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UniProtKB - D3ZAW6 (D3ZAW6_RAT)
Protein
Submitted name:
Transcription factor-binding to IGHM enhancer 3
Gene
Tfe3
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein heterodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- humoral immune response Source: RGD
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of brown fat cell differentiation Source: RGD
- positive regulation of cell adhesion Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of osteoclast differentiation Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor-binding to IGHM enhancer 3Imported |
Gene namesi | Name:Tfe3Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1559642, Tfe3 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Proteomic databases
PaxDbi | D3ZAW6 |
PeptideAtlasi | D3ZAW6 |
PTM databases
iPTMneti | D3ZAW6 |
PhosphoSitePlusi | D3ZAW6 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000009605, Expressed in esophagus and 20 other tissues |
Genevisiblei | D3ZAW6, RN |
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000012830 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 345 – 398 | BHLHInterPro annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 152 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 210 – 247 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 464 – 497 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 531 – 573 | DisorderedSequence analysisAdd BLAST | 43 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 398 – 432 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 87 – 122 | Polar residuesSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the MiT/TFE family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1318, Eukaryota |
GeneTreei | ENSGT00940000157503 |
HOGENOMi | CLU_031638_3_2_1 |
InParanoidi | D3ZAW6 |
OMAi | DEMRWNK |
OrthoDBi | 1211990at2759 |
PhylomeDBi | D3ZAW6 |
TreeFami | TF317174 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR021802, MiT/TFE_C IPR031867, MiT/TFE_N IPR024100, TFE3 |
PANTHERi | PTHR45776:SF3, PTHR45776:SF3, 1 hit |
Pfami | View protein in Pfam PF11851, DUF3371, 1 hit PF00010, HLH, 1 hit PF15951, MITF_TFEB_C_3_N, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
D3ZAW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHATETARD GVEASAEGPR AVFVLLEERR PADSAQLLSL NSLLPESGIV
60 70 80 90 100
ADIELENILD PDSFYELKSQ PLSLRSSLPI SLQATPTTPA TLSASSSAGG
110 120 130 140 150
SRTPAMSSSS SRVLLRQQLM RAQAQEQERR ERREQAAAAP FPSPAPASPA
160 170 180 190 200
ISVIGVSAGG HTLSRPPPAQ VPREVLKVQT HLENPTRYHL QQARRQQVKQ
210 220 230 240 250
YLSTTLGPKL ASQALTPPPG PSSAQPLPAP ETAHATGPTG SAPNSPMALL
260 270 280 290 300
TIGSSSEKEI DDVIDEIISL ESSYNDEMLS YLPGGTAGLQ LPSTLPVSGN
310 320 330 340 350
LLDVYSSQGV ATPAITVSNS CPAELPNIKR EISETEAKAL LKERQKKDNH
360 370 380 390 400
NLIERRRRFN INDRIKELGT LIPKSNDPEM RWNKGTILKA SVDYIRKLQK
410 420 430 440 450
EQQRSKDLES RQRSLEQANR SLQLRIQELE LQAQIHGLPV PPNPGLLSLA
460 470 480 490 500
TSSVSDSLKP EQLDIEEEGR PSTTTFHVSG GPTQNAPPQQ PPAPPSDTLL
510 520 530 540 550
DLHFPSDHLG DLGDPFHLGL EDILMEEEGM VGGLSGGALS PLRAASDPLL
560 570
SSVSPAVSKS SSRRSSFSME DES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC130624 Genomic DNA No translation available. |
RefSeqi | NP_001258156.1, NM_001271227.1 |
Genome annotation databases
Ensembli | ENSRNOT00000012829; ENSRNOP00000012830; ENSRNOG00000009605 |
GeneIDi | 317376 |
KEGGi | rno:317376 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC130624 Genomic DNA No translation available. |
RefSeqi | NP_001258156.1, NM_001271227.1 |
3D structure databases
SMRi | D3ZAW6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000012830 |
PTM databases
iPTMneti | D3ZAW6 |
PhosphoSitePlusi | D3ZAW6 |
Proteomic databases
PaxDbi | D3ZAW6 |
PeptideAtlasi | D3ZAW6 |
Genome annotation databases
Ensembli | ENSRNOT00000012829; ENSRNOP00000012830; ENSRNOG00000009605 |
GeneIDi | 317376 |
KEGGi | rno:317376 |
Organism-specific databases
CTDi | 7030 |
RGDi | 1559642, Tfe3 |
Phylogenomic databases
eggNOGi | KOG1318, Eukaryota |
GeneTreei | ENSGT00940000157503 |
HOGENOMi | CLU_031638_3_2_1 |
InParanoidi | D3ZAW6 |
OMAi | DEMRWNK |
OrthoDBi | 1211990at2759 |
PhylomeDBi | D3ZAW6 |
TreeFami | TF317174 |
Gene expression databases
Bgeei | ENSRNOG00000009605, Expressed in esophagus and 20 other tissues |
Genevisiblei | D3ZAW6, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR021802, MiT/TFE_C IPR031867, MiT/TFE_N IPR024100, TFE3 |
PANTHERi | PTHR45776:SF3, PTHR45776:SF3, 1 hit |
Pfami | View protein in Pfam PF11851, DUF3371, 1 hit PF00010, HLH, 1 hit PF15951, MITF_TFEB_C_3_N, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | D3ZAW6_RAT | |
Accessioni | D3ZAW6Primary (citable) accession number: D3ZAW6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 19, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |