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Entry version 63 (08 May 2019)
Sequence version 2 (15 Jun 2010)
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Protein

Maestro heat-like repeat-containing protein family member 2A

Gene

Mroh2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 2A
Alternative name(s):
HEAT repeat-containing protein 7B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mroh2a
Synonyms:Heatr7b1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3705228 Mroh2a

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003951041 – 1679Maestro heat-like repeat-containing protein family member 2AAdd BLAST1679

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3Z750

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
D3Z750

PeptideAtlas

More...
PeptideAtlasi
D3Z750

PRoteomics IDEntifications database

More...
PRIDEi
D3Z750

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
D3Z750

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
D3Z750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079429 Expressed in 118 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3Z750 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3Z750 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000130508

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati68 – 91HEAT 1Add BLAST24
Repeati92 – 128HEAT 2Add BLAST37
Repeati190 – 229HEAT 3Add BLAST40
Repeati293 – 313HEAT 4Add BLAST21
Repeati314 – 350HEAT 5Add BLAST37
Repeati380 – 417HEAT 6Add BLAST38
Repeati422 – 459HEAT 7Add BLAST38
Repeati571 – 610HEAT 8Add BLAST40
Repeati614 – 654HEAT 9Add BLAST41
Repeati737 – 774HEAT 10Add BLAST38
Repeati848 – 887HEAT 11Add BLAST40
Repeati991 – 1028HEAT 12Add BLAST38
Repeati1219 – 1261HEAT 13Add BLAST43
Repeati1387 – 1425HEAT 14Add BLAST39
Repeati1632 – 1669HEAT 15Add BLAST38

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2032 Eukaryota
ENOG410XQE8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161309

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169806

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D3Z750

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D3Z750

TreeFam database of animal gene trees

More...
TreeFami
TF315201

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

D3Z750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEATELNED MLEEAEHLAL LEPEDDGTFF QVTNLLNIMD SESAKTDTTG
60 70 80 90 100
PGLDMRKTLA SVIITEKATT DPCVVMNALI RCLQMPEIST QRKMNIYNIM
110 120 130 140 150
QEIIQQEGEM EEHCIQRLVA IASKQMRDIT EAEDFETAEV ASETLVALSR
160 170 180 190 200
NHFSLVMYEL QHHLKPLNLT DEFVIVTLAK LANGNVFEFM PYMGITLATI
210 220 230 240 250
FTMLRLANEA KMRQVICSAM ETFCETVQFY LRHLEDSLYP VMTEDQFAVK
260 270 280 290 300
LFPMYRYFVT VWLRHQDLEV KLGVIKSLRP MLSLLLPNDD LREQVYDYIP
310 320 330 340 350
LLLAEFQGTG HWPLFPSLLQ VLRQILEASV TTNTPIPPML LHPIFTELHV
360 370 380 390 400
QVCSKAPAQQ QFSSQNLMEI VHCFIALARS YPKELMKFFF SQVEMSKEAV
410 420 430 440 450
RVGTLALIRA VVSADDPKIN IKTIYLAIRV VKNTLSDTRS KVRMAILRII
460 470 480 490 500
GQLVLSGFQE KIKGWGLKYV SVQLTLSTYK LTNRRECFYQ RDLEEKMVHK
510 520 530 540 550
VTMDTVKIIT SSISGMTNEF WVRLLCYIME TDYTEALTPI CISLTNLAEN
560 570 580 590 600
QIHGKDTEAG IAGKSKHVDL PAPQKLLARL LVLMSSPYKG EGRGIAMLNL
610 620 630 640 650
LRTLSQSIAP SMADMWEQEI PLLVQYLEEH TEFTWNQKTW EDMLIQFLRN
660 670 680 690 700
SLKKTRGTSW SLRLSKELNN QIETFDSPSL EKGFLYRALG FTLGMGLEAD
710 720 730 740 750
RVEVLLLELL YKTDYSNDFD REGVILCFGL CARGQVKTVL NVLQDFEERI
760 770 780 790 800
QESEQSWQIG AWRKDHPWRR ETVKSALMVM YSCVSSYCHP QMLLTHVDSP
810 820 830 840 850
ITSKIIHHYS SSCQDISLKM AFMKSVVQVT NAIKSIQDPE DFQFAHKSAL
860 870 880 890 900
TGLIVVIIKA EPPDHLVSPV RSMAMDALSQ LSTMKPFYSP EESTELMDIS
910 920 930 940 950
IHTVISLQPP GEDNESVKTL YANTMSSLKQ LMEGLLQRQL DPKGLQDTVH
960 970 980 990 1000
LLEKWILSEK EWEREKAMAL HLHLMQIYVQ SIGVCIPLKL GQFGVLVGLI
1010 1020 1030 1040 1050
APCTCDAHRR TRLASINVLS SLLDLHVSQT CSLWGTSKEQ ELQKCKEDLQ
1060 1070 1080 1090 1100
DTDMNKISSA SSRVAKVVCP EFNCDEVVSL IQKLCENIGA MDLQHDRAAV
1110 1120 1130 1140 1150
TWIGIFLQMR VKELEDKVAE ILGAILVHLP VVDHPEVRRH LIEGILLLAH
1160 1170 1180 1190 1200
YHQETVLTSL LRQPLPMESH LTEVWLAVAE NVPFARTMLH GLLGRLQSRF
1210 1220 1230 1240 1250
TAKINATSKA DIWRLAAVDP LMTLCTIQLL MEKMDQDDKF PDLFPDLLYT
1260 1270 1280 1290 1300
FLLQLGSSHG PEAASPVLKT WRLVHTGPLP QEMTLQRCSR SRITIKSMQL
1310 1320 1330 1340 1350
LVKRINREPL EQALEEQSVW SLLENGGTFL EGVSLMARLC MQNMENYMQR
1360 1370 1380 1390 1400
LAELVLTGMG SEILSCCISS TAICVEFMSD PVLHQEKLLR PVVLMLEKGA
1410 1420 1430 1440 1450
GQDKDETLQV LSLRALGNMA LGAPRKVKQY RKLLLEKCLG SLQGQVSSSA
1460 1470 1480 1490 1500
MAEGMEALTK VLAELREGDI GSSFEAISKQ CRAFFDNESE LLRLKAFVLF
1510 1520 1530 1540 1550
GKLTKVVGIS KKHFFKGEVK RGWVSLLLHC QDPCPSVAQA CVATMFQCVH
1560 1570 1580 1590 1600
FWGWKSLESS FGHSNDSINE QMTVFQTNMC SVLAQKKPAV LCGFLLETTV
1610 1620 1630 1640 1650
FMKNNLSRIR IAACNLAGII MKQLSAHYLK KMDLVGLRNS LQDLQLDSDA
1660 1670
GVRRAALETL KVLDSCNQHW LLASPRGLP
Length:1,679
Mass (Da):190,012
Last modified:June 15, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F104A42F23258BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H8M8F5H8M8_MOUSE
Maestro heat-like repeat-containing...
Mroh2a Heatr7b1
1,671Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W219F6W219_MOUSE
Maestro heat-like repeat-containing...
Mroh2a Heatr7b1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC087780 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000061013; ENSMUSP00000130508; ENSMUSG00000079429

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087780 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130508

PTM databases

iPTMnetiD3Z750
PhosphoSitePlusiD3Z750

Proteomic databases

MaxQBiD3Z750
PaxDbiD3Z750
PeptideAtlasiD3Z750
PRIDEiD3Z750

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061013; ENSMUSP00000130508; ENSMUSG00000079429

Organism-specific databases

MGIiMGI:3705228 Mroh2a

Phylogenomic databases

eggNOGiKOG2032 Eukaryota
ENOG410XQE8 LUCA
GeneTreeiENSGT00940000161309
HOGENOMiHOG000169806
InParanoidiD3Z750
PhylomeDBiD3Z750
TreeFamiTF315201

Miscellaneous databases

Protein Ontology

More...
PROi
PR:D3Z750

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079429 Expressed in 118 organ(s), highest expression level in testis
ExpressionAtlasiD3Z750 baseline and differential
GenevisibleiD3Z750 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRO2A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z750
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 8, 2019
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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