UniProtKB - D3Z6W3 (D3Z6W3_MOUSE)
Protein
Submitted name:
Retinol dehydrogenase 8
Gene
Rdh8
Organism
Mus musculus (Mouse)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 66 | NADPUniRule annotation | 1 | |
Binding sitei | 143 | SubstrateUniRule annotation | 1 | |
Active sitei | 156 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 160 | NADPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 40 | NADPUniRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- estradiol 17-beta-dehydrogenase activity Source: InterPro
- retinol dehydrogenase activity Source: MGI
GO - Biological processi
- estrogen biosynthetic process Source: InterPro
- retinol metabolic process Source: MGI
- visual perception Source: MGI
Names & Taxonomyi
Protein namesi | Submitted name: Retinol dehydrogenase 8Imported |
Gene namesi | Name:Rdh8Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685028 Rdh8 |
Subcellular locationi
Other locations
- cytoplasm Source: InterPro
PTM / Processingi
Proteomic databases
PaxDbi | D3Z6W3 |
PRIDEi | D3Z6W3 |
PTM databases
iPTMneti | D3Z6W3 |
PhosphoSitePlusi | D3Z6W3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad |
Structurei
3D structure databases
ProteinModelPortali | D3Z6W3 |
SMRi | D3Z6W3 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG1205 Eukaryota COG1028 LUCA |
GeneTreei | ENSGT00940000155412 |
InParanoidi | D3Z6W3 |
KOi | K11150 |
OMAi | QRYQVVA |
OrthoDBi | 1313182at2759 |
PhylomeDBi | D3Z6W3 |
TreeFami | TF105451 |
Family and domain databases
InterProi | View protein in InterPro IPR011348 17beta_DH IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam |
Pfami | View protein in Pfam PF00106 adh_short, 1 hit |
PIRSFi | PIRSF000095 17beta-HSD, 1 hit |
PRINTSi | PR00081 GDHRDH PR00080 SDRFAMILY |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061 ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
D3Z6W3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASQQRTVLI SGCSSGIGLE LALQLAHDPR QRYQVVATMR DLGKKEPLEA
60 70 80 90 100
AAGEALGKTL SVVQLDVCND ESVTDCLSHI EGGQVDVLVN NAGVGLVGPL
110 120 130 140 150
EGLSLATMQS VFNTNFFGAV RLVKAVLPGM KRRRQGHIVV VSSVMGLQGV
160 170 180 190 200
MFNDVYAASK FALEGFFESL AIQLRQFNIF ISMVEPGPVT TDFEGKLLAQ
210 220 230 240 250
VSKAEFPDTD PDTLGYFRDL YLPASRELFR SVGQSPRDVA QVIAKVIGTT
260 270 280 290 300
RPPLRRQTNT RYLPLTALKA MDPSGSLYVK TAHRLLFRWP HLLNLGLRCL
310
ACGCLPTRVW PRQTEQN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC166365 Genomic DNA No translation available. |
RefSeqi | NP_001025461.1, NM_001030290.1 |
UniGenei | Mm.297661 |
Genome annotation databases
Ensembli | ENSMUST00000066387; ENSMUSP00000067662; ENSMUSG00000053773 |
GeneIDi | 235033 |
KEGGi | mmu:235033 |
UCSCi | uc009ojh.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC166365 Genomic DNA No translation available. |
RefSeqi | NP_001025461.1, NM_001030290.1 |
UniGenei | Mm.297661 |
3D structure databases
ProteinModelPortali | D3Z6W3 |
SMRi | D3Z6W3 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000067662 |
PTM databases
iPTMneti | D3Z6W3 |
PhosphoSitePlusi | D3Z6W3 |
Proteomic databases
PaxDbi | D3Z6W3 |
PRIDEi | D3Z6W3 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000066387; ENSMUSP00000067662; ENSMUSG00000053773 |
GeneIDi | 235033 |
KEGGi | mmu:235033 |
UCSCi | uc009ojh.1 mouse |
Organism-specific databases
CTDi | 50700 |
MGIi | MGI:2685028 Rdh8 |
Phylogenomic databases
eggNOGi | KOG1205 Eukaryota COG1028 LUCA |
GeneTreei | ENSGT00940000155412 |
InParanoidi | D3Z6W3 |
KOi | K11150 |
OMAi | QRYQVVA |
OrthoDBi | 1313182at2759 |
PhylomeDBi | D3Z6W3 |
TreeFami | TF105451 |
Miscellaneous databases
ChiTaRSi | Hsd17b6 mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad |
Family and domain databases
InterProi | View protein in InterPro IPR011348 17beta_DH IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam |
Pfami | View protein in Pfam PF00106 adh_short, 1 hit |
PIRSFi | PIRSF000095 17beta-HSD, 1 hit |
PRINTSi | PR00081 GDHRDH PR00080 SDRFAMILY |
SUPFAMi | SSF51735 SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061 ADH_SHORT, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | D3Z6W3_MOUSE | |
Accessioni | D3Z6W3Primary (citable) accession number: D3Z6W3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | January 16, 2019 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |