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Protein

ATP synthase subunit f, mitochondrial

Gene

Atp5j2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

GO - Biological processi

  • ATP biosynthetic process Source: UniProtKB-KW
  • ATP metabolic process Source: RGD
  • ion transport Source: UniProtKB-KW

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210 Formation of ATP by chemiosmotic coupling
R-RNO-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit f, mitochondrial
Gene namesi
Name:Atp5j2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1596067 Atp5j2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 76HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004166012 – 88ATP synthase subunit f, mitochondrialAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei3PhosphoserineCombined sources1
Modified residuei16N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiD3ZAF6
PeptideAtlasiD3ZAF6
PRIDEiD3ZAF6

PTM databases

iPTMnetiD3ZAF6
PhosphoSitePlusiD3ZAF6

Expressioni

Gene expression databases

BgeeiENSRNOG00000027049
GenevisibleiD3ZAF6 RN

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5ME, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029426

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase F chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4092 Eukaryota
ENOG4111PBN LUCA
GeneTreeiENSGT00510000046986
InParanoidiD3ZAF6
KOiK02130
OMAiHKYVQPK
OrthoDBiEOG091G12MW
PhylomeDBiD3ZAF6
TreeFamiTF342865

Family and domain databases

InterProiView protein in InterPro
IPR019344 F1F0-ATPsyn_F_prd
PANTHERiPTHR13080 PTHR13080, 1 hit
PfamiView protein in Pfam
PF10206 WRW, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3ZAF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIVPLKEK KLMEVKLREL PSWILMRDFT PSGIAGAFRR GYDRYYNKYI
60 70 80
NVRKGSISGI NMVLAAYVVF SYCISYKELK HERRRKYH
Length:88
Mass (Da):10,452
Last modified:April 20, 2010 - v1
Checksum:i3CF729DE8B3E7493
GO

Sequence databases

RefSeqiNP_001258046.1, NM_001271117.1
UniGeneiRn.3543

Genome annotation databases

EnsembliENSRNOT00000033537; ENSRNOP00000029426; ENSRNOG00000027049
GeneIDi690441
KEGGirno:690441

Similar proteinsi

Entry informationi

Entry nameiATPK_RAT
AccessioniPrimary (citable) accession number: D3ZAF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 20, 2010
Last modified: July 18, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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