Tfe3

Functionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

humoral immune response Source: InterPro
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 23885019
positive regulation of cell adhesion Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: UniProtKB
regulation of osteoclast differentiation Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Transcription factor-binding to IGHM enhancer 3Imported
Gene namesⁱ	Name:Tfe3Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome X

Organism-specific databases

Rat genome database More...RGDⁱ	1559642 Tfe3

RGDⁱ

1559642 Tfe3

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D3ZAW6
PeptideAtlas More...PeptideAtlasⁱ	D3ZAW6
PRIDEⁱ	D3ZAW6

PTM databases

iPTMnetⁱ	D3ZAW6
PhosphoSitePlusⁱ	D3ZAW6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000009605 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	D3ZAW6 RN

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000012830

STRINGⁱ

10116.ENSRNOP00000012830

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	345 – 398	BHLHInterPro annotationAdd BLAST		54

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	398 – 432	Sequence analysisAdd BLAST		35

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG410ZYYV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004402
InParanoidⁱ	D3ZAW6
KEGG Orthology (KO) More...KOⁱ	K09105
OMAⁱ	PGTATFH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QCO
PhylomeDBⁱ	D3ZAW6
TreeFamⁱ	TF317174

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR031867 MiT/TFE_N IPR024100 TFE3
PANTHERⁱ	PTHR12565 PTHR12565, 1 hit PTHR12565:SF163 PTHR12565:SF163, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D3ZAW6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSHATETARD GVEASAEGPR AVFVLLEERR PADSAQLLSL NSLLPESGIV 
        60         70         80         90        100
ADIELENILD PDSFYELKSQ PLSLRSSLPI SLQATPTTPA TLSASSSAGG 
       110        120        130        140        150
SRTPAMSSSS SRVLLRQQLM RAQAQEQERR ERREQAAAAP FPSPAPASPA 
       160        170        180        190        200
ISVIGVSAGG HTLSRPPPAQ VPREVLKVQT HLENPTRYHL QQARRQQVKQ 
       210        220        230        240        250
YLSTTLGPKL ASQALTPPPG PSSAQPLPAP ETAHATGPTG SAPNSPMALL 
       260        270        280        290        300
TIGSSSEKEI DDVIDEIISL ESSYNDEMLS YLPGGTAGLQ LPSTLPVSGN 
       310        320        330        340        350
LLDVYSSQGV ATPAITVSNS CPAELPNIKR EISETEAKAL LKERQKKDNH 
       360        370        380        390        400
NLIERRRRFN INDRIKELGT LIPKSNDPEM RWNKGTILKA SVDYIRKLQK 
       410        420        430        440        450
EQQRSKDLES RQRSLEQANR SLQLRIQELE LQAQIHGLPV PPNPGLLSLA 
       460        470        480        490        500
TSSVSDSLKP EQLDIEEEGR PSTTTFHVSG GPTQNAPPQQ PPAPPSDTLL 
       510        520        530        540        550
DLHFPSDHLG DLGDPFHLGL EDILMEEEGM VGGLSGGALS PLRAASDPLL 
       560        570 
SSVSPAVSKS SSRRSSFSME DES

Length:573

Mass (Da):61,601

Last modified:April 20, 2010 - v1

Checksum:ⁱ8193E836528D23CB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC130624 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001258156.1, NM_001271227.1
UniGeneⁱ	Rn.9231

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012829; ENSRNOP00000012830; ENSRNOG00000009605
GeneIDⁱ	317376
KEGGⁱ	rno:317376

Protein	Similar proteins		Species	Score	Length	Source
D3ZAW6	Transcription factor E3		HUMAN		575	UniRef90_P19532
Transcription factor E3		BOVIN		573
Transcription factor E3		MOUSE		572
Transcription factor binding to IGHM enhancer 3		GORGO		575
Uncharacterized protein		PONAB		297
+153

Protein	Similar proteins		Species	Score	Length	Source
D3ZAW6	Transcription factor E3		HUMAN		575	UniRef50_P19532
Transcription factor E3		BOVIN		573
Transcription factor E3		MOUSE		572
Transcription factor binding to IGHM enhancer 3		GORGO		575
Uncharacterized protein		PONAB		297
+210

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC130624 Genomic DNA No translation available.
RefSeqⁱ	NP_001258156.1, NM_001271227.1
UniGeneⁱ	Rn.9231

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000012830

STRINGⁱ

10116.ENSRNOP00000012830

PTM databases

iPTMnetⁱ	D3ZAW6
PhosphoSitePlusⁱ	D3ZAW6

Proteomic databases

PaxDbⁱ	D3ZAW6
PeptideAtlasⁱ	D3ZAW6
PRIDEⁱ	D3ZAW6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012829; ENSRNOP00000012830; ENSRNOG00000009605
GeneIDⁱ	317376
KEGGⁱ	rno:317376

Organism-specific databases

CTDⁱ	7030
RGDⁱ	1559642 Tfe3

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG410ZYYV LUCA
GeneTreeⁱ	ENSGT00390000004402
InParanoidⁱ	D3ZAW6
KOⁱ	K09105
OMAⁱ	PGTATFH
OrthoDBⁱ	EOG091G0QCO
PhylomeDBⁱ	D3ZAW6
TreeFamⁱ	TF317174

Gene expression databases

Bgeeⁱ	ENSRNOG00000009605 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
Genevisibleⁱ	D3ZAW6 RN

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR031867 MiT/TFE_N IPR024100 TFE3
PANTHERⁱ	PTHR12565 PTHR12565, 1 hit PTHR12565:SF163 PTHR12565:SF163, 1 hit
Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3ZAW6_RAT
Accessionⁱ	D3ZAW6Primary (citable) accession number: D3ZAW6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3ZAW6 (D3ZAW6_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription factor-binding to IGHM enhancer 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ