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UniProtKB - D3Z8F6 (D3Z8F6_RAT)

Entry version 65 (02 Dec 2020)
Sequence version 3 (22 Jul 2015)
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Protein
Submitted name:

DENN domain-containing 1B

Gene

Dennd1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DENN domain-containing 1BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dennd1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Rat genome database

More...RGDi		1308441, Dennd1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		D3Z8F6

PeptideAtlas

More...PeptideAtlasi		D3Z8F6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		D3Z8F6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		D3Z8F6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000011063, Expressed in quadriceps femoris and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		D3Z8F6, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000043081

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D3Z8F6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 375UDENNInterPro annotationAdd BLAST362

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni473 – 502DisorderedSequence analysisAdd BLAST30
Regioni664 – 727DisorderedSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi664 – 710PolarSequence analysisAdd BLAST47

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3569, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155446

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008196_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D3Z8F6

Identification of Orthologs from Complete Genome Data

More...OMAi		MHSYFIA

Database of Orthologous Groups

More...OrthoDBi		189322at2759

TreeFam database of animal gene trees

More...TreeFami		TF343037

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR040032, DENND1A/B/C
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

The PANTHER Classification System

More...PANTHERi		PTHR13196, PTHR13196, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50211, DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3Z8F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRRTRENPE RTFDLVLKVK CHASENEDPV VLWKFPEDFG DQEVLQSVPR 
        60         70         80         90        100
FCFPFDVERV SQNQVGQHFT FVLTDMESKQ RFGFCRLTSG GRVCLCILSY 
       110        120        130        140        150
LPWFEVYYKL LNTLADYLAK ELEDDLNETL KSLYSHPVPK ANTPVHLSVH 
       160        170        180        190        200
SCFITPDITG LPTIPESRNL TEYFVAVDVN NMLRLYASML HERRIIITSS 
       210        220        230        240        250
KLSTLTACLH GSAALLYPMY WQHIYIPVLP PHLLDYCCAP MPYLIGIHSS 
       260        270        280        290        300
LIERVKNKSL EDVVMLNVDT NTLESPFNDV NSLPSDVVSA LKNKLKKQST 
       310        320        330        340        350
ATGDGVARAF LRAQAALFGS YRDALRYKPG EPITFCEESF VKHRSSVMKQ 
       360        370        380        390        400
FLETAVNLQL FKQFIDGRLA KLNAGRGFSD IFEEEITSGG FCGGSPRSYQ 
       410        420        430        440        450
QWVYTVKKGG ALFNTAVTKA TPAVRTAYKF AKSHARLGLK EVKSRLRHKD 
       460        470        480        490        500
NEEDYGTCSG LVQYTPVYTL HHERGETREK QKLSQAHLKR PHKSLDGTLY 
       510        520        530        540        550
DDDDDIERAS KISSEDGEET SAYFYESDDS VDAQVKAPYS GEMDLLGEIL 
       560        570        580        590        600
DTLSTHSSDQ GKLAPAKSLD FFRSMDDIDY KPTNKSNAPS ENNLTLLCAS 
       610        620        630        640        650
GDQGEWNLGQ DDSALHGKHL PPSPRKRVCS SGLTDSLFIL KEENTEKPFS 
       660        670        680        690        700
ADSVSVPTVV EKSASTSDSG FQPATPEASQ THKGKPEVKQ TLSQASDDLL 
       710        720        730        740        750
VPSPGNRQST FVPWEKAGKE ETKPSKDVGL LQEVVSLCHM SCDFQQGLNI 
       760
SEESKSENQT
Length:760
Mass (Da):85,027
Last modified:July 22, 2015 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE596350F233E317B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R8I4M0R8I4_RAT
DENN domain-containing 1B
Dennd1b
407Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1M3B0F1M3B0_RAT
DENN domain-containing 1B
Dennd1b
383Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AABR07021080 Genomic DNA No translation available.
AABR07021081 Genomic DNA No translation available.
AABR07021082 Genomic DNA No translation available.
AABR07021083 Genomic DNA No translation available.
AABR07021084 Genomic DNA No translation available.
AABR07021085 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_003751292.1, XM_003751244.2
XP_003752691.1, XM_003752643.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063

Database of genes from NCBI RefSeq genomes

More...GeneIDi		289051

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:289051

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07021080 Genomic DNA No translation available.
AABR07021081 Genomic DNA No translation available.
AABR07021082 Genomic DNA No translation available.
AABR07021083 Genomic DNA No translation available.
AABR07021084 Genomic DNA No translation available.
AABR07021085 Genomic DNA No translation available.
RefSeqiXP_003751292.1, XM_003751244.2
XP_003752691.1, XM_003752643.3

3D structure databases

SMRiD3Z8F6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043081

PTM databases

iPTMnetiD3Z8F6
PhosphoSitePlusiD3Z8F6

Proteomic databases

PaxDbiD3Z8F6
PeptideAtlasiD3Z8F6

Genome annotation databases

EnsembliENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063
GeneIDi289051
KEGGirno:289051

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		163486
RGDi1308441, Dennd1b

Phylogenomic databases

eggNOGiKOG3569, Eukaryota
GeneTreeiENSGT00940000155446
HOGENOMiCLU_008196_4_0_1
InParanoidiD3Z8F6
OMAiMHSYFIA
OrthoDBi189322at2759
TreeFamiTF343037

Enzyme and pathway databases

ReactomeiR-RNO-8876198, RAB GEFs exchange GTP for GDP on RABs

Gene expression databases

BgeeiENSRNOG00000011063, Expressed in quadriceps femoris and 19 other tissues
ExpressionAtlasiD3Z8F6, baseline and differential

Family and domain databases

Gene3Di3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR040032, DENND1A/B/C
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PANTHERiPTHR13196, PTHR13196, 1 hit
PfamiView protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z8F6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z8F6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: December 2, 2020
This is version 65 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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