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Protein
Submitted name:

Neurexin-2

Gene

Nrxn2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-2Imported
Gene namesi
Name:Nrxn2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620211 Nrxn2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1641 – 1661HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500305251029 – 1715Sequence analysisAdd BLAST1687

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000021103 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiD3ZAD6 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 206LAM_G_DOMAINInterPro annotationAdd BLAST179
Domaini202 – 242EGF-likeInterPro annotationAdd BLAST41
Domaini289 – 486LAM_G_DOMAINInterPro annotationAdd BLAST198
Domaini493 – 686LAM_G_DOMAINInterPro annotationAdd BLAST194
Domaini690 – 727EGF-likeInterPro annotationAdd BLAST38
Domaini732 – 907LAM_G_DOMAINInterPro annotationAdd BLAST176
Domaini921 – 1096LAM_G_DOMAINInterPro annotationAdd BLAST176
Domaini1099 – 1136EGF-likeInterPro annotationAdd BLAST38
Domaini1140 – 1348LAM_G_DOMAINInterPro annotationAdd BLAST209

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3514 Eukaryota
ENOG410XNU6 LUCA
GeneTreeiENSGT00760000118991
OMAiEESCANQ
OrthoDBiEOG091G00KC

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037440 Neurexin
IPR003585 Neurexin-like
IPR027789 Syndecan/Neurexin_dom
PANTHERiPTHR44287 PTHR44287, 1 hit
PfamiView protein in Pfam
PF02210 Laminin_G_2, 6 hits
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00181 EGF, 3 hits
SM00282 LamG, 6 hits
SUPFAMiSSF49899 SSF49899, 7 hits
PROSITEiView protein in PROSITE
PS50026 EGF_3, 3 hits
PS50025 LAM_G_DOMAIN, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

D3ZAD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGSRWRPP PQLPPLLLLL ALVAGVRGLE FGGGPGQWAR YARWAGAAST
60 70 80 90 100
GELSFSLRTN ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT
110 120 130 140 150
LQLDTPVADD RWHMVLLTRD ARRTALAVDG EARAAEVRSK RREMQVASDL
160 170 180 190 200
FVGGIPPDVR LSALTLSTVK YEPPFRGLLA NLKLGERPPA LLGSQGLRGA
210 220 230 240 250
AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF CSEEEHPMEG
260 270 280 290 300
PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY
310 320 330 340 350
DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI
360 370 380 390 400
NLGSGAFEAL VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV
410 420 430 440 450
TISVDGILTT TGYTQEDYTM LGSDDFFYIG GSPNTADLPG SPVSNNFMGC
460 470 480 490 500
LKDVVYKNND FKLELSRLAK EGDPKMKLQG DLSFRCEDVA ALDPVTFESP
510 520 530 540 550
EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGA GVGSHSSSQR
560 570 580 590 600
ADYFAMELLD GYLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG
610 620 630 640 650
SISVNSRSTP FLATGESEVL DLESELYLGG LPEGGRVDLP LPPEVWTAAL
660 670 680 690 700
RAGYVGCVRD LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR
710 720 730 740 750
NGGICREGWN RFVCDCIGTG FLGRVCEREA TVLSYDGSMY MKIMLPNAMH
760 770 780 790 800
TEAEDVSLRF MSQRAYGLMM ATTSRESADT LRLELDGGQM KLTVNLDCLR
810 820 830 840 850
VGCAPSAAGK GPETLFAGHK LNDNEWHTVR VVRRGKSLQL SVDNVTVEGQ
860 870 880 890 900
MAGAHTRLEF HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK
910 920 930 940 950
DGDITYCELN ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK
960 970 980 990 1000
TTAPDGLLLF NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN
1010 1020 1030 1040 1050
DNQWHNVVVS RDPGNVHTLK IDSRTVTQHS NGARNLDLKG ELYIGGLSKN
1060 1070 1080 1090 1100
MFSNLPKLVA SRDGFQGCLA SVDLNGRLPD LIADALHRIG QVERGCDGPS
1110 1120 1130 1140 1150
TTCTEESCAN QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT TYIFGKGGAL
1160 1170 1180 1190 1200
ITYTWPPNDR PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ
1210 1220 1230 1240 1250
GTVGVIFNVG TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN
1260 1270 1280 1290 1300
ERYPAGNFDN ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQAAIKI
1310 1320 1330 1340 1350
GGRDQGRPFQ GQVSGLYYNG LKVLALAAES DPNVRTEGHL RLVGEGPSVL
1360 1370 1380 1390 1400
LSAETTATTL LADMATTIME TTTTMATTTT RRGRSPTMRD STTQNTDDLL
1410 1420 1430 1440 1450
VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP
1460 1470 1480 1490 1500
TFYPFLTGVG ATQDTLPPPA ARRPSSGGPC QAERDDSDCE EPVEASGFAS
1510 1520 1530 1540 1550
GEVFDSSLPP TDDEDFYTTF PLVTDRTTLL SPRKPAPRPN LRTDGATGAP
1560 1570 1580 1590 1600
GVLLAPSAPA PNLPAGKMNH RDPLQPLLEN PPLGPGVPTA FEPRRPPPLR
1610 1620 1630 1640 1650
PGVTSVPGFP RLPTANPTGP GERGPPGAVE VIRESSSTTG MVVGIVAAAA
1660 1670 1680 1690 1700
LCILILLYAM YKYRNRDEGS YQVDQSRNYI SNSAQSNGAV VKEKAPAAPK
1710
TPSKAKKNKD KEYYV
Length:1,715
Mass (Da):185,273
Last modified:July 22, 2015 - v3
Checksum:i4528300FC69A3FCE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q63374NRX2A_RAT
Neurexin-2
Nrxn2
1,715Annotation score:
D3ZTM0D3ZTM0_RAT
Neurexin-2
Nrxn2
1,642Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128900 Genomic DNA No translation available.
RefSeqiXP_017444150.1, XM_017588661.1
UniGeneiRn.11282

Genome annotation databases

EnsembliENSRNOT00000031227; ENSRNOP00000029449; ENSRNOG00000021103
GeneIDi116595

Similar proteinsi

Entry informationi

Entry nameiD3ZAD6_RAT
AccessioniPrimary (citable) accession number: D3ZAD6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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