UniProtKB - D3Z8F6 (D3Z8F6_RAT)
Protein
Submitted name:
DENN domain-containing 1B
Gene
Dennd1b
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- phosphatidylinositol phosphate binding Source: GO_Central
- Rab GTPase binding Source: RGD
- Rab guanyl-nucleotide exchange factor activity Source: RGD
GO - Biological processi
- endocytic recycling Source: RGD
- endocytosis Source: GO_Central
- positive regulation of GTPase activity Source: RGD
- regulation of immune response Source: RGD
- T cell receptor signaling pathway Source: RGD
- T-helper 2 cell cytokine production Source: RGD
Keywordsi
Molecular function | Guanine-nucleotide releasing factorARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Submitted name: DENN domain-containing 1BImported |
Gene namesi | Name:Dennd1bImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308441, Dennd1b |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nuclear speck Source: GO_Central
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Cytoplasmic vesicleARBA annotationPTM / Processingi
Proteomic databases
PaxDbi | D3Z8F6 |
PeptideAtlasi | D3Z8F6 |
PTM databases
iPTMneti | D3Z8F6 |
PhosphoSitePlusi | D3Z8F6 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000011063, Expressed in quadriceps femoris and 19 other tissues |
ExpressionAtlasi | D3Z8F6, baseline and differential |
Interactioni
GO - Molecular functioni
- Rab GTPase binding Source: RGD
- Rab guanyl-nucleotide exchange factor activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000043081 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 375 | UDENNInterPro annotationAdd BLAST | 362 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 473 – 502 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 664 – 727 | DisorderedSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 664 – 710 | PolarSequence analysisAdd BLAST | 47 |
Phylogenomic databases
eggNOGi | KOG3569, Eukaryota |
GeneTreei | ENSGT00940000155446 |
HOGENOMi | CLU_008196_4_0_1 |
InParanoidi | D3Z8F6 |
OMAi | MHSYFIA |
OrthoDBi | 189322at2759 |
TreeFami | TF343037 |
Family and domain databases
Gene3Di | 3.40.50.11500, 1 hit |
InterProi | View protein in InterPro IPR001194, cDENN_dom IPR005112, dDENN_dom IPR043153, DENN_C IPR040032, DENND1A/B/C IPR037516, Tripartite_DENN IPR005113, uDENN_dom |
PANTHERi | PTHR13196, PTHR13196, 1 hit |
Pfami | View protein in Pfam PF03455, dDENN, 1 hit PF02141, DENN, 1 hit PF03456, uDENN, 1 hit |
SMARTi | View protein in SMART SM00801, dDENN, 1 hit SM00799, DENN, 1 hit SM00800, uDENN, 1 hit |
PROSITEi | View protein in PROSITE PS50211, DENN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
D3Z8F6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRRTRENPE RTFDLVLKVK CHASENEDPV VLWKFPEDFG DQEVLQSVPR
60 70 80 90 100
FCFPFDVERV SQNQVGQHFT FVLTDMESKQ RFGFCRLTSG GRVCLCILSY
110 120 130 140 150
LPWFEVYYKL LNTLADYLAK ELEDDLNETL KSLYSHPVPK ANTPVHLSVH
160 170 180 190 200
SCFITPDITG LPTIPESRNL TEYFVAVDVN NMLRLYASML HERRIIITSS
210 220 230 240 250
KLSTLTACLH GSAALLYPMY WQHIYIPVLP PHLLDYCCAP MPYLIGIHSS
260 270 280 290 300
LIERVKNKSL EDVVMLNVDT NTLESPFNDV NSLPSDVVSA LKNKLKKQST
310 320 330 340 350
ATGDGVARAF LRAQAALFGS YRDALRYKPG EPITFCEESF VKHRSSVMKQ
360 370 380 390 400
FLETAVNLQL FKQFIDGRLA KLNAGRGFSD IFEEEITSGG FCGGSPRSYQ
410 420 430 440 450
QWVYTVKKGG ALFNTAVTKA TPAVRTAYKF AKSHARLGLK EVKSRLRHKD
460 470 480 490 500
NEEDYGTCSG LVQYTPVYTL HHERGETREK QKLSQAHLKR PHKSLDGTLY
510 520 530 540 550
DDDDDIERAS KISSEDGEET SAYFYESDDS VDAQVKAPYS GEMDLLGEIL
560 570 580 590 600
DTLSTHSSDQ GKLAPAKSLD FFRSMDDIDY KPTNKSNAPS ENNLTLLCAS
610 620 630 640 650
GDQGEWNLGQ DDSALHGKHL PPSPRKRVCS SGLTDSLFIL KEENTEKPFS
660 670 680 690 700
ADSVSVPTVV EKSASTSDSG FQPATPEASQ THKGKPEVKQ TLSQASDDLL
710 720 730 740 750
VPSPGNRQST FVPWEKAGKE ETKPSKDVGL LQEVVSLCHM SCDFQQGLNI
760
SEESKSENQT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R8I4 | M0R8I4_RAT | DENN domain-containing 1B | Dennd1b | 407 | Annotation score: | ||
F1M3B0 | F1M3B0_RAT | DENN domain-containing 1B | Dennd1b | 383 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07021080 Genomic DNA No translation available. AABR07021081 Genomic DNA No translation available. AABR07021082 Genomic DNA No translation available. AABR07021083 Genomic DNA No translation available. AABR07021084 Genomic DNA No translation available. AABR07021085 Genomic DNA No translation available. |
RefSeqi | XP_003751292.1, XM_003751244.2 XP_003752691.1, XM_003752643.3 |
Genome annotation databases
Ensembli | ENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063 |
GeneIDi | 289051 |
KEGGi | rno:289051 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07021080 Genomic DNA No translation available. AABR07021081 Genomic DNA No translation available. AABR07021082 Genomic DNA No translation available. AABR07021083 Genomic DNA No translation available. AABR07021084 Genomic DNA No translation available. AABR07021085 Genomic DNA No translation available. |
RefSeqi | XP_003751292.1, XM_003751244.2 XP_003752691.1, XM_003752643.3 |
3D structure databases
SMRi | D3Z8F6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000043081 |
PTM databases
iPTMneti | D3Z8F6 |
PhosphoSitePlusi | D3Z8F6 |
Proteomic databases
PaxDbi | D3Z8F6 |
PeptideAtlasi | D3Z8F6 |
Genome annotation databases
Ensembli | ENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063 |
GeneIDi | 289051 |
KEGGi | rno:289051 |
Organism-specific databases
CTDi | 163486 |
RGDi | 1308441, Dennd1b |
Phylogenomic databases
eggNOGi | KOG3569, Eukaryota |
GeneTreei | ENSGT00940000155446 |
HOGENOMi | CLU_008196_4_0_1 |
InParanoidi | D3Z8F6 |
OMAi | MHSYFIA |
OrthoDBi | 189322at2759 |
TreeFami | TF343037 |
Enzyme and pathway databases
Reactomei | R-RNO-8876198, RAB GEFs exchange GTP for GDP on RABs |
Gene expression databases
Bgeei | ENSRNOG00000011063, Expressed in quadriceps femoris and 19 other tissues |
ExpressionAtlasi | D3Z8F6, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.11500, 1 hit |
InterProi | View protein in InterPro IPR001194, cDENN_dom IPR005112, dDENN_dom IPR043153, DENN_C IPR040032, DENND1A/B/C IPR037516, Tripartite_DENN IPR005113, uDENN_dom |
PANTHERi | PTHR13196, PTHR13196, 1 hit |
Pfami | View protein in Pfam PF03455, dDENN, 1 hit PF02141, DENN, 1 hit PF03456, uDENN, 1 hit |
SMARTi | View protein in SMART SM00801, dDENN, 1 hit SM00799, DENN, 1 hit SM00800, uDENN, 1 hit |
PROSITEi | View protein in PROSITE PS50211, DENN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3Z8F6_RAT | |
Accessioni | D3Z8F6Primary (citable) accession number: D3Z8F6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | July 22, 2015 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |