NK6 homeobox 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination."
    Awatramani R., Scherer S., Grinspan J., Collarini E., Skoff R., O'Hagan D., Garbern J., Kamholz J.
    J Neurosci 17:6657-6668(1997) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter."
    Komuro I., Schalling M., Jahn L., Bodmer R., Jenkins N.A., Copeland N.G., Izumo S.
    EMBO J 12:1387-1401(1993) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter."
    Komuro I., Schalling M., Jahn L., Bodmer R., Jenkins N.A., Copeland N.G., Izumo S.
    EMBO J 12:1387-1401(1993) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter."
    Komuro I., Schalling M., Jahn L., Bodmer R., Jenkins N.A., Copeland N.G., Izumo S.
    EMBO J 12:1387-1401(1993) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter."
    Komuro I., Schalling M., Jahn L., Bodmer R., Jenkins N.A., Copeland N.G., Izumo S.
    EMBO J 12:1387-1401(1993) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI

GO - Biological processⁱ

• cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas."
    Henseleit K.D., Nelson S.B., Kuhlbrodt K., Hennings J.C., Ericson J., Sander M.
    Development 132:3139-3149(2005) [PubMed] [Europe PMC] [Abstract]
• central nervous system myelination Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure."
    Southwood C., He C., Garbern J., Kamholz J., Arroyo E., Gow A.
    J Neurosci 24:11215-11225(2004) [PubMed] [Europe PMC] [Abstract]
• endocrine pancreas development Source: MGIInferred from genetic interactionⁱ
  • "NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas."
    Henseleit K.D., Nelson S.B., Kuhlbrodt K., Hennings J.C., Ericson J., Sander M.
    Development 132:3139-3149(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • "Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification."
    Vallstedt A., Muhr J., Pattyn A., Pierani A., Mendelsohn M., Sander M., Jessell T.M., Ericson J.
    Neuron 31:743-755(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain."
    Vallstedt A., Klos J.M., Ericson J.
    Neuron 45:55-67(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Gtx, an oligodendrocyte-specific homeodomain protein, has repressor activity."
    Awatramani R., Beesley J., Yang H., Jiang H., Cambi F., Grinspan J., Garbern J., Kamholz J.
    J Neurosci Res 61:376-387(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter."
    Komuro I., Schalling M., Jahn L., Bodmer R., Jenkins N.A., Copeland N.G., Izumo S.
    EMBO J 12:1387-1401(1993) [PubMed] [Europe PMC] [Abstract]
• neuromuscular process controlling balance Source: MGIInferred from mutant phenotypeⁱ
  • "CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure."
    Southwood C., He C., Garbern J., Kamholz J., Arroyo E., Gow A.
    J Neurosci 24:11215-11225(2004) [PubMed] [Europe PMC] [Abstract]
• oligodendrocyte differentiation Source: MGIInferred from genetic interactionⁱ
  • "Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling."
    Cai J., Qi Y., Hu X., Tan M., Liu Z., Zhang J., Li Q., Sander M., Qiu M.
    Neuron 45:41-53(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • "Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification."
    Vallstedt A., Muhr J., Pattyn A., Pierani A., Mendelsohn M., Sander M., Jessell T.M., Ericson J.
    Neuron 31:743-755(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain."
    Vallstedt A., Klos J.M., Ericson J.
    Neuron 45:55-67(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of myelination Source: UniProtKBInferred from mutant phenotypeⁱ
  • "CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure."
    Southwood C., He C., Garbern J., Kamholz J., Arroyo E., Gow A.
    J Neurosci 24:11215-11225(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGIInferred from genetic interactionⁱ
  • "Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification."
    Vallstedt A., Muhr J., Pattyn A., Pierani A., Mendelsohn M., Sander M., Jessell T.M., Ericson J.
    Neuron 31:743-755(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGIInferred from mutant phenotypeⁱ
  • "Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification."
    Vallstedt A., Muhr J., Pattyn A., Pierani A., Mendelsohn M., Sander M., Jessell T.M., Ericson J.
    Neuron 31:743-755(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDANRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KTPALGSLGA 
        60         70         80         90        100
QLPLGTPHGI SDILGRPVGA AGGGLLGSLP RLNGLASSAG VYFGPAAAVA 
       110        120        130        140        150
RGYPKPLAEL PGRPPIFWPG VVQGSPWRDP RLAGSAQAGG VLDKDGKKKH 
       160        170        180        190        200
SRPTFSGQQI FALEKTFEQT KYLAGPERAR LAYSLGMTES QVKVWFQNRR 
       210        220        230        240        250
TKWRKRHAAE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR PLDPNSDDEK 
       260        270 
ITRLLKKHKP SNLALVSPCG GSAGDAL                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ