5W, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009351_2_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		FELGYYQ

Database of Orthologous Groups

More...OrthoDBi		139922at2759

TreeFam database of animal gene trees

More...TreeFami		TF333006

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019003, AMER

The PANTHER Classification System

More...PANTHERi		PTHR22237, PTHR22237, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09422, WTX, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZCP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIQQDETVQ IKRTSTSSDA QDQGAEKGAK NKTAETTEGS TSEPPLSGPG 
        60         70         80         90        100
RLKKTALKLF GGKKGICTLP SFFGGGRSKG SGKGSSKKGL NKSKTHDGLS 
       110        120        130        140        150
ESSHGPEDVV VEETELSTPL SKSPSQFPSS QSAHGALEIG SRHKTSVTEA 
       160        170        180        190        200
VEKAGVEKVP SVHKPKKGLK GFLNSIRRHR KSKVSGADQS GLGAKELEGT 
       210        220        230        240        250
RTMSQEHVSS ISLPSSEEIF RDAIKENTKP QDAPGPKMSP AREHFSLTTE 
       260        270        280        290        300
KTACKNPEKL TMTCASEFMQ PKPILEASSL EEPHTSETEG KVVTGDANPP 
       310        320        330        340        350
NGPVGDQLSL LFGDVTSLKS FDSLTGCGDI IAEQDMDSMT DSMASGGQRA 
       360        370        380        390        400
NRDGTKRSSC LVTYQGGGEE MALPDDDDNE EEEEEDEEVE LEDEEEEVKD 
       410        420        430        440        450
GEEDDDLEYL WASAQIYPRF NMNLGYHTAI SPSHQGYMLL DPVQSYPNLG 
       460        470        480        490        500
LGELLTPQSD QQESAPNSDE GYYDSTTPGF EDDSGEALGL VHRDCLPRDS 
       510        520        530        540        550
YSGDALYEFY EPDDSLEHSP PGDDCLYDLR GRNSEMLDPF LNLEPFSSRP 
       560        570        580        590        600
PGAMETEEER LVTIQKQLLY WELRREQREA QEACAREAHA REAYSRDTHT 
       610        620        630        640        650
RESYGKNTRA RETQALEVHS QEGRVQETKV RQEKPALEYQ MRPLGPSVMG 
       660        670        680        690        700
LVPGTPGGSQ TSHRGTTSAF PATSSSEPDW RDFRPLEKRF EGTCSKKDQS 
       710        720        730        740        750
TCLMQLFQSD AMFEPDMQEA NFGGSPRKAY PSYSPPEEPE EEEDENEGNA 
       760        770        780        790        800
TVSFSQALVE FTSNGNLFTS MSYSSDSDSS FTQNLPELPP MVTFDIADVE 
       810        820        830        840        850
RDGEGKCEEN PEFNNDEDLT ASLEAFELGY YHKHAFNSYH SRFYQGLPWG 
       860        870        880        890        900
VSSLPRYLGL PGVHPRPPPA AMALNRRSRS LDNAETLELE LSSSHLAQGY 
       910        920        930        940        950
VESDELQDHQ EDSDEEGEEE EGEWGRDSPL SLYTEPPGVY DWPPWAHCPV 
       960        970        980        990       1000
PVGPGLAWLS PNQLDEPFNQ SSYVQATCCV PPVAMSVPGR APGDSVSQPA 
      1010       1020       1030       1040       1050
RPSHLPLPMG PCYNLQSQAS QSGRARPRDV LLPVDEPSCS SISGANSLSQ 
      1060       1070       1080       1090       1100
AKPVGITHGI PQLPRVRPEP LQLQPNHYRA SNLDLSKERG EQGASLSTSY 
      1110 
SSTAMNGNLA K
Length:1,111
Mass (Da):121,689
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEC52E2B389EF010
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07038948 Genomic DNA No translation available.
CH473966 Genomic DNA Translation: EDL95988.1

NCBI Reference Sequences

More...RefSeqi		NP_001102790.1, NM_001109320.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000051132; ENSRNOP00000043681; ENSRNOG00000007984

Database of genes from NCBI RefSeq genomes

More...GeneIDi		501584

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:501584

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07038948 Genomic DNA No translation available.
CH473966 Genomic DNA Translation: EDL95988.1
RefSeqiNP_001102790.1, NM_001109320.1

3D structure databases

SMRiD3ZCP6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043681

Proteomic databases

PRIDEiD3ZCP6

Genome annotation databases

EnsembliENSRNOT00000051132; ENSRNOP00000043681; ENSRNOG00000007984
GeneIDi501584
KEGGirno:501584

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		139285
RGDi1560322, Amer1

Phylogenomic databases

eggNOGiENOG502QT5W, Eukaryota
GeneTreeiENSGT00530000063529
HOGENOMiCLU_009351_2_0_1
OMAiFELGYYQ
OrthoDBi139922at2759
TreeFamiTF333006

Enzyme and pathway databases

ReactomeiR-RNO-195253, Degradation of beta-catenin by the destruction complex
R-RNO-196299, Beta-catenin phosphorylation cascade
R-RNO-4641262, Disassembly of the destruction complex and recruitment of AXIN to the membrane

Gene expression databases

BgeeiENSRNOG00000007984, Expressed in skeletal muscle tissue and 19 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR019003, AMER
PANTHERiPTHR22237, PTHR22237, 1 hit
PfamiView protein in Pfam
PF09422, WTX, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZCP6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZCP6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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