Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable ATP-dependent DNA helicase HFM1

Gene

Hfm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi302 – 309ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • oogenesis Source: UniProtKB-KW
  • resolution of meiotic recombination intermediates Source: MGI
  • spermatogenesis Source: UniProtKB-KW

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDifferentiation, Meiosis, Oogenesis, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent DNA helicase HFM1 (EC:3.6.4.12)
Gene namesi
Name:Hfm1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3036246 Hfm1

Pathology & Biotechi

Disruption phenotypei

Male and female mutants are sterile due to severe blockage of spermatogenesis and oogenesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004306421 – 1434Probable ATP-dependent DNA helicase HFM1Add BLAST1434

Proteomic databases

MaxQBiD3Z4R1
PaxDbiD3Z4R1
PRIDEiD3Z4R1

PTM databases

iPTMnetiD3Z4R1
PhosphoSitePlusiD3Z4R1

Expressioni

Gene expression databases

BgeeiENSMUSG00000043410 Expressed in 17 organ(s), highest expression level in testis
ExpressionAtlasiD3Z4R1 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi236907, 2 interactors
STRINGi10090.ENSMUSP00000108310

Structurei

3D structure databases

ProteinModelPortaliD3Z4R1
SMRiD3Z4R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini289 – 476Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST188
Domaini514 – 718Helicase C-terminalPROSITE-ProRule annotationAdd BLAST205
Domaini775 – 1089SEC63Sequence analysisAdd BLAST315

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi410 – 413DEAH boxPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0952 Eukaryota
COG1204 LUCA
GeneTreeiENSGT00550000074822
HOGENOMiHOG000293238
InParanoidiD3Z4R1
KOiK15271
OMAiMTVEQKQ
OrthoDBiEOG091G0BYO
PhylomeDBiD3Z4R1
TreeFamiTF328936

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR004179 Sec63-dom
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF02889 Sec63, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00973 Sec63, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

D3Z4R1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKSDDCFFS MDNLFFSSPD ETENFPVKEK SLDWFLPPAP LISEIPDIQE
60 70 80 90 100
LEEEIESYKL LGKGKMPRML TSNLKIINED TNCISPTQKI HFSYNVHEQD
110 120 130 140 150
YLNLGGSNNN DMSHVAGKLM YGSSQKYKNH MGAKSPSARS SPGDTKLHDV
160 170 180 190 200
AEDRQGTSAF KKRLSRTCDS EHDCDYADGS LNLSSHISPV KLTQTKISKE
210 220 230 240 250
NAWTCSNSKQ KRQYSTNKFK ANDAFSASGI GKDIFKAPSF PAASQPHDIQ
260 270 280 290 300
GITPNGLGSL KAVTEIPAKF RNIFKEFPYF NYIQSKAFDD LLYTDRNFVI
310 320 330 340 350
CAPTGSGKTV VFELAITRLL MEVPLPWLNM KIVYMAPIKA LCSQRFDDWK
360 370 380 390 400
EKFGPVGLNC KELTGDTVMD DLFEIQHANI IITTPEKWDS VTRKWRDNSF
410 420 430 440 450
IQLVRLFLID EVHVIKDENR GPTLEVVVSR MKTVQSLSRD LESASPVPVR
460 470 480 490 500
FVAVSATIPN AEDIAEWLSD GERPAVCLKM DESHRPVKLQ KVVLGFPCSS
510 520 530 540 550
SQTEFKFDLA LNYKVYSVIR TYSDQKPTLV FCSTRKGVQQ AASVLVKDAK
560 570 580 590 600
FIISVEQKLR LQKSAYSIRD SKLKDTLVYG VGYHHAGMEL SDRKLVEGLF
610 620 630 640 650
TSGDLPVLFT TSTLAMGMNM PAHLVVIKST MHYSGGVFEE YSETDILQMI
660 670 680 690 700
GRAGRPQFDT TATAVIMTRL STREKYVQML ACNDTVESSL HRHLIEHLNA
710 720 730 740 750
EIVLHTITDV NIALDWIRST MLYIRALKNP SHYGFSSGLN KDGIEAKLQE
760 770 780 790 800
LCLKNLKDLS SLDLIKMDED VNFKPTEAGR LMAWYYITFE TVKKFCAISG
810 820 830 840 850
KETLLDLISM ISSCNEFLDV QLRISEKRIL NTLNKDPNRI TIRFPMAERI
860 870 880 890 900
KTREMKVNCL IQAQLGCIPI QDFALTQDTV KIFRNGSRIA RWLSDFVAAQ
910 920 930 940 950
EKKFAVLLNS VILTKCFKCK LWENSKHVSK QLDKIGISLS NTMVNAGLTS
960 970 980 990 1000
FKKIEEANAR ELELILNRHP PFGTQIKEAV AHLPKYELEV EQIARYSDIK
1010 1020 1030 1040 1050
AEILVTIILR NFEQLQTKRT APDFHYATLI IGDADNQVVF KHKIMDSVLL
1060 1070 1080 1090 1100
KSGNWVKKID VKRALISEDL SINLISSDYV GLDIHQKFTV FYFGPRKFVN
1110 1120 1130 1140 1150
ETAMERSSET DISHSDYSGR ATATGSSKGM ATCKKPGNRE CHHHCKNKHA
1160 1170 1180 1190 1200
CGHDCCKIGV AQKPEVKESA MSSYLSDLKS RDAVSSLPLA KRLKIQMNKS
1210 1220 1230 1240 1250
QNVDLKEFGF TPRPSLSSIS RSEYLNTPEL SILEQRNQHE IYGKVQQGPS
1260 1270 1280 1290 1300
EYRDKEVLGV NLELGNEVWD DFDDESLIEV MSLSADAEKM AASGFGDTRD
1310 1320 1330 1340 1350
SSLGGSKLPF QKSSSRFQRD NSNSFASSPG KPDAYLRDCS RSSFGLSSVA
1360 1370 1380 1390 1400
EIPQRAENAS LANLQERRPL TLSPVIERMC FAHSKKTPQS PKFKEVDIFI
1410 1420 1430
GNSGSKKEID LSKYYPDDAA EEMKALLGIF NGIF
Length:1,434
Mass (Da):161,379
Last modified:April 5, 2011 - v2
Checksum:i0ADD3ADB0DDA3731
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JED3A0A0G2JED3_MOUSE
Probable ATP-dependent DNA helicase...
Hfm1
410Annotation score:
F6XQ35F6XQ35_MOUSE
Probable ATP-dependent DNA helicase...
Hfm1
626Annotation score:
F7C082F7C082_MOUSE
Probable ATP-dependent DNA helicase...
Hfm1
49Annotation score:
D6RJK3D6RJK3_MOUSE
Probable ATP-dependent DNA helicase...
Hfm1
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137947 Genomic DNA No translation available.
CCDSiCCDS51582.1
RefSeqiNP_808541.2, NM_177873.3
UniGeneiMm.121664

Genome annotation databases

EnsembliENSMUST00000112690; ENSMUSP00000108310; ENSMUSG00000043410
ENSMUST00000117588; ENSMUSP00000112590; ENSMUSG00000043410
GeneIDi330149
KEGGimmu:330149
UCSCiuc012eai.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC137947 Genomic DNA No translation available.
CCDSiCCDS51582.1
RefSeqiNP_808541.2, NM_177873.3
UniGeneiMm.121664

3D structure databases

ProteinModelPortaliD3Z4R1
SMRiD3Z4R1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236907, 2 interactors
STRINGi10090.ENSMUSP00000108310

PTM databases

iPTMnetiD3Z4R1
PhosphoSitePlusiD3Z4R1

Proteomic databases

MaxQBiD3Z4R1
PaxDbiD3Z4R1
PRIDEiD3Z4R1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112690; ENSMUSP00000108310; ENSMUSG00000043410
ENSMUST00000117588; ENSMUSP00000112590; ENSMUSG00000043410
GeneIDi330149
KEGGimmu:330149
UCSCiuc012eai.1 mouse

Organism-specific databases

CTDi164045
MGIiMGI:3036246 Hfm1

Phylogenomic databases

eggNOGiKOG0952 Eukaryota
COG1204 LUCA
GeneTreeiENSGT00550000074822
HOGENOMiHOG000293238
InParanoidiD3Z4R1
KOiK15271
OMAiMTVEQKQ
OrthoDBiEOG091G0BYO
PhylomeDBiD3Z4R1
TreeFamiTF328936

Miscellaneous databases

PROiPR:D3Z4R1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043410 Expressed in 17 organ(s), highest expression level in testis
ExpressionAtlasiD3Z4R1 baseline and differential

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR004179 Sec63-dom
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF02889 Sec63, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00973 Sec63, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHFM1_MOUSE
AccessioniPrimary (citable) accession number: D3Z4R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: April 5, 2011
Last modified: November 7, 2018
This is version 67 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again