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Entry version 74 (31 Jul 2019)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

RNA-binding motif protein 25-like 1

Gene

Rbm25l1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RNA-binding motif protein 25-like 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rbm25l1Imported
Synonyms:RGD1565486Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
1565486 Rbm25l1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
D3Z8R4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3Z8R4

PeptideAtlas

More...
PeptideAtlasi
D3Z8R4

PRoteomics IDEntifications database

More...
PRIDEi
D3Z8R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000002871 Expressed in 9 organ(s), highest expression level in colon

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000003832

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D3Z8R4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 164RRMInterPro annotationAdd BLAST78
Domaini724 – 817PWIInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni173 – 201DisorderedSequence analysisAdd BLAST29
Regioni220 – 242DisorderedSequence analysisAdd BLAST23
Regioni282 – 415DisorderedSequence analysisAdd BLAST134
Regioni472 – 662DisorderedSequence analysisAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili416 – 468Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 242PolyampholyteSequence analysisAdd BLAST16
Compositional biasi472 – 554PolyampholyteSequence analysisAdd BLAST83
Compositional biasi555 – 580AcidicSequence analysisAdd BLAST26
Compositional biasi594 – 613PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2253 Eukaryota
ENOG410ZRGA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111019

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3Z8R4

Identification of Orthologs from Complete Genome Data

More...
OMAi
FGFCEFD

Database of Orthologous Groups

More...
OrthoDBi
885027at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12446 RRM_RBM25, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR002483 PWI_dom
IPR036483 PWI_dom_sf
IPR035979 RBD_domain_sf
IPR034268 RBM25_RRM
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01480 PWI, 1 hit
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00311 PWI, 1 hit
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101233 SSF101233, 1 hit
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51025 PWI, 1 hit
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3Z8R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA
60 70 80 90 100
PTVLVPTVSM VGKHLGARKD HPGLKLKEND ENCGPTTTVF VGNISEKASD
110 120 130 140 150
MLIRQLLAKC GLVLSWKRVQ GASGKLQAFG FCEYKEPEST LRALRLLHDL
160 170 180 190 200
QIGEKKLLVK VDAKTKAQLD EWKAKKKANG NARPETVTND DEEALDEETK
210 220 230 240 250
RRDQMIKGAI EVLIREYSSE LNAPSQESDS HPRKKKKEKK EDIFRRFPVA
260 270 280 290 300
PLIPYPLITK EDINAIEMEE DKRDLISREI SKFRDTHKKL EEEKGKKEKE
310 320 330 340 350
RQEIEKERRE RERERERERE RRERERERER EREREKEKER ERERERDRDR
360 370 380 390 400
DRTKERDRDR ERDRDRDRER SSDRNKDRSR SREKSRDRER EREREREREK
410 420 430 440 450
DKKRDREEDE EDAYERRKLE RKLREKEAAY QERLKNWEIR ERKKTREYEK
460 470 480 490 500
EAEREEERRR EIKAKEAKRL KEFLEDYDDD RDDPKYYRGS ALQKRLRDRE
510 520 530 540 550
KEMEADERDR KREKEELEEI RQRLLAEGHP DPDAELQRME QEAERRRQPQ
560 570 580 590 600
IKQEPESEEE EEEKQEKEEK REEPVEEEEE PEQKPCLKPT LRPISSAPSV
610 620 630 640 650
SSASSNATPN TPGDESPCGI IIPHENSPDQ QQPEEHRPKI GLSLKLGASN
660 670 680 690 700
SPGQPNSVKR KKLPVDSVFN KFEDEDSDDV PRKRKLVPLD YGEDDKNAAK
710 720 730 740 750
GTVNTEEKRK HIKSLIEKIP TAKPELFAYP LDWSIVDSIL MERRIRPWIN
760 770 780 790 800
KKIIEYIGEE EATLVDFVCS KVMAHSSPQS ILDDVAMVLD EEAEVFIVKM
810
WRLLIYETEA KKIGLVK
Length:817
Mass (Da):96,524
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EAA71556D1294F1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AABR07029155 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_003750818.1, XM_003750770.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000003832; ENSRNOP00000003832; ENSRNOG00000002871

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
497865

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07029155 Genomic DNA No translation available.
RefSeqiXP_003750818.1, XM_003750770.3

3D structure databases

SMRiD3Z8R4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003832

Proteomic databases

jPOSTiD3Z8R4
PaxDbiD3Z8R4
PeptideAtlasiD3Z8R4
PRIDEiD3Z8R4

Genome annotation databases

EnsembliENSRNOT00000003832; ENSRNOP00000003832; ENSRNOG00000002871
GeneIDi497865

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
497865
RGDi1565486 Rbm25l1

Phylogenomic databases

eggNOGiKOG2253 Eukaryota
ENOG410ZRGA LUCA
GeneTreeiENSGT00730000111019
InParanoidiD3Z8R4
OMAiFGFCEFD
OrthoDBi885027at2759

Gene expression databases

BgeeiENSRNOG00000002871 Expressed in 9 organ(s), highest expression level in colon

Family and domain databases

CDDicd12446 RRM_RBM25, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR002483 PWI_dom
IPR036483 PWI_dom_sf
IPR035979 RBD_domain_sf
IPR034268 RBM25_RRM
IPR000504 RRM_dom
PfamiView protein in Pfam
PF01480 PWI, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00311 PWI, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF101233 SSF101233, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51025 PWI, 1 hit
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z8R4_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z8R4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: July 31, 2019
This is version 74 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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