PTEN induced putative kinase 1 (Predicted)

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein serine/threonine kinase activity Source: ParkinsonsUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1."
    Pridgeon J.W., Olzmann J.A., Chin L.S., Li L.
    PLoS Biol 5:e172-e172(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• negative regulation of gene expression Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation."
    Wang X., Guo J., Fei E., Mu Y., He S., Che X., Tan J., Xia K., Zhang Z., Wang G., Tang B.
    PLoS One 9:e86276-e86276(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1."
    Pridgeon J.W., Olzmann J.A., Chin L.S., Li L.
    PLoS Biol 5:e172-e172(2007) [PubMed] [Europe PMC] [Abstract]
• peptidyl-serine phosphorylation Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1."
    Pridgeon J.W., Olzmann J.A., Chin L.S., Li L.
    PLoS Biol 5:e172-e172(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Phylogenomic databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAVRQALGRG LQLGRALLLR FAPKPGPVSG WGKPGPGAAW GRGERPGRVS 
        60         70         80         90        100
SPGAQPRPLG LPLPDRYRFF RQSVAGLAAR IQRQFVVRAR GGAGPCGRAV 
       110        120        130        140        150
FLAFGLGLGL IEEKQAESRR AASACQEIQA IFTQKNKQVS DPLDTRRWQG 
       160        170        180        190        200
FRLEDYLIGQ AIGKGCNAAV YEATMPTLPQ HLEKAKHLGL LGKGPDVVSK 
       210        220        230        240        250
GADGEQAPGA PAFPFAIKMM WNISAGSSSE AILSKMSQEL EALGSANRKG 

TLQQFRR                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ