Ddx43

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
helicase activity Source: UniProtKB-KW
RNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	HelicaseUniRule annotation, Hydrolase
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 43Imported
Gene namesⁱ	Name:Ddx43Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:3642857 Ddx43

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	D3Z6P9
PRIDEⁱ	D3Z6P9

PTM databases

iPTMnetⁱ	D3Z6P9
PhosphoSitePlusⁱ	D3Z6P9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000070291 Expressed in 58 organ(s), highest expression level in testis
Genevisibleⁱ	D3Z6P9 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000108994

STRINGⁱ

10090.ENSMUSP00000108994

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	D3Z6P9
SMRⁱ	D3Z6P9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	240 – 268	Q_MOTIFInterPro annotationAdd BLAST	29
Domainⁱ	271 – 446	Helicase ATP-bindingInterPro annotationAdd BLAST	176
Domainⁱ	458 – 623	Helicase C-terminalInterPro annotationAdd BLAST	166

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	240 – 268	Q motifPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0336 Eukaryota ENOG410XR3V LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150858
HOGENOMⁱ	HOG000268804
InParanoidⁱ	D3Z6P9
KEGG Orthology (KO) More...KOⁱ	K17043
OMAⁱ	VLMAERY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05VF
PhylomeDBⁱ	D3Z6P9
TreeFamⁱ	TF312949

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR027417 P-loop_NTPase IPR000629 RNA-helicase_DEAD-box_CS IPR014014 RNA_helicase_DEAD_Q_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit PF00013 KH_1, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit SM00322 KH, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF54791 SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS00039 DEAD_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

D3Z6P9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRREPAANA SSSGVAPRRS STGSRGADRT ATEETNRRGR VGSRGAGGGW 
        60         70         80         90        100
REPAGAAEAT AAGRREPPLC FGVKNDVVGA VIGRGGSKIR EIQNTTNTRI 
       110        120        130        140        150
QVIKGNPEAE IKIFGNKAMQ TKAKTVIDNV VKKQQNYIPG QRVGIIAFQP 
       160        170        180        190        200
TVGADTSTSE SVTDDQPLID WDQIREDALK WEKKKWADLP PIKKNFYIES 
       210        220        230        240        250
ATTSSMSQVQ IDNWRKENFN ITCDDLKDGE KRPIPNPICK FEDAFQSYPE 
       260        270        280        290        300
VMENIKRAGF QKPTPIQSQA WPIVLQGIDL IGVAQTGTGK TLSYLMPGFI 
       310        320        330        340        350
HLDSQPLARE QRNGPGMLVL TPTRELALQV EAECSKYSYG DLKSVCVYGG 
       360        370        380        390        400
GDRDGQIQDV SKGVDIIIAT PGRLNDLQMN NFVNLKSVTY LVLDEADKML 
       410        420        430        440        450
DMGFEPQIMK ILLDVRPDRQ TIMTSATWPY AVRRLAQSYL KEPMIVYVGT 
       460        470        480        490        500
LDLVAVSTVK QNIIITTEEE KRTHIQTFLE NMSPKDKVIV FVSRKAVADH 
       510        520        530        540        550
LSSDLILRHI SVESLHGNRE QSDREKALEN FKTGKVRILI ATDLASRGLD 
       560        570        580        590        600
VHDITHVYNY DFPRNIEEYV HRVGRTGRAG RTGMSITLIT RNDWRVATEL 
       610        620        630        640 
INILERANQN IPEELVLMAE RYKANKLKRE MEKKMGRPQG KPQKFY

Length:646

Mass (Da):72,271

Last modified:April 20, 2010 - v1

Checksum:ⁱ9B3366F944ADE8CD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC138587 Genomic DNA No translation available. AC158987 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001177973.1, NM_001191044.1
UniGeneⁱ	Mm.158166

Genome annotation databases

Ensemblⁱ	ENSMUST00000113367; ENSMUSP00000108994; ENSMUSG00000070291
GeneIDⁱ	100048658
KEGGⁱ	mmu:100048658
UCSC genome browser More...UCSCⁱ	uc012gxe.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
D3Z6P9	DEAD-box helicase 43		RAT		646	UniRef90_D3Z6P9
probable ATP-dependent RNA helicase DDX43		MESAU		644
UPI0003D6EF75		MOUSE		351
UPI00038C1536		MICOH		648
UPI000A316C29		MUSCR		646
+3

Protein	Similar proteins		Species	Score	Length	Source
D3Z6P9	Probable ATP-dependent RNA helicase DDX53	)	HUMAN		631	UniRef50_Q86TM3
Uncharacterized protein		CHLSB		632
DDX53 isoform 1		PONAB		630
Putative ATP-dependent RNA helicase DDX53		MACFA		596
Putative ATP-dependent RNA helicase DDX53		MACMU		596
+361

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC138587 Genomic DNA No translation available. AC158987 Genomic DNA No translation available.
RefSeqⁱ	NP_001177973.1, NM_001191044.1
UniGeneⁱ	Mm.158166

3D structure databases

ProteinModelPortalⁱ	D3Z6P9
SMRⁱ	D3Z6P9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000108994

STRINGⁱ

10090.ENSMUSP00000108994

PTM databases

iPTMnetⁱ	D3Z6P9
PhosphoSitePlusⁱ	D3Z6P9

Proteomic databases

PaxDbⁱ	D3Z6P9
PRIDEⁱ	D3Z6P9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000113367; ENSMUSP00000108994; ENSMUSG00000070291
GeneIDⁱ	100048658
KEGGⁱ	mmu:100048658
UCSCⁱ	uc012gxe.1 mouse

Organism-specific databases

CTDⁱ	55510
MGIⁱ	MGI:3642857 Ddx43

Phylogenomic databases

eggNOGⁱ	KOG0336 Eukaryota ENOG410XR3V LUCA
GeneTreeⁱ	ENSGT00930000150858
HOGENOMⁱ	HOG000268804
InParanoidⁱ	D3Z6P9
KOⁱ	K17043
OMAⁱ	VLMAERY
OrthoDBⁱ	EOG091G05VF
PhylomeDBⁱ	D3Z6P9
TreeFamⁱ	TF312949

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000070291 Expressed in 58 organ(s), highest expression level in testis
Genevisibleⁱ	D3Z6P9 MM

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
Gene3Dⁱ	3.30.1370.10, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR027417 P-loop_NTPase IPR000629 RNA-helicase_DEAD-box_CS IPR014014 RNA_helicase_DEAD_Q_motif
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit PF00013 KH_1, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit SM00322 KH, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit SSF54791 SSF54791, 1 hit
PROSITEⁱ	View protein in PROSITE PS00039 DEAD_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	D3Z6P9_MOUSE
Accessionⁱ	D3Z6P9Primary (citable) accession number: D3Z6P9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 20, 2010
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - D3Z6P9 (D3Z6P9_MOUSE)

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DEAD (Asp-Glu-Ala-Asp) box polypeptide 43

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ