UniProtKB - D3Z9Z0 (D3Z9Z0_RAT)
Protein
Submitted name:
Ankyrin 1
Gene
Ank1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- ATPase binding Source: RGD
- cytoskeletal anchor activity Source: RGD
- enzyme binding Source: RGD
- ion channel binding Source: GO_Central
- protein phosphatase binding Source: RGD
- spectrin binding Source: RGD
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: RGD
- erythrocyte development Source: RGD
- iron ion homeostasis Source: RGD
- monovalent inorganic cation transport Source: RGD
- porphyrin-containing compound biosynthetic process Source: RGD
- positive regulation of organelle organization Source: RGD
- protein localization to plasma membrane Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-445095, Interaction between L1 and Ankyrins R-RNO-447043, Neurofascin interactions R-RNO-6807878, COPI-mediated anterograde transport |
Names & Taxonomyi
Protein namesi | Submitted name: Ankyrin 1ImportedSubmitted name: Ankyrin 1, erythroidImported |
Gene namesi | Name:Ank1Imported ORF Names:rCG_43073Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309620, Ank1 |
Subcellular locationi
Cytoskeleton
- cortical cytoskeleton Source: RGD
- spectrin-associated cytoskeleton Source: RGD
Endoplasmic reticulum
- sarcoplasmic reticulum Source: RGD
Nucleus
- nucleus Source: RGD
Plasma Membrane
- axolemma Source: RGD
- cytoplasmic side of plasma membrane Source: RGD
- plasma membrane Source: RGD
- postsynaptic membrane Source: RGD
- sarcolemma Source: RGD
Other locations
- A band Source: RGD
- M band Source: RGD
- membrane Source: RGD
- neuron projection Source: RGD
- Z disc Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000018241, Expressed in cerebellum and 20 other tissues |
Interactioni
GO - Molecular functioni
- ATPase binding Source: RGD
- enzyme binding Source: RGD
- ion channel binding Source: GO_Central
- protein phosphatase binding Source: RGD
- spectrin binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000062056 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 693 | ANK_REP_REGIONInterPro annotationAdd BLAST | 679 | |
Repeati | 83 – 107 | ANKPROSITE-ProRule annotationAdd BLAST | 25 | |
Repeati | 145 – 177 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 178 – 210 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 211 – 243 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 244 – 276 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 277 – 309 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 310 – 342 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 343 – 375 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 376 – 408 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 409 – 441 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 442 – 474 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 475 – 499 | ANKPROSITE-ProRule annotationAdd BLAST | 25 | |
Repeati | 508 – 540 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 541 – 573 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 574 – 606 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 607 – 639 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 640 – 672 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 828 – 983 | ZU5InterPro annotationAdd BLAST | 156 | |
Domaini | 985 – 1131 | ZU5InterPro annotationAdd BLAST | 147 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 791 – 819 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 1357 – 1380 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1473 – 1498 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 1573 – 1614 | DisorderedSequence analysisAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 944 – 964 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1361 – 1375 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1573 – 1589 | PolarSequence analysisAdd BLAST | 17 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
eggNOGi | KOG4177, Eukaryota |
GeneTreei | ENSGT00940000155760 |
HOGENOMi | CLU_000134_7_3_1 |
OMAi | AQHILCH |
OrthoDBi | 1011028at2759 |
Family and domain databases
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 6 hits PF13606, Ank_3, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 20 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 17 hits PS51145, ZU5, 2 hits |
i Sequence
Sequence statusi: Complete.
D3Z9Z0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAERPRRSGS DPAADAATSF LRAARSGNLD KALDHLRNGV DINTCNQNGL
60 70 80 90 100
NGLHLASKEG HVKMVVELLH KEIILETTTK VRDGFTPLAV ALQQGHENVV
110 120 130 140 150
AHLINYGTKG KVRLPALHIA ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL
160 170 180 190 200
HIAAHYENLN VAQLLLNRGA SVNFTPQNGI TPLHIASRRG NVIMVRLLLD
210 220 230 240 250
RGAQIETRTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA KTKNGLSPIH
260 270 280 290 300
MAAQGDHLDC VRLLLQYNAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK
310 320 330 340 350
GAKPNSRALN GFTPLHIACK KNHIRVMELL LKTGASIDAV TEKVETPLHM
360 370 380 390 400
AARAGHTEVA KYLLQNKAKA NAKAKDDQTP LHCAARIGHT SMVKLLLEND
410 420 430 440 450
ASPNLATTAG HTPLHTAARE GHVDTALALL EKEASQACMT KKGFTPLHVA
460 470 480 490 500
AKYGKVRLAE LLLEHDAHPN AAGKNGLTPL HVAVHHNNLD IVQLLLPRGG
510 520 530 540 550
SPHSPAWNGY TPLHIAAKQN QIEVARSLLQ YGGSANAESV QGVTPLHLAA
560 570 580 590 600
QEGHTEMVAL LLSKQANGNL GNKSGLTPLH LVAQEGHVPV ADVLIKHGVT
610 620 630 640 650
VDATTRMGYT PLHVASHYGN IKLVKFLLQH QADVNAKTKL GYSPLHQAAQ
660 670 680 690 700
QGHTDIVTLL LKNGASPNEV SSNGTTPLAI AKRLGYISVT DVLKVVTDET
710 720 730 740 750
SVVLVSDKHR MSYPETVDEI LDVSEDEGTA HISLTGDELV GSKAERRDSR
760 770 780 790 800
DVGEEKELLD FVPKLDQVVE SPAIPRIPCV TPETVVIRSE DQEQASKEYD
810 820 830 840 850
EDSLIPSSPA TETSDNISPV ASPVHTGFLV SFMVDARGGS MRGSRHNGLR
860 870 880 890 900
VVIPPRTCAA PTRITCRLVK PQKLSTPPPL AEEEGLASRI IALGPTGAQF
910 920 930 940 950
LSPVIVEIPH FASHGRGDRE LVVLRSENGS VWKEHKSRYG ESYLDQILNG
960 970 980 990 1000
MDEELGSLEE LEKKRVCRII TTDFPLYFVI MSRLCQDYDT IGPEGGSLRS
1010 1020 1030 1040 1050
KLVPLVQATF PENAVTKKVK LALQAQPVPD ELVTKLLGNQ ATFSPIVTVE
1060 1070 1080 1090 1100
PRRRKFHRPI GLRIPLPPSW TDNPRDSGEG DTTSLRLLCS VIGGTDQAQW
1110 1120 1130 1140 1150
EDITGTTKLV YANECANFTT NVSARFWLSD CPRTAEAVHF ATLLYKELTA
1160 1170 1180 1190 1200
VPYMAKFVIF AKMNDPREGR LRCYCMTDDK VDKTLEQHEN FVEVARSRDI
1210 1220 1230 1240 1250
EVLEGMPLFA ELSGNLVPVK KAAQQRSFHF QSFRENRLAI PVKVRDSSRE
1260 1270 1280 1290 1300
PGGFLSFLRK PMKYEDAQHI LCHLNVTMPP CTKGSGAEDR RRTLTPLTLR
1310 1320 1330 1340 1350
YSILSESRLG FTSDTDRVEM KMAVIREHLG LSWAVENLYT ALRNIDRSEI
1360 1370 1380 1390 1400
VNMLEGSGRQ SRNLKPDRRH GDREYSLSPS QVNGYSSLQD ELLSPASLHY
1410 1420 1430 1440 1450
ALPSPLCADQ YWNEVAVIDA IPLAATEHDT MLEMSDMQVW SSGLTPSLVT
1460 1470 1480 1490 1500
AEDSSLECSK AEDSDAIPEW KLEGAHSEDT QGPELGSQDL VEDDTVDSDA
1510 1520 1530 1540 1550
TNGLADLLGQ QRVHARITDS PSVRQVLDRS QARTVDWYKQ GSAASYPQEA
1560 1570 1580 1590 1600
AQSSWQEEVT QGPQSFQRRI TTIQGPEPGT LQEYEQVVVS TREHVQRGPP
1610 1620 1630 1640 1650
ESDSPKAGKD PSLWASESAF SQEVQGDELQ NIPGEQVTEE QFTDEQGNIV
1660 1670 1680 1690 1700
TKKIIRKVVR QVDSSGAIDT QQHEEVELRG SGLQPDLIEG RKGAQIVKRA
SLKRGKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07026353 Genomic DNA No translation available. AABR07026354 Genomic DNA No translation available. AABR07026355 Genomic DNA No translation available. AABR07026356 Genomic DNA No translation available. AABR07026357 Genomic DNA No translation available. AABR07026358 Genomic DNA No translation available. AABR07026359 Genomic DNA No translation available. AABR07026360 Genomic DNA No translation available. AABR07026361 Genomic DNA No translation available. CH473970 Genomic DNA Translation: EDM09025.1 |
RefSeqi | NP_001100792.1, NM_001107322.2 |
Genome annotation databases
Ensembli | ENSRNOT00000064070; ENSRNOP00000062056; ENSRNOG00000018241 |
GeneIDi | 306570 |
KEGGi | rno:306570 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07026353 Genomic DNA No translation available. AABR07026354 Genomic DNA No translation available. AABR07026355 Genomic DNA No translation available. AABR07026356 Genomic DNA No translation available. AABR07026357 Genomic DNA No translation available. AABR07026358 Genomic DNA No translation available. AABR07026359 Genomic DNA No translation available. AABR07026360 Genomic DNA No translation available. AABR07026361 Genomic DNA No translation available. CH473970 Genomic DNA Translation: EDM09025.1 |
RefSeqi | NP_001100792.1, NM_001107322.2 |
3D structure databases
SMRi | D3Z9Z0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000062056 |
Proteomic databases
PRIDEi | D3Z9Z0 |
Genome annotation databases
Ensembli | ENSRNOT00000064070; ENSRNOP00000062056; ENSRNOG00000018241 |
GeneIDi | 306570 |
KEGGi | rno:306570 |
Organism-specific databases
CTDi | 286 |
RGDi | 1309620, Ank1 |
Phylogenomic databases
eggNOGi | KOG4177, Eukaryota |
GeneTreei | ENSGT00940000155760 |
HOGENOMi | CLU_000134_7_3_1 |
OMAi | AQHILCH |
OrthoDBi | 1011028at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-445095, Interaction between L1 and Ankyrins R-RNO-447043, Neurofascin interactions R-RNO-6807878, COPI-mediated anterograde transport |
Gene expression databases
Bgeei | ENSRNOG00000018241, Expressed in cerebellum and 20 other tissues |
Family and domain databases
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 6 hits PF13606, Ank_3, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 20 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 17 hits PS51145, ZU5, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3Z9Z0_RAT | |
Accessioni | D3Z9Z0Primary (citable) accession number: D3Z9Z0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |