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Protein
Submitted name:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 43

Gene

Ddx43

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43Imported
Gene namesi
Name:Ddx43Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:3642857 Ddx43

Subcellular locationi

PTM / Processingi

Proteomic databases

PaxDbiD3Z6P9
PRIDEiD3Z6P9

PTM databases

iPTMnetiD3Z6P9
PhosphoSitePlusiD3Z6P9

Expressioni

Gene expression databases

BgeeiENSMUSG00000070291 Expressed in 58 organ(s), highest expression level in testis
GenevisibleiD3Z6P9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108994

Structurei

3D structure databases

ProteinModelPortaliD3Z6P9
SMRiD3Z6P9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini240 – 268Q_MOTIFInterPro annotationAdd BLAST29
Domaini271 – 446Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini458 – 623Helicase C-terminalInterPro annotationAdd BLAST166

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi240 – 268Q motifPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0336 Eukaryota
ENOG410XR3V LUCA
GeneTreeiENSGT00930000150858
HOGENOMiHOG000268804
InParanoidiD3Z6P9
KOiK17043
OMAiVLMAERY
OrthoDBiEOG091G05VF
PhylomeDBiD3Z6P9
TreeFamiTF312949

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00013 KH_1, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00322 KH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z6P9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRREPAANA SSSGVAPRRS STGSRGADRT ATEETNRRGR VGSRGAGGGW
60 70 80 90 100
REPAGAAEAT AAGRREPPLC FGVKNDVVGA VIGRGGSKIR EIQNTTNTRI
110 120 130 140 150
QVIKGNPEAE IKIFGNKAMQ TKAKTVIDNV VKKQQNYIPG QRVGIIAFQP
160 170 180 190 200
TVGADTSTSE SVTDDQPLID WDQIREDALK WEKKKWADLP PIKKNFYIES
210 220 230 240 250
ATTSSMSQVQ IDNWRKENFN ITCDDLKDGE KRPIPNPICK FEDAFQSYPE
260 270 280 290 300
VMENIKRAGF QKPTPIQSQA WPIVLQGIDL IGVAQTGTGK TLSYLMPGFI
310 320 330 340 350
HLDSQPLARE QRNGPGMLVL TPTRELALQV EAECSKYSYG DLKSVCVYGG
360 370 380 390 400
GDRDGQIQDV SKGVDIIIAT PGRLNDLQMN NFVNLKSVTY LVLDEADKML
410 420 430 440 450
DMGFEPQIMK ILLDVRPDRQ TIMTSATWPY AVRRLAQSYL KEPMIVYVGT
460 470 480 490 500
LDLVAVSTVK QNIIITTEEE KRTHIQTFLE NMSPKDKVIV FVSRKAVADH
510 520 530 540 550
LSSDLILRHI SVESLHGNRE QSDREKALEN FKTGKVRILI ATDLASRGLD
560 570 580 590 600
VHDITHVYNY DFPRNIEEYV HRVGRTGRAG RTGMSITLIT RNDWRVATEL
610 620 630 640
INILERANQN IPEELVLMAE RYKANKLKRE MEKKMGRPQG KPQKFY
Length:646
Mass (Da):72,271
Last modified:April 20, 2010 - v1
Checksum:i9B3366F944ADE8CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138587 Genomic DNA No translation available.
AC158987 Genomic DNA No translation available.
RefSeqiNP_001177973.1, NM_001191044.1
UniGeneiMm.158166

Genome annotation databases

EnsembliENSMUST00000113367; ENSMUSP00000108994; ENSMUSG00000070291
GeneIDi100048658
KEGGimmu:100048658
UCSCiuc012gxe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138587 Genomic DNA No translation available.
AC158987 Genomic DNA No translation available.
RefSeqiNP_001177973.1, NM_001191044.1
UniGeneiMm.158166

3D structure databases

ProteinModelPortaliD3Z6P9
SMRiD3Z6P9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108994

PTM databases

iPTMnetiD3Z6P9
PhosphoSitePlusiD3Z6P9

Proteomic databases

PaxDbiD3Z6P9
PRIDEiD3Z6P9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113367; ENSMUSP00000108994; ENSMUSG00000070291
GeneIDi100048658
KEGGimmu:100048658
UCSCiuc012gxe.1 mouse

Organism-specific databases

CTDi55510
MGIiMGI:3642857 Ddx43

Phylogenomic databases

eggNOGiKOG0336 Eukaryota
ENOG410XR3V LUCA
GeneTreeiENSGT00930000150858
HOGENOMiHOG000268804
InParanoidiD3Z6P9
KOiK17043
OMAiVLMAERY
OrthoDBiEOG091G05VF
PhylomeDBiD3Z6P9
TreeFamiTF312949

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070291 Expressed in 58 organ(s), highest expression level in testis
GenevisibleiD3Z6P9 MM

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.30.1370.10, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF00013 KH_1, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00322 KH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54791 SSF54791, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD3Z6P9_MOUSE
AccessioniPrimary (citable) accession number: D3Z6P9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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