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Protein
Submitted name:

DENN domain-containing 1B

Gene

Dennd1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Submitted name:
DENN domain-containing 1BImported
Gene namesi
Name:Dennd1bImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1308441 Dennd1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiD3Z8F6
PeptideAtlasiD3Z8F6

PTM databases

iPTMnetiD3Z8F6
PhosphoSitePlusiD3Z8F6

Expressioni

Gene expression databases

BgeeiENSRNOG00000011063 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiD3Z8F6 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043081

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 375UDENNInterPro annotationAdd BLAST362

Phylogenomic databases

eggNOGiKOG3569 Eukaryota
ENOG410XT3N LUCA
GeneTreeiENSGT00760000118819
InParanoidiD3Z8F6
KOiK20160
OMAiFAKSHAR
OrthoDBiEOG091G083L
TreeFamiTF343037

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

D3Z8F6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRRTRENPE RTFDLVLKVK CHASENEDPV VLWKFPEDFG DQEVLQSVPR
60 70 80 90 100
FCFPFDVERV SQNQVGQHFT FVLTDMESKQ RFGFCRLTSG GRVCLCILSY
110 120 130 140 150
LPWFEVYYKL LNTLADYLAK ELEDDLNETL KSLYSHPVPK ANTPVHLSVH
160 170 180 190 200
SCFITPDITG LPTIPESRNL TEYFVAVDVN NMLRLYASML HERRIIITSS
210 220 230 240 250
KLSTLTACLH GSAALLYPMY WQHIYIPVLP PHLLDYCCAP MPYLIGIHSS
260 270 280 290 300
LIERVKNKSL EDVVMLNVDT NTLESPFNDV NSLPSDVVSA LKNKLKKQST
310 320 330 340 350
ATGDGVARAF LRAQAALFGS YRDALRYKPG EPITFCEESF VKHRSSVMKQ
360 370 380 390 400
FLETAVNLQL FKQFIDGRLA KLNAGRGFSD IFEEEITSGG FCGGSPRSYQ
410 420 430 440 450
QWVYTVKKGG ALFNTAVTKA TPAVRTAYKF AKSHARLGLK EVKSRLRHKD
460 470 480 490 500
NEEDYGTCSG LVQYTPVYTL HHERGETREK QKLSQAHLKR PHKSLDGTLY
510 520 530 540 550
DDDDDIERAS KISSEDGEET SAYFYESDDS VDAQVKAPYS GEMDLLGEIL
560 570 580 590 600
DTLSTHSSDQ GKLAPAKSLD FFRSMDDIDY KPTNKSNAPS ENNLTLLCAS
610 620 630 640 650
GDQGEWNLGQ DDSALHGKHL PPSPRKRVCS SGLTDSLFIL KEENTEKPFS
660 670 680 690 700
ADSVSVPTVV EKSASTSDSG FQPATPEASQ THKGKPEVKQ TLSQASDDLL
710 720 730 740 750
VPSPGNRQST FVPWEKAGKE ETKPSKDVGL LQEVVSLCHM SCDFQQGLNI
760
SEESKSENQT
Length:760
Mass (Da):85,027
Last modified:July 22, 2015 - v3
Checksum:iE596350F233E317B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M3B0F1M3B0_RAT
DENN domain-containing 1B
Dennd1b
383Annotation score:
M0R8I4M0R8I4_RAT
DENN domain-containing 1B
Dennd1b
407Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07021080 Genomic DNA No translation available.
AABR07021081 Genomic DNA No translation available.
AABR07021082 Genomic DNA No translation available.
AABR07021083 Genomic DNA No translation available.
AABR07021084 Genomic DNA No translation available.
AABR07021085 Genomic DNA No translation available.
RefSeqiXP_003751292.1, XM_003751244.2
XP_003752691.1, XM_003752643.3

Genome annotation databases

EnsembliENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063
GeneIDi289051
KEGGirno:289051

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07021080 Genomic DNA No translation available.
AABR07021081 Genomic DNA No translation available.
AABR07021082 Genomic DNA No translation available.
AABR07021083 Genomic DNA No translation available.
AABR07021084 Genomic DNA No translation available.
AABR07021085 Genomic DNA No translation available.
RefSeqiXP_003751292.1, XM_003751244.2
XP_003752691.1, XM_003752643.3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043081

PTM databases

iPTMnetiD3Z8F6
PhosphoSitePlusiD3Z8F6

Proteomic databases

PaxDbiD3Z8F6
PeptideAtlasiD3Z8F6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063
GeneIDi289051
KEGGirno:289051

Organism-specific databases

CTDi163486
RGDi1308441 Dennd1b

Phylogenomic databases

eggNOGiKOG3569 Eukaryota
ENOG410XT3N LUCA
GeneTreeiENSGT00760000118819
InParanoidiD3Z8F6
KOiK20160
OMAiFAKSHAR
OrthoDBiEOG091G083L
TreeFamiTF343037

Enzyme and pathway databases

ReactomeiR-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Gene expression databases

BgeeiENSRNOG00000011063 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasiD3Z8F6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3Z8F6_RAT
AccessioniPrimary (citable) accession number: D3Z8F6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 54 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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