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Entry version 80 (07 Oct 2020)
Sequence version 1 (20 Apr 2010)
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Protein

[F-actin]-monooxygenase MICAL1

Gene

Mical1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H2O2. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.By similarity

Caution

The reaction mechanism is subject to discussion. Some work suggest MICAL enzymes directly oxidize actin methionine residues to produce methionine-(R)-S-oxide. Other publications suggest that the enzyme functions as a NADPH oxidase producing H2O2 (EC 1.6.3.1) and that it is the produced H2O2 that is responsible for the methionine-(R)-S-oxide production.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei95FADBy similarity1
Binding sitei181FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei293FADBy similarity1
Binding sitei393FADBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi681Zinc 1By similarity1
Metal bindingi684Zinc 1By similarity1
Metal bindingi702Zinc 1; via pros nitrogenBy similarity1
Metal bindingi705Zinc 1By similarity1
Metal bindingi708Zinc 2By similarity1
Metal bindingi711Zinc 2By similarity1
Metal bindingi731Zinc 2By similarity1
Metal bindingi734Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi114 – 116FADBy similarity3
Nucleotide bindingi121 – 123FADBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Monooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
[F-actin]-monooxygenase MICAL1Curated (EC:1.14.13.225By similarity)
Alternative name(s):
Molecule interacting with CasL protein 1
Short name:
MICAL-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mical1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20
  • UP000234681 Componentsi: Chromosome 20, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1309386, Mical1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004162991 – 1047[F-actin]-monooxygenase MICAL1Add BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei475PhosphothreonineCombined sources1
Modified residuei616PhosphoserineBy similarity1
Modified residuei777PhosphoserineBy similarity1
Modified residuei781PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3ZBP4

PRoteomics IDEntifications database

More...
PRIDEi
D3ZBP4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3ZBP4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3ZBP4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000000307, Expressed in thymus and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3ZBP4, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STK38 and STK38L. Associates with the SH3 domain of NEDD9.

Interacts with VIM and PLXNA3.

Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D3ZBP4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000000337

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3ZBP4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini507 – 611Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105
Domaini679 – 741LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST63
Domaini905 – 1047bMERBPROSITE-ProRule annotationAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 489Monooxygenase domainBy similarityAdd BLAST489

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili912 – 996Sequence analysisAdd BLAST85

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal coiled coil part contains the plexin-interacting region.By similarity
The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mical family.Curated

Keywords - Domaini

Coiled coil, LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1700, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159117

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000329_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3ZBP4

KEGG Orthology (KO)

More...
KOi
K19947

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMHRAEN

Database of Orthologous Groups

More...
OrthoDBi
430978at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324129

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029937, MICAL1
IPR001781, Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24206:SF59, PTHR24206:SF59, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51848, BMERB, 1 hit
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: D3ZBP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPTSTNPA HDHFETFVQA QLCQDVLSSF QGLCRALGVE SGGGLPQYHK
60 70 80 90 100
IKAQLNYWSA KSLWAKLDKR ASQPAYQQGQ ACTNTKCLVV GAGPCGLRAA
110 120 130 140 150
VELALLGARV VLVEKRTKFS RHNVLHLWPF TIHDLRALGA KKFYGRFCTG
160 170 180 190 200
TLDHISIRQL QLLLLKVALL LGVEIHWGFT FTGLQPPPKK GSGWRARIQP
210 220 230 240 250
SPPAQLASYE FDVLISAGGG KFVPEGFTIR EMRGKLAIGI TANFVNGRTV
260 270 280 290 300
EETQVPEISG VARIYNQKFF QSLLKATGID LENIVYYKDD THYFVMTAKK
310 320 330 340 350
QCLLRLGVLR QDLPETDQLL GKANVVPEAL QQFARAAADF ATQGKLGKLE
360 370 380 390 400
FAQDARGRPD VAAFDFTSMM RSESSARIQE KHGARLLLGL VGDCLVEPFW
410 420 430 440 450
PLGTGVARGF LAAFDAAWMV KRWAEGTGPL ELLAERESLY QLLSQTSPEN
460 470 480 490 500
MHRNVAQYGL DPATRYPNLN LRAVTPNQVQ DLYDIMDKEH ARKKSDETDA
510 520 530 540 550
RKTTTGSAGT EELLHWCQEQ TAGFPGVSVT DFSSSWADGR ALCALVHRLQ
560 570 580 590 600
PGLLEPSELQ GMSALEATAW ALRVAEYELG IIPVLSAQAV VAGSDPLGLI
610 620 630 640 650
AYLSHFHSAF KNTPHSSGLV SQPHGTPSAI LFLGKLQRSL QRTRTKVEEE
660 670 680 690 700
TPCTEEPPVS EPSVPPALPS EHEEAGAEDV CELCGKRLYI LERFCVDGHF
710 720 730 740 750
FHRGCFCCRT CEATLRPGGY GQYPGDGYFY CLQHLPQEDQ KEADNNGSPE
760 770 780 790 800
NQELPTPGDS TTQSGPSSPV PPVTEASPVP SPSQPARRLI RLSSVERLRL
810 820 830 840 850
SSLNIIPDSG VEPPPKPPRS CLDLAQESLK SSFMGWGVLR APQVPEAIEK
860 870 880 890 900
GEEEEEEEEE EEEEEEELPP PLALEVEQSL LTLAKNSGDM TKYPTWRRTL
910 920 930 940 950
MRRAKEEEMK RFCKAQAIQR RLNEIEAAMR ELETEGMKLE VALRKESSSP
960 970 980 990 1000
EKQKKLWLEQ LLQLIQKKNS LVTEEAELMI TVQELDLEEK QRQLDHEFRG
1010 1020 1030 1040
INREETLKTQ ADRLSEDRVL RKLLDVVNQR DALIQFQEER RLREMPV
Length:1,047
Mass (Da):116,672
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB74E4A60CBB65A5B
GO
Isoform 2 (identifier: D3ZBP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-159: Missing.
     192-192: S → N

Show »
Length:974
Mass (Da):108,618
Checksum:iE57042E0598E7B29
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04260787 – 159Missing in isoform 2. CuratedAdd BLAST73
Alternative sequenceiVSP_042608192S → N in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH474025 Genomic DNA Translation: EDL99736.1

NCBI Reference Sequences

More...
RefSeqi
NP_001099867.1, NM_001106397.1 [D3ZBP4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000000337; ENSRNOP00000000337; ENSRNOG00000000307 [D3ZBP4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
294520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:294520

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474025 Genomic DNA Translation: EDL99736.1
RefSeqiNP_001099867.1, NM_001106397.1 [D3ZBP4-1]

3D structure databases

SMRiD3ZBP4
ModBaseiSearch...

Protein-protein interaction databases

IntActiD3ZBP4, 1 interactor
STRINGi10116.ENSRNOP00000000337

PTM databases

iPTMnetiD3ZBP4
PhosphoSitePlusiD3ZBP4

Proteomic databases

PaxDbiD3ZBP4
PRIDEiD3ZBP4

Genome annotation databases

EnsembliENSRNOT00000000337; ENSRNOP00000000337; ENSRNOG00000000307 [D3ZBP4-1]
GeneIDi294520
KEGGirno:294520

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64780
RGDi1309386, Mical1

Phylogenomic databases

eggNOGiKOG1700, Eukaryota
GeneTreeiENSGT00940000159117
HOGENOMiCLU_000329_0_0_1
InParanoidiD3ZBP4
KOiK19947
OMAiCMHRAEN
OrthoDBi430978at2759
TreeFamiTF324129

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3ZBP4

Gene expression databases

BgeeiENSRNOG00000000307, Expressed in thymus and 21 other tissues
GenevisibleiD3ZBP4, RN

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR022735, bMERB_dom
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR002938, FAD-bd
IPR036188, FAD/NAD-bd_sf
IPR029937, MICAL1
IPR001781, Znf_LIM
PANTHERiPTHR24206:SF59, PTHR24206:SF59, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF12130, DUF3585, 1 hit
PF01494, FAD_binding_3, 1 hit
PF00412, LIM, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF51905, SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS51848, BMERB, 1 hit
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMICA1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZBP4
Secondary accession number(s): D3ZJD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 20, 2010
Last modified: October 7, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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