Tp53rk

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tRNA threonylcarbamoyladenosine metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation

Reactomeⁱ

R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: RCG32142, isoform CRA_bImported Submitted name: TP53-regulating kinaseImported
Gene namesⁱ	Name:Tp53rkImported ORF Names:rCG_32142Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	1304911 Tp53rk

RGDⁱ

1304911 Tp53rk

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	D3ZCD7

PRIDEⁱ

D3ZCD7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000007285 Expressed in 9 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000007285 Expressed in 9 organ(s), highest expression level in testis

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000050360

STRINGⁱ

10116.ENSRNOP00000050360

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 244	Protein kinaseInterPro annotationAdd BLAST		221

Phylogenomic databases

eggNOGⁱ	KOG3087 Eukaryota COG3642 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012914
KEGG Orthology (KO) More...KOⁱ	K08851
OMAⁱ	HKLYMEY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LKE
TreeFamⁱ	TF325502

Family and domain databases

InterProⁱ	View protein in InterPro IPR022495 Bud32 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008266 Tyr_kinase_AS
PANTHERⁱ	PTHR12209 PTHR12209, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
TIGRFAMsⁱ	TIGR03724 arch_bud32, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZCD7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGASSEAEA EALAAARERS RLFLSGLELV QQGAEARVFR GRFQGRAAVV 
        60         70         80         90        100
KHRFPKGYRH PELEARLGRR RTVQEARALL RCRRAGIAAP VVFFVDYASN 
       110        120        130        140        150
CLYMEEIEDS VTVRDYIQST METKQDPQCL LDLARKIGQV LARLHDEDLI 
       160        170        180        190        200
HGDLTTSNML LTRPLEQLHI VLIDFGLSFV SGLPEDKGVD LYVLEKAFLS 
       210        220        230        240 
THPHTETVFE AFLKSYGASS KKSDPVLKKL DEVRLRGRKR SMVG

Length:244

Mass (Da):27,428

Last modified:April 20, 2010 - v1

Checksum:ⁱC4726AA49C97DB78

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07054611 Genomic DNA No translation available. CH474005 Genomic DNA Translation: EDL96432.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001102076.1, NM_001108606.1
UniGeneⁱ	Rn.19574

Genome annotation databases

Ensemblⁱ	ENSRNOT00000049082; ENSRNOP00000050360; ENSRNOG00000007285
GeneIDⁱ	362272
KEGGⁱ	rno:362272

Protein	Similar proteins		Species	Score	Length	Source
D3ZCD7	EKC/KEOPS complex subunit Tp53rk		MOUSE		244	UniRef90_Q99PW4
Similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2)		RAT		257
TP53-regulating kinase		MESAU		246
UPI000B4EA0B0		MERUN		248
UPI00038BDEC5		MICOH		246
+8

Protein	Similar proteins		Species	Score	Length	Source
D3ZCD7	EKC/KEOPS complex subunit Tp53rk		MOUSE		244	UniRef50_Q99PW4
Similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2)		RAT		257
TP53-regulating kinase		MESAU		246
TP53-regulating kinase		TARSY		300
TP53 regulating kinase		PONAB		253
+79

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07054611 Genomic DNA No translation available. CH474005 Genomic DNA Translation: EDL96432.1
RefSeqⁱ	NP_001102076.1, NM_001108606.1
UniGeneⁱ	Rn.19574

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000050360

STRINGⁱ

10116.ENSRNOP00000050360

Proteomic databases

PRIDEⁱ	D3ZCD7

PRIDEⁱ

D3ZCD7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000049082; ENSRNOP00000050360; ENSRNOG00000007285
GeneIDⁱ	362272
KEGGⁱ	rno:362272

Organism-specific databases

CTDⁱ	112858
RGDⁱ	1304911 Tp53rk

Phylogenomic databases

eggNOGⁱ	KOG3087 Eukaryota COG3642 LUCA
GeneTreeⁱ	ENSGT00390000012914
KOⁱ	K08851
OMAⁱ	HKLYMEY
OrthoDBⁱ	EOG091G0LKE
TreeFamⁱ	TF325502

Enzyme and pathway databases

Reactomeⁱ	R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation

Reactomeⁱ

R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation

Gene expression databases

Bgeeⁱ	ENSRNOG00000007285 Expressed in 9 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000007285 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

InterProⁱ	View protein in InterPro IPR022495 Bud32 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008266 Tyr_kinase_AS
PANTHERⁱ	PTHR12209 PTHR12209, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
TIGRFAMsⁱ	TIGR03724 arch_bud32, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZCD7_RAT
Accessionⁱ	D3ZCD7Primary (citable) accession number: D3ZCD7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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Supporting data

UniProtKB - D3ZCD7 (D3ZCD7_RAT)

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RCG32142, isoform CRA_b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ