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Protein
Submitted name:

Roundabout homolog 3

Gene

Robo3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-MMU-9010642 ROBO receptors bind AKAP5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Roundabout homolog 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Robo3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1343102 Robo3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3Z4M6

PRoteomics IDEntifications database

More...
PRIDEi
D3Z4M6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032128 Expressed in 59 organ(s), highest expression level in optic eminence

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
D3Z4M6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3Z4M6 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
D3Z4M6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3Z4M6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 160Ig-likeInterPro annotationAdd BLAST97
Domaini166 – 253Ig-likeInterPro annotationAdd BLAST88
Domaini258 – 342Ig-likeInterPro annotationAdd BLAST85
Domaini347 – 440Ig-likeInterPro annotationAdd BLAST94
Domaini450 – 531Ig-likeInterPro annotationAdd BLAST82
Domaini558 – 652Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini672 – 766Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini771 – 869Fibronectin type-IIIInterPro annotationAdd BLAST99

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4222 Eukaryota
ENOG410XPQS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155457

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010267

KEGG Orthology (KO)

More...
KOi
K06755

Database of Orthologous Groups

More...
OrthoDBi
173520at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351053

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR032987 Robo3

The PANTHER Classification System

More...
PANTHERi
PTHR44096:SF3 PTHR44096:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D3Z4M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRYLLKTLL QMNLFADSLA RDISNSSELL FGFNSSLAAL NPSLLPPGDP
60 70 80 90 100
SLNGSRVGPE DAMPRIVEQP PDLVVSRGEP ATLPCRAEGR PRPNIEWYKN
110 120 130 140 150
GARVATARED PRAHRLLLPS GALFFPRIVH GRRSRPDEGV YTCVARNYLG
160 170 180 190 200
AAASRNASLE VAVLRDDFRQ SPGNVVVAVG EPAVMECVPP KGHPEPLVTW
210 220 230 240 250
KKGKIKLKEE EGRITIRGGK LMMSHTFKSD AGMYMCVASN MAGERESGAA
260 270 280 290 300
ELVVLERPSF LRRPINQVVL ADAPVNFLCE VQGDPQPNLH WRKDDGELPA
310 320 330 340 350
GRYEIRSDHS LWIDQVSSED EGTYTCVAEN SVGRAEASGS LSVHVPPQFV
360 370 380 390 400
TKPQNQTVAP GANVSFQCET KGNPPPAIFW QKEGSQVLLF PSQSLQPMGR
410 420 430 440 450
LLVSPRGQLN ITEVKIGDGG YYVCQAVSVA GSILAKALLE IKGASIDGLP
460 470 480 490 500
PIILQGPANQ TLVLGSSVWL PCRVIGNPQP NIQWKKDERW LQGDDSQFNL
510 520 530 540 550
MDNGTLHIAS IQEMDMGFYS CVAKSSIGEA TWNSWLRKQE DWGASPGPAT
560 570 580 590 600
GPSNPPGPPS QPIVTEVTAN SITLTWKPNP QSGATATSYV IEAFSQAAGN
610 620 630 640 650
TWRTVADGVQ LETYTISGLQ PNTIYLFLVR AVGAWGLSEP SPVSEPVQTQ
660 670 680 690 700
DSSLSRPAED PWKGQRGLAE VAVRMQEPTV LGPRTLQVSW TVDGPVQLVQ
710 720 730 740 750
GFRVSWRIAG LDQGSWTMLD LQSPHKQSTV LRGLPPGAQI QIKVQVQGQE
760 770 780 790 800
GLGAESPFVT RSIPEEAPSG PPQGVAVALG GDRNSSVTVS WEPPLPSQRN
810 820 830 840 850
GVITEYQIWC LGNESRFHLN RSAAGWARSV TFSGLLPGQI YRALVAAATS
860 870 880 890 900
AGVGVASAPV LVQLPFPPAA EPGPEVSEGL AERLAKVLRK PAFLAGSSAA
910 920 930 940 950
CGALLLGFCA ALYRRQKQRK ELSHYTASFA YTPAVSFPHS EGLSGSSSRP
960 970 980 990 1000
PMGLGPAAYP WLADSWPHPP RSPSAQEPRG SCCPSNPDPD DRYYNEAGIS
1010 1020 1030 1040 1050
LYLAQTARGA NASGEGPVYS TIDPVGEELQ TFHGGFPQHS SGDPSTWSQY
1060 1070 1080 1090 1100
APPEWSEGDS GARGGQGKLL GKPVQMPSLS WPEALPPPPP SCELSCPEGP
1110 1120 1130 1140 1150
EEELKGSSDL EEWCPPVPEK SHLVGSSSSG ACMVAPAPRD TPSPTSSYGQ
1160 1170 1180 1190 1200
QSTATLTPSP PDPPQPPTDI PHLHQMPRRV PLGPSSPLSV SQPALSSHDG
1210 1220 1230 1240 1250
RPVGLGAGPV LSYHASPSPV PSTASSAPGR TRQVTGEMTP PLHGHRARIR
1260 1270 1280 1290 1300
KKPKALPYRR EHSPGDLPPP PLPPPEEETS WPLGLRAAGS MSSLERERSG
1310 1320 1330 1340 1350
ERRVVQAVPL GAQPLGAQRG PHPDAALLGC AAEEAWLPYG RPSFLSHGQG
1360 1370 1380 1390 1400
TSTCSTAGSN SSRGSNSSRG SRGSRGPGRS RSRSRSQSQS QRPGRNRREE

PR
Length:1,402
Mass (Da):149,899
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC50BA767FE5F789B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Z2I4ROBO3_MOUSE
Roundabout homolog 3
Robo3 Rbig1
1,366Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QPQ1E9QPQ1_MOUSE
Roundabout homolog 3
Robo3
1,380Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SU85A0A1L1SU85_MOUSE
Roundabout homolog 3
Robo3 mCG_4134
1,345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC138284 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001158239.1, NM_001164767.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.212826

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000115038; ENSMUSP00000110690; ENSMUSG00000032128

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19649

UCSC genome browser

More...
UCSCi
uc012gqz.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138284 Genomic DNA No translation available.
RefSeqiNP_001158239.1, NM_001164767.1
UniGeneiMm.212826

3D structure databases

ProteinModelPortaliD3Z4M6
SMRiD3Z4M6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiD3Z4M6
PRIDEiD3Z4M6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115038; ENSMUSP00000110690; ENSMUSG00000032128
GeneIDi19649
KEGGimmu:19649
UCSCiuc012gqz.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64221
MGIiMGI:1343102 Robo3

Phylogenomic databases

eggNOGiKOG4222 Eukaryota
ENOG410XPQS LUCA
GeneTreeiENSGT00940000155457
HOGENOMiHOG000010267
KOiK06755
OrthoDBi173520at2759
TreeFamiTF351053

Enzyme and pathway databases

ReactomeiR-MMU-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-MMU-9010642 ROBO receptors bind AKAP5

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032128 Expressed in 59 organ(s), highest expression level in optic eminence
ExpressionAtlasiD3Z4M6 baseline and differential
GenevisibleiD3Z4M6 MM

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR032987 Robo3
PANTHERiPTHR44096:SF3 PTHR44096:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 3 hits
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z4M6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z4M6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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