NK6 homeobox 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 9254678
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • 8096811
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • 8096811
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 8096811
• transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • 8096811

GO - Biological processⁱ

• cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 15944193
• central nervous system myelination Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 15601927
• endocrine pancreas development Source: MGIInferred from genetic interactionⁱ
  • 15944193
• negative regulation of cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • 11567614
• negative regulation of glial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • 15629702
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 10931524
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 8096811
• neuromuscular process controlling balance Source: MGIInferred from mutant phenotypeⁱ
  • 15601927
• oligodendrocyte differentiation Source: MGIInferred from genetic interactionⁱ
  • 15629701
• positive regulation of cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • 11567614
• positive regulation of glial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • 15629702
• regulation of myelination Source: UniProtKBInferred from mutant phenotypeⁱ
  • 15601927
• regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGIInferred from genetic interactionⁱ
  • 11567614
• regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGIInferred from mutant phenotypeⁱ
  • 11567614

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDANRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KTPALGSLGA 
        60         70         80         90        100
QLPLGTPHGI SDILGRPVGA AGGGLLGSLP RLNGLASSAG VYFGPAAAVA 
       110        120        130        140        150
RGYPKPLAEL PGRPPIFWPG VVQGSPWRDP RLAGSAQAGG VLDKDGKKKH 
       160        170        180        190        200
SRPTFSGQQI FALEKTFEQT KYLAGPERAR LAYSLGMTES QVKVWFQNRR 
       210        220        230        240        250
TKWRKRHAAE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR PLDPNSDDEK 
       260        270 
ITRLLKKHKP SNLALVSPCG GSAGDAL                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ