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Protein
Submitted name:

Roundabout homolog 3

Gene

Robo3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-MMU-9010642 ROBO receptors bind AKAP5

Names & Taxonomyi

Protein namesi
Submitted name:
Roundabout homolog 3Imported
Gene namesi
Name:Robo3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1343102 Robo3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiD3Z4M6
PRIDEiD3Z4M6

Expressioni

Gene expression databases

BgeeiENSMUSG00000032128 Expressed in 59 organ(s), highest expression level in optic eminence
ExpressionAtlasiD3Z4M6 baseline and differential
GenevisibleiD3Z4M6 MM

Structurei

3D structure databases

ProteinModelPortaliD3Z4M6
SMRiD3Z4M6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 160Ig-likeInterPro annotationAdd BLAST97
Domaini166 – 253Ig-likeInterPro annotationAdd BLAST88
Domaini258 – 342Ig-likeInterPro annotationAdd BLAST85
Domaini347 – 440Ig-likeInterPro annotationAdd BLAST94
Domaini450 – 531Ig-likeInterPro annotationAdd BLAST82
Domaini558 – 652Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini672 – 766Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini771 – 869Fibronectin type-IIIInterPro annotationAdd BLAST99

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00930000150875
HOGENOMiHOG000010267
KOiK06755
OrthoDBiEOG091G00CG
TreeFamiTF351053

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR032987 Robo3
PANTHERiPTHR44096:SF3 PTHR44096:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D3Z4M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRYLLKTLL QMNLFADSLA RDISNSSELL FGFNSSLAAL NPSLLPPGDP
60 70 80 90 100
SLNGSRVGPE DAMPRIVEQP PDLVVSRGEP ATLPCRAEGR PRPNIEWYKN
110 120 130 140 150
GARVATARED PRAHRLLLPS GALFFPRIVH GRRSRPDEGV YTCVARNYLG
160 170 180 190 200
AAASRNASLE VAVLRDDFRQ SPGNVVVAVG EPAVMECVPP KGHPEPLVTW
210 220 230 240 250
KKGKIKLKEE EGRITIRGGK LMMSHTFKSD AGMYMCVASN MAGERESGAA
260 270 280 290 300
ELVVLERPSF LRRPINQVVL ADAPVNFLCE VQGDPQPNLH WRKDDGELPA
310 320 330 340 350
GRYEIRSDHS LWIDQVSSED EGTYTCVAEN SVGRAEASGS LSVHVPPQFV
360 370 380 390 400
TKPQNQTVAP GANVSFQCET KGNPPPAIFW QKEGSQVLLF PSQSLQPMGR
410 420 430 440 450
LLVSPRGQLN ITEVKIGDGG YYVCQAVSVA GSILAKALLE IKGASIDGLP
460 470 480 490 500
PIILQGPANQ TLVLGSSVWL PCRVIGNPQP NIQWKKDERW LQGDDSQFNL
510 520 530 540 550
MDNGTLHIAS IQEMDMGFYS CVAKSSIGEA TWNSWLRKQE DWGASPGPAT
560 570 580 590 600
GPSNPPGPPS QPIVTEVTAN SITLTWKPNP QSGATATSYV IEAFSQAAGN
610 620 630 640 650
TWRTVADGVQ LETYTISGLQ PNTIYLFLVR AVGAWGLSEP SPVSEPVQTQ
660 670 680 690 700
DSSLSRPAED PWKGQRGLAE VAVRMQEPTV LGPRTLQVSW TVDGPVQLVQ
710 720 730 740 750
GFRVSWRIAG LDQGSWTMLD LQSPHKQSTV LRGLPPGAQI QIKVQVQGQE
760 770 780 790 800
GLGAESPFVT RSIPEEAPSG PPQGVAVALG GDRNSSVTVS WEPPLPSQRN
810 820 830 840 850
GVITEYQIWC LGNESRFHLN RSAAGWARSV TFSGLLPGQI YRALVAAATS
860 870 880 890 900
AGVGVASAPV LVQLPFPPAA EPGPEVSEGL AERLAKVLRK PAFLAGSSAA
910 920 930 940 950
CGALLLGFCA ALYRRQKQRK ELSHYTASFA YTPAVSFPHS EGLSGSSSRP
960 970 980 990 1000
PMGLGPAAYP WLADSWPHPP RSPSAQEPRG SCCPSNPDPD DRYYNEAGIS
1010 1020 1030 1040 1050
LYLAQTARGA NASGEGPVYS TIDPVGEELQ TFHGGFPQHS SGDPSTWSQY
1060 1070 1080 1090 1100
APPEWSEGDS GARGGQGKLL GKPVQMPSLS WPEALPPPPP SCELSCPEGP
1110 1120 1130 1140 1150
EEELKGSSDL EEWCPPVPEK SHLVGSSSSG ACMVAPAPRD TPSPTSSYGQ
1160 1170 1180 1190 1200
QSTATLTPSP PDPPQPPTDI PHLHQMPRRV PLGPSSPLSV SQPALSSHDG
1210 1220 1230 1240 1250
RPVGLGAGPV LSYHASPSPV PSTASSAPGR TRQVTGEMTP PLHGHRARIR
1260 1270 1280 1290 1300
KKPKALPYRR EHSPGDLPPP PLPPPEEETS WPLGLRAAGS MSSLERERSG
1310 1320 1330 1340 1350
ERRVVQAVPL GAQPLGAQRG PHPDAALLGC AAEEAWLPYG RPSFLSHGQG
1360 1370 1380 1390 1400
TSTCSTAGSN SSRGSNSSRG SRGSRGPGRS RSRSRSQSQS QRPGRNRREE

PR
Length:1,402
Mass (Da):149,899
Last modified:April 20, 2010 - v1
Checksum:iC50BA767FE5F789B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Z2I4ROBO3_MOUSE
Roundabout homolog 3
Robo3 Rbig1
1,366Annotation score:
E9QPQ1E9QPQ1_MOUSE
Roundabout homolog 3
Robo3
1,380Annotation score:
A0A1L1SU85A0A1L1SU85_MOUSE
Roundabout homolog 3
Robo3 mCG_4134
1,345Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138284 Genomic DNA No translation available.
RefSeqiNP_001158239.1, NM_001164767.1
UniGeneiMm.212826

Genome annotation databases

EnsembliENSMUST00000115038; ENSMUSP00000110690; ENSMUSG00000032128
GeneIDi19649
KEGGimmu:19649
UCSCiuc012gqz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138284 Genomic DNA No translation available.
RefSeqiNP_001158239.1, NM_001164767.1
UniGeneiMm.212826

3D structure databases

ProteinModelPortaliD3Z4M6
SMRiD3Z4M6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD3Z4M6
PRIDEiD3Z4M6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115038; ENSMUSP00000110690; ENSMUSG00000032128
GeneIDi19649
KEGGimmu:19649
UCSCiuc012gqz.1 mouse

Organism-specific databases

CTDi64221
MGIiMGI:1343102 Robo3

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00930000150875
HOGENOMiHOG000010267
KOiK06755
OrthoDBiEOG091G00CG
TreeFamiTF351053

Enzyme and pathway databases

ReactomeiR-MMU-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-MMU-9010642 ROBO receptors bind AKAP5

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032128 Expressed in 59 organ(s), highest expression level in optic eminence
ExpressionAtlasiD3Z4M6 baseline and differential
GenevisibleiD3Z4M6 MM

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR032987 Robo3
PANTHERiPTHR44096:SF3 PTHR44096:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiD3Z4M6_MOUSE
AccessioniPrimary (citable) accession number: D3Z4M6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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