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Protein

Coiled-coil domain-containing protein 78

Gene

Ccdc78

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 78
Gene namesi
Name:Ccdc78
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2685784 Ccdc78

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004158051 – 437Coiled-coil domain-containing protein 78Add BLAST437

Proteomic databases

EPDiD3Z5T1
MaxQBiD3Z5T1
PaxDbiD3Z5T1
PRIDEiD3Z5T1

PTM databases

PhosphoSitePlusiD3Z5T1

Expressioni

Gene expression databases

BgeeiENSMUSG00000071202 Expressed in 17 organ(s), highest expression level in lung

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093155

Structurei

3D structure databases

SMRiD3Z5T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili83 – 114Sequence analysisAdd BLAST32
Coiled coili147 – 287Sequence analysisAdd BLAST141
Coiled coili360 – 408Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the CCDC78 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG0Z Eukaryota
ENOG410Z48M LUCA
GeneTreeiENSGT00390000013678
HOGENOMiHOG000111436
InParanoidiD3Z5T1
OMAiHLGRYKQ
OrthoDBiEOG091G0H5Z
PhylomeDBiD3Z5T1
TreeFamiTF336362

Family and domain databases

InterProiView protein in InterPro
IPR039873 CCDC78
IPR029329 DUF4472
PANTHERiPTHR22106 PTHR22106, 2 hits
PfamiView protein in Pfam
PF14739 DUF4472, 1 hit

Sequencei

Sequence statusi: Complete.

D3Z5T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQRPELLSS MEYVASPDPK PGVPLRVAEN VAPGAEDWLP SASGHLAWAT
60 70 80 90 100
SLETEHQTHL ELSEEQRLQI SKELVDLQIA THHLREQHEA EVFELRREIL
110 120 130 140 150
RLESRVLELE LHGNGACQGH KVQPMANLGQ HQVPPLEPPG GQQKLQEELK
160 170 180 190 200
WLLEHHRARQ QALETQVGVL SQQLQGAREE ARTTGQQLAS QAMVLASCKG
210 220 230 240 250
QLRQAEAENT QLQLQLKKMN EEYAVRLQHY ARETVENASS TNQAALQAFL
260 270 280 290 300
ESTLQDIRAA HRTREQQLAQ AARTYRKRLA DLNQRQELLL TTCRATFATA
310 320 330 340 350
INLEPLPMHW ATELSHPREN EYGRHRTLLL YPEKGSGETS KENKSQPLAL
360 370 380 390 400
DTASWAQIQQ RLQDFSQDTQ AELERERAQL MVRATMAEQQ LSELQEYVDQ
410 420 430
HLGRYKQEIL KLRKLVNIGD PQGVEAVSSP GSGGARL
Length:437
Mass (Da):49,472
Last modified:April 5, 2011 - v2
Checksum:iFAD68A601FFCC216
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134908 Genomic DNA No translation available.
CCDSiCCDS50035.1
RefSeqiNP_001159401.1, NM_001165929.1
UniGeneiMm.328867

Genome annotation databases

EnsembliENSMUST00000095500; ENSMUSP00000093155; ENSMUSG00000071202
GeneIDi381077
KEGGimmu:381077
UCSCiuc012ank.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134908 Genomic DNA No translation available.
CCDSiCCDS50035.1
RefSeqiNP_001159401.1, NM_001165929.1
UniGeneiMm.328867

3D structure databases

SMRiD3Z5T1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093155

PTM databases

PhosphoSitePlusiD3Z5T1

Proteomic databases

EPDiD3Z5T1
MaxQBiD3Z5T1
PaxDbiD3Z5T1
PRIDEiD3Z5T1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095500; ENSMUSP00000093155; ENSMUSG00000071202
GeneIDi381077
KEGGimmu:381077
UCSCiuc012ank.1 mouse

Organism-specific databases

CTDi124093
MGIiMGI:2685784 Ccdc78

Phylogenomic databases

eggNOGiENOG410IG0Z Eukaryota
ENOG410Z48M LUCA
GeneTreeiENSGT00390000013678
HOGENOMiHOG000111436
InParanoidiD3Z5T1
OMAiHLGRYKQ
OrthoDBiEOG091G0H5Z
PhylomeDBiD3Z5T1
TreeFamiTF336362

Miscellaneous databases

PROiPR:D3Z5T1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071202 Expressed in 17 organ(s), highest expression level in lung

Family and domain databases

InterProiView protein in InterPro
IPR039873 CCDC78
IPR029329 DUF4472
PANTHERiPTHR22106 PTHR22106, 2 hits
PfamiView protein in Pfam
PF14739 DUF4472, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCD78_MOUSE
AccessioniPrimary (citable) accession number: D3Z5T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 53 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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