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Protein
Submitted name:

Ankyrin repeat domain-containing protein 26

Gene

Ankrd26

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin repeat domain-containing protein 26Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankrd26Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917887 Ankrd26

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
D3Z482

PeptideAtlas

More...
PeptideAtlasi
D3Z482

PRoteomics IDEntifications database

More...
PRIDEi
D3Z482

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000007827 Expressed in 229 organ(s), highest expression level in rostral migratory stream

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
D3Z482 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
D3Z482, 36 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D3Z482

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 211ANK_REP_REGIONInterPro annotationAdd BLAST166
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati80 – 112ANKPROSITE-ProRule annotationAdd BLAST33
Repeati113 – 145ANKPROSITE-ProRule annotationAdd BLAST33
Repeati146 – 178ANKPROSITE-ProRule annotationAdd BLAST33
Repeati179 – 211ANKPROSITE-ProRule annotationAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili718 – 759Sequence analysisAdd BLAST42
Coiled coili767 – 787Sequence analysisAdd BLAST21
Coiled coili795 – 843Sequence analysisAdd BLAST49
Coiled coili879 – 906Sequence analysisAdd BLAST28
Coiled coili911 – 938Sequence analysisAdd BLAST28
Coiled coili950 – 1012Sequence analysisAdd BLAST63
Coiled coili1024 – 1058Sequence analysisAdd BLAST35
Coiled coili1066 – 1086Sequence analysisAdd BLAST21
Coiled coili1094 – 1142Sequence analysisAdd BLAST49
Coiled coili1158 – 1178Sequence analysisAdd BLAST21
Coiled coili1214 – 1359Sequence analysisAdd BLAST146
Coiled coili1371 – 1391Sequence analysisAdd BLAST21
Coiled coili1409 – 1443Sequence analysisAdd BLAST35
Coiled coili1495 – 1515Sequence analysisAdd BLAST21
Coiled coili1537 – 1564Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHJ1 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153661

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033957

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHQQFPR

Database of Orthologous Groups

More...
OrthoDBi
305292at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333496

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

D3Z482-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIFGFRSK GPSPLGPSAR PRSNCVGFGR ESASGSHVPR YHIHDKDMGK
60 70 80 90 100
IHKAASVGDV AKVQHILILG KSGVNDRDKK DRTALHLACA YGHPEVVTLL
110 120 130 140 150
VERKCEIDAR DSESSTALIK AVQCQEEECA AILLDHGADP NVMDSSGNTA
160 170 180 190 200
LHYAVYSENT SMAAKLLAHN ANIEAKNKDD LTPMLLAVKE NKQHIVEFLV
210 220 230 240 250
KKKASIHAVD QLGSNRQMFE YDGKRLQRSE NSNPVDNGSE DGSLTRSYNT
260 270 280 290 300
PGPADSWPTS DEEDYNFDNK NVPKINLTEL WTAAQQSRKN QTKCGFEELD
310 320 330 340 350
NGARFDDSDS PSESEDAIEV EPAPSVRVQT LSPSRQSPDP VEGATELAIE
360 370 380 390 400
GEENGTDVIE SASQEQPNHD NLTRADGWHK SNKSEMMSAL GLGEDEDEHS
410 420 430 440 450
PWDSESISES VSLKDVGHFS GTADQTGKRR AHGQIEDVTY IPSCMSGSRS
460 470 480 490 500
FKMAKLEESR NVGLPVAHME APRKYAIMEP TIERRAPVLN KTETVGMTDA
510 520 530 540 550
QTFKSEPESV SREEQTRLSG SEDSQQKVEE KRKYKNNEAE PSGNLYSGAA
560 570 580 590 600
DGGADVKPQS GDTENQQSPR EGSEGRGSGP ALLMKEAKKM ENEKWVSREP
610 620 630 640 650
ARTAMSERTG LPTGGWPQMQ DGSCWSDTDQ SEARPTKKTS SKHNKDSGQT
660 670 680 690 700
AAVDNLDDFT ESSETASEDH ELQGPDSESI LCAIEHLRLE CKDTASLLKI
710 720 730 740 750
RDAVYSYKRL IELKRSHCEL LTGKLKRMEN KYKGLQKEMS ETEEVKSRLE
760 770 780 790 800
HEKVGWEQEL CRLRFALKQE EEKRRSADQL SEKTSEQLRR KGEQCQSEVE
810 820 830 840 850
ARQQLEASLR TLEMELKTVK SHLNQVLEER NETQRQLSRE QNARMLQDGI
860 870 880 890 900
LASHLCKQKE IEMTQKKMTS EVSVSHEKEK DLLHKNQRLQ DEVAVLRLEM
910 920 930 940 950
DTIKSHNQEK EKRYLEDIKI ANEKNDNLQR MVKLNEETFT KTIFQYTGQL
960 970 980 990 1000
NSLKAENTML SSKLDNEKQN KERLETDVES FRSRLASALH DHAEIQTAKR
1010 1020 1030 1040 1050
DLEIAFQRAR DEWFRVKDKM NFDMSNLRDN NEVLSQQLSK TERKLNSLEI
1060 1070 1080 1090 1100
EFHHTKDELR EKTLALKHAQ RDLSQTQCQM KEVEHMFQDE QGKVSKFMGK
1110 1120 1130 1140 1150
QESIEERLAQ LQSENTLLRQ QLDDAANKAE SKDKTIVNIQ DQFQDVLTRF
1160 1170 1180 1190 1200
QAESQRHSLR LEDRNQELVS ECSHLRERLC QYENEKAERE VVVRQLQQEL
1210 1220 1230 1240 1250
ADTLKKQSMS EASLEVSSRY RSNLEEEARD LKKKLGQLRS QLQEARDQHR
1260 1270 1280 1290 1300
EAVHHAEKME DHLQKLELEK SKFEITIKKQ SEEIDQLQEN LSRVNLSEED
1310 1320 1330 1340 1350
KEKLQKLTEL KESLECTVDQ EQKRSSALEK ELAEFKEVLK MTKKELNEYE
1360 1370 1380 1390 1400
NRELNLRQDI KNNHLEMDIP VSTLIKKIDD LTAKLETASS KCLHLGKKNQ
1410 1420 1430 1440 1450
LLQQELLLMR TIQKKCGKLE KNKKQLEQEV VNLRSHMEKN MVEHSQAQQY
1460 1470 1480 1490 1500
AREVEERARQ DLVEKLKQVN LFLQAQAASQ ESLEQLRENS NASVRSQMEL
1510 1520 1530 1540 1550
RIKDLESQLY RMKAQEDFDK IELEKYKQLY QEEFRARKSL SSKLNKTSEK
1560 1570 1580 1590 1600
LEEASSKLLL EEQQNRSLLS TLSTRPVVEC PCVGSFHNSL VFNRTLIPRE
1610 1620 1630 1640 1650
NIVVPTSGLQ PSNKRVEIYL TKMHQELEKS INRELKEATA ELESEFCRVS
1660 1670 1680
PLGSATKASQ DQLSDASQEF IDILKKKYMI C
Length:1,681
Mass (Da):192,226
Last modified:April 20, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8914BBD28D90A89
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q811D2ANR26_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd26 Kiaa1074
1,581Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC036121 Genomic DNA No translation available.
AC140192 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001074581.1, NM_001081112.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.276116

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000112830; ENSMUSP00000108449; ENSMUSG00000007827

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
232339

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:232339

UCSC genome browser

More...
UCSCi
uc009dlr.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036121 Genomic DNA No translation available.
AC140192 Genomic DNA No translation available.
RefSeqiNP_001074581.1, NM_001081112.1
UniGeneiMm.276116

3D structure databases

SMRiD3Z482
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiD3Z482, 36 interactors

Proteomic databases

MaxQBiD3Z482
PeptideAtlasiD3Z482
PRIDEiD3Z482

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112830; ENSMUSP00000108449; ENSMUSG00000007827
GeneIDi232339
KEGGimmu:232339
UCSCiuc009dlr.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22852
MGIiMGI:1917887 Ankrd26

Phylogenomic databases

eggNOGiENOG410IHJ1 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000153661
HOGENOMiHOG000033957
OMAiDHQQFPR
OrthoDBi305292at2759
TreeFamiTF333496

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000007827 Expressed in 229 organ(s), highest expression level in rostral migratory stream
GenevisibleiD3Z482 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR039497 CC144C-like_CC_dom
IPR021885 DUF3496
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF14915 CCDC144C, 1 hit
PF12001 DUF3496, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3Z482_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3Z482
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 20, 2010
Last sequence update: April 20, 2010
Last modified: January 16, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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