UniProtKB - D3Z4R4 (D3Z4R4_MOUSE)
Protein
Submitted name:
NK6 homeobox 2
Gene
Nkx6-2
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 148 – 207 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell differentiation Source: MGI
- central nervous system myelination Source: MGI
- endocrine pancreas development Source: MGI
- negative regulation of cell fate commitment Source: MGI
- negative regulation of glial cell differentiation Source: MGI
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- neuromuscular process controlling balance Source: MGI
- oligodendrocyte differentiation Source: MGI
- positive regulation of cell fate commitment Source: MGI
- positive regulation of glial cell differentiation Source: MGI
- regulation of myelination Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGI
- regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGI
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: NK6 homeobox 2Imported |
Gene namesi | Name:Nkx6-2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352738, Nkx6-2 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000041309, Expressed in midbrain and 112 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 146 – 206 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 132 – 154 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 210 – 257 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 212 – 235 | PolyampholyteSequence analysisAdd BLAST | 24 |
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0847, Eukaryota |
GeneTreei | ENSGT00940000161547 |
HOGENOMi | CLU_064820_1_1_1 |
OMAi | MYFSPAV |
OrthoDBi | 1263401at2759 |
TreeFami | TF327063 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
D3Z4R4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDANRPGAFV LSSAPLAALH NMAEMKTSLF PYALQGPAGF KTPALGSLGA
60 70 80 90 100
QLPLGTPHGI SDILGRPVGA AGGGLLGSLP RLNGLASSAG VYFGPAAAVA
110 120 130 140 150
RGYPKPLAEL PGRPPIFWPG VVQGSPWRDP RLAGSAQAGG VLDKDGKKKH
160 170 180 190 200
SRPTFSGQQI FALEKTFEQT KYLAGPERAR LAYSLGMTES QVKVWFQNRR
210 220 230 240 250
TKWRKRHAAE MASAKKKQDS DAEKLKVGGS DAEDDDEYNR PLDPNSDDEK
260 270
ITRLLKKHKP SNLALVSPCG GSAGDAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC112670 Genomic DNA No translation available. |
RefSeqi | NP_899071.2, NM_183248.3 |
Genome annotation databases
Ensembli | ENSMUST00000097974; ENSMUSP00000095588; ENSMUSG00000041309 ENSMUST00000106095; ENSMUSP00000101701; ENSMUSG00000041309 |
GeneIDi | 14912 |
KEGGi | mmu:14912 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC112670 Genomic DNA No translation available. |
RefSeqi | NP_899071.2, NM_183248.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000101701 |
Protocols and materials databases
Antibodypediai | 56219, 76 antibodies |
DNASUi | 14912 |
Genome annotation databases
Ensembli | ENSMUST00000097974; ENSMUSP00000095588; ENSMUSG00000041309 ENSMUST00000106095; ENSMUSP00000101701; ENSMUSG00000041309 |
GeneIDi | 14912 |
KEGGi | mmu:14912 |
Organism-specific databases
CTDi | 84504 |
MGIi | MGI:1352738, Nkx6-2 |
Phylogenomic databases
eggNOGi | KOG0847, Eukaryota |
GeneTreei | ENSGT00940000161547 |
HOGENOMi | CLU_064820_1_1_1 |
OMAi | MYFSPAV |
OrthoDBi | 1263401at2759 |
TreeFami | TF327063 |
Miscellaneous databases
BioGRID-ORCSi | 14912, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041309, Expressed in midbrain and 112 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3Z4R4_MOUSE | |
Accessioni | D3Z4R4Primary (citable) accession number: D3Z4R4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |