Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 92 (10 Feb 2021)
Sequence version 1 (20 Apr 2010)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

CD163 antigen (Predicted)

Gene

Cd163

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2168880, Scavenging of heme from plasma

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CD163 antigen (Predicted)Imported
Submitted name:
CD163 moleculeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cd163Imported
Synonyms:Cd163_predictedImported
ORF Names:rCG_29882Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
1310382, Cd163

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1047 – 1067HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 139PROSITE-ProRule annotation
Disulfide bondi88 ↔ 149PROSITE-ProRule annotation
Disulfide bondi119 ↔ 129PROSITE-ProRule annotation
Disulfide bondi183 ↔ 247PROSITE-ProRule annotation
Disulfide bondi196 ↔ 257PROSITE-ProRule annotation
Disulfide bondi227 ↔ 237PROSITE-ProRule annotation
Disulfide bondi290 ↔ 354PROSITE-ProRule annotation
Disulfide bondi303 ↔ 364PROSITE-ProRule annotation
Disulfide bondi334 ↔ 344PROSITE-ProRule annotation
Disulfide bondi443 ↔ 453PROSITE-ProRule annotation
Disulfide bondi504 ↔ 568PROSITE-ProRule annotation
Disulfide bondi517 ↔ 578PROSITE-ProRule annotation
Disulfide bondi548 ↔ 558PROSITE-ProRule annotation
Disulfide bondi609 ↔ 673PROSITE-ProRule annotation
Disulfide bondi622 ↔ 683PROSITE-ProRule annotation
Disulfide bondi653 ↔ 663PROSITE-ProRule annotation
Disulfide bondi746 ↔ 810PROSITE-ProRule annotation
Disulfide bondi759 ↔ 820PROSITE-ProRule annotation
Disulfide bondi790 ↔ 800PROSITE-ProRule annotation
Disulfide bondi853 ↔ 917PROSITE-ProRule annotation
Disulfide bondi866 ↔ 927PROSITE-ProRule annotation
Disulfide bondi897 ↔ 907PROSITE-ProRule annotation
Disulfide bondi956 ↔ 1020PROSITE-ProRule annotation
Disulfide bondi969 ↔ 1030PROSITE-ProRule annotation
Disulfide bondi1000 ↔ 1010PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3Z9U2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000010253, Expressed in spleen and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3Z9U2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000058828

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3Z9U2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 150SRCRInterPro annotationAdd BLAST101
Domaini157 – 258SRCRInterPro annotationAdd BLAST102
Domaini265 – 365SRCRInterPro annotationAdd BLAST101
Domaini372 – 474SRCRInterPro annotationAdd BLAST103
Domaini479 – 579SRCRInterPro annotationAdd BLAST101
Domaini584 – 684SRCRInterPro annotationAdd BLAST101
Domaini721 – 821SRCRInterPro annotationAdd BLAST101
Domaini826 – 928SRCRInterPro annotationAdd BLAST103
Domaini931 – 1031SRCRInterPro annotationAdd BLAST101

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ5W, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155987

Identification of Orthologs from Complete Genome Data

More...
OMAi
SGQVWRH

Database of Orthologous Groups

More...
OrthoDBi
1095487at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00530, SRCR, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258, SPERACTRCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00202, SR, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56487, SSF56487, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00420, SRCR_1, 4 hits
PS50287, SRCR_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3Z9U2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKNRMVLLG GAGSPGYKGF VHLGFFVVAV SSLLSVSAVT QAPEGRKKEL
60 70 80 90 100
RLAGGENNCS GRVELKIHEK WGTVCGNGWS MNEVSVVCQQ LGCPTLIKAP
110 120 130 140 150
GWANASAGSG DIWMDKVSCT GNESALWDCK HEGWGKHNCT HEQDAGVTCA
160 170 180 190 200
DGSNLEMRLV NSGDNRCSGR VEIKFQGKWG TVCDDNFSKD HASVICKQLG
210 220 230 240 250
CGSAISFSGS AKLGAGSGQI WLDDLACNGN ESAIWDCKHR GWGRHNCDHA
260 270 280 290 300
EDVGVICLDG ADLSLRLVDG VSKCSGRLEV RFQGEWGTVC DDSWDRRDAS
310 320 330 340 350
VVCKQLGCPT AITAIGRVNA SEGSGPIWLD SISCEGHEPA LWECKHQEWG
360 370 380 390 400
KHYCNHKEDA GVTCSDGADL ELRLVGGGSR CAGMVEVEIQ KLTGKVCSRG
410 420 430 440 450
WTLTDADVVC RQLGCGSALQ TQSKIYSKTK TEATNTWLFP GSCSGNETSL
460 470 480 490 500
WQCKNWQWGG LSCDHFEEAQ VTCSGHRKPR LVGGEIPCSG RVEVKHGDTW
510 520 530 540 550
GSVCDFDLSL EAAGVVCREL QCGTVVSILG GAHFGEGSGQ IWGEEFQCSG
560 570 580 590 600
DESHLSLCSV APPLDRTCSH SRDVSIVCSR YIDIRLADGK SSCEGRVELK
610 620 630 640 650
TLGAWGPLCS SHWDIEDAHV LCQQLKCGVA LSTPGGAHFG KGAGQVWRHK
660 670 680 690 700
FHCTGTEEHI GDCPMTALGT PMCSDGQVAS VICSGNQSHT LLPCSSSSSV
710 720 730 740 750
QTTSSTIAKD SDVPCIASGQ LRLVGGGGRC AGRVEVYHEG SWGTICDDSW
760 770 780 790 800
DLTDANVVCK QLDCGVAINA TGSAYFGEGT GDIWLDEIDC SGKESHIWQC
810 820 830 840 850
HSHGWGRHNC RHKEDAGVVC SEFMSLRLTN EAHRVNCTGR LEVFYNGTWG
860 870 880 890 900
SIGSSNMSPT TVGVVCRQLG CADNGTVKPT SSDKTPTRPM WTDSVQCPKG
910 920 930 940 950
VDTLWQCPSS PWKQRQASPS QESWIVCDDK IRLQEGHTDC SGRVEIWHRG
960 970 980 990 1000
SWGTVCDDSW DLNDAEVACK QLGCGQAVEA LKEAAFGPGT GPIWLNEMKC
1010 1020 1030 1040 1050
RGNESSLWDC PARPWSHSDC GHKEDASVKC LPRMTLESQH GTGHSTLTAL
1060 1070 1080 1090 1100
LVCGAILLVL LIAFLLWTLK RRQTQRLTVS SRGEVLIHQV QYQEMDSKTD
1110 1120
DLDLLKSSGW HLRNLDMTAS
Length:1,120
Mass (Da):120,722
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AEE35F82FD74030
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JVY2A0A0G2JVY2_RAT
CD163 molecule
Cd163
1,111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07062026 Genomic DNA No translation available.
CH473964 Genomic DNA Translation: EDM01961.1

NCBI Reference Sequences

More...
RefSeqi
NP_001101357.1, NM_001107887.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000068407; ENSRNOP00000058828; ENSRNOG00000010253

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
312701

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:312701

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062026 Genomic DNA No translation available.
CH473964 Genomic DNA Translation: EDM01961.1
RefSeqiNP_001101357.1, NM_001107887.1

3D structure databases

SMRiD3Z9U2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058828

Proteomic databases

PRIDEiD3Z9U2

Genome annotation databases

EnsembliENSRNOT00000068407; ENSRNOP00000058828; ENSRNOG00000010253
GeneIDi312701
KEGGirno:312701

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9332
RGDi1310382, Cd163

Phylogenomic databases

eggNOGiENOG502QQ5W, Eukaryota
GeneTreeiENSGT00940000155987
OMAiSGQVWRH
OrthoDBi1095487at2759

Enzyme and pathway databases

ReactomeiR-RNO-2168880, Scavenging of heme from plasma

Gene expression databases

BgeeiENSRNOG00000010253, Expressed in spleen and 20 other tissues
ExpressionAtlasiD3Z9U2, baseline and differential

Family and domain databases

Gene3Di3.10.250.10, 9 hits
InterProiView protein in InterPro
IPR001190, SRCR
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
PfamiView protein in Pfam
PF00530, SRCR, 9 hits
PRINTSiPR00258, SPERACTRCPTR
SMARTiView protein in SMART
SM00202, SR, 9 hits
SUPFAMiSSF56487, SSF56487, 9 hits
PROSITEiView protein in PROSITE
PS00420, SRCR_1, 4 hits
PS50287, SRCR_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z9U2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z9U2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 10, 2021
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again