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Protein

WNT1-inducible-signaling pathway protein 3

Gene

Wisp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Appears to be required for normal postnatal skeletal growth and cartilage homeostasis.By similarity

GO - Molecular functioni

  • growth factor activity Source: UniProtKB-KW
  • heparin binding Source: GO_Central
  • insulin-like growth factor binding Source: InterPro
  • integrin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 3
Short name:
WISP-3
Alternative name(s):
CCN family member 6
Gene namesi
Name:Wisp3
Synonyms:Ccn6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2685581 Wisp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000041585524 – 354WNT1-inducible-signaling pathway protein 3By similarityAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi209 ↔ 238By similarity
Disulfide bondi219 ↔ 223By similarity
Disulfide bondi247 ↔ 252By similarity
Disulfide bondi268 ↔ 305By similarity
Disulfide bondi285 ↔ 319By similarity
Disulfide bondi296 ↔ 335By similarity
Disulfide bondi299 ↔ 337By similarity
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiD3Z5L9
PeptideAtlasiD3Z5L9
PRIDEiD3Z5L9

PTM databases

iPTMnetiD3Z5L9
PhosphoSitePlusiD3Z5L9

Expressioni

Gene expression databases

BgeeiENSMUSG00000062074 Expressed in 18 organ(s), highest expression level in thymus

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076003

Structurei

3D structure databases

ProteinModelPortaliD3Z5L9
SMRiD3Z5L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 117IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini208 – 253TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini268 – 342CTCKPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJZE Eukaryota
ENOG4110BH0 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
InParanoidiD3Z5L9
OMAiCQRNCRD
OrthoDBiEOG091G0SQP
PhylomeDBiD3Z5L9
TreeFamiTF326070

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D3Z5L9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLLFCTLL MTGLTQLCCR TQGSAPQDST PGGRPGAALE VYQRTEVCRW
60 70 80 90 100
PCRCPPQRPT CPPGVSLVRD GCGCCKVCAK QPGDTCNEAE ICDPHKGLYC
110 120 130 140 150
DYSGDTPRYE TGVCAYLVAV GCEFNRVYYQ NGQVFQPHPL FSCLCVSGAI
160 170 180 190 200
GCTPLFIPKL AGSNCSAAKG RRKTDPPNCG RGTLQQQNSA SYKTMSAYRN
210 220 230 240 250
LPLTWRKKCL VQATKWTPCS RTCGMGISNR VTNDNANCEM RKERRLCYIQ
260 270 280 290 300
PCSRNTSQAV KIPRGETCQP TFQLPKAEKF VFSGCSSTQS YRPTFCGICL
310 320 330 340 350
DKRCCVPNKS KMITVRFDCP SEGSFKWQML WVTSCVCQRD CREPGDIFSE

LRIL
Length:354
Mass (Da):39,379
Last modified:April 5, 2011 - v2
Checksum:iF45C5CD8896D1647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153958 Genomic DNA No translation available.
CCDSiCCDS48537.1
RefSeqiNP_001120848.1, NM_001127376.1
UniGeneiMm.208111

Genome annotation databases

EnsembliENSMUST00000076713; ENSMUSP00000076003; ENSMUSG00000062074
GeneIDi327743
KEGGimmu:327743
UCSCiuc011xcu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153958 Genomic DNA No translation available.
CCDSiCCDS48537.1
RefSeqiNP_001120848.1, NM_001127376.1
UniGeneiMm.208111

3D structure databases

ProteinModelPortaliD3Z5L9
SMRiD3Z5L9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076003

PTM databases

iPTMnetiD3Z5L9
PhosphoSitePlusiD3Z5L9

Proteomic databases

PaxDbiD3Z5L9
PeptideAtlasiD3Z5L9
PRIDEiD3Z5L9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076713; ENSMUSP00000076003; ENSMUSG00000062074
GeneIDi327743
KEGGimmu:327743
UCSCiuc011xcu.1 mouse

Organism-specific databases

CTDi8838
MGIiMGI:2685581 Wisp3

Phylogenomic databases

eggNOGiENOG410IJZE Eukaryota
ENOG4110BH0 LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
InParanoidiD3Z5L9
OMAiCQRNCRD
OrthoDBiEOG091G0SQP
PhylomeDBiD3Z5L9
TreeFamiTF326070

Miscellaneous databases

PROiPR:D3Z5L9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062074 Expressed in 18 organ(s), highest expression level in thymus

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWISP3_MOUSE
AccessioniPrimary (citable) accession number: D3Z5L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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