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Entry version 71 (13 Feb 2019)
Sequence version 1 (20 Apr 2010)
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Protein
Submitted name:

TPX2, microtubule nucleation factor

Gene

Tpx2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6804756 Regulation of TP53 Activity through Phosphorylation
R-RNO-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TPX2, microtubule nucleation factorImported
Submitted name:
TPX2, microtubule-associated protein homolog (Xenopus laevis) (Predicted), isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tpx2Imported
Synonyms:Tpx2_predictedImported
ORF Names:rCG_37362Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
1311894 Tpx2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000008165 Expressed in 9 organ(s), highest expression level in testis

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000010851

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D3ZA78

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 68Aurora-A_bindInterPro annotationAdd BLAST68
Domaini364 – 487TPX2_importinInterPro annotationAdd BLAST124
Domaini660 – 716TPX2InterPro annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili24 – 44Sequence analysisAdd BLAST21
Coiled coili658 – 712Sequence analysisAdd BLAST55

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIEY Eukaryota
ENOG4110SQ6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009842

KEGG Orthology (KO)

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KOi
K16812

Identification of Orthologs from Complete Genome Data

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OMAi
APTDFIN

Database of Orthologous Groups

More...
OrthoDBi
1390734at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328997

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015128 Aurora-A-bd
IPR027329 TPX2_C
IPR027330 TPX2_central_dom
IPR009675 TPX2_fam

The PANTHER Classification System

More...
PANTHERi
PTHR14326 PTHR14326, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09041 Aurora-A_bind, 1 hit
PF06886 TPX2, 1 hit
PF12214 TPX2_importin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3ZA78-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQVPTAYSF DAPTDFINFS SLDAEEDTEN IDSWFDEKAN LENKFLRQSG
60 70 80 90 100
IGEPFQGKTS LRKAKLQQGC VTPLKAVDNT YYKETEKENL QKQSIPSNDC
110 120 130 140 150
PSLNAKRAVT GTTPIQPQRR SVRLSAQKDL EQKEKNHVAS VEMKAKRCTA
160 170 180 190 200
PTTDYPPNKK MKVSHKKKPE EEEEGSAPAT SRKDETLERA KGKHTVPAVP
210 220 230 240 250
PAREKTVKST EEQELEKSLR MQQEVVEMRK KNEEFKKLAL AGPGQPVKKS
260 270 280 290 300
TSQVTKTVDF HFLTDERIKQ HPKSQEEYKE VNFMSELRKH SSTPARGTRG
310 320 330 340 350
CTIIKPFNLS KGKKRTFDEA ASTYVPIAQQ VEAFHKRTPN RYHLRNKKDE
360 370 380 390 400
SLLPSKPVNK IVRDPQTPIL QTKYRARAVT CKSAAEKEAE ELEKLQQYKF
410 420 430 440 450
KARELDPRIF ESGPILPKRP PVKPPTQPVG FDLEIEKRIH ERESKKKPED
460 470 480 490 500
EQFEFHSRPC PTKILEDVVG VPEKKVIPAT VPKSPVFALK NRIRVPVKED
510 520 530 540 550
EEEEKPVVIK AQPVPHYGVP YKPPIPETRN VEVCPFSFDT RDKERQLQKE
560 570 580 590 600
KKIKEMQKGE VPKFKALPVP HFDTINLPEK KVKNATQAEP FSLETDKRGA
610 620 630 640 650
YKAEIWKHQL EEEQKQQKEA ACFKARPNTV IFQEPFVPKK EKKSAAENPS
660 670 680 690 700
GSLVQEPFQL ATEKRAKERQ ELEKKMAEME AWKLQQLAEV RQQEEEQQKE
710 720 730 740
ELARLRKELV HKANPIRKYS AVEVKSSELP LTVPVSPKFS TRFQ
Length:744
Mass (Da):85,451
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75E8CA51D5D3CD0B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR07054333 Genomic DNA No translation available.
CH474050 Genomic DNA Translation: EDL86036.1
CH474050 Genomic DNA Translation: EDL86037.1

NCBI Reference Sequences

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RefSeqi
NP_001101260.1, NM_001107790.1
XP_006235332.1, XM_006235270.3
XP_006235334.1, XM_006235272.3
XP_006235335.1, XM_006235273.3
XP_017447266.1, XM_017591777.1
XP_017447267.1, XM_017591778.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.161631

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000010851; ENSRNOP00000010851; ENSRNOG00000008165
ENSRNOT00000088481; ENSRNOP00000068619; ENSRNOG00000008165

Database of genes from NCBI RefSeq genomes

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GeneIDi
311546

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:311546

UCSC genome browser

More...
UCSCi
RGD:1311894 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054333 Genomic DNA No translation available.
CH474050 Genomic DNA Translation: EDL86036.1
CH474050 Genomic DNA Translation: EDL86037.1
RefSeqiNP_001101260.1, NM_001107790.1
XP_006235332.1, XM_006235270.3
XP_006235334.1, XM_006235272.3
XP_006235335.1, XM_006235273.3
XP_017447266.1, XM_017591777.1
XP_017447267.1, XM_017591778.1
UniGeneiRn.161631

3D structure databases

SMRiD3ZA78
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010851

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010851; ENSRNOP00000010851; ENSRNOG00000008165
ENSRNOT00000088481; ENSRNOP00000068619; ENSRNOG00000008165
GeneIDi311546
KEGGirno:311546
UCSCiRGD:1311894 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22974
RGDi1311894 Tpx2

Phylogenomic databases

eggNOGiENOG410IIEY Eukaryota
ENOG4110SQ6 LUCA
GeneTreeiENSGT00390000009842
KOiK16812
OMAiAPTDFIN
OrthoDBi1390734at2759
TreeFamiTF328997

Enzyme and pathway databases

ReactomeiR-RNO-6804756 Regulation of TP53 Activity through Phosphorylation
R-RNO-8854518 AURKA Activation by TPX2

Gene expression databases

BgeeiENSRNOG00000008165 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR015128 Aurora-A-bd
IPR027329 TPX2_C
IPR027330 TPX2_central_dom
IPR009675 TPX2_fam
PANTHERiPTHR14326 PTHR14326, 1 hit
PfamiView protein in Pfam
PF09041 Aurora-A_bind, 1 hit
PF06886 TPX2, 1 hit
PF12214 TPX2_importin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3ZA78_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3ZA78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 13, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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