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Entry version 83 (08 May 2019)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

Dystonin

Gene

Dst

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi7138 – 7149PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi7174 – 7185PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-446107 Type I hemidesmosome assembly

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DystoninImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DstImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Rat genome database

More...
RGDi
1306566 Dst

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonPROSITE-ProRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3ZC56

PeptideAtlas

More...
PeptideAtlasi
D3ZC56

PRoteomics IDEntifications database

More...
PRIDEi
D3ZC56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000012207 Expressed in 9 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZC56

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 150Calponin-homology (CH)InterPro annotationAdd BLAST116
Domaini163 – 267Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini899 – 956SH3InterPro annotationAdd BLAST58
Domaini7125 – 7160EF-handInterPro annotationAdd BLAST36
Domaini7161 – 7196EF-handInterPro annotationAdd BLAST36
Domaini7201 – 7279GARInterPro annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili12 – 39Sequence analysisAdd BLAST28
Coiled coili471 – 491Sequence analysisAdd BLAST21
Coiled coili689 – 709Sequence analysisAdd BLAST21
Coiled coili753 – 780Sequence analysisAdd BLAST28
Coiled coili852 – 872Sequence analysisAdd BLAST21
Coiled coili1111 – 1148Sequence analysisAdd BLAST38
Coiled coili1220 – 1254Sequence analysisAdd BLAST35
Coiled coili1430 – 1460Sequence analysisAdd BLAST31
Coiled coili3341 – 3361Sequence analysisAdd BLAST21
Coiled coili3565 – 3585Sequence analysisAdd BLAST21
Coiled coili3602 – 3622Sequence analysisAdd BLAST21
Coiled coili3646 – 3673Sequence analysisAdd BLAST28
Coiled coili3813 – 3833Sequence analysisAdd BLAST21
Coiled coili3862 – 3882Sequence analysisAdd BLAST21
Coiled coili4161 – 4202Sequence analysisAdd BLAST42
Coiled coili4274 – 4301Sequence analysisAdd BLAST28
Coiled coili4429 – 4449Sequence analysisAdd BLAST21
Coiled coili4486 – 4513Sequence analysisAdd BLAST28
Coiled coili4741 – 4761Sequence analysisAdd BLAST21
Coiled coili4868 – 4891Sequence analysisAdd BLAST24
Coiled coili4985 – 5019Sequence analysisAdd BLAST35
Coiled coili5032 – 5059Sequence analysisAdd BLAST28
Coiled coili5132 – 5152Sequence analysisAdd BLAST21
Coiled coili5176 – 5203Sequence analysisAdd BLAST28
Coiled coili5211 – 5231Sequence analysisAdd BLAST21
Coiled coili5465 – 5485Sequence analysisAdd BLAST21
Coiled coili5683 – 5710Sequence analysisAdd BLAST28
Coiled coili6122 – 6149Sequence analysisAdd BLAST28
Coiled coili6228 – 6258Sequence analysisAdd BLAST31
Coiled coili6501 – 6521Sequence analysisAdd BLAST21
Coiled coili6883 – 6913Sequence analysisAdd BLAST31
Coiled coili7091 – 7111Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
KOG0517 Eukaryota
KOG4286 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155008

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKTNWDG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169:SF24 PTHR23169:SF24, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 2 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 18 hits
PF18373 Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 9 hits
SM00150 SPEC, 35 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZC56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGYLSPAAY LYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM
60 70 80 90 100
KVRKHVNDLY EDLRDGHNLI SLLEVLSGDT LPRERDFLKT LRLPREKGRM
110 120 130 140 150
RFHRLQNVQI ALDYLKRRQV KLVNIRNDDI TDGNPKLTLG LIWTIILHFQ
160 170 180 190 200
ISDIHVTGES EDMSAKERLL LWTQQATEGY AGVRCENFTT CWRDGKLFNA
210 220 230 240 250
IIHKYRPDLI DMNTVAVQSN LANLEHAFYV AEKIGVIRLL DPEDVDVSSP
260 270 280 290 300
DEKSVITYVS SLYDAFPKVP EGGEGIGAND VEVKWIEYQN MVNYLIQWIR
310 320 330 340 350
HHVVTMSERT FPNNPLELKA LYNQYLQFKE KEIPPKETEK SKIKRLYKLL
360 370 380 390 400
EIWIEFGRIK LLQGYHPNDI EKEWGKLIIA MLEREKALRP EVERLDMLQQ
410 420 430 440 450
IATRVQRDSV SCEDKLMLAR NALQSDSKRL ESGVQFQNEA EIAGYILECE
460 470 480 490 500
NLLRQHVIDV QILLDGKYYQ AEQLVQRVAK LRDEILALRN ECSAVYSKGR
510 520 530 540 550
MLTTEQTKLM ISGITQSLNS GFAQTLHPSL NSGLTQSLTP SLTSSSVTSG
560 570 580 590 600
LSSGMTSRLT PSVTPAYTPG FPSVVAPNFS VGVEPNSLQT LKLMQIRKPL
610 620 630 640 650
LKSSLLDQNL TEEEVNMKFV QDLLNWVDEM QVQLDRTEWG SDLPSVESHL
660 670 680 690 700
ENHKNVHRAI EEFESSLKEA KISEIQMTAP LKLSYTDKLH RLESQYAKLL
710 720 730 740 750
NTSRNQERHL DTLHNFVTRA TNELIWLNEK EESEVAYDWS ERNSNVARKK
760 770 780 790 800
GYHAELMREL EQKEESIKAV QEIAEQLLLE SHPARLTIEA YKAAMQTQWS
810 820 830 840 850
WILQLCQCVE QHIQENTAYF EFFNDAKEAT DYLRNLKDAI QRKYVCDRSS
860 870 880 890 900
SIRKLEDLVQ ESMEEKEELL QYRSVVAGLM GRAKTVVQLK PRNPDNPLKT
910 920 930 940 950
SIPIKAICDY RQIEITIYKD DECVLANNSH RAKWKVISPT GNEAMVPSVC
960 970 980 990 1000
FTVPPPNKEA VDFANRIEQQ YQSVLTLWHE SHVNMKSIVS WHYLVNEIDR
1010 1020 1030 1040 1050
IRASNVASIK TMLPGEHQQV LSNLQSRLED FLEDSQESQI FSGSDITQLE
1060 1070 1080 1090 1100
KEVNVCRKYY QELLKSAERE EQEESVYNLY VSEVRNIRLR LESCEDRLIR
1110 1120 1130 1140 1150
QIRTPLERDD LHESMLRITE QEKLKKELER LKDDLEAITN KCEEFFSQAA
1160 1170 1180 1190 1200
DSPSVPALRS ELSVVLQSMS QIYSMSATYV EKLKTVNLVL KNTQAAEALV
1210 1220 1230 1240 1250
KLYETKLCEE EAVIADKNNI ENLMSTLKQW RSEVDEKREV FHALEDELQK
1260 1270 1280 1290 1300
AKAISDEMFK THKERDLDFD WHKEKADQLV ERWQSVHVQI DNRLRDLEGI
1310 1320 1330 1340 1350
GKSLKHYRDS YHPLDDWIQQ IETTQRKIQE NQPENSKALA VQLNQQKMLV
1360 1370 1380 1390 1400
SEIEVKQSKM DECQKYSEQY SAAVKDYELQ TMTYRAMVDS QQKSPMKRRR
1410 1420 1430 1440 1450
IQSSADLIIQ EFMDLRTRYT ALVTLMTQYI KFAGDSLKRL EEEEKSLDEE
1460 1470 1480 1490 1500
KKQHVEKAKE LQKWVSNISE TLGDGERAGK PHFSKQQISS KEISAKKEQF
1510 1520 1530 1540 1550
SEALQNTQIF LAKHGDKLTE EDRSDLEKQV KTLQEGYNLL FSESLKQQEL
1560 1570 1580 1590 1600
QPSGEAKVKV EEKPDKVIAG TINQTTGEVL SVFQAVLRGL IDYETGIRLL
1610 1620 1630 1640 1650
EAQLVISGLI SPELRKCFDL KDAERHGLVD EQILGQLKEL NEAKQIISTA
1660 1670 1680 1690 1700
SPTMIPVLDS LDRGVISESV AIRVLEILLS TDSLVVPATG EHLTLQKAFQ
1710 1720 1730 1740 1750
QNLISSALFS KVLERQAACK DLIDPCTSEK VSLTDMVQRS ILQENTRMWL
1760 1770 1780 1790 1800
LPVRPQEAGR ITLKCGRSVS ILRAAHEGII DRETMFRLLG AQLLSGGLVD
1810 1820 1830 1840 1850
CNSGQKMTVE EALAEGVIDR DTASSILTYQ VRTGGILHSN PAKRLTVDEA
1860 1870 1880 1890 1900
VQCELITSSS ALLVLEAQRG YVGLIWPHSG EIFPTASSLE QELITNELAC
1910 1920 1930 1940 1950
KILNGRQKIA ALYFPETSQV IDLDAARRLG IIDNNTASVL KHVTLPDKMP
1960 1970 1980 1990 2000
DLGDLEACKN ARKWLSFCKF QPSTAHHYTQ EEDGSDGDEP VAAQSSEQTK
2010 2020 2030 2040 2050
KLFLSYLMVN SYMDANTGRR LLLHDGDLEE AVGMLLESCG AELGAGTAVR
2060 2070 2080 2090 2100
ESLSVLPVPD ASPDCASSRE KHGCSTLAAG SDKCHYRHPG HKGPLENAKW
2110 2120 2130 2140 2150
DLNGELCEMG NNEDSGELPR LENLTDTTVA QKAGGPSSVR VPKPTSYSTQ
2160 2170 2180 2190 2200
PELKNQSELD TEASPDEGIH SGVCTSETSR LCDASETEDE DHIQKGPSVF
2210 2220 2230 2240 2250
DYSPRLSALL SHDLLRHSQG SFSDTPKNTG YLCEASTLSS GDQSVLADQS
2260 2270 2280 2290 2300
TGEKLQDQFL GIAAISVSLQ GAPCGQTPVD NGCSNCQVHY SSDEYMSDAS
2310 2320 2330 2340 2350
AESGTTRQTS ETEKTGSEVE DDSCTMIPGD GSCNANPSAC RPLSLKGAID
2360 2370 2380 2390 2400
AGDYETSLLA GQQSDTATDS DSDDYFYDTP LFEDEDHDSL ILQGDDHDCL
2410 2420 2430 2440 2450
QPEDYDTLQE ENDKTPPPDD IFYDVLKENE NPESSPGGMD ESLSAGGKVH
2460 2470 2480 2490 2500
FPQGFLVGTK RPELYVVDQK QFNLGDSDKM RERLAEPVPE SETPSDLEHS
2510 2520 2530 2540 2550
ESDSLTDGEI TGRKESLGTS VTPGGRWRGD REECDTSQES QSDTDGVGFV
2560 2570 2580 2590 2600
QSIESSRLYM SDGSDRDEED NGTYSSEDDD DRGGGGQEVA GENGEPSDPA
2610 2620 2630 2640 2650
SHNQLYTATV KESGAETQSV RDTILLDRMH GYSPLEKQQR GRVLQPESAG
2660 2670 2680 2690 2700
KRGRDTERSN HPELTTEADE EDRASVSTHM ATTGVSLSNA QGTASENVEL
2710 2720 2730 2740 2750
VQGPGSTDIL KDEDEYLENG SPKNGQPSNK IVCSEAGLGG GPSEESHLSF
2760 2770 2780 2790 2800
TVSNRGQRGT GRGQVKGRDG KNSQGVGEMS IQETGFREDG GLMSSPEEGE
2810 2820 2830 2840 2850
EERCLNPFPN GIATGSPNTG ESLFTPLLTH TEELRHRGDP NTATMTLDCE
2860 2870 2880 2890 2900
AKDGQTGLRE SPVLLETLAE IFDTSASKET HADPTSALRS SGVKSQVKED
2910 2920 2930 2940 2950
SLTGGSEKET GPFTSPERCD KCVNVDVLES NKHTPSCAFI ASPPMKDDLP
2960 2970 2980 2990 3000
TVTNAEEKPV IPQGDWPSGA KIQPSGACVK GSMSEGKAGI PHFTPEHSDT
3010 3020 3030 3040 3050
TLSLLPQKSV AECGGNTDFV QAQLHMNGVR NTSDNTLDVG CPRLESSREK
3060 3070 3080 3090 3100
ERTEKQPHGE RTSSPRPQER VHTPEFGEDG GTLKSGLDKV QMNLQDVGDP
3110 3120 3130 3140 3150
SACTGTTISI QNLIKRAILS ELPNETSNVP SPGVSPINNS SEEKAENRGD
3160 3170 3180 3190 3200
PLCIASLLEI LKQDQHTQET PGTSELIKVL TQTACNPEER GLVSGLFPPQ
3210 3220 3230 3240 3250
LKNVFCKLLL DGYSAEREQA EALKQTPGAA PEMVEEKPCD CSDLKSKEGN
3260 3270 3280 3290 3300
HYTPNPQTVR EAGVEHSGVH TAALPRDEEF GELCSEPPDH SECTSGSKEI
3310 3320 3330 3340 3350
SSDDNTKEKC SNGLQQCLQH TEKMHEYLAL LQDMKPPLDN QAAMENSLEA
3360 3370 3380 3390 3400
LKNQLKQLET FELGLAPMAV FLRKDLKLAE EFLKSFPSDL PGRHHEELSK
3410 3420 3430 3440 3450
SHERLQNAFE SLSSVSSQRM KLITLAIDTE TSKLAVRHED FLHRLTSYSD
3460 3470 3480 3490 3500
WVSEKSRSVA DIQTVNVQDT ELVKNSVKFL KNVLTDLSHT KVQLETTAFD
3510 3520 3530 3540 3550
IQSFISDYAQ DLSPNQSRQL LRLLNTTQKC FLDVQELVTS EVVRLETLLQ
3560 3570 3580 3590 3600
LEQELGHQKV VAERQQEYKE KLQGLCDLLT QTENRLISHQ ETFVIGDGTV
3610 3620 3630 3640 3650
ELKKYQSKQE ELQRDMQGST QALAEIVRNT EIFLKESGDE LSQEDKALIE
3660 3670 3680 3690 3700
QKLNEAKVKC EQLNLKAEQS TKELDKVVTA ALKEETEKVA AARQLEESKT
3710 3720 3730 3740 3750
KIENLLNWLS NVEKDSEGSG RLHTQPLEQN GTHLHEGDGT SEAGEEDEVN
3760 3770 3780 3790 3800
GNLLETDAEG HGGMTEGNLN QQYEKVKAQH EKIVAQHQAV IMATQSAQAL
3810 3820 3830 3840 3850
LEKQGHHLSP EEKEKLQANV QELKAHYETV LAECEKKVKL THSLQEELEK
3860 3870 3880 3890 3900
FDADCGEFEH WLQQSEQELE NLEAGADDLS GLTDKLARQK SFSEDVISHK
3910 3920 3930 3940 3950
GDLRYITISG NRVMEAAKSC SKRDGDRIGK DSLETSATHR EVQTKLDQVT
3960 3970 3980 3990 4000
DRFRCLYSKC SVLGNNLKDL VDKYQHYEDA SCGLLSGLQA CEAKASRHLL
4010 4020 4030 4040 4050
EPIALDPKNL QRQLEETKAL QGQISSQQAA VEKLKKTAEV LLDAKGSLLP
4060 4070 4080 4090 4100
AKNDIQKTLD DIVGRYDDLS KSVNERNEKL QITLTRSLSV QDGLDEMLDW
4110 4120 4130 4140 4150
MGSVESSLVK QGQVPLNSTA LQDLISKNIM LDQDITGRQS SINAMNEKVK
4160 4170 4180 4190 4200
TFIETTDPST ASSLQAKMKD LSARFSEASQ KHKEKLAKMV ELKSKVEEFE
4210 4220 4230 4240 4250
KLSDKLQTFL ETQSQALTEV DMPGKDVPEL SQHMQESTTK FLEHRKDLEA
4260 4270 4280 4290 4300
LHSLLKEISS HGLPGDKALV FEKTNNLSKK FKELEDTIQE KKEALSSCQE
4310 4320 4330 4340 4350
QLSAFHDLAQ SLKTWIKETT KQVPIVKPSF GTEDLEKSLE ETKKLQEKWS
4360 4370 4380 4390 4400
LKTPEIHKAN NSGVSLCNLL SALISPAKAI AAARSGGVIL NGEGTDTNTQ
4410 4420 4430 4440 4450
DFLANKGLTS IKTDMTDISH SYEDLGLLLK DKIVELNTKL SKLQKAQEES
4460 4470 4480 4490 4500
SAMMQWLQKM NKTASRWRQT PTPADSESVK IQVEQNKSFE AELKQNVNKV
4510 4520 4530 4540 4550
QELKDKLAEL LKENPEAPEA PSWKQTMAEM DTKWQELNQL TIDRQQKLEE
4560 4570 4580 4590 4600
SSNNLSQFQT TEAQLKQWLV EKELMVSVLG PLSTDPNMLN TQKQQAQILL
4610 4620 4630 4640 4650
QEFDTRKPQY EQLTAAGQGI LSRPGEDPSL HGIVKEQLAA VTQKWDNLTG
4660 4670 4680 4690 4700
QLRDRCDWID QAIVKSTQYQ SLLRSLSGTL TELDEKLSSS LISGTLPDAV
4710 4720 4730 4740 4750
NQQLEAAQKL KQEIEQQTPK IKEAQTLCED LSALVKEEYL RAELSRQLEG
4760 4770 4780 4790 4800
VLKSFKDIEQ KTENHVQHLQ SACASSHQFQ QMSKDFQAWL DAKKEEQRNS
4810 4820 4830 4840 4850
PPISAKLDVL ESLLKAQKDF GKTFTEQSNI YEKTVAEGEN LLSKTQGAEK
4860 4870 4880 4890 4900
AALQLQLNTI KTDWDRFRKQ VKEREEKLKE SLEKALRYRE QVDTLQPWVD
4910 4920 4930 4940 4950
KCQHSLESVK LSLDPADTER SITELKTLQK EMDHHFGTLE LLNNSANSLL
4960 4970 4980 4990 5000
SVCEVDKEVV TEGNKSLIQK VNVVTEQLQS KKVSLENMAQ KFKEFQEVSK
5010 5020 5030 5040 5050
DAKRQLQDTK EQLEVYQSLG PQACSNKHLT MLQAQQKSLQ TLKHQVDSAR
5060 5070 5080 5090 5100
RLAQDLVMEA TDPKGTSDVL SQAETLAEEH RGLSQQVDEK CSFLETKLQG
5110 5120 5130 5140 5150
LGHFQNTIRE MFSQFTEFDD ELDSMAPVGR DVETLQKQKA SMQTFLKKLE
5160 5170 5180 5190 5200
ALITSNDSAN RTCKMMLATE ETSPDLIGVK RDLEALSKQC NKLLDRAKTR
5210 5220 5230 5240 5250
EEQVSGATEK LEEFHRKLEE FSTLLQKAEE HEESQGPVGT ETDAINQQLD
5260 5270 5280 5290 5300
VFKIFQKEEI EPLQAKQQDV NWLGQGLIQS AAANTCTQGL EHDLDSINAR
5310 5320 5330 5340 5350
WKTLNKKVAQ RTSQLQEALL HCGRFQDALE SLLSWMADTE ELVANQKPPS
5360 5370 5380 5390 5400
AEFKVVKAQI QEQKLLQRLL EDRKSTVEAI KREGEKIAAS AEPADRVKLS
5410 5420 5430 5440 5450
RQLSLLDSRW EMLLSRAEAR NRQLEGISVV AQEFHETLEP LNEWLTAVEK
5460 5470 5480 5490 5500
KLANSEPIGT QAPKLEEQIA QHKVLEDDIT SHNKQLHQAV SIGQSLKVLS
5510 5520 5530 5540 5550
SREDKDLVQS KLDSLQVWYF EIQEKSHSRS ELLQQALCNA KIFGEDEVEL
5560 5570 5580 5590 5600
MNWLNEAHGK LSKLSVQDHS TEALWRQRAE LRALQEDILL RKQSVDQALL
5610 5620 5630 5640 5650
NGLELLKQTT GDEVLIIQDK LEAIKARYKD ITKLSADVAK TLEHALQLAG
5660 5670 5680 5690 5700
QLQSKHKELC NWLDRVEVEL LSYETQGLKG EAASQVQERQ KELKNEVRNN
5710 5720 5730 5740 5750
KALLDSLNEV SSALLELVPW RAREGLEKTV AEDNERYRLV SDTITQKVEE
5760 5770 5780 5790 5800
IDAAILRSQQ FDQAADAELS WITETQKKLM SLGCIRLEQD QTSAQLQAQK
5810 5820 5830 5840 5850
AFTMDILRHK DIIDELVTSG HKIMTTSSEE EKQSMKKKLD KVLKKYDAIC
5860 5870 5880 5890 5900
QINSERHLQL ERAQSLVSQF WETYEELWPW LMETQQIISQ LPAPALEYET
5910 5920 5930 5940 5950
LRRQQEEHRQ LRELIAEHKP HIDKMNKTGP QLLELSPKEG VHIQEKYVAA
5960 5970 5980 5990 6000
DTLYSQIKED VKKRAVVLDE AISQSTQFHD KIDQILESLE RIAERLRQPP
6010 6020 6030 6040 6050
SISAEVEKIK EQIGENKSVS VDMEKLQPLY ETLRQRGEEM IARSEGTEKD
6060 6070 6080 6090 6100
ISAKAVQDKL DQMVFIWGSI HTLVEDREAK LLDVMELAEK FWCDHMSLVV
6110 6120 6130 6140 6150
TTKDTQDFIR DLEDPGIDPS VVKQQQEAAE AIREEIDGLQ EELDMVITLG
6160 6170 6180 6190 6200
SELIAACGEP DKPIVKKSID ELNSAWDSLN KAWKDRIDRL GEAMQAAVQY
6210 6220 6230 6240 6250
QDGLQAIFDW VDIAGNKLAT MSPIGTDLET VKQQIEELKQ FKSEAYQQQI
6260 6270 6280 6290 6300
EMERLNHQAE LLLKKVTEEV DKHTVQDPLM ELKLIWDSLD ERIVSRQHKL
6310 6320 6330 6340 6350
EGALLALGQF QHALDELLAW LTHTKGLLSE QKPVGGDPKA IEIELAKHHV
6360 6370 6380 6390 6400
LQNDVLAHQS TVEAVNKAGN DLIESSEGEE ASNLQYKLRI LNQRWQDILE
6410 6420 6430 6440 6450
KTDQRKQQLD SALRQAKGFH GEIEDLQQWL TDTERHLLAS KPLGGLPETA
6460 6470 6480 6490 6500
REQLNAHMEV CTAFAIKEET YKNLMLRGQQ MLARCPRSVE TNIDQDITNL
6510 6520 6530 6540 6550
KEKWESVKSK LNEKKTKLEE ALHLAMEFHN SLQDFINWLT QAEQTLNVAS
6560 6570 6580 6590 6600
RPSLILDTIL FQIDEHKVFA NEVNSHREQI IELDKTGTHL KYFSQKQDVV
6610 6620 6630 6640 6650
LIKNLLISVQ SRWEKVVQRL VERGRSLDEA RKRAKQFHEA WSKLMEWLED
6660 6670 6680 6690 6700
SEKSLDSELE IANDPDKIKA QLVQHKEFQK SLGGKHSVYD TTNRTGRSLK
6710 6720 6730 6740 6750
EKTSLADDTL KLENMLSELR DKWDTICGKS VERQNKLEEA LLFSGQFTDA
6760 6770 6780 6790 6800
LQALIDWLYR VEPQLAEDQP VHGDIDLVMN LIDNHKVFQK ELGKRTSSVQ
6810 6820 6830 6840 6850
ALKRSARELI EGSRDDSSWV RVQMQELSTR WETVCALSIS KQTRLESALQ
6860 6870 6880 6890 6900
QAEEFHSVVH TLLEWLAEAE QTLRFHGALP DDEDALRTLI EQHKEFMKKL
6910 6920 6930 6940 6950
EEKRAELNKA TGMGDALLTA CHPDSITTIK HWITIIQARF EEVLAWAKQH
6960 6970 6980 6990 7000
QQRLAGALAG LIAKQELLEN LLAWLQWAET TLTEKDKEVI PQEIEEVKTL
7010 7020 7030 7040 7050
IAEHQTFMEE MTRKQPDVDK VTKTYKRRAA DPPSLQSHIP VLDKGRAGRK
7060 7070 7080 7090 7100
RFPASGLYPS GSQTQIETKN PRANLLVSKW QQVWLLALER RRKLNDALDR
7110 7120 7130 7140 7150
LEELREFANF DFDIWRKKYM RWMNHKKSRV MDFFRRIDKD QDGKITRQEF
7160 7170 7180 7190 7200
IDGILSSKFP TSRLEMSAVA DIFDRDGDGY IDYYEFVAAL HPNKDAYKPI
7210 7220 7230 7240 7250
TDADKIEDEV TRQVAKCKCA KRFQVEQIGD NKYRFFLGNQ FGDSQQLRLV
7260 7270 7280 7290 7300
RILRSTVMVR VGGGWMALDE FLVKNDPCRA KGRTNMELRE KFILADGASQ
7310 7320 7330 7340 7350
GMAAFRPRGR RSRPSSRGAS PNRSTSASSH ACQAASPQVP AAASTPKILH
7360 7370 7380 7390 7400
PLTRNYGKPW LANSKMSTPC KAAECPDFPV SSAEGTPIQG SKLRLPGYLS
7410 7420 7430 7440 7450
GKGFHSGEDN ALITTAASRV RTQFAESRKT PSRPGSRAGS KAGSRASSRR
7460 7470 7480 7490 7500
GSDASDFDIS EIQSVCSDVE TVPQTHRPAP RAGSRPSTAK PSKIPTPQRK
7510
SPASKLDKSS KR
Length:7,512
Mass (Da):847,207
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46EB8D1936A54348
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07067283 Genomic DNA No translation available.
AABR07067284 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000044452; ENSRNOP00000043470; ENSRNOG00000012207

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07067283 Genomic DNA No translation available.
AABR07067284 Genomic DNA No translation available.

3D structure databases

SMRiD3ZC56
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

jPOSTiD3ZC56
PeptideAtlasiD3ZC56
PRIDEiD3ZC56

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044452; ENSRNOP00000043470; ENSRNOG00000012207

Organism-specific databases

RGDi1306566 Dst

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
KOG0517 Eukaryota
KOG4286 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000155008
OMAiIKTNWDG

Enzyme and pathway databases

ReactomeiR-RNO-2022090 Assembly of collagen fibrils and other multimeric structures
R-RNO-446107 Type I hemidesmosome assembly

Gene expression databases

BgeeiENSRNOG00000012207 Expressed in 9 organ(s), highest expression level in brain

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR23169:SF24 PTHR23169:SF24, 2 hits
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 2 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 18 hits
PF18373 Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 9 hits
SM00150 SPEC, 35 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 2 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZC56_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZC56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: May 8, 2019
This is version 83 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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