UniProtKB - D3Z8L7 (RRAS_RAT)
Protein
Ras-related protein R-Ras
Gene
Rras
Organism
Rattus norvegicus (Rat)
Status
Functioni
Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.By similarity
Catalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 44 | GTPBy similarity | 9 | |
Nucleotide bindingi | 83 – 87 | GTPBy similarity | 5 | |
Nucleotide bindingi | 142 – 145 | GTPBy similarity | 4 | |
Nucleotide bindingi | 172 – 174 | GTPBy similarity | 3 |
GO - Molecular functioni
- GDP binding Source: RGD
- GTPase activity Source: RGD
- GTP binding Source: GO_Central
- protein-containing complex binding Source: RGD
GO - Biological processi
- face morphogenesis Source: RGD
- leukocyte differentiation Source: RGD
- negative regulation of cell migration Source: RGD
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of endothelial cell-matrix adhesion via fibronectin Source: RGD
- positive regulation of endothelial cell migration Source: RGD
- positive regulation of vasculogenesis Source: RGD
- Ras protein signal transduction Source: GO_Central
- regulation of ERK1 and ERK2 cascade Source: RGD
- regulation of protein kinase B signaling Source: RGD
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-416550, Sema4D mediated inhibition of cell attachment and migration |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Rras |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311443, Rras |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine.By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000408475 | 1 – 215 | Ras-related protein R-RasAdd BLAST | 215 | |
PropeptideiPRO_0000408476 | 216 – 218 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 215 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.By similarity
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, PrenylationProteomic databases
jPOSTi | D3Z8L7 |
PaxDbi | D3Z8L7 |
PeptideAtlasi | D3Z8L7 |
PRIDEi | D3Z8L7 |
PTM databases
SwissPalmi | D3Z8L7 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000037247, Expressed in lung and 22 other tissues |
Genevisiblei | D3Z8L7, RN |
Interactioni
Subunit structurei
Interacts with PLCE1 (By similarity).
Interacts (active GTP-bound form preferentially) with RGS14 (PubMed:19319189).
Interacts with OSBPL3 (By similarity).
Interacts with ZDHHC19 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
CORUMi | D3Z8L7 |
STRINGi | 10116.ENSRNOP00000027809 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 58 – 66 | Effector region | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | D3Z8L7 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | D3Z8L7 |
TreeFami | TF312796 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
D3Z8L7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GNGFLLVFAI NDRQSFIEVS KLFTQILRVK DRDDFPIVLV GNKADLETQR
160 170 180 190 200
QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRTV RKYQEQELPP
210
SPPSAPRKKD GRCPCVLL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 142 | N → S in FQ211166 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FQ211166 mRNA No translation available. CH473979 Genomic DNA Translation: EDM07427.1 |
RefSeqi | NP_001101951.1, NM_001108481.1 |
Genome annotation databases
Ensembli | ENSRNOT00000027809; ENSRNOP00000027809; ENSRNOG00000037247 |
GeneIDi | 361568 |
KEGGi | rno:361568 |
UCSCi | RGD:1311443, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FQ211166 mRNA No translation available. CH473979 Genomic DNA Translation: EDM07427.1 |
RefSeqi | NP_001101951.1, NM_001108481.1 |
3D structure databases
SMRi | D3Z8L7 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | D3Z8L7 |
STRINGi | 10116.ENSRNOP00000027809 |
PTM databases
SwissPalmi | D3Z8L7 |
Proteomic databases
jPOSTi | D3Z8L7 |
PaxDbi | D3Z8L7 |
PeptideAtlasi | D3Z8L7 |
PRIDEi | D3Z8L7 |
Genome annotation databases
Ensembli | ENSRNOT00000027809; ENSRNOP00000027809; ENSRNOG00000037247 |
GeneIDi | 361568 |
KEGGi | rno:361568 |
UCSCi | RGD:1311443, rat |
Organism-specific databases
CTDi | 6237 |
RGDi | 1311443, Rras |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | D3Z8L7 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | D3Z8L7 |
TreeFami | TF312796 |
Enzyme and pathway databases
Reactomei | R-RNO-416550, Sema4D mediated inhibition of cell attachment and migration |
Miscellaneous databases
PROi | PR:D3Z8L7 |
Gene expression databases
Bgeei | ENSRNOG00000037247, Expressed in lung and 22 other tissues |
Genevisiblei | D3Z8L7, RN |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RRAS_RAT | |
Accessioni | D3Z8L7Primary (citable) accession number: D3Z8L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 31, 2011 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families