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UniProtKB - D3ZCD7 (D3ZCD7_RAT)
Protein
Non-specific serine/threonine protein kinase
Gene
Tp53rk
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- p53 binding Source: RGD
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: RGD
- protein serine kinase activity Source: RHEA
GO - Biological processi
- protein phosphorylation Source: RGD
- tRNA processing Source: UniProtKB-KW
- tRNA threonylcarbamoyladenosine metabolic process Source: GO_Central
Keywordsi
Molecular function | KinaseARBA annotation, Transferase |
Biological process | tRNA processingARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-6804756, Regulation of TP53 Activity through Phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:Tp53rkImported ORF Names:rCG_32142Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1304911, Tp53rk |
Subcellular locationi
Nucleus
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
- EKC/KEOPS complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000007285, Expressed in testis and 21 other tissues |
Interactioni
GO - Molecular functioni
- p53 binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000050360 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 244 | Protein kinaseInterPro annotationAdd BLAST | 221 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3087, Eukaryota |
GeneTreei | ENSGT00390000012914 |
HOGENOMi | CLU_063953_1_1_1 |
OMAi | HKLYMEY |
OrthoDBi | 1425238at2759 |
TreeFami | TF325502 |
Family and domain databases
InterProi | View protein in InterPro IPR022495, Bud32 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008266, Tyr_kinase_AS |
PANTHERi | PTHR12209, PTHR12209, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
TIGRFAMsi | TIGR03724, arch_bud32, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZCD7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGASSEAEA EALAAARERS RLFLSGLELV QQGAEARVFR GRFQGRAAVV
60 70 80 90 100
KHRFPKGYRH PELEARLGRR RTVQEARALL RCRRAGIAAP VVFFVDYASN
110 120 130 140 150
CLYMEEIEDS VTVRDYIQST METKQDPQCL LDLARKIGQV LARLHDEDLI
160 170 180 190 200
HGDLTTSNML LTRPLEQLHI VLIDFGLSFV SGLPEDKGVD LYVLEKAFLS
210 220 230 240
THPHTETVFE AFLKSYGASS KKSDPVLKKL DEVRLRGRKR SMVG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07054611 Genomic DNA No translation available. CH474005 Genomic DNA Translation: EDL96432.1 |
RefSeqi | NP_001102076.1, NM_001108606.1 |
Genome annotation databases
Ensembli | ENSRNOT00000049082; ENSRNOP00000050360; ENSRNOG00000007285 |
GeneIDi | 362272 |
KEGGi | rno:362272 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07054611 Genomic DNA No translation available. CH474005 Genomic DNA Translation: EDL96432.1 |
RefSeqi | NP_001102076.1, NM_001108606.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000050360 |
Genome annotation databases
Ensembli | ENSRNOT00000049082; ENSRNOP00000050360; ENSRNOG00000007285 |
GeneIDi | 362272 |
KEGGi | rno:362272 |
Organism-specific databases
CTDi | 112858 |
RGDi | 1304911, Tp53rk |
Phylogenomic databases
eggNOGi | KOG3087, Eukaryota |
GeneTreei | ENSGT00390000012914 |
HOGENOMi | CLU_063953_1_1_1 |
OMAi | HKLYMEY |
OrthoDBi | 1425238at2759 |
TreeFami | TF325502 |
Enzyme and pathway databases
Reactomei | R-RNO-6804756, Regulation of TP53 Activity through Phosphorylation |
Gene expression databases
Bgeei | ENSRNOG00000007285, Expressed in testis and 21 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR022495, Bud32 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008266, Tyr_kinase_AS |
PANTHERi | PTHR12209, PTHR12209, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
TIGRFAMsi | TIGR03724, arch_bud32, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZCD7_RAT | |
Accessioni | D3ZCD7Primary (citable) accession number: D3ZCD7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 19, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |