UniProtKB - D3Z8F6 (D3Z8F6_RAT)

BLAST

>tr|D3Z8F6|D3Z8F6_RAT DENN domain-containing 1B OS=Rattus norvegicus OX=10116 GN=Dennd1b PE=1 SV=3
MDRRTRENPERTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEVLQSVPRFCFPFDVERV
SQNQVGQHFTFVLTDMESKQRFGFCRLTSGGRVCLCILSYLPWFEVYYKLLNTLADYLAK
ELEDDLNETLKSLYSHPVPKANTPVHLSVHSCFITPDITGLPTIPESRNLTEYFVAVDVN
NMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAP
MPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFNDVNSLPSDVVSALKNKLKKQST
ATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAVNLQL
FKQFIDGRLAKLNAGRGFSDIFEEEITSGGFCGGSPRSYQQWVYTVKKGGALFNTAVTKA
TPAVRTAYKFAKSHARLGLKEVKSRLRHKDNEEDYGTCSGLVQYTPVYTLHHERGETREK
QKLSQAHLKRPHKSLDGTLYDDDDDIERASKISSEDGEETSAYFYESDDSVDAQVKAPYS
GEMDLLGEILDTLSTHSSDQGKLAPAKSLDFFRSMDDIDYKPTNKSNAPSENNLTLLCAS
GDQGEWNLGQDDSALHGKHLPPSPRKRVCSSGLTDSLFILKEENTEKPFSADSVSVPTVV
EKSASTSDSGFQPATPEASQTHKGKPEVKQTLSQASDDLLVPSPGNRQSTFVPWEKAGKE
ETKPSKDVGLLQEVVSLCHMSCDFQQGLNISEESKSENQT

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History
Entry version 54 (12 Sep 2018)
Sequence version 3 (22 Jul 2015)
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Protein

Submitted name:

DENN domain-containing 1B

Gene

Dennd1b

Organism

Rattus norvegicus (Rat)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endocytic recycling Source: Ensembl
positive regulation of GTPase activity Source: Ensembl
T cell receptor signaling pathway Source: Ensembl
T-helper 2 cell cytokine production Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: DENN domain-containing 1BImported
Gene namesⁱ	Name:Dennd1bImported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 13

Organism-specific databases

Rat genome database More...RGDⁱ	1308441 Dennd1b

RGDⁱ

1308441 Dennd1b

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D3Z8F6
PeptideAtlas More...PeptideAtlasⁱ	D3Z8F6

PTM databases

iPTMnetⁱ	D3Z8F6
PhosphoSitePlusⁱ	D3Z8F6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000011063 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasⁱ	D3Z8F6 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

Rab guanyl-nucleotide exchange factor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000043081

STRINGⁱ

10116.ENSRNOP00000043081

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 375	UDENNInterPro annotationAdd BLAST		362

Phylogenomic databases

eggNOGⁱ	KOG3569 Eukaryota ENOG410XT3N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118819
InParanoidⁱ	D3Z8F6
KEGG Orthology (KO) More...KOⁱ	K20160
OMAⁱ	FAKSHAR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G083L
TreeFamⁱ	TF343037

Family and domain databases

InterProⁱ	View protein in InterPro IPR001194 cDENN_dom IPR005112 dDENN_dom IPR037516 Tripartite_DENN IPR005113 uDENN_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03455 dDENN, 1 hit PF02141 DENN, 1 hit PF03456 uDENN, 1 hit
SMARTⁱ	View protein in SMART SM00801 dDENN, 1 hit SM00799 DENN, 1 hit SM00800 uDENN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50211 DENN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.ⁱShow all

D3Z8F6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MDRRTRENPE RTFDLVLKVK CHASENEDPV VLWKFPEDFG DQEVLQSVPR 
        60         70         80         90        100
FCFPFDVERV SQNQVGQHFT FVLTDMESKQ RFGFCRLTSG GRVCLCILSY 
       110        120        130        140        150
LPWFEVYYKL LNTLADYLAK ELEDDLNETL KSLYSHPVPK ANTPVHLSVH 
       160        170        180        190        200
SCFITPDITG LPTIPESRNL TEYFVAVDVN NMLRLYASML HERRIIITSS 
       210        220        230        240        250
KLSTLTACLH GSAALLYPMY WQHIYIPVLP PHLLDYCCAP MPYLIGIHSS 
       260        270        280        290        300
LIERVKNKSL EDVVMLNVDT NTLESPFNDV NSLPSDVVSA LKNKLKKQST 
       310        320        330        340        350
ATGDGVARAF LRAQAALFGS YRDALRYKPG EPITFCEESF VKHRSSVMKQ 
       360        370        380        390        400
FLETAVNLQL FKQFIDGRLA KLNAGRGFSD IFEEEITSGG FCGGSPRSYQ 
       410        420        430        440        450
QWVYTVKKGG ALFNTAVTKA TPAVRTAYKF AKSHARLGLK EVKSRLRHKD 
       460        470        480        490        500
NEEDYGTCSG LVQYTPVYTL HHERGETREK QKLSQAHLKR PHKSLDGTLY 
       510        520        530        540        550
DDDDDIERAS KISSEDGEET SAYFYESDDS VDAQVKAPYS GEMDLLGEIL 
       560        570        580        590        600
DTLSTHSSDQ GKLAPAKSLD FFRSMDDIDY KPTNKSNAPS ENNLTLLCAS 
       610        620        630        640        650
GDQGEWNLGQ DDSALHGKHL PPSPRKRVCS SGLTDSLFIL KEENTEKPFS 
       660        670        680        690        700
ADSVSVPTVV EKSASTSDSG FQPATPEASQ THKGKPEVKQ TLSQASDDLL 
       710        720        730        740        750
VPSPGNRQST FVPWEKAGKE ETKPSKDVGL LQEVVSLCHM SCDFQQGLNI 
       760
SEESKSENQT

Length:760

Mass (Da):85,027

Last modified:July 22, 2015 - v3

Checksum:ⁱE596350F233E317B

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	F1M3B0	F1M3B0_RAT		DENN domain-containing 1B DENN domain-containing 1B	Dennd1b	383	Annotation score:
	M0R8I4	M0R8I4_RAT		DENN domain-containing 1B DENN domain-containing 1B	Dennd1b	407	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07021080 Genomic DNA No translation available. AABR07021081 Genomic DNA No translation available. AABR07021082 Genomic DNA No translation available. AABR07021083 Genomic DNA No translation available. AABR07021084 Genomic DNA No translation available. AABR07021085 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_003751292.1, XM_003751244.2 XP_003752691.1, XM_003752643.3

Genome annotation databases

Ensemblⁱ	ENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063
GeneIDⁱ	289051
KEGGⁱ	rno:289051

Protein	Similar proteins		Species	Score	Length	Source
D3Z8F6	DENN domain-containing protein 1B		MOUSE		766	UniRef90_Q3U1T9
UPI000B4FC451		MERUN		759
Isoform 2 of DENN domain-containing protein 1B		MOUSE		691

Protein	Similar proteins		Species	Score	Length	Source
D3Z8F6	DENN domain-containing protein 1B		MOUSE		766	UniRef50_Q3U1T9
DENN domain-containing protein 1A		CRIGR		413
Uncharacterized protein		XENLA		668
DENN domain containing 1B		XENTR		628
DENN domain-containing protein 1B isoform C		ALLMI		722
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07021080 Genomic DNA No translation available. AABR07021081 Genomic DNA No translation available. AABR07021082 Genomic DNA No translation available. AABR07021083 Genomic DNA No translation available. AABR07021084 Genomic DNA No translation available. AABR07021085 Genomic DNA No translation available.
RefSeqⁱ	XP_003751292.1, XM_003751244.2 XP_003752691.1, XM_003752643.3

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000043081

STRINGⁱ

10116.ENSRNOP00000043081

PTM databases

iPTMnetⁱ	D3Z8F6
PhosphoSitePlusⁱ	D3Z8F6

Proteomic databases

PaxDbⁱ	D3Z8F6
PeptideAtlasⁱ	D3Z8F6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000043907; ENSRNOP00000043081; ENSRNOG00000011063
GeneIDⁱ	289051
KEGGⁱ	rno:289051

Organism-specific databases

CTDⁱ	163486
RGDⁱ	1308441 Dennd1b

Phylogenomic databases

eggNOGⁱ	KOG3569 Eukaryota ENOG410XT3N LUCA
GeneTreeⁱ	ENSGT00760000118819
InParanoidⁱ	D3Z8F6
KOⁱ	K20160
OMAⁱ	FAKSHAR
OrthoDBⁱ	EOG091G083L
TreeFamⁱ	TF343037

Enzyme and pathway databases

Reactomeⁱ	R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Reactomeⁱ

R-RNO-8876198 RAB GEFs exchange GTP for GDP on RABs

Gene expression databases

Bgeeⁱ	ENSRNOG00000011063 Expressed in 9 organ(s), highest expression level in testis
ExpressionAtlasⁱ	D3Z8F6 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR001194 cDENN_dom IPR005112 dDENN_dom IPR037516 Tripartite_DENN IPR005113 uDENN_dom
Pfamⁱ	View protein in Pfam PF03455 dDENN, 1 hit PF02141 DENN, 1 hit PF03456 uDENN, 1 hit
SMARTⁱ	View protein in SMART SM00801 dDENN, 1 hit SM00799 DENN, 1 hit SM00800 uDENN, 1 hit
PROSITEⁱ	View protein in PROSITE PS50211 DENN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3Z8F6_RAT
Accessionⁱ	D3Z8F6Primary (citable) accession number: D3Z8F6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	July 22, 2015
	Last modified:	September 12, 2018
	This is version 54 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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UniProtKB - D3Z8F6 (D3Z8F6_RAT)

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DENN domain-containing 1B

Dennd1b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Computationally mapped potential isoform sequencesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ