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Protein
Submitted name:

Retinol dehydrogenase 8

Gene

Rdh8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66NADPUniRule annotation1
Binding sitei143SubstrateUniRule annotation1
Active sitei156Proton acceptorUniRule annotation1
Binding sitei160NADPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 40NADPUniRule annotationAdd BLAST29

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: InterPro
  • retinol dehydrogenase activity Source: MGI

GO - Biological processi

  • estrogen biosynthetic process Source: InterPro
  • retinol metabolic process Source: MGI
  • visual perception Source: MGI

Names & Taxonomyi

Protein namesi
Submitted name:
Retinol dehydrogenase 8Imported
Gene namesi
Name:Rdh8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2685028 Rdh8

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiD3Z6W3
PRIDEiD3Z6W3

PTM databases

iPTMnetiD3Z6W3
PhosphoSitePlusiD3Z6W3

Expressioni

Gene expression databases

BgeeiENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067662

Structurei

3D structure databases

ProteinModelPortaliD3Z6W3
SMRiD3Z6W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00930000150823
InParanoidiD3Z6W3
KOiK11150
OMAiQRYQVVA
OrthoDBiEOG091G0BYI
PhylomeDBiD3Z6W3
TreeFamiTF105451

Family and domain databases

InterProiView protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PIRSFiPIRSF000095 17beta-HSD, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z6W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQQRTVLI SGCSSGIGLE LALQLAHDPR QRYQVVATMR DLGKKEPLEA
60 70 80 90 100
AAGEALGKTL SVVQLDVCND ESVTDCLSHI EGGQVDVLVN NAGVGLVGPL
110 120 130 140 150
EGLSLATMQS VFNTNFFGAV RLVKAVLPGM KRRRQGHIVV VSSVMGLQGV
160 170 180 190 200
MFNDVYAASK FALEGFFESL AIQLRQFNIF ISMVEPGPVT TDFEGKLLAQ
210 220 230 240 250
VSKAEFPDTD PDTLGYFRDL YLPASRELFR SVGQSPRDVA QVIAKVIGTT
260 270 280 290 300
RPPLRRQTNT RYLPLTALKA MDPSGSLYVK TAHRLLFRWP HLLNLGLRCL
310
ACGCLPTRVW PRQTEQN
Length:317
Mass (Da):34,700
Last modified:April 20, 2010 - v1
Checksum:i0FF14A16B858D1F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166365 Genomic DNA No translation available.
RefSeqiNP_001025461.1, NM_001030290.1
UniGeneiMm.297661

Genome annotation databases

EnsembliENSMUST00000066387; ENSMUSP00000067662; ENSMUSG00000053773
GeneIDi235033
KEGGimmu:235033
UCSCiuc009ojh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166365 Genomic DNA No translation available.
RefSeqiNP_001025461.1, NM_001030290.1
UniGeneiMm.297661

3D structure databases

ProteinModelPortaliD3Z6W3
SMRiD3Z6W3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067662

PTM databases

iPTMnetiD3Z6W3
PhosphoSitePlusiD3Z6W3

Proteomic databases

PaxDbiD3Z6W3
PRIDEiD3Z6W3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066387; ENSMUSP00000067662; ENSMUSG00000053773
GeneIDi235033
KEGGimmu:235033
UCSCiuc009ojh.1 mouse

Organism-specific databases

CTDi50700
MGIiMGI:2685028 Rdh8

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00930000150823
InParanoidiD3Z6W3
KOiK11150
OMAiQRYQVVA
OrthoDBiEOG091G0BYI
PhylomeDBiD3Z6W3
TreeFamiTF105451

Miscellaneous databases

ChiTaRSiHsd17b6 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053773 Expressed in 3 organ(s), highest expression level in female gonad

Family and domain databases

InterProiView protein in InterPro
IPR011348 17beta_DH
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PIRSFiPIRSF000095 17beta-HSD, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3Z6W3_MOUSE
AccessioniPrimary (citable) accession number: D3Z6W3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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