Transcription factor-binding to IGHM enhancer 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin."
    Huan C., Sashital D., Hailemariam T., Kelly M.L., Roman C.A.
    J. Biol. Chem. 280:30225-30235(2005) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• humoral immune response Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cold-induced thermogenesis Source: YuBioLab <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis."
    Fujimoto Y., Nakagawa Y., Satoh A., Okuda K., Shingyouchi A., Naka A., Matsuzaka T., Iwasaki H., Kobayashi K., Yahagi N., Shimada M., Yatoh S., Suzuki H., Yogosawa S., Izumi T., Sone H., Urayama O., Yamada N., Shimano H.
    Endocrinology 154:3577-3588(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell adhesion Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin."
    Huan C., Sashital D., Hailemariam T., Kelly M.L., Roman C.A.
    J. Biol. Chem. 280:30225-30235(2005) [PubMed] [Europe PMC] [Abstract]
  • "TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes."
    Willett R., Martina J.A., Zewe J.P., Wills R., Hammond G.R.V., Puertollano R.
    Nat. Commun. 8:1580-1580(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• regulation of osteoclast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development."
    Steingrimsson E., Tessarollo L., Pathak B., Hou L., Arnheiter H., Copeland N.G., Jenkins N.A.
    Proc. Natl. Acad. Sci. U.S.A. 99:4477-4482(2002) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: RGDInferred from sequence orthologyⁱ
  • "Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity."
    Huan C., Kelly M.L., Steele R., Shapira I., Gottesman S.R.S., Roman C.A.J.
    Nat. Immunol. 7:1082-1091(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSHATETARD GVEASAEGPR AVFVLLEERR PADSAQLLSL NSLLPESGIV 
        60         70         80         90        100
ADIELENILD PDSFYELKSQ PLSLRSSLPI SLQATPTTPA TLSASSSAGG 
       110        120        130        140        150
SRTPAMSSSS SRVLLRQQLM RAQAQEQERR ERREQAAAAP FPSPAPASPA 
       160        170        180        190        200
ISVIGVSAGG HTLSRPPPAQ VPREVLKVQT HLENPTRYHL QQARRQQVKQ 
       210        220        230        240        250
YLSTTLGPKL ASQALTPPPG PSSAQPLPAP ETAHATGPTG SAPNSPMALL 
       260        270        280        290        300
TIGSSSEKEI DDVIDEIISL ESSYNDEMLS YLPGGTAGLQ LPSTLPVSGN 
       310        320        330        340        350
LLDVYSSQGV ATPAITVSNS CPAELPNIKR EISETEAKAL LKERQKKDNH 
       360        370        380        390        400
NLIERRRRFN INDRIKELGT LIPKSNDPEM RWNKGTILKA SVDYIRKLQK 
       410        420        430        440        450
EQQRSKDLES RQRSLEQANR SLQLRIQELE LQAQIHGLPV PPNPGLLSLA 
       460        470        480        490        500
TSSVSDSLKP EQLDIEEEGR PSTTTFHVSG GPTQNAPPQQ PPAPPSDTLL 
       510        520        530        540        550
DLHFPSDHLG DLGDPFHLGL EDILMEEEGM VGGLSGGALS PLRAASDPLL 
       560        570 
SSVSPAVSKS SSRRSSFSME DES                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ