Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Eph receptor A2 (Predicted)

Gene

Epha2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei647ATPUniRule annotation1
Active sitei740Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi620 – 628ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2682334 EPH-Ephrin signaling
R-RNO-3928663 EPHA-mediated growth cone collapse
R-RNO-3928665 EPH-ephrin mediated repulsion of cells

Names & Taxonomyi

Protein namesi
Submitted name:
Eph receptor A2 (Predicted)Imported
Gene namesi
Name:Epha2Imported
Synonyms:Epha2_predictedImported
ORF Names:rCG_31362Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1307204 Epha2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei536 – 559HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501408758520 – 977Sequence analysisAdd BLAST958

Proteomic databases

PeptideAtlasiD3ZBN3
PRIDEiD3ZBN3

Expressioni

Gene expression databases

BgeeiENSRNOG00000009222

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012328

Structurei

3D structure databases

SMRiD3ZBN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 205Eph LBDInterPro annotationAdd BLAST179
Domaini329 – 433Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini439 – 530Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini614 – 876Protein kinaseInterPro annotationAdd BLAST263
Domaini905 – 969SAMInterPro annotationAdd BLAST65

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00910000144084
InParanoidiD3ZBN3
KOiK05103
OMAiCSPGFFK
OrthoDBiEOG091G00W0

Family and domain databases

CDDicd10480 EphR_LBD_A2, 1 hit
cd00063 FN3, 2 hits
Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR034263 EphA2_rcpt_lig-bd
IPR001090 Ephrin_rcpt_lig-bd_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR008979 Galactose-bd-like_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR016257 Tyr_kinase_ephrin_rcpt
IPR001426 Tyr_kinase_rcpt_V_CS
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF01404 Ephrin_lbd, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF00536 SAM_1, 1 hit
PIRSFiPIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00615 EPH_lbd, 1 hit
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF49785 SSF49785, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS51550 EPH_LBD, 1 hit
PS50853 FN3, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00790 RECEPTOR_TYR_KIN_V_1, 1 hit
PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

D3ZBN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRAAGFCL ALLWGCALAA AAAQGKEVVL LDFAAMKGEL GWLTHPYGKG
60 70 80 90 100
WDLMQNIMND MPIYMYSVCN VVSGDQDNWL RTNWVYREEA ERIFIELKFT
110 120 130 140 150
VRDCNSFPGG ASSCKETFNL YYAESDVDYG TNFQKRQFTK IDTIAPDEIT
160 170 180 190 200
VSSDFEARNV KLNVEERMVG PLTRKGFYLA FQDIGACVAL LSVRVYYKKC
210 220 230 240 250
PEMLQSLARF PETIAVAVSD AQPLATVAGT CVDHAVVPYG GEGPLMHCTV
260 270 280 290 300
DGEWLVPIGQ CLCQEGYEKV EDACQACSPG FFKSEASESP CLQCPEHTLP
310 320 330 340 350
STEGATSCQC EEGYFRAPED PLSMPCTRPP SAPHYLTAIG MGAKVELRWT
360 370 380 390 400
APQDTGGRKD IVYSVTCEQC WPESGECGSC EASVQYSEPP QALTRTSVTV
410 420 430 440 450
SDLEPHMNYT FTVEARNGVS DLVNSRSFRT ASVSINQTEP PKVRLEDRST
460 470 480 490 500
TSLSVAWSIP VPQQSRVWKY EVTYRKKGDA NSYNVHRTDG FSVTLDGLAP
510 520 530 540 550
GTTYLVQVQA LTQEGQGAGS KVHEFQTLST EGSATMAVIG GVAVGVVLLL
560 570 580 590 600
VLAGIGFFIH RRRRNLRARQ SSEDVYFSKS EQLKPLKTYV DPHTYEDPNQ
610 620 630 640 650
AVLKFTTEIH PSCVSRQKVI GAGEFGEVYK GTLKSSSGKK EIPVAIKTLK
660 670 680 690 700
AGYTEKQRVD FLSEASIMGQ FSHHNIIRLE GVVSKYKPMM IITEYMENGA
710 720 730 740 750
LDKFLREKDG EFSVLQLVGM LRGIASGMKY LANMNYVHRD LAARNILVNS
760 770 780 790 800
NLVCKVSDFG LSRVLEDDPE ATYTTSGGKI PIRWTAPEAI SYRKFTSASD
810 820 830 840 850
VWSYGIVMWE VMTYGERPYW ELSNHEVMKA INDGFRLPTP MDCPSAIYQL
860 870 880 890 900
MMQCWQQERS RRPKFADIVS ILDKLIRAPD SLKTLADFDP RVSIRLPSTS
910 920 930 940 950
GSEGVPFRTV SEWLESIKMQ QYTEHFMVAG YTAIEKVVQM SNDDIKRIGV
960 970
RLPGHQKRIA YSLLGLKDQV NTVGIPI
Length:977
Mass (Da):108,741
Last modified:July 22, 2015 - v3
Checksum:i480C4F6DF2FA7373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120594 Genomic DNA No translation available.
CH473968 Genomic DNA Translation: EDL80978.1
RefSeqiNP_001102447.1, NM_001108977.1
UniGeneiRn.23415

Genome annotation databases

EnsembliENSRNOT00000012328; ENSRNOP00000012328; ENSRNOG00000009222
GeneIDi366492
KEGGirno:366492

Similar proteinsi

Entry informationi

Entry nameiD3ZBN3_RAT
AccessioniPrimary (citable) accession number: D3ZBN3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: June 20, 2018
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health