Rdh8

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	66	NADPUniRule annotation	1
Binding siteⁱ	143	SubstrateUniRule annotation	1
Active siteⁱ	156	Proton acceptorUniRule annotation	1
Binding siteⁱ	160	NADPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	12 – 40	NADPUniRule annotationAdd BLAST		29

GO - Molecular functionⁱ

estradiol 17-beta-dehydrogenase activity Source: InterPro
retinol dehydrogenase activity
Source: MGI
Inferred from direct assayⁱ
- 15755727

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

estrogen biosynthetic process Source: InterPro
retinol metabolic process
Source: MGI
Inferred from direct assayⁱ
- 15755727
visual perception
Source: MGI
Inferred from mutant phenotypeⁱ
- 15755727

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Retinol dehydrogenase 8Imported
Gene namesⁱ	Name:Rdh8Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:2685028 Rdh8

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D3Z6W3
PRIDEⁱ	D3Z6W3

PTM databases

iPTMnetⁱ	D3Z6W3
PhosphoSitePlusⁱ	D3Z6W3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad

Bgeeⁱ

ENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000067662

STRINGⁱ

10090.ENSMUSP00000067662

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D3Z6W3
SMRⁱ	D3Z6W3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1205 Eukaryota COG1028 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150823
InParanoidⁱ	D3Z6W3
KEGG Orthology (KO) More...KOⁱ	K11150
OMAⁱ	QRYQVVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BYI
PhylomeDBⁱ	D3Z6W3
TreeFamⁱ	TF105451

Family and domain databases

InterProⁱ	View protein in InterPro IPR011348 17beta_DH IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PIRSFⁱ	PIRSF000095 17beta-HSD, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D3Z6W3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASQQRTVLI SGCSSGIGLE LALQLAHDPR QRYQVVATMR DLGKKEPLEA 
        60         70         80         90        100
AAGEALGKTL SVVQLDVCND ESVTDCLSHI EGGQVDVLVN NAGVGLVGPL 
       110        120        130        140        150
EGLSLATMQS VFNTNFFGAV RLVKAVLPGM KRRRQGHIVV VSSVMGLQGV 
       160        170        180        190        200
MFNDVYAASK FALEGFFESL AIQLRQFNIF ISMVEPGPVT TDFEGKLLAQ 
       210        220        230        240        250
VSKAEFPDTD PDTLGYFRDL YLPASRELFR SVGQSPRDVA QVIAKVIGTT 
       260        270        280        290        300
RPPLRRQTNT RYLPLTALKA MDPSGSLYVK TAHRLLFRWP HLLNLGLRCL 
       310 
ACGCLPTRVW PRQTEQN

Length:317

Mass (Da):34,700

Last modified:April 20, 2010 - v1

Checksum:ⁱ0FF14A16B858D1F0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC166365 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001025461.1, NM_001030290.1
UniGeneⁱ	Mm.297661

Genome annotation databases

Ensemblⁱ	ENSMUST00000066387; ENSMUSP00000067662; ENSMUSG00000053773
GeneIDⁱ	235033
KEGGⁱ	mmu:235033
UCSC genome browser More...UCSCⁱ	uc009ojh.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
D3Z6W3	Uncharacterized protein		NEOLE		317	UniRef90_D3Z6W3
RCG31734		RAT		312
retinol dehydrogenase 8		MESAU		312
Retinol dehydrogenase 8		CRIGR		110
UPI000A305C44		MUSPA		317
+6

Protein	Similar proteins		Species	Score	Length	Source
D3Z6W3	Retinol dehydrogenase 8		HUMAN		311	UniRef50_Q9NYR8
Retinol dehydrogenase 8		BOVIN		312
Uncharacterized protein		COLAP		331
Uncharacterized protein		Cebus capucinus imitator		331
Retinol dehydrogenase 8		GORGO		331
+382

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC166365 Genomic DNA No translation available.
RefSeqⁱ	NP_001025461.1, NM_001030290.1
UniGeneⁱ	Mm.297661

3D structure databases

ProteinModelPortalⁱ	D3Z6W3
SMRⁱ	D3Z6W3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000067662

STRINGⁱ

10090.ENSMUSP00000067662

PTM databases

iPTMnetⁱ	D3Z6W3
PhosphoSitePlusⁱ	D3Z6W3

Proteomic databases

PaxDbⁱ	D3Z6W3
PRIDEⁱ	D3Z6W3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000066387; ENSMUSP00000067662; ENSMUSG00000053773
GeneIDⁱ	235033
KEGGⁱ	mmu:235033
UCSCⁱ	uc009ojh.1 mouse

Organism-specific databases

CTDⁱ	50700
MGIⁱ	MGI:2685028 Rdh8

Phylogenomic databases

eggNOGⁱ	KOG1205 Eukaryota COG1028 LUCA
GeneTreeⁱ	ENSGT00930000150823
InParanoidⁱ	D3Z6W3
KOⁱ	K11150
OMAⁱ	QRYQVVA
OrthoDBⁱ	EOG091G0BYI
PhylomeDBⁱ	D3Z6W3
TreeFamⁱ	TF105451

Miscellaneous databases

ChiTaRSⁱ	Hsd17b6 mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad

Bgeeⁱ

ENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad

Family and domain databases

InterProⁱ	View protein in InterPro IPR011348 17beta_DH IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PIRSFⁱ	PIRSF000095 17beta-HSD, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3Z6W3_MOUSE
Accessionⁱ	D3Z6W3Primary (citable) accession number: D3Z6W3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - D3Z6W3 (D3Z6W3_MOUSE)

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Retinol dehydrogenase 8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ