UniProtKB - D3Z7B6 (D3Z7B6_MOUSE)
Protein
Suppressor of fused homolog
Gene
Sufu
Organism
Mus musculus (Mouse)
Status
Functioni
Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).UniRule annotation
GO - Molecular functioni
- transcription factor binding Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental proteinUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of fused homologUniRule annotation |
Gene namesi | Name:SufuImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1345643, Sufu |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000025231, Expressed in ear vesicle and 295 other tissues |
ExpressionAtlasi | D3Z7B6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 240 | SUFUInterPro annotationAdd BLAST | 177 | |
Domaini | 253 – 433 | SUFU_CInterPro annotationAdd BLAST | 181 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 319 – 351 | DisorderedSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the SUFU family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00390000009747 |
Family and domain databases
Gene3Di | 3.30.1360.230, 1 hit |
InterProi | View protein in InterPro IPR020941, SUFU-like_domain IPR024314, SUFU_C IPR038489, SUFU_C_sf IPR037181, SUFU_N IPR007768, Suppressor_of_fused IPR016591, Suppressor_of_fused_euk |
PANTHERi | PTHR10928, PTHR10928, 1 hit |
Pfami | View protein in Pfam PF05076, SUFU, 1 hit PF12470, SUFU_C, 1 hit |
PIRSFi | PIRSF011844, Suppressor_of_fused_protein, 1 hit |
SUPFAMi | SSF103359, SSF103359, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
D3Z7B6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN
60 70 80 90 100
PLQVTAIVKY WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG
110 120 130 140 150
DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ
160 170 180 190 200
SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVRT PFGVVTFLQI
210 220 230 240 250
VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH
260 270 280 290 300
LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDEEDSRS ICLGTQPRRL
310 320 330 340 350
SGKDTEQIRE TLRRGLEINS KPVLPPINSQ RQNGLTHDRA PSRKDSLGSD
360 370 380 390 400
SSTAIIPHEL IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI
410 420 430 440 450
TGDMAITFVS TGVEGAFATE EHPYAAHGPW LQVRRSLSSF SSSSCSSLAA
460
CPPLPHHPKD RPLWLPC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Z0P7 | SUFU_MOUSE | Suppressor of fused homolog | Sufu | 484 | Annotation score: | ||
A0A0R4J1M0 | A0A0R4J1M0_MOUSE | Suppressor of fused homolog | Sufu | 297 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114539 Genomic DNA No translation available. AC156982 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000118440; ENSMUSP00000113073; ENSMUSG00000025231 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC114539 Genomic DNA No translation available. AC156982 Genomic DNA No translation available. |
3D structure databases
SMRi | D3Z7B6 |
ModBasei | Search... |
Proteomic databases
jPOSTi | D3Z7B6 |
MaxQBi | D3Z7B6 |
PeptideAtlasi | D3Z7B6 |
PRIDEi | D3Z7B6 |
Protocols and materials databases
Antibodypediai | 1768, 276 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000118440; ENSMUSP00000113073; ENSMUSG00000025231 |
Organism-specific databases
MGIi | MGI:1345643, Sufu |
Phylogenomic databases
GeneTreei | ENSGT00390000009747 |
Miscellaneous databases
ChiTaRSi | Sufu, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025231, Expressed in ear vesicle and 295 other tissues |
ExpressionAtlasi | D3Z7B6, baseline and differential |
Family and domain databases
Gene3Di | 3.30.1360.230, 1 hit |
InterProi | View protein in InterPro IPR020941, SUFU-like_domain IPR024314, SUFU_C IPR038489, SUFU_C_sf IPR037181, SUFU_N IPR007768, Suppressor_of_fused IPR016591, Suppressor_of_fused_euk |
PANTHERi | PTHR10928, PTHR10928, 1 hit |
Pfami | View protein in Pfam PF05076, SUFU, 1 hit PF12470, SUFU_C, 1 hit |
PIRSFi | PIRSF011844, Suppressor_of_fused_protein, 1 hit |
SUPFAMi | SSF103359, SSF103359, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3Z7B6_MOUSE | |
Accessioni | D3Z7B6Primary (citable) accession number: D3Z7B6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | August 12, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |