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Protein

Bridging integrator 2

Gene

Bin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Inhibits phagocytosis (By similarity). Plays a role in podosome formation.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Bridging integrator 2
Gene namesi
Name:Bin2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3611448 Bin2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004160991 – 489Bridging integrator 2Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273PhosphoserineBy similarity1
Modified residuei357PhosphoserineBy similarity1
Modified residuei380PhosphoserineCombined sources1
Modified residuei392PhosphoserineBy similarity1
Modified residuei420PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiD3Z6Q9
MaxQBiD3Z6Q9
PeptideAtlasiD3Z6Q9
PRIDEiD3Z6Q9

PTM databases

iPTMnetiD3Z6Q9
PhosphoSitePlusiD3Z6Q9
SwissPalmiD3Z6Q9

Interactioni

Subunit structurei

Homodimer. Interacts with BIN1. Interacts with ARHGEF6 (via SH3 domain), ARHGEF7 (via SH3 domain), SH3GL1, SH3GL2 and SH3GL3. Identified in a complex with ARHGEF6 and GIT2 (By similarity).By similarity

Protein-protein interaction databases

IntActiD3Z6Q9, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliD3Z6Q9
SMRiD3Z6Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 244BARPROSITE-ProRule annotationAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi253 – 448Ser-richAdd BLAST196

Domaini

The BAR domain mediates dimerization and interaction with membranes enriched in phosphatidylinositides.By similarity

Phylogenomic databases

HOGENOMiHOG000252987
InParanoidiD3Z6Q9
PhylomeDBiD3Z6Q9

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR003005 Amphiphysin
IPR004148 BAR_dom
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PRINTSiPR01251 AMPHIPHYSIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

D3Z6Q9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGKAGGAA GLFAKQMQKK FSRAQEKVLQ KLGKTVETKD ERFEQSASNF
60 70 80 90 100
YQQQAEGHKL YKDLKNFLSA VKVMHESSKR VSETLQEVYS SDWDGHEDLK
110 120 130 140 150
AIVGNNDLLW EDYEEKLADQ ALRTMENYVS QFSEIKERIA KRGRKLVDYD
160 170 180 190 200
SARHHLEAVQ NAKKKDDAKM AKAEEDFSKA QIVFEDLNQE LLEELPILYN
210 220 230 240 250
SRIGCYVTVF QNISNLRDVF YREMSKLNHN LYEVMSKLEK QHSNKVFVVK
260 270 280 290 300
GLSSSSRRSL VISPPVQSCA ASSPVSPVSP VSPVTSPTSP SATSEPESVS
310 320 330 340 350
ATGEELTSEA GGEDSCESQE SLKDEEADEA QSETSSSLPA CNGPTPAPAS
360 370 380 390 400
PAAEVGSQEE ALSSSAQSPG RGQTGKDTPS PGDVVLRARA SSEGAEQSKR
410 420 430 440 450
AASIQRTSAP PSRPPPPRAS GSGSCNAPGS PEGSSQLCSP RASPDASSNP
460 470 480
EPAETREKEG AGSSGPEEPR AVSTKSATQA SGGLVGLFL
Length:489
Mass (Da):52,554
Last modified:April 20, 2010 - v1
Checksum:i8E207C53B1D31A99
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R270S4R270_MOUSE
Bridging integrator 2
Bin2
505Annotation score:
S4R1B8S4R1B8_MOUSE
Bridging integrator 2
Bin2
478Annotation score:
S4R2J8S4R2J8_MOUSE
Bridging integrator 2
Bin2
473Annotation score:
S4R171S4R171_MOUSE
Bridging integrator 2
Bin2
210Annotation score:
S4R1Q1S4R1Q1_MOUSE
Bridging integrator 2
Bin2
160Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123724 Genomic DNA No translation available.
UniGeneiMm.451225

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123724 Genomic DNA No translation available.
UniGeneiMm.451225

3D structure databases

ProteinModelPortaliD3Z6Q9
SMRiD3Z6Q9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3Z6Q9, 1 interactor

PTM databases

iPTMnetiD3Z6Q9
PhosphoSitePlusiD3Z6Q9
SwissPalmiD3Z6Q9

Proteomic databases

EPDiD3Z6Q9
MaxQBiD3Z6Q9
PeptideAtlasiD3Z6Q9
PRIDEiD3Z6Q9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:3611448 Bin2

Phylogenomic databases

HOGENOMiHOG000252987
InParanoidiD3Z6Q9
PhylomeDBiD3Z6Q9

Miscellaneous databases

PROiPR:D3Z6Q9
SOURCEiSearch...

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR003005 Amphiphysin
IPR004148 BAR_dom
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PRINTSiPR01251 AMPHIPHYSIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBIN2_MOUSE
AccessioniPrimary (citable) accession number: D3Z6Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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