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UniProtKB - D3Z4D9 (D3Z4D9_MOUSE)

Entry version 72 (19 Jan 2022)
Sequence version 2 (19 Feb 2014)
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Protein
Submitted name:

C2 domain-containing protein 3

Gene

C2cd3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
C2 domain-containing protein 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2cd3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2142166, C2cd3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000047248

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		D3Z4D9

PeptideAtlas

More...PeptideAtlasi		D3Z4D9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		333259

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000047248, Expressed in secondary oocyte and 274 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D3Z4D9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 92C2InterPro annotationAdd BLAST92
Domaini152 – 286C2InterPro annotationAdd BLAST135
Domaini367 – 495C2InterPro annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 368DisorderedSequence analysisAdd BLAST50
Regioni567 – 593DisorderedSequence analysisAdd BLAST27
Regioni660 – 687DisorderedSequence analysisAdd BLAST28
Regioni721 – 782DisorderedSequence analysisAdd BLAST62
Regioni800 – 899DisorderedSequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi321 – 341Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi348 – 368Polar residuesSequence analysisAdd BLAST21
Compositional biasi660 – 679Polar residuesSequence analysisAdd BLAST20
Compositional biasi721 – 738Polar residuesSequence analysisAdd BLAST18
Compositional biasi803 – 817Acidic residuesSequence analysisAdd BLAST15
Compositional biasi822 – 854Polar residuesSequence analysisAdd BLAST33

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00510000048072

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010824_0_0_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

D3Z4D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RQTRPVACSF CPEFSHHIEF PCNLVTQHCS GEACFLAELL EFAEIIFAIY 
        60         70         80         90        100
HENTKSVSDI TSIQSCKDYL LGIVKVPTKD LLVKRSGITG WYPVILPEDK 
       110        120        130        140        150
GLPQDLDLMQ KIVGGLELSV SFAHPGDRER VLEAAELLGW SFESIPKDLV 
       160        170        180        190        200
KKEEEVPATV TISTPRLWLP IHCVLLAGHM NIHKNTYCYL RYKLYNQEAF 
       210        220        230        240        250
WTPLRKPKES TNKNQVLITF KASKRAEVTR SQSLLWYFRE EKLEIQVWRA 
       260        270        280        290        300
YGNDNLERPH QTDSWIGSAY VDLSRLGEKS PRTLTISGVY PLFGRNASDL 
       310        320        330        340        350
SGAALRIHVL LSPLSPHTEP ARELDSMDCS SHSESEQHPR KSDALQLSPP 
       360        370        380        390        400
HVLQTSPTST QVHGNSAAAQ VCPAQEGPPE LAGTFAVSIL VERAMHLSLK 
       410        420        430        440        450
GSPLTDRKVS VPSCCVSFAT ATELSPVYTH VVENTDSPIW GFHQQARLSK 
       460        470        480        490        500
ELLLDPHQTL VFKVWHKGDE ERVVGFASVD LSPLLSGFQF ICGWYNITDF 
       510        520        530        540        550
SGECQGQIKV AISPMESLMH LKEERQARRG IDTPGALIPL FSALSFPASA 
       560        570        580        590        600
GCDAFPRPIA RHVEGQLAHT SPKEDGLSSP ARNGAIRSQA ARHEEHVQNI 
       610        620        630        640        650
RRFHESLQHG EAVLTSDEKL TTAPSSSHTS ILTSLRKNLS ELDEIQKYFS 
       660        670        680        690        700
QKLSKPFLPF SSQSSPAVSQ SQESQRDPVA AGTGRQDPEN QCILEKSNHL 
       710        720        730        740        750
VSQVSSLISD LQTLTRGSQA ALTSQQARSR SRAVTTIPDA QGTEAAGEGS 
       760        770        780        790        800
TTLEEPLAGA IEASTDSLPP PVEEPSKGGG MLHESLEQTM PITRVQSIDD 
       810        820        830        840        850
TEVGPDYSDE DYEEDIIEPR TLNEITTVTD RTSPWSSFMS DMSEVLSPQP 
       860        870        880        890 
TEVQREGPSC PPEPFPREEL KVKSSPQKAG SPCPEALSPQ TLLHPSQPS
Length:899
Mass (Da):99,138
Last modified:February 19, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB06C6A65C9AA9628
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q52KB6C2CD3_MOUSE
C2 domain-containing protein 3
C2cd3 Hty
2,323Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z640D3Z640_MOUSE
C2 domain-containing protein 3
C2cd3
1,566Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q526E9Q526_MOUSE
C2 domain-containing protein 3
C2cd3
2,130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXB2V9GXB2_MOUSE
C2 domain-containing protein 3
C2cd3
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH58D6RH58_MOUSE
C2 domain-containing protein 3
C2cd3
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000120196; ENSMUSP00000113728; ENSMUSG00000047248

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiD3Z4D9
ModBaseiSearch...

Proteomic databases

MaxQBiD3Z4D9
PeptideAtlasiD3Z4D9
ProteomicsDBi333259

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48039, 147 antibodies from 19 providers

Genome annotation databases

EnsembliENSMUST00000120196; ENSMUSP00000113728; ENSMUSG00000047248

Organism-specific databases

MGIiMGI:2142166, C2cd3
VEuPathDBiHostDB:ENSMUSG00000047248

Phylogenomic databases

GeneTreeiENSGT00510000048072
HOGENOMiCLU_010824_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C2cd3, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000047248, Expressed in secondary oocyte and 274 other tissues

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
PfamiView protein in Pfam
PF00168, C2, 1 hit
SUPFAMiSSF49562, SSF49562, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z4D9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z4D9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: February 19, 2014
Last modified: January 19, 2022
This is version 72 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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